{"id":"https://openalex.org/W2065581822","doi":"https://doi.org/10.1172/jci106417","title":"Studies in vivo and in vitro on an abnormality in the metabolism of C3 in a patient with increased susceptibility to infection","display_name":"Studies in vivo and in vitro on an abnormality in the metabolism of C3 in a patient with increased susceptibility to infection","publication_year":1970,"publication_date":"1970-11-01","ids":{"openalex":"https://openalex.org/W2065581822","doi":"https://doi.org/10.1172/jci106417","mag":"2065581822","pmid":"https://pubmed.ncbi.nlm.nih.gov/4097977","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/535775"},"language":"en","primary_location":{"id":"doi:10.1172/jci106417","doi":"https://doi.org/10.1172/jci106417","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci106417","pdf_url":"http://www.jci.org/articles/view/106417/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/106417/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113519981","display_name":"Chester A. Alper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chester A. Alper","raw_affiliation_strings":["Children's Hospital Medical Center, Boston, Massachusetts 02115, the","Departments of Pediatrics and Medicine, Harvard Medical School, Boston, Massachusetts 02115","LUMIAN WATSON From the Blood Grouping Laboratory and the Department of Medicine,","Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, Boston, Massachusetts 02118, and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Medical Center, Boston, Massachusetts 02115, the","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Departments of Pediatrics and Medicine, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"LUMIAN WATSON From the Blood Grouping Laboratory and the Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, Boston, Massachusetts 02118, and the","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109144441","display_name":"Neil Remington Abramson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Abramson","raw_affiliation_strings":["Children's Hospital Medical Center , Boston , Massachusetts 02115 , the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Medical Center , Boston , Massachusetts 02115 , the","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032789644","display_name":"Richard B. Johnston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard B. Johnston","raw_affiliation_strings":["Children's Hospital Medical Center, Boston, Massachusetts 02115, the","Departments of Pediatrics and Medicine, Harvard Medical School, Boston, Massachusetts 02115","LUMIAN WATSON From the Blood Grouping Laboratory and the Department of Medicine,","Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, Boston, Massachusetts 02118, and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Medical Center, Boston, Massachusetts 02115, the","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Departments of Pediatrics and Medicine, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"LUMIAN WATSON From the Blood Grouping Laboratory and the Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, Boston, Massachusetts 02118, and the","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066662456","display_name":"James H. Jandl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James H. Jandl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111433586","display_name":"Fred S. Rosen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred S. Rosen","raw_affiliation_strings":["Children's Hospital Medical Center, Boston, Massachusetts 02115, the","Departments of Pediatrics and Medicine, Harvard Medical School, Boston, Massachusetts 02115","LUMIAN WATSON From the Blood Grouping Laboratory and the Department of Medicine,","Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, Boston, Massachusetts 02118, and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Medical Center, Boston, Massachusetts 02115, the","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Departments of Pediatrics and Medicine, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"LUMIAN WATSON From the Blood Grouping Laboratory and the Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, Boston, Massachusetts 02118, and the","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":6.192,"has_fulltext":true,"cited_by_count":142,"citation_normalized_percentile":{"value":0.96604046,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"49","issue":"11","first_page":"1975","last_page":"1985"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.8009999990463257},{"id":"https://openalex.org/keywords/c3b","display_name":"C3b","score":0.7429999709129333},{"id":"https://openalex.org/keywords/c3c","display_name":"C3c","score":0.7900000214576721},{"id":"https://openalex.org/keywords/c3a","display_name":"C3a","score":0.7620000243186951},{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.8690000176429749},{"id":"https://openalex.org/keywords/urticaria","display_name":"urticaria","score":0.777999997138977},{"id":"https://openalex.org/keywords/plasma-transfusion","display_name":"plasma transfusion","score":0.5519999861717224},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.34200000762939453},{"id":"https://openalex.org/keywords/electrophoretic-heterogeneity","display_name":"electrophoretic heterogeneity","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7609593868255615},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6797485947608948},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5827206373214722},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.5289663672447205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40448492765426636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38299205899238586},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3533369302749634},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22722777724266052},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15641871094703674},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000362","descriptor_name":"Agar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001609","descriptor_name":"Beta-Globulins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004586","descriptor_name":"Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004796","descriptor_name":"Clinical Enzyme Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007122","descriptor_name":"Immunoelectrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007456","descriptor_name":"Iodine Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012712","descriptor_name":"Serum Globulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci106417","doi":"https://doi.org/10.1172/jci106417","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci106417","pdf_url":"http://www.jci.org/articles/view/106417/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:535775","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/535775","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:4097977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4097977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci106417","doi":"https://doi.org/10.1172/jci106417","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci106417","pdf_url":"http://www.jci.org/articles/view/106417/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2065581822.pdf","grobid_xml":"https://content.openalex.org/works/W2065581822.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1495213486","https://openalex.org/W1522956225","https://openalex.org/W1544793479","https://openalex.org/W1553166102","https://openalex.org/W1964899349","https://openalex.org/W1966497279","https://openalex.org/W1967833287","https://openalex.org/W1990986783","https://openalex.org/W1991473086","https://openalex.org/W2015259499","https://openalex.org/W2019524205","https://openalex.org/W2022838108","https://openalex.org/W2027793259","https://openalex.org/W2032566319","https://openalex.org/W2043396888","https://openalex.org/W2051880735","https://openalex.org/W2052308950","https://openalex.org/W2094388155","https://openalex.org/W2143151997","https://openalex.org/W2149550178","https://openalex.org/W2158300157","https://openalex.org/W2167065708","https://openalex.org/W2174200965","https://openalex.org/W2321234878","https://openalex.org/W2336361427","https://openalex.org/W2405798383","https://openalex.org/W2406151020","https://openalex.org/W2411239092","https://openalex.org/W2417453837","https://openalex.org/W2418768792","https://openalex.org/W2489461349","https://openalex.org/W3024412946","https://openalex.org/W4231291566","https://openalex.org/W4249192139"],"related_works":["https://openalex.org/W2440453320","https://openalex.org/W2010928819","https://openalex.org/W1905838633","https://openalex.org/W7097909178","https://openalex.org/W1752381316","https://openalex.org/W1967833287","https://openalex.org/W2183243259","https://openalex.org/W2336361427","https://openalex.org/W2316219066","https://openalex.org/W2015454596"],"abstract_inverted_index":{"In":[0],"a":[1,118,154,173,259,278,365],"patient":[2,213],"with":[3,296,352,370],"increased":[4,275],"susceptibility":[5],"to":[6,25,137,152,171,195,211,239],"infection,":[7],"lowered":[8],"serum":[9,91,234],"C3":[10,22,37,58,65,73,127,180,231,351,367,378],"concentration,":[11],"and":[12,54,90,243,281,302,330],"continuously":[13],"circulating":[14],"C3b,":[15],"it":[16,178],"was":[17,23,38,74,134,157,159,177,271,315,332,344],"shown":[18,136,333],"that":[19,347,376],"purified":[20],"(125)I-labeled":[21],"converted":[24],"labeled":[26],"C3b":[27,194,244,329],"shortly":[28],"after":[29,277,282],"intravenous":[30],"administration.":[31],"The":[32,51,126,203,228,267,310,322],"fractional":[33,262],"catabolic":[34,263],"rate":[35,53,264],"of":[36,45,57,64,72,93,117,193,205,208,216,300,328,340,350,377],"approximately":[39],"five":[40],"times":[41,288],"normal":[42,124,209,284],"at":[43,286],"10%":[44],"the":[46,87,105,115,144,163,179,185,191,200,212,297,303,319,325,337,348],"plasma":[47,210],"pool":[48,55],"per":[49],"hr.":[50],"synthesis":[52],"distribution":[56],"were":[59,97,101,197,232,294],"normal.":[60,266],"Despite":[61],"this":[62,255],"evidence":[63,343],"instability":[66],"in":[67,76,86,104,143,162,230,261,318,324],"vivo,":[68],"no":[69,79,246],"accelerated":[70],"inactivation":[71],"found":[75],"vitro.":[77],"Similarly,":[78],"free":[80],"proteolytic":[81],"activity":[82],"could":[83,108,245],"be":[84,109,138,172,248],"detected":[85],"patient's":[88,106,145,164,201,268,320],"serum,":[89,107],"concentrations":[92],"known":[94],"protease":[95],"inhibitors":[96],"normal.Complement-mediated":[98],"functions,":[99],"which":[100,129,153],"markedly":[102],"deficient":[103],"restored":[110],"partially":[111,219],"or":[112,141,182,187,220],"completely":[113,221],"by":[114,362],"addition":[116],"5-6S":[119],"heat-labile":[120],"beta":[121,150],"pseudoglobulin":[122,151],"from":[123,199,237,307],"serum.":[125,146,165,202,321],"proinactivator,":[128],"has":[130],"these":[131],"physicochemical":[132],"characteristics,":[133],"also":[135,345],"either":[139],"absent":[140],"nonfunctional":[142],"An":[147],"unidentified":[148],"6S":[149],"monospecific":[155],"antiserum":[156],"available":[158],"not":[160,170],"detectable":[161],"This":[166],"last":[167],"protein":[168],"appeared":[169],"complement":[174],"component,":[175],"nor":[176],"inactivator":[181],"proinactivator.":[183],"Finally,":[184],"substance":[186],"substances":[188],"necessary":[189],"for":[190,222,313,357],"conversion":[192,368],"C3c":[196,331],"missing":[198],"administration":[204],"500":[206],"ml":[207],"corrected":[214],"all":[215],"his":[217],"abnormalities":[218],"as":[223,225,334,336],"long":[224],"17":[226],"days.":[227],"changes":[229],"dramatic;":[233],"concentration":[235],"rose":[236],"8":[238],"70":[240],"mg/100":[241],"ml,":[242],"longer":[247],"detected.":[249],"A":[250],"second":[251],"metabolic":[252],"study":[253],"during":[254],"normalization":[256],"period":[257],"showed":[258],"decrease":[260],"toward":[265],"histamine":[269,305],"excretion":[270],"constantly":[272],"elevated":[273],"but":[274],"further":[276],"warm":[279],"shower":[280],"receiving":[283],"plasma;":[285],"both":[287],"he":[289],"had":[290],"urticaria.":[291],"These":[292],"observations":[293],"consistent":[295],"endogenous":[298],"production":[299],"C3a":[301,314],"resulting":[304],"release":[306],"mast":[308],"cells.":[309],"inactivating":[311],"mechanism":[312],"apparently":[316],"intact":[317],"difference":[323],"electrophoretic":[326,338,372],"mobilities":[327],"well":[335],"heterogeneity":[339],"C3c.":[341],"Suggestive":[342],"presented":[346],"form":[349],"an":[353,371],"activated":[354],"combining":[355],"site":[356],"red":[358],"cells,":[359],"previously":[360],"postulated":[361],"others,":[363],"is":[364],"transient":[366],"product":[369],"mobility":[373],"slower":[374],"than":[375],"on":[379],"agarose":[380],"electrophoresis.":[381]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}