{"id":"https://openalex.org/W2065877720","doi":"https://doi.org/10.1371/journal.pone.0103615","title":"Host Adaptation of Chlamydia pecorum towards Low Virulence Evident in Co-Evolution of the ompA, incA, and ORF663 Loci","display_name":"Host Adaptation of Chlamydia pecorum towards Low Virulence Evident in Co-Evolution of the ompA, incA, and ORF663 Loci","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2065877720","doi":"https://doi.org/10.1371/journal.pone.0103615","mag":"2065877720","pmid":"https://pubmed.ncbi.nlm.nih.gov/25084532","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4118914"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0103615","doi":"https://doi.org/10.1371/journal.pone.0103615","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0103615","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0103615&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0103615&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081925203","display_name":"Khalil Yousef Mohamad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147048","display_name":"Infectiologie et sant\u00e9 publique","ror":"https://ror.org/0454zjr22","country_code":"FR","type":"facility","lineage":["https://openalex.org/I110017253","https://openalex.org/I4210088668","https://openalex.org/I4210147048"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Khalil Yousef Mohamad","raw_affiliation_strings":["INRA, UR1282, Infectiologie Animale et Sant\u00e9 Publique, Nouzilly, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRA, UR1282, Infectiologie Animale et Sant\u00e9 Publique, Nouzilly, France","institution_ids":["https://openalex.org/I4210147048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066488896","display_name":"Bernhard Kaltenboeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernhard Kaltenboeck","raw_affiliation_strings":["Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, United States of America","institution_ids":["https://openalex.org/I82497590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016336544","display_name":"Kh. Shamsur Rahman","orcid":"https://orcid.org/0000-0001-7243-8501","observed_orcids":["https://orcid.org/0000-0001-7243-8501"]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kh. Shamsur Rahman","raw_affiliation_strings":["Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, United States of America","institution_ids":["https://openalex.org/I82497590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029988752","display_name":"Simone Magnino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116218","display_name":"Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna \"Bruno Ubertini\"","ror":"https://ror.org/02qcq7v36","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210116218"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simone Magnino","raw_affiliation_strings":["Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna \"Bruno Ubertini\", National Reference Laboratory for Animal Chlamydioses, Sezione Diagnostica di Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna \"Bruno Ubertini\", National Reference Laboratory for Animal Chlamydioses, Sezione Diagnostica di Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I4210116218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003173519","display_name":"Konrad Sachse","orcid":"https://orcid.org/0000-0003-1230-1786","observed_orcids":["https://orcid.org/0000-0003-1230-1786"]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Konrad Sachse","raw_affiliation_strings":["Friedrich-Loeffler-Institut Jena, OIE and National Reference Laboratory for Chlamydiosis, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich-Loeffler-Institut Jena, OIE and National Reference Laboratory for Chlamydiosis, Jena, Germany","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068071874","display_name":"Annie Rodolakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147048","display_name":"Infectiologie et sant\u00e9 publique","ror":"https://ror.org/0454zjr22","country_code":"FR","type":"facility","lineage":["https://openalex.org/I110017253","https://openalex.org/I4210088668","https://openalex.org/I4210147048"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Annie Rodolakis","raw_affiliation_strings":["INRA, UR1282, Infectiologie Animale et Sant\u00e9 Publique, Nouzilly, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRA, UR1282, Infectiologie Animale et Sant\u00e9 Publique, Nouzilly, France","institution_ids":["https://openalex.org/I4210147048"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5081925203"],"corresponding_institution_ids":["https://openalex.org/I4210147048"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.478,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.92334975,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"8","first_page":"e103615","last_page":"e103615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlamydia-pecorum","display_name":"Chlamydia pecorum","score":1.0},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.7570000290870667},{"id":"https://openalex.org/keywords/host-adaptation","display_name":"host adaptation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/ompa","display_name":"OmpA","score":0.9589999914169312},{"id":"https://openalex.org/keywords/inca","display_name":"Inca","score":0.984000027179718},{"id":"https://openalex.org/keywords/coevolution","display_name":"coevolution","score":0.8149999976158142},{"id":"https://openalex.org/keywords/ruminants","display_name":"ruminants","score":0.5910000205039978},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.9559999704360962},{"id":"https://openalex.org/keywords/koala","display_name":"Phascolarctos cinereus","score":0.8640000224113464},{"id":"https://openalex.org/keywords/bacterial-typing","display_name":"strain typing","score":0.5720000267028809},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.6570000052452087},{"id":"https://openalex.org/keywords/asymptomatic-infection","display_name":"asymptomatic infection","score":0.503000020980835},{"id":"https://openalex.org/keywords/epidemiological-indicators","display_name":"epidemiological indicators","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.9564370512962341},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8359131813049316},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5099438428878784},{"id":"https://openalex.org/C2776914050","wikidata":"https://www.wikidata.org/wiki/Q19597524","display_name":"Host adaptation","level":4,"score":0.48236268758773804},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.44399189949035645},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4380629360675812},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3720850944519043},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.35621196031570435}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002689","descriptor_name":"Chlamydia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002689","descriptor_name":"Chlamydia","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D002690","descriptor_name":"Chlamydia Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002690","descriptor_name":"Chlamydia Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020080","descriptor_name":"Tandem Repeat Sequences","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048368","descriptor_name":"Phascolarctidae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0103615","doi":"https://doi.org/10.1371/journal.pone.0103615","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0103615","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0103615&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4118914","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4118914","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:25084532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25084532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02636775v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.inrae.fr/hal-02636775","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.plosone.org/","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:ac6f93788ead44e8b74bdd40372a7515","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ac6f93788ead44e8b74bdd40372a7515","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 8, p e103615 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1124975","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Host_Adaptation_of_Chlamydia_pecorum_towards_Low_Virulence_Evident_in_Co_Evolution_of_the_ompA_incA_and_ORF663_Loci/1124975","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0103615","doi":"https://doi.org/10.1371/journal.pone.0103615","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0103615","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0103615&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309904","display_name":"Auburn University","ror":"https://ror.org/02v80fc35"},{"id":"https://openalex.org/F4320323910","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2065877720.pdf","grobid_xml":"https://content.openalex.org/works/W2065877720.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W335653305","https://openalex.org/W1491279263","https://openalex.org/W1819261013","https://openalex.org/W1968655020","https://openalex.org/W1976892036","https://openalex.org/W1978038179","https://openalex.org/W1981220695","https://openalex.org/W1987292348","https://openalex.org/W1991222987","https://openalex.org/W1996894787","https://openalex.org/W2013116915","https://openalex.org/W2028788448","https://openalex.org/W2033820637","https://openalex.org/W2035129390","https://openalex.org/W2038834609","https://openalex.org/W2039681484","https://openalex.org/W2041347575","https://openalex.org/W2053590846","https://openalex.org/W2060023957","https://openalex.org/W2080498768","https://openalex.org/W2088106455","https://openalex.org/W2093475818","https://openalex.org/W2097078034","https://openalex.org/W2099063411","https://openalex.org/W2102989300","https://openalex.org/W2112814753","https://openalex.org/W2120163168","https://openalex.org/W2120772351","https://openalex.org/W2122550614","https://openalex.org/W2124809474","https://openalex.org/W2133656633","https://openalex.org/W2139735227","https://openalex.org/W2142458780","https://openalex.org/W2143694840","https://openalex.org/W2148017997","https://openalex.org/W2152207030","https://openalex.org/W2153926948","https://openalex.org/W2155755205","https://openalex.org/W2395466852","https://openalex.org/W2407793649","https://openalex.org/W2416941267"],"related_works":["https://openalex.org/W4388714043","https://openalex.org/W2155755205","https://openalex.org/W1968655020","https://openalex.org/W7047376770","https://openalex.org/W7143524208","https://openalex.org/W2142458780","https://openalex.org/W2051387273","https://openalex.org/W2153926948","https://openalex.org/W2058511686","https://openalex.org/W2280688822"],"abstract_inverted_index":{"Chlamydia":[0],"(C.)":[1],"pecorum,":[2],"an":[3],"obligate":[4],"intracellular":[5],"bacterium,":[6],"may":[7],"cause":[8],"severe":[9],"diseases":[10],"in":[11,27,111,137],"ruminants,":[12],"swine":[13],"and":[14,31,45,61,139,147,154,164,199],"koalas,":[15],"although":[16],"asymptomatic":[17,49],"infections":[18],"are":[19],"the":[20,28,69,142,183,211],"norm.":[21],"Recently,":[22],"we":[23,52],"identified":[24,195],"genetic":[25,145],"polymorphisms":[26],"ompA,":[29,152,162],"incA":[30,70,113,140],"ORF663":[32,138,155,165],"genes":[33],"that":[34],"potentially":[35],"differentiate":[36],"between":[37,144],"high-virulence":[38],"C.":[39],"pecorum":[40],"isolates":[41,47,167,208],"from":[42,48,168,178],"diseased":[43,179],"animals":[44,170,180],"low-virulence":[46,189],"animals.":[50],"Here,":[51],"expand":[53],"these":[54,214],"findings":[55],"by":[56,188],"including":[57],"additional":[58],"ruminant,":[59],"swine,":[60],"koala":[62],"strains.":[63,190],"Coding":[64],"tandem":[65],"repeats":[66,77],"(CTRs)":[67],"at":[68],"locus":[71],"encoded":[72],"a":[73,105],"variable":[74],"number":[75,107],"of":[76,78,86,108,122,151,161,202,213],"APA":[79],"or":[80,96],"AGA":[81],"amino":[82,109],"acid":[83],"motifs.":[84],"Addition":[85],"any":[87],"non-APA/AGA":[88],"repeat":[89],"motif,":[90],"such":[91],"as":[92,103],"APEVPA,":[93],"APAVPA,":[94],"APE,":[95],"APAPE,":[97],"associated":[98],"with":[99,126],"low":[100,127,157],"virulence":[101,128],"(P<10-4),":[102],"did":[104],"high":[106,120],"acids":[110],"all":[112,206],"CTRs":[114,124],"(P":[115,129],"=":[116,130],"0.0028).":[117],"In":[118],"ORF663,":[119],"numbers":[121],"15-mer":[123],"correlated":[125],"0.0001).":[131],"Correction":[132],"for":[133,216],"ompA":[134],"phylogram":[135],"position":[136],"abolished":[141],"correlation":[143],"changes":[146],"virulence,":[148],"demonstrating":[149,210],"co-evolution":[150],"incA,":[153,163],"towards":[156],"virulence.":[158],"Pairwise":[159],"divergence":[160],"among":[166,175,205],"healthy":[169],"was":[171],"significantly":[172],"higher":[173],"than":[174],"strains":[176,198,204],"isolated":[177],"(P\u226410-5),":[181],"confirming":[182],"longer":[184],"evolutionary":[185],"path":[186],"traversed":[187],"All":[191],"three":[192],"markers":[193,215],"combined":[194],"43":[196],"unique":[197],"4":[200],"pairs":[201],"identical":[203],"57":[207],"tested,":[209],"suitability":[212],"epidemiological":[217],"investigations.":[218]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}