{"id":"https://openalex.org/W2065760818","doi":"https://doi.org/10.1016/j.etp.2009.03.002","title":"Cytoskeletal modulation and tyrosine phosphorylation of tight junction proteins are associated with mainstream cigarette smoke-induced permeability of airway epithelium","display_name":"Cytoskeletal modulation and tyrosine phosphorylation of tight junction proteins are associated with mainstream cigarette smoke-induced permeability of airway epithelium","publication_year":2009,"publication_date":"2009-04-20","ids":{"openalex":"https://openalex.org/W2065760818","doi":"https://doi.org/10.1016/j.etp.2009.03.002","mag":"2065760818","pmid":"https://pubmed.ncbi.nlm.nih.gov/19376691"},"language":"en","primary_location":{"id":"doi:10.1016/j.etp.2009.03.002","doi":"https://doi.org/10.1016/j.etp.2009.03.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.etp.2009.03.002","pdf_url":null,"source":{"id":"https://openalex.org/S93526581","display_name":"Experimental and Toxicologic Pathology","issn_l":"0940-2993","issn":["0940-2993","1618-1433"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Toxicologic Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110909654","display_name":"Dorian S. Olivera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorian Olivera","raw_affiliation_strings":["Division of Pathophysiology, Lovelace Respiratory Research Institute, 2425 Ridgecrest SE, Albuquerque, NM 87108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathophysiology, Lovelace Respiratory Research Institute, 2425 Ridgecrest SE, Albuquerque, NM 87108, USA","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052422120","display_name":"Cindy Knall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I147853995","display_name":"University of Alaska Anchorage","ror":"https://ror.org/03k3c2t50","country_code":"US","type":"education","lineage":["https://openalex.org/I147853995"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy Knall","raw_affiliation_strings":["WWAMI Biomedical Program, University of Alaska, Anchorage, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WWAMI Biomedical Program, University of Alaska, Anchorage, AL, USA","institution_ids":["https://openalex.org/I147853995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024661130","display_name":"Susan E. Boggs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Boggs","raw_affiliation_strings":["Division of Pathophysiology, Lovelace Respiratory Research Institute, 2425 Ridgecrest SE, Albuquerque, NM 87108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathophysiology, Lovelace Respiratory Research Institute, 2425 Ridgecrest SE, Albuquerque, NM 87108, USA","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110056694","display_name":"JeanClare Seagrave","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"JeanClare Seagrave","raw_affiliation_strings":["Division of Toxicology, Lovelace Respiratory Research Institute, 2425 Ridgecrest, SE, Albuquerque, NM 87108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Toxicology, Lovelace Respiratory Research Institute, 2425 Ridgecrest, SE, Albuquerque, NM 87108, USA","institution_ids":["https://openalex.org/I1305258596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110056694"],"corresponding_institution_ids":["https://openalex.org/I1305258596"],"apc_list":null,"apc_paid":null,"fwci":2.3366,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.85916542,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"62","issue":"2","first_page":"133","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.05950000137090683,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cigarette-smoke","display_name":"cigarette smoke","score":0.949999988079071},{"id":"https://openalex.org/keywords/mainstream-smoke","display_name":"mainstream smoke","score":0.6990000009536743},{"id":"https://openalex.org/keywords/airway-epithelium","display_name":"airway epithelium","score":0.8420000076293945},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.7409999966621399},{"id":"https://openalex.org/keywords/epithelial-permeability","display_name":"epithelial permeability","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.8029999732971191},{"id":"https://openalex.org/keywords/actin-polymerization","display_name":"actin polymerization","score":0.8930000066757202},{"id":"https://openalex.org/keywords/myosin-phosphatase","display_name":"myosin phosphatase","score":0.8669999837875366},{"id":"https://openalex.org/keywords/myosin-light-chain","display_name":"myosin light chain","score":0.9459999799728394},{"id":"https://openalex.org/keywords/rho-kinase","display_name":"Rho kinase","score":0.9620000123977661},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.9290000200271606},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/calu-3-cells","display_name":"Calu-3 cells","score":0.875},{"id":"https://openalex.org/keywords/macromolecular-permeability","display_name":"macromolecule permeability","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.6765919327735901},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6621547937393188},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6207098364830017},{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.6038489937782288},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.5910597443580627},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5172851085662842},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.46317699551582336},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.45314982533454895},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.4399581253528595},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4366668462753296},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.43012234568595886},{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.419299840927124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39226841926574707},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.37711426615715027},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27502208948135376},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.10834258794784546},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012906","descriptor_name":"Smoke","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.etp.2009.03.002","doi":"https://doi.org/10.1016/j.etp.2009.03.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.etp.2009.03.002","pdf_url":null,"source":{"id":"https://openalex.org/S93526581","display_name":"Experimental and Toxicologic Pathology","issn_l":"0940-2993","issn":["0940-2993","1618-1433"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Toxicologic Pathology","raw_type":"journal-article"},{"id":"pmid:19376691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19376691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7587043683","display_name":"New Mexico NIEHS Center","funder_award_id":"P30ES012072","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7940826662","display_name":"Early Biomarkers of Lung cancer by Gene Array Analysis","funder_award_id":"5r03ca091218-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8903540085","display_name":null,"funder_award_id":"R03CA91218","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1953757484","https://openalex.org/W1968099474","https://openalex.org/W1978610529","https://openalex.org/W1984047231","https://openalex.org/W1994930629","https://openalex.org/W1997087774","https://openalex.org/W2015319243","https://openalex.org/W2015551022","https://openalex.org/W2017259440","https://openalex.org/W2020993672","https://openalex.org/W2032295238","https://openalex.org/W2032925493","https://openalex.org/W2040645020","https://openalex.org/W2055881161","https://openalex.org/W2069061599","https://openalex.org/W2086798106","https://openalex.org/W2094385830","https://openalex.org/W2095870712","https://openalex.org/W2098306620","https://openalex.org/W2110953677","https://openalex.org/W2112545191","https://openalex.org/W2116052541","https://openalex.org/W2131200617","https://openalex.org/W2142083272","https://openalex.org/W2144750575","https://openalex.org/W2147091482","https://openalex.org/W2151117730","https://openalex.org/W2161046233","https://openalex.org/W2169358061","https://openalex.org/W2170609639"],"related_works":["https://openalex.org/W2095870712","https://openalex.org/W4404376001","https://openalex.org/W2415032012","https://openalex.org/W2059830823","https://openalex.org/W2721499927","https://openalex.org/W2318051184","https://openalex.org/W2181000927","https://openalex.org/W2333653669","https://openalex.org/W4321019493","https://openalex.org/W1984047231"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}