{"id":"https://openalex.org/W2065634680","doi":"https://doi.org/10.1038/hr.2010.264","title":"The role of oxidative stress in the pathophysiology of hypertension","display_name":"The role of oxidative stress in the pathophysiology of hypertension","publication_year":2011,"publication_date":"2011-01-13","ids":{"openalex":"https://openalex.org/W2065634680","doi":"https://doi.org/10.1038/hr.2010.264","mag":"2065634680","pmid":"https://pubmed.ncbi.nlm.nih.gov/21228777"},"language":"en","primary_location":{"id":"doi:10.1038/hr.2010.264","doi":"https://doi.org/10.1038/hr.2010.264","is_oa":true,"landing_page_url":"https://doi.org/10.1038/hr.2010.264","pdf_url":"https://www.nature.com/articles/hr2010264.pdf","source":{"id":"https://openalex.org/S67902008","display_name":"Hypertension Research","issn_l":"0916-9636","issn":["0916-9636","1348-4214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/hr2010264.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039329214","display_name":"Ram\u00f3n Rodrigo","orcid":"https://orcid.org/0000-0003-1724-571X","observed_orcids":["https://orcid.org/0000-0003-1724-571X"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Ram\u00f3n Rodrigo","raw_affiliation_strings":["Renal Pathophysiology Laboratory, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. rrodrigo@med.uchile.cl","Renal Pathophysiology Laboratory, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Pathophysiology Laboratory, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. rrodrigo@med.uchile.cl","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Renal Pathophysiology Laboratory, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110994981","display_name":"Jaime Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Jaime Gonz\u00e1lez","raw_affiliation_strings":["Renal Pathophysiology Laboratory, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Pathophysiology Laboratory, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068395058","display_name":"Fabio Paoletto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Fabio Paoletto","raw_affiliation_strings":["Renal Pathophysiology Laboratory, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Pathophysiology Laboratory, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039329214"],"corresponding_institution_ids":["https://openalex.org/I69737025"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":null,"fwci":2.1045,"has_fulltext":true,"cited_by_count":455,"citation_normalized_percentile":{"value":0.90896159,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"34","issue":"4","first_page":"431","last_page":"440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7260000109672546},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.9620000123977661},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.7860000133514404},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.8669999837875366},{"id":"https://openalex.org/keywords/antioxidant-vitamins","display_name":"antioxidant vitamins","score":0.6669999957084656},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.875},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":1.0},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9020000100135803},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/urotensin-ii","display_name":"urotensin II","score":0.9890000224113464},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9909999966621399},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8795857429504395},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7515486478805542},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.6454737186431885},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6135414242744446},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5602587461471558},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5340648293495178},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4614414572715759},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.4346129298210144},{"id":"https://openalex.org/C2780189551","wikidata":"https://www.wikidata.org/wiki/Q4065146","display_name":"Vasoprotective","level":3,"score":0.4299715757369995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4117850065231323},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4114604890346527},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3914695680141449},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3148994445800781},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3137668967247009},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2711585760116577}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/hr.2010.264","doi":"https://doi.org/10.1038/hr.2010.264","is_oa":true,"landing_page_url":"https://doi.org/10.1038/hr.2010.264","pdf_url":"https://www.nature.com/articles/hr2010264.pdf","source":{"id":"https://openalex.org/S67902008","display_name":"Hypertension Research","issn_l":"0916-9636","issn":["0916-9636","1348-4214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension Research","raw_type":"journal-article"},{"id":"pmid:21228777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21228777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension research : official journal of the Japanese Society of Hypertension","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/hr.2010.264","doi":"https://doi.org/10.1038/hr.2010.264","is_oa":true,"landing_page_url":"https://doi.org/10.1038/hr.2010.264","pdf_url":"https://www.nature.com/articles/hr2010264.pdf","source":{"id":"https://openalex.org/S67902008","display_name":"Hypertension Research","issn_l":"0916-9636","issn":["0916-9636","1348-4214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2065634680.pdf","grobid_xml":"https://content.openalex.org/works/W2065634680.grobid-xml"},"referenced_works_count":163,"referenced_works":["https://openalex.org/W58062360","https://openalex.org/W68743804","https://openalex.org/W82043028","https://openalex.org/W1539402591","https://openalex.org/W1619369754","https://openalex.org/W1628191959","https://openalex.org/W1678920698","https://openalex.org/W1834667461","https://openalex.org/W1838917319","https://openalex.org/W1965946150","https://openalex.org/W1966330450","https://openalex.org/W1966409424","https://openalex.org/W1972214265","https://openalex.org/W1973637176","https://openalex.org/W1975341980","https://openalex.org/W1977014512","https://openalex.org/W1978290051","https://openalex.org/W1978631786","https://openalex.org/W1981277278","https://openalex.org/W1981921279","https://openalex.org/W1982944285","https://openalex.org/W1984829837","https://openalex.org/W1990223276","https://openalex.org/W1990566689","https://openalex.org/W1991061419","https://openalex.org/W1995077681","https://openalex.org/W1995731966","https://openalex.org/W1998973745","https://openalex.org/W1999806108","https://openalex.org/W2000379709","https://openalex.org/W2000756775","https://openalex.org/W2001259350","https://openalex.org/W2002115840","https://openalex.org/W2002425900","https://openalex.org/W2002503460","https://openalex.org/W2004301150","https://openalex.org/W2007025675","https://openalex.org/W2008402132","https://openalex.org/W2011145327","https://openalex.org/W2011200561","https://openalex.org/W2011612683","https://openalex.org/W2012619772","https://openalex.org/W2012765930","https://openalex.org/W2013275659","https://openalex.org/W2015542500","https://openalex.org/W2018211784","https://openalex.org/W2019686722","https://openalex.org/W2020016552","https://openalex.org/W2022205617","https://openalex.org/W2023062207","https://openalex.org/W2024932335","https://openalex.org/W2025764018","https://openalex.org/W2026213662","https://openalex.org/W2027071069","https://openalex.org/W2027393096","https://openalex.org/W2028468705","https://openalex.org/W2028835073","https://openalex.org/W2031005241","https://openalex.org/W2032536546","https://openalex.org/W2033571559","https://openalex.org/W2035617135","https://openalex.org/W2039795231","https://openalex.org/W2040802598","https://openalex.org/W2042038416","https://openalex.org/W2045067074","https://openalex.org/W2049250281","https://openalex.org/W2050548878","https://openalex.org/W2050962873","https://openalex.org/W2052597386","https://openalex.org/W2052894208","https://openalex.org/W2053607045","https://openalex.org/W2056429367","https://openalex.org/W2058242086","https://openalex.org/W2059216373","https://openalex.org/W2059505479","https://openalex.org/W2062150885","https://openalex.org/W2062786004","https://openalex.org/W2064510060","https://openalex.org/W2070402476","https://openalex.org/W2070763907","https://openalex.org/W2071506405","https://openalex.org/W2072210075","https://openalex.org/W2073900470","https://openalex.org/W2076368393","https://openalex.org/W2077885706","https://openalex.org/W2078608838","https://openalex.org/W2080607234","https://openalex.org/W2081376324","https://openalex.org/W2082286023","https://openalex.org/W2082760278","https://openalex.org/W2083762023","https://openalex.org/W2084611725","https://openalex.org/W2085855801","https://openalex.org/W2089258885","https://openalex.org/W2089611683","https://openalex.org/W2095951471","https://openalex.org/W2097334774","https://openalex.org/W2099273954","https://openalex.org/W2101658535","https://openalex.org/W2101848184","https://openalex.org/W2102420999","https://openalex.org/W2102523096","https://openalex.org/W2104882897","https://openalex.org/W2106991607","https://openalex.org/W2108246384","https://openalex.org/W2110470817","https://openalex.org/W2112726636","https://openalex.org/W2115693238","https://openalex.org/W2118287470","https://openalex.org/W2118747132","https://openalex.org/W2119371294","https://openalex.org/W2119523842","https://openalex.org/W2120981143","https://openalex.org/W2122983268","https://openalex.org/W2123162884","https://openalex.org/W2123617367","https://openalex.org/W2123861048","https://openalex.org/W2125468637","https://openalex.org/W2126085531","https://openalex.org/W2127723812","https://openalex.org/W2128215212","https://openalex.org/W2130586046","https://openalex.org/W2139755134","https://openalex.org/W2141541615","https://openalex.org/W2143033384","https://openalex.org/W2144640120","https://openalex.org/W2146426188","https://openalex.org/W2146736971","https://openalex.org/W2148313399","https://openalex.org/W2148531805","https://openalex.org/W2148594211","https://openalex.org/W2149062689","https://openalex.org/W2149413458","https://openalex.org/W2151918491","https://openalex.org/W2154899903","https://openalex.org/W2155121555","https://openalex.org/W2155536801","https://openalex.org/W2155603952","https://openalex.org/W2155820191","https://openalex.org/W2156106643","https://openalex.org/W2156648526","https://openalex.org/W2157552205","https://openalex.org/W2160369271","https://openalex.org/W2162679716","https://openalex.org/W2168880260","https://openalex.org/W2168975002","https://openalex.org/W2183573605","https://openalex.org/W2184309797","https://openalex.org/W2188875900","https://openalex.org/W2192223169","https://openalex.org/W2213651169","https://openalex.org/W2225273165","https://openalex.org/W2326888563","https://openalex.org/W2331402538","https://openalex.org/W2335084303","https://openalex.org/W2344300526","https://openalex.org/W2396326578","https://openalex.org/W2409148968","https://openalex.org/W2417906231","https://openalex.org/W2885024962","https://openalex.org/W4245957869","https://openalex.org/W4285719527","https://openalex.org/W4385616926"],"related_works":["https://openalex.org/W2346931507","https://openalex.org/W2099273954","https://openalex.org/W2281422803","https://openalex.org/W1975781920","https://openalex.org/W2187540790","https://openalex.org/W2077281334","https://openalex.org/W2036336318","https://openalex.org/W2947293374","https://openalex.org/W1827761626","https://openalex.org/W4294608914"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":37},{"year":2024,"cited_by_count":44},{"year":2023,"cited_by_count":58},{"year":2022,"cited_by_count":53},{"year":2021,"cited_by_count":47},{"year":2020,"cited_by_count":44},{"year":2019,"cited_by_count":26},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
