{"id":"https://openalex.org/W2065613337","doi":"https://doi.org/10.1371/journal.pone.0026860","title":"Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice","display_name":"Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice","publication_year":2011,"publication_date":"2011-12-08","ids":{"openalex":"https://openalex.org/W2065613337","doi":"https://doi.org/10.1371/journal.pone.0026860","mag":"2065613337","pmid":"https://pubmed.ncbi.nlm.nih.gov/22174735","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3234245"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0026860","doi":"https://doi.org/10.1371/journal.pone.0026860","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0026860","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0026860&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0026860&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106124878","display_name":"Mian Bi","orcid":"https://orcid.org/0000-0002-4383-3606","observed_orcids":["https://orcid.org/0000-0002-4383-3606"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mian Bi","raw_affiliation_strings":["Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013357578","display_name":"Arne Ittner","orcid":"https://orcid.org/0000-0001-5244-6897","observed_orcids":["https://orcid.org/0000-0001-5244-6897"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Arne Ittner","raw_affiliation_strings":["Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia","Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030210067","display_name":"Yazi Diana Ke","orcid":"https://orcid.org/0000-0002-1423-0451","observed_orcids":["https://orcid.org/0000-0002-1423-0451"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yazi D. Ke","raw_affiliation_strings":["Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045325665","display_name":"J\u00fcrgen G\u00f6tz","orcid":"https://orcid.org/0000-0001-8501-7896","observed_orcids":["https://orcid.org/0000-0001-8501-7896","https://orcid.org/0000-0002-2003-9135"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen G\u00f6tz","raw_affiliation_strings":["Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073763982","display_name":"Lars Matthias Ittner","orcid":"https://orcid.org/0000-0001-6738-3825","observed_orcids":["https://orcid.org/0000-0001-6738-3825"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Lars M. Ittner","raw_affiliation_strings":["Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073763982"],"corresponding_institution_ids":["https://openalex.org/I129604602"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":7.0277,"has_fulltext":true,"cited_by_count":157,"citation_normalized_percentile":{"value":0.98422995,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"6","issue":"12","first_page":"e26860","last_page":"e26860"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/active-immunization","display_name":"active immunization","score":0.8180000185966492},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9679999947547913},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8009999990463257},{"id":"https://openalex.org/keywords/frontotemporal-dementia","display_name":"frontotemporal dementia","score":0.9710000157356262},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.6964277029037476},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6549304723739624},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5818637609481812},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.5758463740348816},{"id":"https://openalex.org/C2778943623","wikidata":"https://www.wikidata.org/wiki/Q3425478","display_name":"Active immunization","level":4,"score":0.5523211359977722},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.5474432706832886},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5462980270385742},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.5131803154945374},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.49490541219711304},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.4893309473991394},{"id":"https://openalex.org/C2908656565","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrocytosis","level":3,"score":0.45617035031318665},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4375998079776764},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4295691251754761},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.42521989345550537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39068129658699036},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.32957756519317627},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.3225501477718353},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.308366984128952},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.30274486541748047},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.11893671751022339},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0026860","doi":"https://doi.org/10.1371/journal.pone.0026860","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0026860","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0026860&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2244037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3234245","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3234245","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3234245","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22174735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22174735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.287.8145","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.287.8145","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/dd/3a/PLoS_One_2011_Dec_8_6(12)_e26860.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:29e3b76dd46d4a588dd2a1f981760b07","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/29e3b76dd46d4a588dd2a1f981760b07","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 12, p e26860 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0026860","doi":"https://doi.org/10.1371/journal.pone.0026860","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0026860","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0026860&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2065613337.pdf","grobid_xml":"https://content.openalex.org/works/W2065613337.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1511517753","https://openalex.org/W1608225731","https://openalex.org/W1968937229","https://openalex.org/W1978116973","https://openalex.org/W1997826645","https://openalex.org/W1998592142","https://openalex.org/W2007313489","https://openalex.org/W2020416783","https://openalex.org/W2021370614","https://openalex.org/W2022532556","https://openalex.org/W2035156043","https://openalex.org/W2040949523","https://openalex.org/W2049823387","https://openalex.org/W2056666417","https://openalex.org/W2064038516","https://openalex.org/W2064342657","https://openalex.org/W2088983023","https://openalex.org/W2091173932","https://openalex.org/W2091935655","https://openalex.org/W2099340107","https://openalex.org/W2105704879","https://openalex.org/W2121713269","https://openalex.org/W2135309154","https://openalex.org/W2135661040","https://openalex.org/W2138878035","https://openalex.org/W2159899308","https://openalex.org/W2164627569","https://openalex.org/W2165284149","https://openalex.org/W2316522881"],"related_works":["https://openalex.org/W2052006751","https://openalex.org/W2071921522","https://openalex.org/W2021026087","https://openalex.org/W2044799286","https://openalex.org/W34248026","https://openalex.org/W2772204364","https://openalex.org/W6987647446","https://openalex.org/W2121713269","https://openalex.org/W2130030563","https://openalex.org/W2061425816"],"abstract_inverted_index":{"In":[0,151,176],"Alzheimer's":[1],"disease":[2],"(AD)":[3],"brains,":[4],"the":[5,42,51,113,183,196],"microtubule-associated":[6],"protein":[7],"tau":[8,81,92,127,135,170],"and":[9,18,47,74,101,131],"amyloid-\u03b2":[10],"(A\u03b2)":[11],"deposit":[12],"as":[13],"intracellular":[14],"neurofibrillary":[15],"tangles":[16],"(NFTs)":[17],"extracellular":[19],"plaques,":[20],"respectively.":[21],"Tau":[22],"deposits":[23],"are":[24,37,55,109],"furthermore":[25],"found":[26,181],"in":[27,68,90,128,160,182,201],"a":[28],"significant":[29],"number":[30],"of":[31,44,143,149,169,198],"frontotemporal":[32],"dementia":[33],"cases.":[34],"These":[35],"diseases":[36],"characterized":[38],"by":[39],"progressive":[40],"neurodegeneration,":[41],"loss":[43],"intellectual":[45],"capabilities":[46],"behavioral":[48],"changes.":[49],"Unfortunately,":[50],"currently":[52],"available":[53],"therapies":[54],"limited":[56],"to":[57,87,98,124,163],"symptomatic":[58],"relief.":[59],"While":[60],"active":[61,122],"immunization":[62,78,123,194],"against":[63,79],"A\u03b2":[64],"has":[65,82],"shown":[66,86],"efficacy":[67],"both":[69],"various":[70],"AD":[71],"mouse":[72],"models":[73],"patients":[75],"with":[76,203],"AD,":[77],"pathogenic":[80,126],"only":[83],"recently":[84],"been":[85],"prevent":[88],"pathology":[89,145,156,200],"young":[91],"transgenic":[93,136],"mice.":[94,166],"However,":[95],"if":[96],"translated":[97],"humans,":[99],"diagnosis":[100],"treatment":[102],"would":[103],"be":[104],"routinely":[105],"done":[106],"when":[107],"symptoms":[108],"overt,":[110],"meaning":[111],"that":[112,139,192],"histopathological":[114],"changes":[115],"have":[116,140],"already":[117],"progressed.":[118],"Therefore,":[119],"we":[120],"used":[121],"target":[125],"4,":[129],"8,":[130],"18":[132],"months-old":[133],"P301L":[134],"pR5":[137,165],"mice":[138],"an":[141],"onset":[142],"NFT":[144,155,199],"at":[146,171],"6":[147],"months":[148],"age.":[150],"all":[152],"age":[153],"groups,":[154],"was":[157,174,180],"significantly":[158],"reduced":[159],"treated":[161,185],"compared":[162],"control":[164],"Similarly,":[167],"phosphorylation":[168],"pathological":[172],"sites":[173],"reduced.":[175],"addition,":[177],"increased":[178],"astrocytosis":[179],"oldest":[184],"group.":[186],"Taken":[187],"together,":[188],"our":[189],"data":[190],"suggests":[191],"tau-targeted":[193],"slows":[195],"progression":[197],"mice,":[202],"practical":[204],"implications":[205],"for":[206],"human":[207],"patients.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":29},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}