{"id":"https://openalex.org/W2065606405","doi":"https://doi.org/10.1371/journal.pone.0122691","title":"Use of Renin-Angiotensin System Inhibitors Is Associated with Reduction of Fracture Risk in Hemodialysis Patients","display_name":"Use of Renin-Angiotensin System Inhibitors Is Associated with Reduction of Fracture Risk in Hemodialysis Patients","publication_year":2015,"publication_date":"2015-04-13","ids":{"openalex":"https://openalex.org/W2065606405","doi":"https://doi.org/10.1371/journal.pone.0122691","mag":"2065606405","pmid":"https://pubmed.ncbi.nlm.nih.gov/25874620","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4395204"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0122691","doi":"https://doi.org/10.1371/journal.pone.0122691","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0122691","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0122691&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0122691&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101583718","display_name":"Suguru Yamamoto","orcid":"https://orcid.org/0000-0002-8279-2966","observed_orcids":["https://orcid.org/0000-0002-8279-2966"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Suguru Yamamoto","raw_affiliation_strings":["Department of Clinical Nephroscience, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan","Department of Clinical Nephroscience, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan","Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Nephroscience, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]},{"raw_affiliation_string":"Department of Clinical Nephroscience, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]},{"raw_affiliation_string":"Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ryo Kido","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257019","display_name":"Institute for Health Outcomes & Process Evaluation Research","ror":"https://ror.org/04t0wry96","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405257019"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Kido","raw_affiliation_strings":["Institute for Health Outcomes and Process Evaluation Research (iHope International), Kyoto, Japan; Medical Examination Center, Inagi Municipal Hospital, Tokyo, Japan","Institute for Health Outcomes and Process Evaluation Research (iHope International), Kyoto, Japan","Medical Examination Center, Inagi Municipal Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Health Outcomes and Process Evaluation Research (iHope International), Kyoto, Japan; Medical Examination Center, Inagi Municipal Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4405257019"]},{"raw_affiliation_string":"Institute for Health Outcomes and Process Evaluation Research (iHope International), Kyoto, Japan","institution_ids":["https://openalex.org/I4405257019"]},{"raw_affiliation_string":"Medical Examination Center, Inagi Municipal Hospital, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104594513","display_name":"Yoshihiro \u00d4nishi","orcid":"https://orcid.org/0009-0005-3097-277X","observed_orcids":["https://orcid.org/0009-0005-3097-277X"]},"institutions":[{"id":"https://openalex.org/I4405257019","display_name":"Institute for Health Outcomes & Process Evaluation Research","ror":"https://ror.org/04t0wry96","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405257019"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Onishi","raw_affiliation_strings":["Institute for Health Outcomes and Process Evaluation Research (iHope International), Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Health Outcomes and Process Evaluation Research (iHope International), Kyoto, Japan","institution_ids":["https://openalex.org/I4405257019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057534039","display_name":"Shingo Fukuma","orcid":"https://orcid.org/0000-0002-8379-8761","observed_orcids":["https://orcid.org/0000-0002-8379-8761"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4405257019","display_name":"Institute for Health Outcomes & Process Evaluation Research","ror":"https://ror.org/04t0wry96","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405257019"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shingo Fukuma","raw_affiliation_strings":["Institute for Health Outcomes and Process Evaluation Research (iHope International), Kyoto, Japan; Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan; Center for Innovative Research for Communities and Clinical Excellence (CIRC2LE), Fukushima Medical University, Fukushima, Japan","Center for Innovative Research for Communities and Clinical Excellence (CIRC2LE), Fukushima Medical University, Fukushima, Japan","Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan","Institute for Health Outcomes and Process Evaluation Research (iHope International), Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Health Outcomes and Process Evaluation Research (iHope International), Kyoto, Japan; Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan; Center for Innovative Research for Communities and Clinical Excellence (CIRC2LE), Fukushima Medical University, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085","https://openalex.org/I22299242"]},{"raw_affiliation_string":"Center for Innovative Research for Communities and Clinical Excellence (CIRC2LE), Fukushima Medical University, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]},{"raw_affiliation_string":"Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Institute for Health Outcomes and Process Evaluation Research (iHope International), Kyoto, Japan","institution_ids":["https://openalex.org/I4405257019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071555943","display_name":"Tadao Akizawa","orcid":"https://orcid.org/0000-0002-6150-9201","observed_orcids":["https://orcid.org/0000-0002-6150-9201"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadao Akizawa","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086510056","display_name":"Masafumi Fukagawa","orcid":"https://orcid.org/0000-0002-7832-2339","observed_orcids":["https://orcid.org/0000-0002-7832-2339"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]},{"id":"https://openalex.org/I4210115139","display_name":"Tokai University Hospital","ror":"https://ror.org/01gvmn480","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115139"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masafumi Fukagawa","raw_affiliation_strings":["Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan","institution_ids":["https://openalex.org/I1314466530","https://openalex.org/I4210115139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042461409","display_name":"Junichiro James Kazama","orcid":"https://orcid.org/0000-0001-7710-2660","observed_orcids":["https://orcid.org/0000-0001-7710-2660"]},"institutions":[{"id":"https://openalex.org/I4210124653","display_name":"Niigata University Medical and Dental Hospital","ror":"https://ror.org/03b0x6j22","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210124653"]},{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junichiro J. Kazama","raw_affiliation_strings":["Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan; Blood Purification Center, Niigata University Medical and Dental Hospital, Niigata, Japan","Blood Purification Center, Niigata University Medical and Dental Hospital, Niigata, Japan","Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan; Blood Purification Center, Niigata University Medical and Dental Hospital, Niigata, Japan","institution_ids":["https://openalex.org/I4210124653","https://openalex.org/I71395657"]},{"raw_affiliation_string":"Blood Purification Center, Niigata University Medical and Dental Hospital, Niigata, Japan","institution_ids":["https://openalex.org/I4210124653"]},{"raw_affiliation_string":"Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042533774","display_name":"Ichiei Narita","orcid":"https://orcid.org/0000-0001-7692-3096","observed_orcids":["https://orcid.org/0000-0001-7692-3096"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichiei Narita","raw_affiliation_strings":["Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018869061","display_name":"Shunichi Fukuhara","orcid":"https://orcid.org/0000-0001-7199-1495","observed_orcids":["https://orcid.org/0000-0001-7199-1495"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunichi Fukuhara","raw_affiliation_strings":["Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan; Center for Innovative Research for Communities and Clinical Excellence (CIRC2LE), Fukushima Medical University, Fukushima, Japan","Center for Innovative Research for Communities and Clinical Excellence (CIRC2LE), Fukushima Medical University, Fukushima, Japan","Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan; Center for Innovative Research for Communities and Clinical Excellence (CIRC2LE), Fukushima Medical University, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085","https://openalex.org/I22299242"]},{"raw_affiliation_string":"Center for Innovative Research for Communities and Clinical Excellence (CIRC2LE), Fukushima Medical University, Fukushima, Japan","institution_ids":["https://openalex.org/I130830085"]},{"raw_affiliation_string":"Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5101583718"],"corresponding_institution_ids":["https://openalex.org/I71395657"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":5.3948,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.95565596,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"4","first_page":"e0122691","last_page":"e0122691"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renin-angiotensin-system-inhibitors","display_name":"renin-angiotensin system inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fracture-risk","display_name":"fracture risk","score":0.718999981880188},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/secondary-hyperparathyroidism","display_name":"secondary hyperparathyroidism","score":0.996999979019165},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.824999988079071},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.8799999952316284},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.996999979019165},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.7289999723434448},{"id":"https://openalex.org/keywords/intact-parathyroid-hormone","display_name":"intact parathyroid hormone","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8560734987258911},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.7828119993209839},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.685394287109375},{"id":"https://openalex.org/C2778838027","wikidata":"https://www.wikidata.org/wiki/Q3622611","display_name":"Secondary hyperparathyroidism","level":4,"score":0.6281216144561768},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.5571491718292236},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5509084463119507},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.5397418737411499},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.478878915309906},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46634289622306824},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.45476892590522766},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4012219309806824},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.3900585174560547},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3846387565135956},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.3741265833377838},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006962","descriptor_name":"Hyperparathyroidism, Secondary","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006962","descriptor_name":"Hyperparathyroidism, Secondary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006962","descriptor_name":"Hyperparathyroidism, Secondary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0122691","doi":"https://doi.org/10.1371/journal.pone.0122691","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0122691","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0122691&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:25874620","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25874620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4395204","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4395204/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.806.4479","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.806.4479","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d9/5c/pone.0122691.PMC4395204.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:dda9e2ed8b7641c79db5cb432189e9d2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dda9e2ed8b7641c79db5cb432189e9d2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 4, p e0122691 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0122691","doi":"https://doi.org/10.1371/journal.pone.0122691","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0122691","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0122691&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4720417110","display_name":"Protein-bound uremic toxins-induced functional abnormalities of HDL cholesterol for prevention of atherosclerosis accelerated by chronic kidney disease","funder_award_id":"15K09249","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5746084430","display_name":"Large-scale observational study of hemodialysis patients designed to evaluate associations between practice patterns, biomarkers, and clinical outcomes","funder_award_id":"25461257","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320322359","display_name":"Kyowa Hakko Kirin","ror":"https://ror.org/0586k5242"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2065606405.pdf","grobid_xml":"https://content.openalex.org/works/W2065606405.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W93801189","https://openalex.org/W1494926937","https://openalex.org/W1534554675","https://openalex.org/W1586217614","https://openalex.org/W1942368718","https://openalex.org/W1981997645","https://openalex.org/W1983133134","https://openalex.org/W1986858837","https://openalex.org/W1988943870","https://openalex.org/W1994983581","https://openalex.org/W2005359013","https://openalex.org/W2008614129","https://openalex.org/W2012820109","https://openalex.org/W2013103507","https://openalex.org/W2024594848","https://openalex.org/W2034121143","https://openalex.org/W2035221187","https://openalex.org/W2039397162","https://openalex.org/W2045667831","https://openalex.org/W2048928355","https://openalex.org/W2063880582","https://openalex.org/W2068537889","https://openalex.org/W2107207648","https://openalex.org/W2122037712","https://openalex.org/W2129352623","https://openalex.org/W2130357226","https://openalex.org/W2138829372","https://openalex.org/W2144915294","https://openalex.org/W2146806054","https://openalex.org/W2148121447","https://openalex.org/W2170261061","https://openalex.org/W2328615536","https://openalex.org/W2475261460","https://openalex.org/W2548549197","https://openalex.org/W3010153256","https://openalex.org/W4237871677","https://openalex.org/W4291182867"],"related_works":["https://openalex.org/W7096802417","https://openalex.org/W2740391179","https://openalex.org/W4397048177","https://openalex.org/W4388297504","https://openalex.org/W2012820109","https://openalex.org/W2160374584","https://openalex.org/W7159747943","https://openalex.org/W2617327571","https://openalex.org/W4280531874","https://openalex.org/W2065163078"],"abstract_inverted_index":{"BACKGROUND:":[0],"Patients":[1],"with":[2,28,68,75,152,239,249],"chronic":[3],"kidney":[4],"disease,":[5],"especially":[6],"those":[7],"undergoing":[8],"dialysis":[9],"treatment":[10],"and":[11,102,129,216,226],"having":[12],"secondary":[13,69,121,250],"hyperparathyroidism,":[14],"have":[15],"a":[16,55,90,153,240],"high":[17],"risk":[18],"of":[19,39,45,92,100,120,139,156,229,234,243],"bone":[20,30],"fracture.":[21],"The":[22,95,136,187],"renin-angiotensin":[23],"system":[24],"(RAS)":[25],"is":[26,237],"associated":[27,151,238],"osteoclastic":[29],"resorption.":[31],"We":[32],"aimed":[33],"to":[34,63,106],"examine":[35],"whether":[36],"the":[37,43,98,118,145,222],"use":[38,99,149],"RAS":[40,235],"inhibitors":[41,236],"reduces":[42],"incidence":[44,137],"fracture":[46,107],"in":[47,246],"hemodialysis":[48,66,247],"patients.":[49],"METHODS":[50],"AND":[51],"FINDINGS:":[52],"This":[53,168],"was":[54,108,142,150,170],"multicenter,":[56],"3-year,":[57],"prospective,":[58],"observational":[59],"study.":[60],"From":[61],"2008":[62],"2011,":[64],"maintenance":[65],"patients":[67,248],"hyperparathyroidism":[70,122],"(N":[71],"=":[72,177,185,202],"3,276)":[73],"treated":[74],"angiotensin":[76],"converting":[77],"enzyme":[78],"inhibitor":[79],"(ACEI)/angiotensin":[80],"II":[81],"receptor":[82],"blocker":[83],"(ARB)":[84],"at":[85],"baseline":[86],"were":[87,133,194],"followed":[88],"for":[89,221],"mean":[91],"2.7":[93],"years.":[94],"association":[96,169],"between":[97],"ACEI/ARB":[101,148],"hospitalization":[103,141,158,245],"rate":[104,155,242],"owing":[105],"examined":[109],"by":[110,117,174,191],"using":[111],"Cox":[112],"regression":[113],"models.":[114],"Effect":[115],"modifications":[116],"severity":[119],"(intact":[123],"parathyroid":[124],"hormone":[125],"[iPTH]":[126],"level),":[127],"sex,":[128],"systolic":[130,180],"blood":[131,181],"pressure":[132,182],"also":[134],"examined.":[135],"proportion":[138],"fracture-related":[140,157,244],"5.42%":[143],"throughout":[144],"observation":[146],"period.":[147],"lower":[154,241],"(adjusted":[159],"hazard":[160,188],"ratio,":[161],"0.65;":[162],"95%":[163],"confidence":[164],"interval":[165],"[CI],":[166],"0.45-0.92).":[167],"not":[171,198],"significantly":[172],"affected":[173],"sex":[175],"(P":[176,184,201],"0.56)":[178],"or":[179],"levels":[183,193],"0.87).":[186],"ratios":[189],"adjusted":[190],"iPTH":[192],"qualitatively":[195],"different,":[196],"but":[197],"statistically":[199],"significant":[200],"0.11):":[203],"0.77":[204],"(95%":[205,209,213,218],"CI,":[206,210,214,219],"0.42-1.39),":[207],"0.38":[208],"0.20-0.73),":[211],"0.59":[212],"0.29-1.21),":[215],"1.29":[217],"0.58-2.42)":[220],"first,":[223],"second,":[224],"third":[225],"fourth":[227],"quartiles":[228],"iPTH,":[230],"respectively.":[231],"CONCLUSIONS:":[232],"Use":[233],"hyperparathyroidism.":[251],"TRIAL":[252],"REGISTRATION:":[253],"ClinicalTrials.gov":[254],"NCT00995163.":[255]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
