{"id":"https://openalex.org/W2065720448","doi":"https://doi.org/10.3892/ijo.2012.1672","title":"BML-275, an AMPK inhibitor, induces DNA damage, G2/M arrest and apoptosis in human pancreatic cancer cells","display_name":"BML-275, an AMPK inhibitor, induces DNA damage, G2/M arrest and apoptosis in human pancreatic cancer cells","publication_year":2012,"publication_date":"2012-10-17","ids":{"openalex":"https://openalex.org/W2065720448","doi":"https://doi.org/10.3892/ijo.2012.1672","mag":"2065720448","pmid":"https://pubmed.ncbi.nlm.nih.gov/23076030","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3583630"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.2012.1672","doi":"https://doi.org/10.3892/ijo.2012.1672","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2012.1672","pdf_url":"http://www.spandidos-publications.com/10.3892/ijo.2012.1672/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/ijo.2012.1672/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019799355","display_name":"Hong\u2010Quan Duong","orcid":"https://orcid.org/0000-0003-1793-9826","observed_orcids":["https://orcid.org/0000-0003-1793-9826"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HONG-QUAN DUONG","raw_affiliation_strings":["Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084285685","display_name":"Jae Seok Hwang","orcid":"https://orcid.org/0000-0002-1510-3534","observed_orcids":["https://orcid.org/0000-0002-1510-3534"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JAE SEOK HWANG","raw_affiliation_strings":["Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052099934","display_name":"Hee Jeong Kim","orcid":"https://orcid.org/0000-0002-4509-953X","observed_orcids":["https://orcid.org/0000-0002-4509-953X","https://orcid.org/0009-0004-2294-9206","https://orcid.org/0000-0002-1343-8138"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HEE JEONG KIM","raw_affiliation_strings":["Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057283425","display_name":"Yeon\u2010Sun Seong","orcid":"https://orcid.org/0000-0002-4743-8048","observed_orcids":["https://orcid.org/0000-0002-4743-8048"]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"YEON-SUN SEONG","raw_affiliation_strings":["WCU Research Center of Nanobiomedical Science, Dankook University, Cheonan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WCU Research Center of Nanobiomedical Science, Dankook University, Cheonan, Republic of Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110693758","display_name":"Insoo Bae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"INSOO BAE","raw_affiliation_strings":["Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593","https://openalex.org/I4390039356"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5057283425","https://openalex.org/A5110693758"],"corresponding_institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593","https://openalex.org/I4390039356","https://openalex.org/I89015989"],"apc_list":null,"apc_paid":null,"fwci":0.6299,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.6280478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"41","issue":"6","first_page":"2227","last_page":"2236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/compound-c","display_name":"compound C","score":0.9539999961853027},{"id":"https://openalex.org/keywords/ampk-inhibition","display_name":"AMPK inhibition","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9509999752044678},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.75},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.699999988079071},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9480000138282776},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":1.0},{"id":"https://openalex.org/keywords/ampkalpha","display_name":"AMPK\u03b1","score":0.8500000238418579},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7630000114440918},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.7275060415267944},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6670000553131104},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6058860421180725},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5916036367416382},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5732265710830688},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5484951734542847},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.5377690196037292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5168219208717346},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5044218301773071},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5026373863220215},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4665987491607666},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.4459538757801056},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41724318265914917},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3725665211677551},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3043198585510254},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27788710594177246},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.23923376202583313},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.15618392825126648},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11906152963638306},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.05985727906227112},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059565","descriptor_name":"G2 Phase Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059566","descriptor_name":"M Phase Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3892/ijo.2012.1672","doi":"https://doi.org/10.3892/ijo.2012.1672","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2012.1672","pdf_url":"http://www.spandidos-publications.com/10.3892/ijo.2012.1672/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2587692","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3583630","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3583630","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3583630","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Oncol","raw_type":"Text"},{"id":"pmid:23076030","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23076030","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"},{"id":"pmh:oai:kumel.medlib.dsmc.or.kr:2015.oak/35964","doi":null,"is_oa":true,"landing_page_url":"http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35964","pdf_url":null,"source":{"id":"https://openalex.org/S4377196386","display_name":"KUMeL Repository (Keimyung University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52010207","host_organization_name":"Keimyung University","host_organization_lineage":["https://openalex.org/I52010207"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.3892/ijo.2012.1672","doi":"https://doi.org/10.3892/ijo.2012.1672","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2012.1672","pdf_url":"http://www.spandidos-publications.com/10.3892/ijo.2012.1672/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1561916700","display_name":null,"funder_award_id":"P30CA051008","funder_id":"https://openalex.org/F4320310223","funder_display_name":"Georgetown University"},{"id":"https://openalex.org/G3922794474","display_name":null,"funder_award_id":"R31-10069","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G8348209452","display_name":"Nrf2 a new therapeutic target for human pancreatic ductal adenocarcinoma.","funder_award_id":"R03CA152530","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8934995667","display_name":null,"funder_award_id":"R31-10069","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G9000862544","display_name":"Georgetown University Lombardi Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA051008","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310223","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2065720448.pdf","grobid_xml":"https://content.openalex.org/works/W2065720448.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1233353675","https://openalex.org/W1526987695","https://openalex.org/W1544512904","https://openalex.org/W1565979608","https://openalex.org/W1576811559","https://openalex.org/W1912697127","https://openalex.org/W1967052208","https://openalex.org/W1967880683","https://openalex.org/W1970205234","https://openalex.org/W1972779889","https://openalex.org/W1973892737","https://openalex.org/W1976650605","https://openalex.org/W1980356545","https://openalex.org/W1982085282","https://openalex.org/W1984525744","https://openalex.org/W1985264467","https://openalex.org/W1987080455","https://openalex.org/W1990246155","https://openalex.org/W1999866626","https://openalex.org/W2000237223","https://openalex.org/W2027442494","https://openalex.org/W2037426867","https://openalex.org/W2039259411","https://openalex.org/W2041893091","https://openalex.org/W2042571375","https://openalex.org/W2042657387","https://openalex.org/W2051171548","https://openalex.org/W2056225291","https://openalex.org/W2061126081","https://openalex.org/W2065910656","https://openalex.org/W2067979493","https://openalex.org/W2072270661","https://openalex.org/W2072362263","https://openalex.org/W2077813812","https://openalex.org/W2078291117","https://openalex.org/W2079795968","https://openalex.org/W2085262142","https://openalex.org/W2085516015","https://openalex.org/W2086997734","https://openalex.org/W2095454212","https://openalex.org/W2098947405","https://openalex.org/W2110223248","https://openalex.org/W2114147584","https://openalex.org/W2114825009","https://openalex.org/W2123556516","https://openalex.org/W2124037827","https://openalex.org/W2135424721","https://openalex.org/W2137642531","https://openalex.org/W2140662194","https://openalex.org/W2144626362","https://openalex.org/W2147594695","https://openalex.org/W2149785020","https://openalex.org/W2158734599","https://openalex.org/W2161735692","https://openalex.org/W2271708163","https://openalex.org/W2407479275","https://openalex.org/W6631481655"],"related_works":["https://openalex.org/W2145869398","https://openalex.org/W2049693797","https://openalex.org/W2792073784","https://openalex.org/W4382751971","https://openalex.org/W2947070210","https://openalex.org/W2998023201","https://openalex.org/W1655218945","https://openalex.org/W3206026485","https://openalex.org/W2789498550","https://openalex.org/W1995318661"],"abstract_inverted_index":{"Adenosine":[0],"monophosphate-activated":[1],"protein":[2],"kinase":[3],"(AMPK)":[4],"is":[5,25],"a":[6,30,215],"principal":[7],"intracellular":[8,107,171],"energy":[9,13,17],"sensor":[10],"which":[11],"regulates":[12],"producing":[14],"pathways":[15,19],"and":[16,44,97,119,147,176,201,209],"requiring":[18],"when":[20],"the":[21,49,53,65,83,104,128,142,153,168,183,206],"cellular":[22],"AMP/ATP":[23],"ratio":[24],"altered.":[26],"BML-275":[27,58,68,81,101,122,190],"(compound":[28],"C),":[29],"well-known":[31],"inhibitor":[32],"of":[33,86,106,115,133,144,155,165,170,205,218],"AMPK,":[34,219],"has":[35],"been":[36],"found":[37],"to":[38,151],"induce":[39],"apoptosis":[40,177,202],"in":[41,59,75,127],"myeloma,":[42],"glioma":[43],"prostate":[45],"cancer":[46,60,78,90],"cells.":[47],"However,":[48],"mechanisms":[50],"responsible":[51],"for":[52,71,228],"selective":[54],"apoptotic":[55],"effect(s)":[56,74],"by":[57,113,136,158,195,210],"cells":[61],"remain":[62],"unknown.":[63],"In":[64,99],"present":[66],"study,":[67],"was":[69],"investigated":[70],"its":[72,192,221],"antitumor":[73,193,226],"human":[76,88],"pancreatic":[77,89,229],"cell":[79,84,91,124,179],"lines.":[80],"inhibited":[82],"proliferation":[85],"4":[87],"lines":[92],"(MIA":[93],"PaCa-2,":[94],"Panc-1,":[95],"Colo-357":[96],"AsPC-1).":[98],"addition,":[100],"significantly":[102,140],"increased":[103,167],"generation":[105,135,169],"reactive":[108],"oxygen":[109],"species":[110],"(ROS),":[111],"followed":[112],"induction":[114,143,154],"DNA":[116,145,173,199],"damage":[117,146,174,200],"signaling":[118,175],"apoptosis.":[120],"Furthermore,":[121],"induced":[123],"cycle":[125,180],"arrest":[126,157,181,213],"G2/M":[129,156,184,212],"phase.":[130,185],"The":[131],"inhibition":[132,204],"ROS":[134,197],"N-acetyl":[137],"cysteine":[138],"(NAC)":[139],"prevented":[141],"apoptosis,":[148],"but":[149],"failed":[150],"prevent":[152],"BML-275.":[159],"Small":[160],"interfering":[161],"RNA":[162],"(siRNA)-mediated":[163],"knockdown":[164],"AMPK\u03b1":[166],"ROS,":[172],"without":[178],"at":[182],"These":[186],"findings":[187],"suggest":[188],"that":[189],"exerts":[191],"effects":[194],"inducing":[196,211],"generation,":[198],"via":[203,214],"AMPK":[207],"pathway":[208,216],"independent":[217],"implicating":[220],"potential":[222],"application":[223],"as":[224],"an":[225],"agent":[227],"cancer.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}