{"id":"https://openalex.org/W2065836980","doi":"https://doi.org/10.1055/s-0030-1263662","title":"Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome","display_name":"Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome","publication_year":2010,"publication_date":"2010-08-01","ids":{"openalex":"https://openalex.org/W2065836980","doi":"https://doi.org/10.1055/s-0030-1263662","mag":"2065836980"},"language":"en","primary_location":{"id":"doi:10.1055/s-0030-1263662","doi":"https://doi.org/10.1055/s-0030-1263662","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0030-1263662","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020113820","display_name":"Christian Alexander Bauer","orcid":"https://orcid.org/0000-0003-1349-0160","observed_orcids":["https://orcid.org/0000-0003-1349-0160"]},"institutions":[{"id":"https://openalex.org/I4210121101","display_name":"M\u00fcnchen Klinik","ror":"https://ror.org/03pfshj32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210121101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C Bauer","raw_affiliation_strings":["Medizinische Klinik Innenstadt, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik Innenstadt, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I4210121101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037139474","display_name":"Peter Duewell","orcid":"https://orcid.org/0000-0003-0836-6448","observed_orcids":["https://orcid.org/0000-0003-0836-6448"]},"institutions":[{"id":"https://openalex.org/I4210121101","display_name":"M\u00fcnchen Klinik","ror":"https://ror.org/03pfshj32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210121101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P D\u00fcwell","raw_affiliation_strings":["Medizinische Klinik Innenstadt, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik Innenstadt, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I4210121101"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C Mayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121101","display_name":"M\u00fcnchen Klinik","ror":"https://ror.org/03pfshj32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210121101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C Mayer","raw_affiliation_strings":["Medizinische Klinik Innenstadt, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik Innenstadt, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I4210121101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108481381","display_name":"HA Lehr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"HA Lehr","raw_affiliation_strings":["Institut Universitaire de Pathologie, Universit\u00e9 de Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Universitaire de Pathologie, Universit\u00e9 de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046186975","display_name":"Katherine A. Fitzgerald","orcid":"https://orcid.org/0000-0003-3175-609X","observed_orcids":["https://orcid.org/0000-0003-3175-609X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Fitzgerald","raw_affiliation_strings":["Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108087342","display_name":"J\u00fcrg Tschopp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J Tschopp","raw_affiliation_strings":["Department of Biochemistry, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036493478","display_name":"Stefan Endres","orcid":"https://orcid.org/0000-0002-4703-537X","observed_orcids":["https://orcid.org/0000-0002-4703-537X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Endres","raw_affiliation_strings":["Abteilung f\u00fcr Klinische Pharmakologie, Medizinische Klinik Innenstadt, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung f\u00fcr Klinische Pharmakologie, Medizinische Klinik Innenstadt, M\u00fcnchen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009349672","display_name":"Eicke Latz","orcid":"https://orcid.org/0000-0003-1488-5666","observed_orcids":["https://orcid.org/0000-0003-1488-5666"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Latz","raw_affiliation_strings":["Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, United States","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002385911","display_name":"Max M. Schnurr","orcid":"https://orcid.org/0000-0001-6538-2474","observed_orcids":["https://orcid.org/0000-0001-6538-2474"]},"institutions":[{"id":"https://openalex.org/I4210121101","display_name":"M\u00fcnchen Klinik","ror":"https://ror.org/03pfshj32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210121101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Schnurr","raw_affiliation_strings":["Medizinische Klinik Innenstadt, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik Innenstadt, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I4210121101"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.26,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.55339137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"48","issue":"08","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.824999988079071},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9070000052452087},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/asc","display_name":"ASC","score":0.628000020980835},{"id":"https://openalex.org/keywords/cathepsin-b","display_name":"cathepsin B","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cathepsin-l","display_name":"cathepsin L","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9100000262260437},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8410000205039978},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.9589850902557373},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8728566765785217},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.7041811943054199},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.6786656379699707},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6020316481590271},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46970292925834656},{"id":"https://openalex.org/C139964883","wikidata":"https://www.wikidata.org/wiki/Q14901964","display_name":"Caspase 1","level":4,"score":0.46830832958221436},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4589049220085144},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29255998134613037},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2796795964241028},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2118816077709198},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09749370813369751}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0030-1263662","doi":"https://doi.org/10.1055/s-0030-1263662","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0030-1263662","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1971869495","https://openalex.org/W4284882930","https://openalex.org/W4282923105","https://openalex.org/W3190897514","https://openalex.org/W2898787183","https://openalex.org/W2127751274","https://openalex.org/W1995721213","https://openalex.org/W2066327704","https://openalex.org/W45063001","https://openalex.org/W4386747341"],"abstract_inverted_index":{"Aims:":[0],"The":[1,232],"proinflammatory":[2,193],"cytokines":[3,30,112,194],"IL-1\u03b2":[4,61,129,135,156],"and":[5,26,91,109,166,168,188],"IL-18":[6],"are":[7,31],"central":[8],"players":[9],"in":[10,51,63,72,89,115,123,130,139,195,227],"the":[11,34,39,45,48,152,217,228,242],"pathogenesis":[12],"of":[13,23,47,74,111,128,176,192,200,208,224,244],"inflammatory":[14],"bowel":[15],"disease":[16,100],"(IBD).":[17],"In":[18],"response":[19,64],"to":[20,65],"a":[21,131,181,205,221,238],"variety":[22],"microbial":[24],"components":[25],"crystalline":[27],"substances,":[28],"both":[29],"processed":[32],"via":[33,151],"caspase-1":[35,150,201],"activating":[36],"multi-protein":[37],"complex,":[38],"NLRP3":[40,49,153,212,218,233],"inflammasome.":[41,154],"Here,":[42],"we":[43],"examined":[44],"role":[46],"inflammasome":[50,219,234],"experimental":[52],"colitis":[53,107,184,230],"induced":[54,88],"by":[55,94],"dextran":[56,66],"sulfate":[57,67],"sodium":[58,68],"(DSS).":[59],"Methods:":[60],"production":[62],"(DSS)":[69],"was":[70,87,103,137,158],"studied":[71],"macrophages":[73,140],"wild-type":[75],"(WT),":[76],"caspase-1\u2013/\u2013,":[77],"NLRP3\u2013/\u2013,":[78],"ASC\u2013/\u2013,":[79],"cathepsin":[80,83,164],"B\u2013/\u2013":[81],"or":[82,144],"L\u2013/\u2013":[84],"mice.":[85],"Colitis":[86],"C57BL/6":[90],"NLRP3\u2013/\u2013":[92,178],"mice":[93,179,187],"oral":[95,174],"DSS":[96,122,148,229],"administration.":[97],"A":[98],"clinical":[99],"activity":[101],"score":[102],"evaluated":[104],"daily.":[105],"Histological":[106],"severity":[108],"expression":[110],"were":[113],"determined":[114],"colonic":[116,196],"tissue.":[117,197],"Results:":[118],"Macrophages":[119],"incubated":[120],"with":[121,202,248],"vitro":[124],"secreted":[125],"high":[126],"levels":[127,191],"caspase-":[132],"1-dependent":[133],"manner.":[134],"secretion":[136,157],"abrogated":[138],"lacking":[141],"NLRP3,":[142],"ASC":[143],"caspase-1,":[145],"indicating":[146],"that":[147],"activates":[149],"Moreover,":[155],"dependent":[159],"on":[160],"phagocytosis,":[161],"lysosomal":[162],"maturation,":[163],"B":[165],"L,":[167],"reactive":[169],"oxygen":[170],"species":[171],"(ROS).":[172],"After":[173],"administration":[175],"DSS,":[177],"developed":[180],"less":[182],"severe":[183],"than":[185],"WT":[186],"produced":[189],"lower":[190],"Pharmacological":[198],"inhibition":[199],"pralnacasan":[203],"achieved":[204],"comparable":[206],"level":[207],"mucosal":[209],"protection":[210],"as":[211,220,237],"deficiency.":[213],"Conclusions:":[214],"We":[215],"identified":[216],"critical":[222],"check-point":[223],"intestinal":[225],"inflammation":[226],"model.":[231],"may":[235],"serve":[236],"novel":[239],"target":[240],"for":[241,246],"development":[243],"therapeutics":[245],"patients":[247],"IBD.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":10},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
