{"id":"https://openalex.org/W2065745489","doi":"https://doi.org/10.1097/mph.0000000000000282","title":"Safety and Outcomes of Extracorporeal Photopheresis With the Therakos Cellex System for Graft-Versus-Host Disease in Pediatric Patients","display_name":"Safety and Outcomes of Extracorporeal Photopheresis With the Therakos Cellex System for Graft-Versus-Host Disease in Pediatric Patients","publication_year":2014,"publication_date":"2014-11-06","ids":{"openalex":"https://openalex.org/W2065745489","doi":"https://doi.org/10.1097/mph.0000000000000282","mag":"2065745489","pmid":"https://pubmed.ncbi.nlm.nih.gov/25374287"},"language":"en","primary_location":{"id":"doi:10.1097/mph.0000000000000282","doi":"https://doi.org/10.1097/mph.0000000000000282","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mph.0000000000000282","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002390465","display_name":"Vedat Uygun","orcid":"https://orcid.org/0000-0003-3257-7798","observed_orcids":["https://orcid.org/0000-0003-3257-7798"]},"institutions":[{"id":"https://openalex.org/I128277893","display_name":"Bah\u00e7e\u015fehir University","ror":"https://ror.org/00yze4d93","country_code":"TR","type":"education","lineage":["https://openalex.org/I128277893"]},{"id":"https://openalex.org/I197907453","display_name":"Akdeniz University","ror":"https://ror.org/01m59r132","country_code":"TR","type":"education","lineage":["https://openalex.org/I197907453"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Vedat Uygun","raw_affiliation_strings":["*Bah\u00e7e\u015fehir University School of Medicine \u2020Medical Park Antalya Hospital, Pediatric Hematology and Bone Marrow Transplantation Unit \u00a7Department of Pediatric Hematology & Oncology, Akdeniz University School of Medicine, Antalya \u2021Bah\u00e7e\u015fehir University School of Medicine, Medical Park Goztepe Hospital, Pediatric Hematology and Bone Marrow Transplantation Unit, Istanbul, Turkey","Bah\u00e7e\u015fehir University School of Medicine","Medical Park Antalya Hospital, Pediatric Hematology and Bone Marrow Transplantation Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Bah\u00e7e\u015fehir University School of Medicine \u2020Medical Park Antalya Hospital, Pediatric Hematology and Bone Marrow Transplantation Unit \u00a7Department of Pediatric Hematology & Oncology, Akdeniz University School of Medicine, Antalya \u2021Bah\u00e7e\u015fehir University School of Medicine, Medical Park Goztepe Hospital, Pediatric Hematology and Bone Marrow Transplantation Unit, Istanbul, Turkey","institution_ids":["https://openalex.org/I128277893","https://openalex.org/I197907453"]},{"raw_affiliation_string":"Bah\u00e7e\u015fehir University School of Medicine","institution_ids":["https://openalex.org/I128277893"]},{"raw_affiliation_string":"Medical Park Antalya Hospital, Pediatric Hematology and Bone Marrow Transplantation Unit","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001607798","display_name":"Hayriye Dalo\u011flu","orcid":"https://orcid.org/0009-0008-6996-0292","observed_orcids":["https://orcid.org/0009-0008-6996-0292"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hayriye Daloglu","raw_affiliation_strings":["Medical Park Antalya Hospital, Pediatric Hematology and Bone Marrow Transplantation Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Park Antalya Hospital, Pediatric Hematology and Bone Marrow Transplantation Unit","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074049908","display_name":"G\u00fcls\u00fcn Karasu","orcid":"https://orcid.org/0000-0001-5700-5919","observed_orcids":["https://orcid.org/0000-0001-5700-5919"]},"institutions":[{"id":"https://openalex.org/I128277893","display_name":"Bah\u00e7e\u015fehir University","ror":"https://ror.org/00yze4d93","country_code":"TR","type":"education","lineage":["https://openalex.org/I128277893"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Gulsun Karasu","raw_affiliation_strings":["Bah\u00e7e\u015fehir University School of Medicine","Bah\u00e7e\u015fehir University School of Medicine, Medical Park Goztepe Hospital, Pediatric Hematology and Bone Marrow Transplantation Unit, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bah\u00e7e\u015fehir University School of Medicine","institution_ids":["https://openalex.org/I128277893"]},{"raw_affiliation_string":"Bah\u00e7e\u015fehir University School of Medicine, Medical Park Goztepe Hospital, Pediatric Hematology and Bone Marrow Transplantation Unit, Istanbul, Turkey","institution_ids":["https://openalex.org/I128277893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023604710","display_name":"Volkan Hazar","orcid":"https://orcid.org/0000-0002-1407-2334","observed_orcids":["https://orcid.org/0000-0002-1407-2334"]},"institutions":[{"id":"https://openalex.org/I197907453","display_name":"Akdeniz University","ror":"https://ror.org/01m59r132","country_code":"TR","type":"education","lineage":["https://openalex.org/I197907453"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Volkan Hazar","raw_affiliation_strings":["Department of Pediatric Hematology & Oncology, Akdeniz University School of Medicine, Antalya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology & Oncology, Akdeniz University School of Medicine, Antalya","institution_ids":["https://openalex.org/I197907453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111747430","display_name":"Akif Ye\u015filipek","orcid":"https://orcid.org/0000-0002-4514-8637","observed_orcids":["https://orcid.org/0000-0002-4514-8637"]},"institutions":[{"id":"https://openalex.org/I128277893","display_name":"Bah\u00e7e\u015fehir University","ror":"https://ror.org/00yze4d93","country_code":"TR","type":"education","lineage":["https://openalex.org/I128277893"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Akif Ye\u015filipek","raw_affiliation_strings":["Bah\u00e7e\u015fehir University School of Medicine","Medical Park Antalya Hospital, Pediatric Hematology and Bone Marrow Transplantation Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bah\u00e7e\u015fehir University School of Medicine","institution_ids":["https://openalex.org/I128277893"]},{"raw_affiliation_string":"Medical Park Antalya Hospital, Pediatric Hematology and Bone Marrow Transplantation Unit","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002390465","https://openalex.org/A5074049908","https://openalex.org/A5111747430"],"corresponding_institution_ids":["https://openalex.org/I128277893","https://openalex.org/I197907453"],"apc_list":null,"apc_paid":null,"fwci":1.9092,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.86997939,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"37","issue":"3","first_page":"209","last_page":"214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracorporeal-photopheresis","display_name":"extracorporeal photopheresis","score":1.0},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9729999899864197},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.8830000162124634},{"id":"https://openalex.org/keywords/acute-graft-versus-host-disease","display_name":"acute graft-versus-host disease","score":0.9229999780654907},{"id":"https://openalex.org/keywords/chronic-graft-versus-host-disease","display_name":"chronic graft-versus-host disease","score":0.9670000076293945},{"id":"https://openalex.org/keywords/overlap-syndrome","display_name":"overlap syndrome","score":0.9860000014305115},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.8389999866485596},{"id":"https://openalex.org/keywords/skin-involvement","display_name":"skin involvement","score":0.7770000100135803},{"id":"https://openalex.org/keywords/gastrointestinal-involvement","display_name":"gastrointestinal involvement","score":0.9589999914169312},{"id":"https://openalex.org/keywords/liver-involvement","display_name":"liver involvement","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C2909962264","wikidata":"https://www.wikidata.org/wiki/Q774032","display_name":"Extracorporeal Photopheresis","level":4,"score":0.9809344410896301},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9146353602409363},{"id":"https://openalex.org/C2781468836","wikidata":"https://www.wikidata.org/wiki/Q774032","display_name":"Photopheresis","level":3,"score":0.9076436758041382},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.6132279634475708},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5011298656463623},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4985778331756592},{"id":"https://openalex.org/C2779915274","wikidata":"https://www.wikidata.org/wiki/Q1115882","display_name":"Extracorporeal","level":2,"score":0.42375144362449646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.369989275932312},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3428398370742798}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002405","descriptor_name":"Catheterization, Central Venous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012449","descriptor_name":"Safety","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017893","descriptor_name":"Photopheresis","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D017893","descriptor_name":"Photopheresis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/mph.0000000000000282","doi":"https://doi.org/10.1097/mph.0000000000000282","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mph.0000000000000282","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},{"id":"pmid:25374287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25374287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric hematology/oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1491993932","https://openalex.org/W1577231343","https://openalex.org/W1927508910","https://openalex.org/W1974258585","https://openalex.org/W1974724095","https://openalex.org/W1974732979","https://openalex.org/W1977308392","https://openalex.org/W1980924218","https://openalex.org/W1986335519","https://openalex.org/W1993705466","https://openalex.org/W2004307688","https://openalex.org/W2007928850","https://openalex.org/W2012202072","https://openalex.org/W2015224199","https://openalex.org/W2020304926","https://openalex.org/W2024145834","https://openalex.org/W2037015581","https://openalex.org/W2040841640","https://openalex.org/W2043483672","https://openalex.org/W2044533575","https://openalex.org/W2046465273","https://openalex.org/W2057225148","https://openalex.org/W2076326759","https://openalex.org/W2083167331","https://openalex.org/W2087581939","https://openalex.org/W2088904548","https://openalex.org/W2095383631","https://openalex.org/W2117535648","https://openalex.org/W2129128251","https://openalex.org/W2133104010","https://openalex.org/W2157979692","https://openalex.org/W2162729702","https://openalex.org/W2165859652","https://openalex.org/W2166670863","https://openalex.org/W2397869486","https://openalex.org/W2618073389"],"related_works":["https://openalex.org/W1986335519","https://openalex.org/W2936920349","https://openalex.org/W3130159041","https://openalex.org/W2064452196","https://openalex.org/W2004307688","https://openalex.org/W4296616173","https://openalex.org/W4210359431","https://openalex.org/W2140427845","https://openalex.org/W2075926167","https://openalex.org/W3193375281"],"abstract_inverted_index":{"Extracorporeal":[0],"photopheresis":[1,24],"(ECP)":[2],"is":[3,14,164],"a":[4,15,165],"difficult":[5],"procedure":[6],"to":[7,120,145],"perform":[8],"in":[9,38,49,94,102,126,171],"the":[10,26,59,160,174],"pediatric":[11,20],"population.":[12],"This":[13],"retrospective":[16],"review":[17],"of":[18,96,104,117,130,176],"12":[19],"patients":[21,99,107,110,140],"who":[22],"underwent":[23],"with":[25,141,159],"Therakos":[27,161],"Cellex":[28,162],"system":[29,163],"for":[30,61,72,79,86,169],"graft-versus-host":[31],"disease":[32],"(GVHD).":[33],"Acute":[34],"GVHD":[35,46,170],"(aGVHD)":[36],"occurred":[37,48,125],"6":[39,105],"patients,":[40,53],"and":[41,44,51,64,82,101],"overlap":[42],"syndrome":[43],"chronic":[45],"(cGVHD)":[47],"4":[50,103,139],"2":[52,73,77,80],"respectively.":[54],"The":[55],"ECP":[56,135,158],"regimen":[57],"was":[58,92],"same":[60],"all":[62],"aGVHD":[63,98],"cGVHD":[65,106],"patients:":[66],"initially,":[67],"every":[68,76,84],"week":[69],"(2":[70],"sessions/wk)":[71],"months;":[74,81],"next,":[75],"weeks":[78],"finally,":[83],"month":[85],"at":[87,179],"least":[88,180],"1":[89],"year.":[90],"Improvement":[91],"observed":[93],"7":[95],"10":[97],"(70%)":[100],"(66%).":[108],"Eleven":[109],"had":[111],"skin":[112],"involvement":[113,124,143],"before":[114],"ECP;":[115],"9":[116],"them":[118,131],"responded":[119],"treatment":[121,136,167],"(81%).":[122],"Gastrointestinal":[123],"8":[127],"patients;":[128],"5":[129],"experienced":[132],"improvement":[133],"during":[134],"(62%).":[137],"All":[138],"liver":[142],"failed":[144],"respond.":[146],"No":[147],"serious":[148],"adverse":[149],"reactions":[150],"occurred.":[151],"In":[152],"conclusion,":[153],"our":[154],"study":[155],"demonstrates":[156],"that":[157],"safe":[166],"option":[168],"children,":[172],"allowing":[173],"tapering":[175],"immunosuppressants":[177],"by":[178],"half.":[181]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
