{"id":"https://openalex.org/W2065644272","doi":"https://doi.org/10.1021/bi981185d","title":"Three Residues Predicted by Molecular Modeling To Interact with the Purine Moiety Alter Ligand Binding and Channel Gating in Cyclic Nucleotide-Gated Channels","display_name":"Three Residues Predicted by Molecular Modeling To Interact with the Purine Moiety Alter Ligand Binding and Channel Gating in Cyclic Nucleotide-Gated Channels","publication_year":1998,"publication_date":"1998-11-12","ids":{"openalex":"https://openalex.org/W2065644272","doi":"https://doi.org/10.1021/bi981185d","mag":"2065644272","pmid":"https://pubmed.ncbi.nlm.nih.gov/9860838"},"language":"en","primary_location":{"id":"doi:10.1021/bi981185d","doi":"https://doi.org/10.1021/bi981185d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi981185d","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030546377","display_name":"Sean\u2010Patrick Scott","orcid":"https://orcid.org/0000-0002-8480-1547","observed_orcids":["https://orcid.org/0000-0002-8480-1547"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean-Patrick Scott","raw_affiliation_strings":["Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108693784","display_name":"Jacqueline C. Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline C. Tanaka","raw_affiliation_strings":["Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.4649,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.5978203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"37","issue":"49","first_page":"17239","last_page":"17252"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclic-nucleotide-gated-channels","display_name":"cyclic nucleotide-gated channels","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nucleotide-selectivity","display_name":"nucleotide selectivity","score":0.8859999775886536},{"id":"https://openalex.org/keywords/camp-activation","display_name":"cAMP activation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/nucleotide-binding-domain","display_name":"nucleotide-binding domain","score":0.7509999871253967},{"id":"https://openalex.org/keywords/channel-gating","display_name":"channel gating","score":0.6399999856948853},{"id":"https://openalex.org/keywords/c-linker","display_name":"C-linker","score":0.9139999747276306},{"id":"https://openalex.org/keywords/thermodynamic-cycle-analysis","display_name":"thermodynamic cycle analysis","score":0.781000018119812},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.7689999938011169},{"id":"https://openalex.org/keywords/sensory-transduction","display_name":"sensory transduction","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C131829789","wikidata":"https://www.wikidata.org/wiki/Q425087","display_name":"Cyclic nucleotide-gated ion channel","level":5,"score":0.871655285358429},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.643657922744751},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.6339072585105896},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.545994758605957},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.5297729969024658},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5001757144927979},{"id":"https://openalex.org/C113027372","wikidata":"https://www.wikidata.org/wiki/Q24768350","display_name":"Cyclic nucleotide-binding domain","level":4,"score":0.48476141691207886},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.42533060908317566},{"id":"https://openalex.org/C45516822","wikidata":"https://www.wikidata.org/wiki/Q6382011","display_name":"KcsA potassium channel","level":4,"score":0.422702431678772},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.40350788831710815},{"id":"https://openalex.org/C2778524494","wikidata":"https://www.wikidata.org/wiki/Q967433","display_name":"Cyclic nucleotide","level":4,"score":0.31626203656196594},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.24634012579917908},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22823914885520935},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15804803371429443},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10044097900390625}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005071","descriptor_name":"Evoked Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009532","descriptor_name":"Nickel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011685","descriptor_name":"Purine Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054815","descriptor_name":"Cyclic Nucleotide-Gated Cation Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi981185d","doi":"https://doi.org/10.1021/bi981185d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi981185d","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:9860838","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9860838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1017987844","display_name":null,"funder_award_id":"EY07035","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G589194517","display_name":null,"funder_award_id":"EY06640","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1483050234","https://openalex.org/W1966616037","https://openalex.org/W1983659508","https://openalex.org/W2033434600","https://openalex.org/W2044672033","https://openalex.org/W2047891873","https://openalex.org/W2064364104","https://openalex.org/W2089128598","https://openalex.org/W2097823677","https://openalex.org/W2141524439","https://openalex.org/W2144529674","https://openalex.org/W2153987916","https://openalex.org/W2167111177","https://openalex.org/W2167689408"],"related_works":["https://openalex.org/W1986393620","https://openalex.org/W155505279","https://openalex.org/W2097823677","https://openalex.org/W2412248657","https://openalex.org/W2097924434","https://openalex.org/W2159772387","https://openalex.org/W2051009040","https://openalex.org/W1993461423","https://openalex.org/W2092603342","https://openalex.org/W2087662647"],"abstract_inverted_index":{"Cytoplasmic":[0],"cAMP":[1],"and":[2,22,39,66,146,157,182],"cGMP":[3],"are":[4,143],"soluble":[5],"cellular":[6],"messengers":[7],"that":[8,54,126,139,167,183],"directly":[9],"activate":[10],"cyclic":[11],"nucleotide-gated":[12],"(CNG)":[13],"channels.":[14,110],"These":[15,164],"channels":[16,29],"mediate":[17],"sensory":[18],"transduction":[19],"in":[20,30,169,194],"photoreceptors":[21],"olfactory":[23,95],"neurons.":[24],"The":[25],"closely":[26],"related":[27],"CNG":[28,71,96,109],"these":[31,85],"cell":[32],"types":[33],"have":[34,41],"different":[35],"nucleotide":[36,48,60,77,104],"activation":[37,105],"profiles,":[38],"we":[40,52,83],"investigated":[42],"the":[43,55,59,76,89,93,103,107,136,141,152,158,172,175,179,187,191],"molecular":[44],"basis":[45],"of":[46,58,75,92,106,135,155,160,171,190],"their":[47],"selectivity":[49],"properties.":[50],"Previously,":[51],"predicted":[53],"purine":[56,176],"moiety":[57],"interacts":[61],"with":[62,88,118,162,178,186],"residues":[63,87,91,142,173,181],"F533,":[64],"K596,":[65],"D604":[67],"(bovine":[68],"rod":[69,108],"alpha":[70],"channel":[72,130,192],"subunit":[73],"sequences)":[74],"binding":[78],"domain.":[79],"In":[80,111],"this":[81],"study,":[82],"replaced":[84,117],"three":[86],"corresponding":[90],"bovine":[94],"channel.":[97],"Mutations":[98],"at":[99],"each":[100],"position":[101],"altered":[102],"a":[112],"mutant":[113],"where":[114],"K596":[115],"was":[116],"arginine,":[119],"cAMP-activated":[120],"currents":[121],"were":[122],"enhanced":[123],"8-12-fold,":[124],"suggesting":[125],"residue":[127],"596":[128],"influences":[129],"gating.":[131],"Thermodynamic":[132],"cycle":[133],"analysis":[134],"data":[137,165],"showed":[138],"(1)":[140],"energetically":[144],"coupled":[145],"(2)":[147],"energetic":[148],"coupling":[149],"exists":[150],"between":[151],"potentiating":[153],"effects":[154],"Ni2+":[156,195],"replacement":[159],"F533":[161,184],"tyrosine.":[163],"suggest":[166],"changes":[168],"one":[170],"alter":[174],"contacts":[177],"other":[180],"communicates":[185],"C-linker":[188],"region":[189],"involved":[193],"potentiation.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
