{"id":"https://openalex.org/W2065718554","doi":"https://doi.org/10.1172/jci109836","title":"Diamine oxidase (histaminase). A circulating marker for rat intestinal mucosal maturation and integrity.","display_name":"Diamine oxidase (histaminase). A circulating marker for rat intestinal mucosal maturation and integrity.","publication_year":1980,"publication_date":"1980-07-01","ids":{"openalex":"https://openalex.org/W2065718554","doi":"https://doi.org/10.1172/jci109836","mag":"2065718554","pmid":"https://pubmed.ncbi.nlm.nih.gov/6772669","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/371506"},"language":"en","primary_location":{"id":"doi:10.1172/jci109836","doi":"https://doi.org/10.1172/jci109836","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci109836","pdf_url":"http://www.jci.org/articles/view/109836/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/109836/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108373053","display_name":"G D Luk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G D Luk","raw_affiliation_strings":["Departments of Medicine and Oncology , Johns Hopkins University School of Medicine , Johns Hopkins Hospital , Baltimore , Maryland 21205","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Oncology , Johns Hopkins University School of Medicine , Johns Hopkins Hospital , Baltimore , Maryland 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109140138","display_name":"T. M. Bayless","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T M Bayless","raw_affiliation_strings":["Departments of Medicine and Oncology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Oncology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058612163","display_name":"Stephen B. Baylin","orcid":"https://orcid.org/0000-0003-3697-3798","observed_orcids":["https://orcid.org/0000-0003-3697-3798"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S B Baylin","raw_affiliation_strings":["Departments of Medicine and Oncology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Oncology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":2.1375,"has_fulltext":true,"cited_by_count":250,"citation_normalized_percentile":{"value":0.87549216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"66","issue":"1","first_page":"66","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.058400001376867294,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.04809999838471413,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diamine-oxidase","display_name":"diamine oxidase","score":0.996999979019165},{"id":"https://openalex.org/keywords/intestinal-mucosal-integrity","display_name":"intestinal mucosal integrity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/small-intestine-development","display_name":"small intestine development","score":0.6579999923706055},{"id":"https://openalex.org/keywords/neonatal-rats","display_name":"neonatal rats","score":0.6859999895095825},{"id":"https://openalex.org/keywords/intestinal-injury","display_name":"intestinal injury","score":0.4650000035762787},{"id":"https://openalex.org/keywords/lactase","display_name":"lactase","score":0.6790000200271606},{"id":"https://openalex.org/keywords/maltase","display_name":"maltase","score":0.921999990940094},{"id":"https://openalex.org/keywords/sucrase","display_name":"sucrase","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2779053737","wikidata":"https://www.wikidata.org/wiki/Q414006","display_name":"Diamine oxidase","level":3,"score":0.9873143434524536},{"id":"https://openalex.org/C2776039999","wikidata":"https://www.wikidata.org/wiki/Q2138267","display_name":"Sucrase","level":3,"score":0.6877856254577637},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6647039651870728},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6566489934921265},{"id":"https://openalex.org/C2778649499","wikidata":"https://www.wikidata.org/wiki/Q416589","display_name":"Maltase","level":3,"score":0.6551912426948547},{"id":"https://openalex.org/C2778974006","wikidata":"https://www.wikidata.org/wiki/Q379764","display_name":"Lactase","level":3,"score":0.5774641633033752},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.5683783888816833},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.565101146697998},{"id":"https://openalex.org/C2779183435","wikidata":"https://www.wikidata.org/wiki/Q3313854","display_name":"Amine oxidase (copper-containing)","level":4,"score":0.5562512874603271},{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.5071887969970703},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.4923444986343384},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4764276444911957},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.4499342739582062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.418140172958374},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3723590075969696},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.32750657200813293},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.295644611120224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23778989911079407}],"mesh":[{"descriptor_ui":"D000520","descriptor_name":"alpha-Glucosidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006631","descriptor_name":"Amine Oxidase (Copper-Containing)","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006631","descriptor_name":"Amine Oxidase (Copper-Containing)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009997","descriptor_name":"Osmotic Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013431","descriptor_name":"Sulfates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci109836","doi":"https://doi.org/10.1172/jci109836","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci109836","pdf_url":"http://www.jci.org/articles/view/109836/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:371506","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/371506","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:6772669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6772669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1172/jci109836","doi":"https://doi.org/10.1172/jci109836","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci109836","pdf_url":"http://www.jci.org/articles/view/109836/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2065718554.pdf","grobid_xml":"https://content.openalex.org/works/W2065718554.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1435427137","https://openalex.org/W1775749144","https://openalex.org/W1970775871","https://openalex.org/W2000505146","https://openalex.org/W2015406374","https://openalex.org/W2029081094","https://openalex.org/W2055436487","https://openalex.org/W2060013283","https://openalex.org/W2061742546","https://openalex.org/W2071041178","https://openalex.org/W2081226136","https://openalex.org/W2085316635","https://openalex.org/W2085969488","https://openalex.org/W2091249772","https://openalex.org/W2119616560","https://openalex.org/W2271445967","https://openalex.org/W2410423297","https://openalex.org/W2418076444","https://openalex.org/W4299796191"],"related_works":["https://openalex.org/W2020146381","https://openalex.org/W2162673292","https://openalex.org/W2064105138","https://openalex.org/W1988469124","https://openalex.org/W2034058635","https://openalex.org/W2007484365","https://openalex.org/W1837892416","https://openalex.org/W2342205909","https://openalex.org/W2413095059","https://openalex.org/W2055436487"],"abstract_inverted_index":{"Diamine":[0,79,147,239],"oxidase":[1,29,80,117,148,216,225,240],"(histaminase)":[2],"is":[3,242],"an":[4],"enzyme":[5,199],"found":[6],"in":[7,10,42,55,81,119,150,197,222,252],"high":[8],"concentrations":[9],"the":[11,33,37,43,47,56,82,108,198,227],"intestinal":[12,122,172,246],"mucosa":[13,38],"of":[14,27,36,49,111,158,229,261],"humans":[15],"and":[16,24,46,66,99,113,140,162,208,210,213,264],"other":[17],"mammalian":[18],"species.":[19],"We":[20],"investigated":[21],"whether":[22],"plasma":[23,214,223],"mucosal":[25,50,160,190,212,230,247,262],"levels":[26,123,204,218,255],"diamine":[28,116,215,224],"activity":[30,149,217,241],"reflect":[31],"both":[32],"maturational":[34],"status":[35],"during":[39,52],"its":[40,53],"development":[41],"newborn":[44],"rate":[45],"degree":[48,228],"damage":[51,184,231],"injury":[54],"adult":[57,104,145],"rat.":[58],"Litter":[59],"mates":[60],"were":[61,174],"reared":[62],"under":[63],"identical":[64],"conditions":[65],"killed":[67],"at":[68,87,96,102,137,143],"different":[69],"ages":[70],"from":[71],"day":[72,75],"0":[73],"to":[74,107,181,185,250],"40":[76],"after":[77],"birth.":[78],"small":[83],"intestine":[84],"was":[85,154,193],"low":[86],"birth,":[88],"increased":[89],"gradually":[90],"with":[91,121,168,176],"age,":[92],"reached":[93,134],"a":[94,135,194,259],"peak":[95,136],"22":[97],"d,":[98,139],"then":[100,141,206],"remained":[101,142],"normal":[103,144],"levels,":[105],"similar":[106],"developmental":[109],"patterns":[110],"maltase":[112,207],"sucrase.":[114],"Plasma":[115],"rose":[118],"parallel":[120],"(n":[124,232],"=":[125,128,233],"500,":[126],"r":[127],"0.84,":[129],"P":[130,235],"less":[131,155,236],"than":[132,156,237],"0.001),":[133],"24":[138],"levels.":[146],"15":[151],"nonintestinal":[152,164],"tissues":[153],"5%":[157],"ileal":[159],"activity,":[161],"no":[163],"activities":[165,200],"showed":[166],"increase":[167],"age.":[169],"Adult":[170],"rat":[171],"loops":[173],"perfused":[175],"hyperosmolar":[177],"sodium":[178],"sulfate":[179],"solutions":[180],"produce":[182],"selective":[183],"villus":[186],"mucosa.":[187],"With":[188],"increasing":[189],"damage,":[191],"there":[192],"progressive":[195],"decrease":[196,221],"studied;":[201],"first,":[202],"lactase":[203],"fell,":[205],"sucrase,":[209],"finally":[211],"fell.":[219],"The":[220],"reflected":[226],"29,":[234],"0.04).":[238],"thus":[243],"unique":[244],"among":[245],"enzymes":[248],"studied":[249],"date":[251],"that":[253],"circulating":[254],"can":[256],"serve":[257],"as":[258],"marker":[260],"maturation":[263],"integrity.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}