{"id":"https://openalex.org/W2065880732","doi":"https://doi.org/10.1016/0014-5793(85)81237-0","title":"Nutrient insulin secretagogues decrease 45Ca2+ efflux from islet cells by a mechanism other than the inhibition of the Na+\u2010Ca2+ countertransport","display_name":"Nutrient insulin secretagogues decrease 45Ca2+ efflux from islet cells by a mechanism other than the inhibition of the Na+\u2010Ca2+ countertransport","publication_year":1985,"publication_date":"1985-07-22","ids":{"openalex":"https://openalex.org/W2065880732","doi":"https://doi.org/10.1016/0014-5793(85)81237-0","mag":"2065880732","pmid":"https://pubmed.ncbi.nlm.nih.gov/3926535"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(85)81237-0","doi":"https://doi.org/10.1016/0014-5793(85)81237-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(85)81237-0","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2885%2981237-0","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2885%2981237-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076977607","display_name":"Jean\u2010Claude Henquin","orcid":"https://orcid.org/0000-0002-4267-4797","observed_orcids":["https://orcid.org/0000-0002-4267-4797"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J.C. Henquin","raw_affiliation_strings":["Unite\u0301 de Diabe\u0301tologie et Nutrition, University of Louvain, Faculty of Medicine, UCL 54.74, B 1200 Brussels, Belgium","Unit\u00e9 de Diab\u00e9tologie et Nutrition, University of Louvain Faculty of Medicine, UCL 54.74, B-1200 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 de Diabe\u0301tologie et Nutrition, University of Louvain, Faculty of Medicine, UCL 54.74, B 1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Unit\u00e9 de Diab\u00e9tologie et Nutrition, University of Louvain Faculty of Medicine, UCL 54.74, B-1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054775332","display_name":"Rosario de Miguel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"R. de Miguel","raw_affiliation_strings":["Unite\u0301 de Diabe\u0301tologie et Nutrition, University of Louvain, Faculty of Medicine, UCL 54.74, B 1200 Brussels, Belgium","Unit\u00e9 de Diab\u00e9tologie et Nutrition, University of Louvain Faculty of Medicine, UCL 54.74, B-1200 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 de Diabe\u0301tologie et Nutrition, University of Louvain, Faculty of Medicine, UCL 54.74, B 1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Unit\u00e9 de Diab\u00e9tologie et Nutrition, University of Louvain Faculty of Medicine, UCL 54.74, B-1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109891108","display_name":"Maria Grazia Garrino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M.G. Garrino","raw_affiliation_strings":["Unite\u0301 de Diabe\u0301tologie et Nutrition, University of Louvain, Faculty of Medicine, UCL 54.74, B 1200 Brussels, Belgium","Unit\u00e9 de Diab\u00e9tologie et Nutrition, University of Louvain Faculty of Medicine, UCL 54.74, B-1200 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 de Diabe\u0301tologie et Nutrition, University of Louvain, Faculty of Medicine, UCL 54.74, B 1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Unit\u00e9 de Diab\u00e9tologie et Nutrition, University of Louvain Faculty of Medicine, UCL 54.74, B-1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111479756","display_name":"Mp. Hermans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M. Hermans","raw_affiliation_strings":["Unite\u0301 de Diabe\u0301tologie et Nutrition, University of Louvain, Faculty of Medicine, UCL 54.74, B 1200 Brussels, Belgium","Unit\u00e9 de Diab\u00e9tologie et Nutrition, University of Louvain Faculty of Medicine, UCL 54.74, B-1200 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 de Diabe\u0301tologie et Nutrition, University of Louvain, Faculty of Medicine, UCL 54.74, B 1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Unit\u00e9 de Diab\u00e9tologie et Nutrition, University of Louvain Faculty of Medicine, UCL 54.74, B-1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050215643","display_name":"Myriam Nenquin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M. Nenquin","raw_affiliation_strings":["Unite\u0301 de Diabe\u0301tologie et Nutrition, University of Louvain, Faculty of Medicine, UCL 54.74, B 1200 Brussels, Belgium","Unit\u00e9 de Diab\u00e9tologie et Nutrition, University of Louvain Faculty of Medicine, UCL 54.74, B-1200 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite\u0301 de Diabe\u0301tologie et Nutrition, University of Louvain, Faculty of Medicine, UCL 54.74, B 1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Unit\u00e9 de Diab\u00e9tologie et Nutrition, University of Louvain Faculty of Medicine, UCL 54.74, B-1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I95674353"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":1.5662,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.81823847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"187","issue":"1","first_page":"177","last_page":"181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7720000147819519},{"id":"https://openalex.org/keywords/calcium-efflux","display_name":"calcium efflux","score":0.9179999828338623},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.9020000100135803},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.8960000276565552},{"id":"https://openalex.org/keywords/sodium-dependence","display_name":"sodium dependence","score":0.5830000042915344},{"id":"https://openalex.org/keywords/choline-salts","display_name":"choline salts","score":0.6499999761581421},{"id":"https://openalex.org/keywords/islet-perifusion","display_name":"islet perifusion","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.8598411083221436},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.600139856338501},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5933405160903931},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.586143970489502},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5695564150810242},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5468475818634033},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.42979955673217773},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3007770776748657},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2813078463077545},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004533","descriptor_name":"Egtazic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007651","descriptor_name":"Keto Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015636","descriptor_name":"Magnesium Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/0014-5793(85)81237-0","doi":"https://doi.org/10.1016/0014-5793(85)81237-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(85)81237-0","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2885%2981237-0","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:3926535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3926535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:55172","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.1/55172","pdf_url":null,"source":{"id":"https://openalex.org/S4306401902","display_name":"Digital Access to Libraries (Universit\u00e9 catholique de Louvain (UCL), l'Universit\u00e9 de Namur (UNamur) and the Universit\u00e9 Saint-Louis (USL-B))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95674353","host_organization_name":"UCLouvain","host_organization_lineage":["https://openalex.org/I95674353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article de p\u00c3\u00a9riodique (Journal article)"}],"best_oa_location":{"id":"doi:10.1016/0014-5793(85)81237-0","doi":"https://doi.org/10.1016/0014-5793(85)81237-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(85)81237-0","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2885%2981237-0","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2065880732.pdf","grobid_xml":"https://content.openalex.org/works/W2065880732.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1506999217","https://openalex.org/W1809343331","https://openalex.org/W1841945620","https://openalex.org/W1983408914","https://openalex.org/W1994924615","https://openalex.org/W2005678050","https://openalex.org/W2017662382","https://openalex.org/W2019876423","https://openalex.org/W2023262252","https://openalex.org/W2040015414","https://openalex.org/W2046615551","https://openalex.org/W2070198103","https://openalex.org/W2070518546","https://openalex.org/W2078470986","https://openalex.org/W2089274815","https://openalex.org/W2090278189","https://openalex.org/W2092720691","https://openalex.org/W2107931331","https://openalex.org/W2114539713","https://openalex.org/W2176847545","https://openalex.org/W2415819391"],"related_works":["https://openalex.org/W7011917643","https://openalex.org/W1506999217","https://openalex.org/W1969865124","https://openalex.org/W2395091103","https://openalex.org/W68536260","https://openalex.org/W2046615551","https://openalex.org/W2019876423","https://openalex.org/W340592189","https://openalex.org/W334609432","https://openalex.org/W1997760561"],"abstract_inverted_index":{"The":[0],"mechanism":[1,106],"whereby":[2],"nutrient":[3,95],"insulin":[4,96],"secretagogues":[5,97],"decrease":[6,98],"45Ca2+":[7,33,63,99],"efflux":[8,34,47,78,100],"from":[9,56,101],"islet":[10,102],"cells":[11,103],"is":[12,91],"controversial.":[13],"It":[14,90],"was":[15,83],"studied":[16],"with":[17,21],"mouse":[18],"islets":[19],"perifused":[20],"Ca2+-free":[22],"solutions.":[23],"In":[24],"the":[25,46,77,109,112,120],"presence":[26],"of":[27,39,74,111,119],"Na+,":[28],"glucose":[29,55,87],"and":[30],"ketoisocaproate":[31],"inhibited":[32,62],"by":[35,49,86,104,116],"about":[36],"50%.":[37],"Substitution":[38],"choline+":[40],"salts":[41,44],"for":[42],"Na+":[43,71,75],"decreased":[45,76],"rate":[48,79],"45%,":[50],"but":[51,65],"did":[52],"not":[53],"prevent":[54],"decreasing":[57],"it":[58,82],"further.":[59],"Ketoisocaproate":[60],"also":[61],"efflux,":[64],"less":[66],"markedly":[67],"than":[68,108],"in":[69,122],"an":[70],"medium.":[72],"Omission":[73],"even":[80],"when":[81],"already":[84],"lowered":[85],"or":[88],"ketoisocaproate.":[89],"thus":[92],"clear":[93],"that":[94],"a":[105],"other":[107],"inhibition":[110],"Na+-Ca2+":[113],"countertransport,":[114],"possibly":[115],"increasing":[117],"sequestration":[118],"ion":[121],"cellular":[123],"organelles.":[124]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}