{"id":"https://openalex.org/W206575601","doi":null,"title":"Chemotherapy-induced peripheral neuropathy.","display_name":"Chemotherapy-induced peripheral neuropathy.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W206575601","mag":"206575601","pmid":"https://pubmed.ncbi.nlm.nih.gov/10975744"},"language":"en","primary_location":{"id":"pmid:10975744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10975744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the peripheral nervous system : JPNS","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113531127","display_name":"Pieter H. E. Hilkens","orcid":"https://orcid.org/0009-0002-2344-9348","observed_orcids":["https://orcid.org/0009-0002-2344-9348"]},"institutions":[{"id":"https://openalex.org/I4210152306","display_name":"Rijnstate Hospital","ror":"https://ror.org/0561z8p38","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210152306"]},{"id":"https://openalex.org/I4405267285","display_name":"Daniel den Hoed Kliniek","ror":"https://ror.org/020rz5h24","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908","https://openalex.org/I4405267285"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P H Hilkens","raw_affiliation_strings":["Department of Neurology, Rijnstate Hospital Arnhem, Dr. Daniel den Hoed Cancer Center Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Rijnstate Hospital Arnhem, Dr. Daniel den Hoed Cancer Center Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I4210152306","https://openalex.org/I4405267285"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010891460","display_name":"Martin J. van den Bent","orcid":"https://orcid.org/0000-0001-5710-5127","observed_orcids":["https://orcid.org/0000-0001-5710-5127"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J ven den Bent","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1926,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.51959882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"2","issue":"4","first_page":"350","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemotherapy-induced-peripheral-neuropathy","display_name":"chemotherapy-induced peripheral neuropathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/axonal-polyneuropathy","display_name":"axonal neuropathy","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":1.0},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":1.0},{"id":"https://openalex.org/keywords/suramin","display_name":"suramin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cumulative-dose","display_name":"cumulative dose","score":0.593999981880188},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/neuroprotective-agents","display_name":"neuroprotective agents","score":0.8149999976158142},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.859000027179718},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neuropathy-pathogenesis","display_name":"neuropathy pathogenesis","score":0.7080000042915344},{"id":"https://openalex.org/keywords/nerve-biopsy","display_name":"nerve biopsy","score":0.6259999871253967},{"id":"https://openalex.org/keywords/neurophysiological-findings","display_name":"neurophysiological findings","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.9099056124687195},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.786526083946228},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.6600396633148193},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6281269788742065},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.570110023021698},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5467591881752014},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.5319075584411621},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.52730393409729},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49297285079956055},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.49226537346839905},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.45649993419647217},{"id":"https://openalex.org/C2779289229","wikidata":"https://www.wikidata.org/wiki/Q17153857","display_name":"Chemotherapy-induced peripheral neuropathy","level":4,"score":0.4234028458595276},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.28365328907966614},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22277674078941345},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.18492355942726135},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.060838669538497925},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:10975744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10975744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the peripheral nervous system : JPNS","raw_type":"Journal Article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/186acc48-a6fa-4897-865c-8c49abcff465","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/186acc48-a6fa-4897-865c-8c49abcff465","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Peripheral Nervous System, 2(4), 350 - 361. Wiley-Blackwell Publishing Ltd","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/186acc48-a6fa-4897-865c-8c49abcff465","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/186acc48-a6fa-4897-865c-8c49abcff465","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hilkens, PHE & van den Bent, M 1997, 'Chemotherapy-induced Peripheral Neuropathy', Journal of the Peripheral Nervous System, vol. 2, no. 4, pp. 350-361.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:206575601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10975744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1807128448","https://openalex.org/W4255729497","https://openalex.org/W165066229","https://openalex.org/W2040848336","https://openalex.org/W2409158047","https://openalex.org/W83622341","https://openalex.org/W1992820423","https://openalex.org/W3110910928","https://openalex.org/W3195835309","https://openalex.org/W2143487217"],"abstract_inverted_index":{"Peripheral":[0],"neurotoxicity":[1,58,92,165],"is":[2,59,93,112],"an":[3,60,94],"important":[4,61,95],"side-effect":[5,98],"of":[6,72,77,84,86,99,105,109,117,127,161],"several":[7,131],"chemotherapeutic":[8],"agents.":[9,129],"These":[10],"agents":[11,88],"may":[12,19,173],"cause":[13],"a":[14,124],"usually":[15],"axonal":[16],"neuropathy,":[17],"which":[18,57],"ultimately":[20],"lead":[21,174],"to":[22,74,157,175],"severe":[23],"and":[24,27,42,50,67,80,96,136],"disabling":[25],"symptoms":[26],"signs.":[28],"We":[29],"describe":[30],"in":[31],"this":[32,172],"review":[33,121],"the":[34,43,53,70,82,106,115,144,159],"pathogenesis,":[35],"clinical":[36,145],"presentation,":[37],"neurophysiologic":[38],"findings,":[39],"nerve":[40,132],"biopsies":[41],"relation":[44],"between":[45],"cumulative":[46],"dosage/dosage":[47],"per":[48],"cycle":[49],"neuropathy":[51],"for":[52,56,114],"cytostatic":[54],"drugs":[55,111,149],"side-effect:":[62],"cisplatin,":[63],"vincristine,":[64],"paclitaxel,":[65],"docetaxel":[66],"suramin.":[68],"With":[69],"development":[71],"strategies":[73],"circumvent":[75],"toxicities":[76],"other":[78],"organs":[79],"with":[81,123],"use":[83],"combinations":[85],"neurotoxic":[87],"such":[89],"as":[90,140],"cisplatin/paclitaxel,":[91],"dose-limiting":[97],"many":[100],"treatment":[101,178],"regimens.":[102,179],"Detailed":[103],"knowledge":[104],"neurologic":[107],"side-effects":[108],"these":[110,148,162],"essential":[113],"management":[116],"their":[118],"neurotoxicity.":[119],"The":[120],"concludes":[122],"short":[125],"discussion":[126],"neuroprotective":[128,142],"Although":[130],"growth":[133],"factors,":[134,143],"gluthatione":[135],"ethiofos":[137],"hold":[138],"promise":[139],"possible":[141],"data":[146],"on":[147],"are":[150,155],"still":[151],"limited.":[152],"New":[153],"trials":[154],"needed":[156],"confirm":[158],"value":[160],"drugs.":[163],"If":[164],"could":[166],"indeed":[167],"be":[168],"prevented":[169],"or":[170],"delayed,":[171],"more":[176],"effective":[177]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}