{"id":"https://openalex.org/W2065600162","doi":"https://doi.org/10.1016/j.biomaterials.2008.12.066","title":"In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery","display_name":"In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery","publication_year":2009,"publication_date":"2009-01-27","ids":{"openalex":"https://openalex.org/W2065600162","doi":"https://doi.org/10.1016/j.biomaterials.2008.12.066","mag":"2065600162","pmid":"https://pubmed.ncbi.nlm.nih.gov/19176244"},"language":"en","primary_location":{"id":"doi:10.1016/j.biomaterials.2008.12.066","doi":"https://doi.org/10.1016/j.biomaterials.2008.12.066","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biomaterials.2008.12.066","pdf_url":null,"source":{"id":"https://openalex.org/S163807576","display_name":"Biomaterials","issn_l":"0142-9612","issn":["0142-9612","1878-5905"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061981995","display_name":"Kiran Sonaje","orcid":"https://orcid.org/0000-0001-5868-8280","observed_orcids":["https://orcid.org/0000-0001-5868-8280"]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kiran Sonaje","raw_affiliation_strings":["Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041519726","display_name":"Yu-Hsin Lin","orcid":"https://orcid.org/0000-0003-1947-1809","observed_orcids":["https://orcid.org/0000-0003-1947-1809"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Hsin Lin","raw_affiliation_strings":["Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, ROC","Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, ROC","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056571860","display_name":"Jyuhn-Huarng Juang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jyuhn-Huarng Juang","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Chung Gung University and Memorial Hospital, Kweishan, Taoyuan, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Chung Gung University and Memorial Hospital, Kweishan, Taoyuan, Taiwan, ROC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026217046","display_name":"Shiaw\u2010Pyng Wey","orcid":"https://orcid.org/0000-0002-7222-2601","observed_orcids":["https://orcid.org/0000-0002-7222-2601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiaw-Pyng Wey","raw_affiliation_strings":["Department of Medical Imaging and Radiological Sciences, Chung Gung University, Kweishan, Taoyuan, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Imaging and Radiological Sciences, Chung Gung University, Kweishan, Taoyuan, Taiwan, ROC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109460130","display_name":"Chiung-Tong Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165441096","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I165441096"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chiung-Tong Chen","raw_affiliation_strings":["Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli, Taiwan, ROC","institution_ids":["https://openalex.org/I165441096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008387139","display_name":"Hsing\u2010Wen Sung","orcid":"https://orcid.org/0000-0002-0789-5236","observed_orcids":["https://orcid.org/0000-0002-0789-5236"]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Hsing-Wen Sung","raw_affiliation_strings":["Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC","institution_ids":["https://openalex.org/I25846049"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008387139","https://openalex.org/A5109460130"],"corresponding_institution_ids":["https://openalex.org/I165441096","https://openalex.org/I25846049"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":19.0752,"has_fulltext":false,"cited_by_count":299,"citation_normalized_percentile":{"value":0.99944134,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"30","issue":"12","first_page":"2329","last_page":"2339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-insulin-delivery","display_name":"oral insulin delivery","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nanoparticle-self-assembly","display_name":"nanoparticle self-assembly","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ph-sensitive-nanoparticles","display_name":"pH-responsive nanoparticles","score":0.8230000138282776},{"id":"https://openalex.org/keywords/poly-gamma-glutamic-acid","display_name":"poly-\u03b3-glutamic acid","score":0.9700000286102295},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.9980000257492065},{"id":"https://openalex.org/keywords/caco-2-cell-monolayers","display_name":"Caco-2 cell monolayers","score":0.7789999842643738},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.859000027179718},{"id":"https://openalex.org/keywords/insulin-pharmacokinetics","display_name":"insulin pharmacokinetics","score":0.7739999890327454},{"id":"https://openalex.org/keywords/insulin-pharmacodynamics","display_name":"insulin pharmacodynamics","score":0.9390000104904175},{"id":"https://openalex.org/keywords/relative-bioavailability","display_name":"relative bioavailability","score":0.7360000014305115},{"id":"https://openalex.org/keywords/hypoglycemic-effect","display_name":"hypoglycemic effect","score":0.8970000147819519},{"id":"https://openalex.org/keywords/diabetic-rats","display_name":"diabetic rats","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7139996290206909},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6542297005653381},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.606655478477478},{"id":"https://openalex.org/C2994527087","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin delivery","level":4,"score":0.6023460030555725},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.520054280757904},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.46477654576301575},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4253599941730499},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36260634660720825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3058967590332031},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1995607614517212},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1686054766178131},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.10032325983047485},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09107246994972229},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.07292857766151428},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biomaterials.2008.12.066","doi":"https://doi.org/10.1016/j.biomaterials.2008.12.066","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biomaterials.2008.12.066","pdf_url":null,"source":{"id":"https://openalex.org/S163807576","display_name":"Biomaterials","issn_l":"0142-9612","issn":["0142-9612","1878-5905"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials","raw_type":"journal-article"},{"id":"pmid:19176244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19176244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3021389711","display_name":null,"funder_award_id":"NSC97-2120-M-007-001","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"}],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1548725377","https://openalex.org/W1980439325","https://openalex.org/W1985119102","https://openalex.org/W1986689667","https://openalex.org/W1990129537","https://openalex.org/W1992156667","https://openalex.org/W1994638195","https://openalex.org/W1999934318","https://openalex.org/W2010408887","https://openalex.org/W2019718881","https://openalex.org/W2019836676","https://openalex.org/W2022580407","https://openalex.org/W2023456252","https://openalex.org/W2024299064","https://openalex.org/W2035886098","https://openalex.org/W2036100809","https://openalex.org/W2040272006","https://openalex.org/W2044952691","https://openalex.org/W2047894913","https://openalex.org/W2053944183","https://openalex.org/W2065602354","https://openalex.org/W2066043435","https://openalex.org/W2066662632","https://openalex.org/W2068601883","https://openalex.org/W2072051252","https://openalex.org/W2087421919","https://openalex.org/W2091918414","https://openalex.org/W2093024718","https://openalex.org/W2125100502","https://openalex.org/W2133591717","https://openalex.org/W2137489919","https://openalex.org/W2138181294","https://openalex.org/W2148315383","https://openalex.org/W2152186576","https://openalex.org/W2153192347","https://openalex.org/W2160474915","https://openalex.org/W2292343120","https://openalex.org/W3099920771"],"related_works":["https://openalex.org/W2284424014","https://openalex.org/W1975239267","https://openalex.org/W1990932004","https://openalex.org/W2565373971","https://openalex.org/W4412798962","https://openalex.org/W2032364556","https://openalex.org/W2988168093","https://openalex.org/W3191830091","https://openalex.org/W2083341767","https://openalex.org/W4389146356"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":22},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":36}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}