{"id":"https://openalex.org/W2065724543","doi":"https://doi.org/10.1177/0269881108091588","title":"A non-inferiority comparison of duloxetine and venlafaxine in the treatment of adult patients with generalized anxiety disorder","display_name":"A non-inferiority comparison of duloxetine and venlafaxine in the treatment of adult patients with generalized anxiety disorder","publication_year":2008,"publication_date":"2008-06-01","ids":{"openalex":"https://openalex.org/W2065724543","doi":"https://doi.org/10.1177/0269881108091588","mag":"2065724543","pmid":"https://pubmed.ncbi.nlm.nih.gov/18635722"},"language":"en","primary_location":{"id":"doi:10.1177/0269881108091588","doi":"https://doi.org/10.1177/0269881108091588","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0269881108091588","pdf_url":null,"source":{"id":"https://openalex.org/S136368880","display_name":"Journal of Psychopharmacology","issn_l":"0269-8811","issn":["0269-8811","1461-7285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068499328","display_name":"Christer Allgulander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"C Allgulander","raw_affiliation_strings":["Department of Clinical Neuroscience, Section of Psychiatry, Karolinska                         Institutet, Stockholm, Sweden,","Department of Clinical Neuroscience, Section of Psychiatry, Karolinska Institutet, Stockholm, Sweden. christer.allgulander@ki.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Section of Psychiatry, Karolinska                         Institutet, Stockholm, Sweden,","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Section of Psychiatry, Karolinska Institutet, Stockholm, Sweden. christer.allgulander@ki.se","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016082897","display_name":"David Nutt","orcid":"https://orcid.org/0000-0002-1286-1401","observed_orcids":["https://orcid.org/0000-0002-1286-1401"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D Nutt","raw_affiliation_strings":["Psychopharmacology Unit, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychopharmacology Unit, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113644572","display_name":"Michael J. Detke","orcid":"https://orcid.org/0000-0002-2195-8651","observed_orcids":["https://orcid.org/0000-0002-2195-8651"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Detke","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA, Department of Psychiatry, McLean Hospital/Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA, Department of Psychiatry, McLean Hospital/Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I168537998","https://openalex.org/I2801148111","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083162003","display_name":"J. Erickson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]},{"id":"https://openalex.org/I4405272581","display_name":"Orexigen Therapeutics (United States)","ror":"https://ror.org/04cnvsy93","country_code":"US","type":"company","lineage":["https://openalex.org/I4405272581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Erickson","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA, Department of Psychiatry, McLean Hospital/Harvard Medical School, Boston, MA, USA, Orexigen Therapeutics, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA, Department of Psychiatry, McLean Hospital/Harvard Medical School, Boston, MA, USA, Orexigen Therapeutics, San Diego, CA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I168537998","https://openalex.org/I2801148111","https://openalex.org/I4405272581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025291909","display_name":"Marcus Spann","orcid":"https://orcid.org/0000-0002-4909-4226","observed_orcids":["https://orcid.org/0000-0002-4909-4226"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Spann","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102916328","display_name":"Daniel J. Walker","orcid":"https://orcid.org/0000-0002-9369-6953","observed_orcids":["https://orcid.org/0000-0002-9369-6953"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Walker","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000881645","display_name":"Susan G. Ball","orcid":"https://orcid.org/0000-0001-9866-6721","observed_orcids":["https://orcid.org/0000-0001-9866-6721"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SG Ball","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I168537998","https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011296527","display_name":"JM Russell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JM Russell","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I168537998"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":6.7106,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.95908893,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"4","first_page":"417","last_page":"425"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.06159999966621399,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duloxetine","display_name":"duloxetine","score":0.8080000281333923},{"id":"https://openalex.org/keywords/venlafaxine-extended-release","display_name":"venlafaxine extended release","score":0.9760000109672546},{"id":"https://openalex.org/keywords/generalized-anxiety-disorder","display_name":"generalized anxiety disorder","score":1.0},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.9679999947547913},{"id":"https://openalex.org/keywords/antidepressant-comparison","display_name":"antidepressant comparison","score":0.6290000081062317},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6790000200271606},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.7710000276565552},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8849999904632568},{"id":"https://openalex.org/keywords/hamilton-anxiety-rating-scale","display_name":"Hamilton Anxiety Rating Scale","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2780764818","wikidata":"https://www.wikidata.org/wiki/Q411932","display_name":"Duloxetine","level":3,"score":0.9604223966598511},{"id":"https://openalex.org/C2776466888","wikidata":"https://www.wikidata.org/wiki/Q898407","display_name":"Venlafaxine","level":4,"score":0.7842235565185547},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7125606536865234},{"id":"https://openalex.org/C2910564767","wikidata":"https://www.wikidata.org/wiki/Q411932","display_name":"Duloxetine Hydrochloride","level":4,"score":0.6398342847824097},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6343969106674194},{"id":"https://openalex.org/C2779911313","wikidata":"https://www.wikidata.org/wiki/Q845224","display_name":"Generalized anxiety disorder","level":3,"score":0.6048849821090698},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5510591864585876},{"id":"https://openalex.org/C2909532165","wikidata":"https://www.wikidata.org/wiki/Q898407","display_name":"Venlafaxine Hydrochloride","level":5,"score":0.5018393993377686},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.5009078979492188},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4542674124240875},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.41945844888687134},{"id":"https://openalex.org/C2777696351","wikidata":"https://www.wikidata.org/wiki/Q5644839","display_name":"Hamilton Anxiety Rating Scale","level":3,"score":0.41585278511047363},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.39108705520629883},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3615415096282959},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3115297555923462},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.17182296514511108},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.13671371340751648},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068736","descriptor_name":"Duloxetine Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069470","descriptor_name":"Venlafaxine Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003511","descriptor_name":"Cyclohexanols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003511","descriptor_name":"Cyclohexanols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/0269881108091588","doi":"https://doi.org/10.1177/0269881108091588","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0269881108091588","pdf_url":null,"source":{"id":"https://openalex.org/S136368880","display_name":"Journal of Psychopharmacology","issn_l":"0269-8811","issn":["0269-8811","1461-7285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:18635722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18635722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of psychopharmacology (Oxford, England)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W30380521","https://openalex.org/W1803107438","https://openalex.org/W1970833744","https://openalex.org/W1982499183","https://openalex.org/W1987414908","https://openalex.org/W1995051494","https://openalex.org/W1996039326","https://openalex.org/W2025707558","https://openalex.org/W2027248760","https://openalex.org/W2048519309","https://openalex.org/W2070555238","https://openalex.org/W2084977025","https://openalex.org/W2135917232","https://openalex.org/W2151852296","https://openalex.org/W2160070901","https://openalex.org/W2166281097","https://openalex.org/W2186657631","https://openalex.org/W2994350641","https://openalex.org/W3090293687","https://openalex.org/W3171418018","https://openalex.org/W4254565755","https://openalex.org/W4255396331","https://openalex.org/W4297952226"],"related_works":["https://openalex.org/W2048519309","https://openalex.org/W2104134406","https://openalex.org/W2031937662","https://openalex.org/W2105710387","https://openalex.org/W2792650294","https://openalex.org/W2379813354","https://openalex.org/W2040179400","https://openalex.org/W2348857241","https://openalex.org/W2032747942","https://openalex.org/W2015426052"],"abstract_inverted_index":{"The":[0,27],"present":[1],"study":[2],"is":[3],"a":[4,31,213],"non-inferiority":[5,28,74,118,210],"comparison":[6],"of":[7,20,47,59,173,226],"duloxetine":[8,48,102,127,179],"60-120":[9,49,201],"mg/day":[10,16,50,202,222],"and":[11,51,69,145,167,186,206,211],"venlafaxine":[12,52,106,132,187,219],"extended-release":[13],"(XR)":[14],"75-225":[15,53,221],"for":[17,56,72,178,209,223],"the":[18,57,94,117,120,224],"treatment":[19,58,225],"adults":[21,227],"with":[22,126,197,218,228],"generalized":[23],"anxiety":[24],"disorder":[25],"(GAD).":[26],"test":[29],"was":[30,78,175],"prespecified":[32],"plan":[33],"to":[34,101],"pool":[35],"data":[36],"from":[37],"two":[38],"nearly":[39],"identical":[40],"10-week,":[41],"multicentre,":[42],"randomized,":[43],"placebo-controlled,":[44],"double-blind":[45],"studies":[46],"mg/":[54],"day":[55],"GAD.":[60,229],"An":[61],"independent":[62],"expert":[63],"consensus":[64],"panel":[65],"provided":[66],"six":[67],"statistical":[68,205],"clinical":[70,207],"criteria":[71,208],"determining":[73],"between":[75],"treatments.":[76],"Response":[77,162],"defined":[79],"as":[80],">":[81],"or":[82,111,131,157,183,192],"=50%":[83],"reduction":[84],"in":[85],"Hamilton":[86],"Anxiety":[87],"Rating":[88],"Scale":[89],"(HAMA)":[90],"total":[91],"score.":[92],"In":[93],"pooled":[95],"sample,":[96],"patients":[97,122,150],"were":[98,124,143,164],"randomly":[99],"assigned":[100],"(n":[103,108,113,128,134,151],"=":[104,109,114,129,135,152,158,184,193],"320),":[105],"XR":[107,133,188,220],"333)":[110],"placebo":[112,198],"331).":[115],"For":[116],"analysis,":[119],"per-protocol":[121],"who":[123],"treated":[125],"239)":[130],"262)":[136],"improved":[137],"significantly":[138,176],"more":[139],"(mean":[140],"HAMA":[141],"reductions":[142],"-15.4":[144],"-15.2,":[146],"respectively)":[147],"than":[148],"placebo-treated":[149],"267;":[153],"-11.6,":[154],"P":[155,181,190],"<":[156,182,191],"0.001,":[159],"both":[160],"comparisons).":[161],"rates":[163],"56%,":[165],"58%":[166],"40%,":[168],"respectively.":[169],"Discontinuation":[170],"rate":[171],"because":[172],"AEs":[174],"higher":[177],"(13.4%,":[180],"0.001)":[185],"(11.4%,":[189],"0.01)":[194],"groups":[195],"compared":[196,217],"(5.4%).":[199],"Duloxetine":[200],"met":[203],"all":[204],"exhibited":[212],"similar":[214],"tolerability":[215],"profile":[216]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}