{"id":"https://openalex.org/W2065774348","doi":"https://doi.org/10.1001/archinte.145.9.1725","title":"Streptokinase Therapy of Pulmonary Emboli With Heparin-Associated Thrombocytopenia","display_name":"Streptokinase Therapy of Pulmonary Emboli With Heparin-Associated Thrombocytopenia","publication_year":1985,"publication_date":"1985-09-01","ids":{"openalex":"https://openalex.org/W2065774348","doi":"https://doi.org/10.1001/archinte.145.9.1725","mag":"2065774348","pmid":"https://pubmed.ncbi.nlm.nih.gov/4026502"},"language":"en","primary_location":{"id":"doi:10.1001/archinte.145.9.1725","doi":"https://doi.org/10.1001/archinte.145.9.1725","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinte.145.9.1725","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024634769","display_name":"Jeffrey I. Cohen","orcid":"https://orcid.org/0000-0003-0238-7176","observed_orcids":["https://orcid.org/0000-0003-0238-7176"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J. I. Cohen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5024634769"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1939,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.80650685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"145","issue":"9","first_page":"1725","last_page":"1725"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-embolism","display_name":"pulmonary embolism","score":0.8840000033378601},{"id":"https://openalex.org/keywords/heparin-associated-thrombocytopenia","display_name":"heparin-associated thrombocytopenia","score":0.9570000171661377},{"id":"https://openalex.org/keywords/streptokinase","display_name":"streptokinase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.9150000214576721},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.5730000138282776},{"id":"https://openalex.org/keywords/blood-transfusion-therapy","display_name":"transfusion therapy","score":0.6470000147819519},{"id":"https://openalex.org/keywords/lung-perfusion-defects","display_name":"lung perfusion defects","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2776336681","wikidata":"https://www.wikidata.org/wiki/Q416485","display_name":"Streptokinase","level":3,"score":0.9159635305404663},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9143193364143372},{"id":"https://openalex.org/C2776472838","wikidata":"https://www.wikidata.org/wiki/Q1598365","display_name":"Heparin-induced thrombocytopenia","level":3,"score":0.8592130541801453},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.7089343070983887},{"id":"https://openalex.org/C2776265017","wikidata":"https://www.wikidata.org/wiki/Q220570","display_name":"Pulmonary embolism","level":2,"score":0.5951014757156372},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.5905488729476929},{"id":"https://openalex.org/C2911040393","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin sodium","level":3,"score":0.5847654342651367},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.5582194924354553},{"id":"https://openalex.org/C2779612170","wikidata":"https://www.wikidata.org/wiki/Q474880","display_name":"Argatroban","level":4,"score":0.5084599256515503},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.41777941584587097},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4002501964569092},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36653438210487366},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3620065748691559},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3455957770347595},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.27898597717285156},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.12264564633369446},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.08226278424263},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011655","descriptor_name":"Pulmonary Embolism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011655","descriptor_name":"Pulmonary Embolism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013300","descriptor_name":"Streptokinase","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013300","descriptor_name":"Streptokinase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1001/archinte.145.9.1725","doi":"https://doi.org/10.1001/archinte.145.9.1725","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinte.145.9.1725","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},{"id":"doi:10.1001/archinte.1985.00360090201031","doi":"https://doi.org/10.1001/archinte.1985.00360090201031","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinte.1985.00360090201031","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:4026502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4026502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of internal medicine","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2036274916","https://openalex.org/W2048963722","https://openalex.org/W2076315269","https://openalex.org/W2463321826"],"related_works":["https://openalex.org/W2159851784","https://openalex.org/W2397290832","https://openalex.org/W2008822263","https://openalex.org/W130075085","https://openalex.org/W2011422729","https://openalex.org/W2400595966","https://openalex.org/W1969218939","https://openalex.org/W1967219940","https://openalex.org/W4229613762","https://openalex.org/W2413715473"],"abstract_inverted_index":{"A":[0],"59-year-old":[1],"man":[2],"developed":[3],"pulmonary":[4],"emboli":[5],"with":[6,13,22,45],"heparin-associated":[7,46],"thrombocytopenia.":[8],"He":[9,20],"was":[10],"treated":[11],"simultaneously":[12],"intravenous":[14],"streptokinase":[15],"and":[16,31,48,68],"oral":[17],"warfarin":[18],"sodium.":[19],"responded":[21],"complete":[23],"resolution":[24],"of":[25],"perfusion":[26],"defects":[27],"on":[28],"lung":[29],"scan":[30],"did":[32],"not":[33],"have":[34],"any":[35],"hemorrhagic":[36],"or":[37],"thrombotic":[38],"problems.":[39],"Although":[40],"optimal":[41],"therapy":[42,53],"for":[43,64],"patients":[44],"thrombocytopenia":[47],"thrombosis":[49],"is":[50],"unknown,":[51],"fibrinolytic":[52],"may":[54],"be":[55],"useful":[56],"despite":[57],"thrombocytopenia,":[58],"provided":[59],"appropriate":[60],"resources":[61],"are":[62],"available":[63],"careful":[65],"patient":[66],"monitoring":[67],"transfusion":[69],"therapy.":[70]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}