{"id":"https://openalex.org/W2065491387","doi":"https://doi.org/10.1080/07391102.2003.10506931","title":"The Role of Hydrophobic Interactions in Amyloidogenesis: Example of Prion-Related Polypeptides","display_name":"The Role of Hydrophobic Interactions in Amyloidogenesis: Example of Prion-Related Polypeptides","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W2065491387","doi":"https://doi.org/10.1080/07391102.2003.10506931","mag":"2065491387","pmid":"https://pubmed.ncbi.nlm.nih.gov/14616031"},"language":"en","primary_location":{"id":"doi:10.1080/07391102.2003.10506931","doi":"https://doi.org/10.1080/07391102.2003.10506931","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07391102.2003.10506931","pdf_url":null,"source":{"id":"https://openalex.org/S178711970","display_name":"Journal of Biomolecular Structure and Dynamics","issn_l":"0739-1102","issn":["0739-1102","1538-0254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular Structure and Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000225034","display_name":"Olga Tcherkasskaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Tcherkasskaya","raw_affiliation_strings":["Department of Biochemistry & Molecular Biology, Georgetown University School of Medicine, Washington DC, USA. ovt@georgetown.edu","Dept. of Biochemistry & Molecular Biology , Georgetown University School of Medicine , Washington , DC , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Biology, Georgetown University School of Medicine, Washington DC, USA. ovt@georgetown.edu","institution_ids":["https://openalex.org/I184565670"]},{"raw_affiliation_string":"Dept. of Biochemistry & Molecular Biology , Georgetown University School of Medicine , Washington , DC , USA","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William Sanders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Sanders","raw_affiliation_strings":["Dept. of Biochemistry & Molecular Biology, Georgetown University School of Medicine, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biochemistry & Molecular Biology, Georgetown University School of Medicine, Washington, DC, USA","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024229254","display_name":"Veeradej Chynwat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veeradej Chynwat","raw_affiliation_strings":["Department of Chemistry, Georgetown University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Georgetown University, Washington, DC, USA","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111907133","display_name":"Eugene A. Davidson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene A. Davidson","raw_affiliation_strings":["Dept. of Biochemistry & Molecular Biology, Georgetown University School of Medicine, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biochemistry & Molecular Biology, Georgetown University School of Medicine, Washington, DC, USA","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063918229","display_name":"Cindy Orser","orcid":"https://orcid.org/0000-0002-6027-3268","observed_orcids":["https://orcid.org/0000-0002-6027-3268"]},"institutions":[{"id":"https://openalex.org/I4210089452","display_name":"Aret\u00e9 Associates (United States)","ror":"https://ror.org/00cmpcq57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210089452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy S. Orser","raw_affiliation_strings":["Aret\u00e9 Associates, Gaithersburg, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aret\u00e9 Associates, Gaithersburg, MD, USA","institution_ids":["https://openalex.org/I4210089452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5658,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.58766486,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"21","issue":"3","first_page":"353","last_page":"365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.859000027179718},{"id":"https://openalex.org/keywords/amyloidogenesis","display_name":"amyloidogenesis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/prion-protein","display_name":"prion protein","score":0.9760000109672546},{"id":"https://openalex.org/keywords/prpsc","display_name":"PrPSc","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cellular-prion-protein","display_name":"cellular prion protein","score":0.703000009059906},{"id":"https://openalex.org/keywords/alpha-helix-to-beta-sheet-transition","display_name":"alpha-helix to beta-sheet transition","score":0.8069999814033508},{"id":"https://openalex.org/keywords/peptide-aggregation","display_name":"peptide aggregation","score":0.5720000267028809},{"id":"https://openalex.org/keywords/beta-sheet-formation","display_name":"\u03b2-sheet formation","score":0.800000011920929},{"id":"https://openalex.org/keywords/trifluoroethanol","display_name":"trifluoroethanol","score":0.7689999938011169},{"id":"https://openalex.org/keywords/acetonitrile","display_name":"acetonitrile","score":0.9750000238418579},{"id":"https://openalex.org/keywords/peptide-conformation","display_name":"peptide conformation","score":0.550000011920929},{"id":"https://openalex.org/keywords/prion-conversion","display_name":"prion conversion","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.804137647151947},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.7879496812820435},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6428074240684509},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5837514996528625},{"id":"https://openalex.org/C62614982","wikidata":"https://www.wikidata.org/wiki/Q904984","display_name":"Protein secondary structure","level":2,"score":0.5543187260627747},{"id":"https://openalex.org/C159547669","wikidata":"https://www.wikidata.org/wiki/Q283449","display_name":"Beta sheet","level":3,"score":0.550815224647522},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4672638773918152},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4304071068763733},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.4295889735221863},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4267970025539398},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.41804829239845276},{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.41477128863334656},{"id":"https://openalex.org/C90260826","wikidata":"https://www.wikidata.org/wiki/Q899157","display_name":"Hydrophobic effect","level":2,"score":0.41333702206611633},{"id":"https://openalex.org/C158711907","wikidata":"https://www.wikidata.org/wiki/Q1768467","display_name":"Fluorescence spectroscopy","level":3,"score":0.41009145975112915},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.3494507968425751},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.25315696001052856},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23903748393058777},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09346926212310791},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0787876546382904},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017096","descriptor_name":"Prion Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/07391102.2003.10506931","doi":"https://doi.org/10.1080/07391102.2003.10506931","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07391102.2003.10506931","pdf_url":null,"source":{"id":"https://openalex.org/S178711970","display_name":"Journal of Biomolecular Structure and Dynamics","issn_l":"0739-1102","issn":["0739-1102","1538-0254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular Structure and Dynamics","raw_type":"journal-article"},{"id":"pmid:14616031","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14616031","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomolecular structure & dynamics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5378966527","display_name":"A Catalytic Conformational Prion Sensor","funder_award_id":"1r43hl070399-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7987788407","display_name":null,"funder_award_id":"1R43 HL70399-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1489708565","https://openalex.org/W1542546682","https://openalex.org/W1544487163","https://openalex.org/W1573986638","https://openalex.org/W1678216887","https://openalex.org/W1859033693","https://openalex.org/W1879803811","https://openalex.org/W1960408443","https://openalex.org/W1964249554","https://openalex.org/W1967733770","https://openalex.org/W1971804606","https://openalex.org/W1976317909","https://openalex.org/W1980125299","https://openalex.org/W1985020792","https://openalex.org/W1988858296","https://openalex.org/W1991347541","https://openalex.org/W1995335567","https://openalex.org/W2007242005","https://openalex.org/W2008307658","https://openalex.org/W2009552737","https://openalex.org/W2024895112","https://openalex.org/W2025211528","https://openalex.org/W2025568734","https://openalex.org/W2028120920","https://openalex.org/W2029243412","https://openalex.org/W2029406653","https://openalex.org/W2034476449","https://openalex.org/W2038940699","https://openalex.org/W2039873895","https://openalex.org/W2050163971","https://openalex.org/W2050407809","https://openalex.org/W2058925087","https://openalex.org/W2064877487","https://openalex.org/W2067474488","https://openalex.org/W2068334126","https://openalex.org/W2070114315","https://openalex.org/W2072244190","https://openalex.org/W2074335610","https://openalex.org/W2075086095","https://openalex.org/W2075482445","https://openalex.org/W2076146345","https://openalex.org/W2077494556","https://openalex.org/W2080675825","https://openalex.org/W2080751623","https://openalex.org/W2082993709","https://openalex.org/W2085899859","https://openalex.org/W2089491263","https://openalex.org/W2092625134","https://openalex.org/W2093861673","https://openalex.org/W2095306729","https://openalex.org/W2096601751","https://openalex.org/W2101579398","https://openalex.org/W2101912586","https://openalex.org/W2119932601","https://openalex.org/W2136355739","https://openalex.org/W2139441575","https://openalex.org/W2141292050","https://openalex.org/W2146129321","https://openalex.org/W2148130200","https://openalex.org/W2153439292","https://openalex.org/W2172055093","https://openalex.org/W2408722881","https://openalex.org/W2555674569","https://openalex.org/W2768578200","https://openalex.org/W2950571356","https://openalex.org/W3151652689","https://openalex.org/W3156807887","https://openalex.org/W4249223763"],"related_works":["https://openalex.org/W2095306729","https://openalex.org/W201006271","https://openalex.org/W2285785796","https://openalex.org/W7216959655","https://openalex.org/W2021511025","https://openalex.org/W1581477304","https://openalex.org/W1985020792","https://openalex.org/W2153102663","https://openalex.org/W1991919068","https://openalex.org/W2560180168"],"abstract_inverted_index":{"Conversion":[0],"of":[1,6,49,53,59,94,107,135,147,161,178,187,193,198],"the":[2,7,12,30,35,41,50,54,92,95,101,105,111,115,133,151,159,162,168,179,185,188,196,202],"non-infectious,":[3],"cellular":[4],"form":[5,14],"prion":[8,55],"protein":[9],"(PrP(C))":[10],"to":[11,18,24,37,91],"infectious":[13],"(PrP(Sc))":[15],"is":[16],"thought":[17],"be":[19,209],"driven":[20],"by":[21,141],"an":[22],"alpha-helical":[23],"beta-sheet":[25,190],"conformational":[26,152],"transition.":[27],"To":[28],"reveal":[29],"sequence":[31],"determinants":[32],"which":[33,205],"encourage":[34],"transition":[36],"beta-fold,":[38],"we":[39],"study":[40],"synthetic":[42],"peptides":[43,60],"associated":[44],"with":[45],"hydrophobic":[46,173],"conserved":[47],"fragments":[48],"N-terminal":[51],"region":[52],"protein.":[56],"The":[57,83],"structure":[58,102,139],"in":[61,123,183,201,206],"solution":[62],"was":[63],"probed":[64],"under":[65],"various":[66],"thermodynamic":[67],"conditions":[68],"employing":[69],"circular":[70,142],"dichroism":[71],"and":[72,158],"steady":[73],"state":[74],"fluorescence":[75,84],"spectroscopy":[76],"as":[77,79,214,216],"well":[78,215],"dye":[80],"binding":[81],"assays.":[82],"methods":[85],"utilized":[86],"pyrene":[87],"residues":[88],"covalently":[89],"attached":[90],"end":[93],"model":[96],"peptides.":[97],"In":[98],"aqueous":[99],"solutions,":[100],"assessments":[103],"indicate":[104,171],"formation":[106,186],"metastable":[108],"peptide":[109,116,180,203],"aggregates;":[110],"molecular":[112,124,220],"conformations":[113],"within":[114,211,217],"micelles":[117],"are":[118],"largely":[119],"coiled.":[120],"This":[121],"stage":[122],"assembly":[125],"exists":[126],"without":[127],"significant":[128],"beta-strand":[129,156],"formation,":[130,157],"i.e.,":[131],"before":[132],"appearance":[134],"any":[136],"ordered":[137],"secondary":[138],"detectable":[140],"dichroism.":[143],"At":[144],"moderate":[145],"concentrations":[146],"trifluoroethanol":[148],"and/or":[149],"acetonitrile,":[150],"ensemble":[153],"shifts":[154],"towards":[155],"population":[160],"amorphous":[163],"aggregates":[164],"decreases":[165],"significantly.":[166],"Overall,":[167],"present":[169],"data":[170],"that":[172],"interactions":[174,200],"between":[175],"side":[176],"chains":[177],"variants":[181],"prevent,":[182],"fact,":[184],"rigid":[189],"structures.":[191],"Encouragement":[192],"beta-folds":[194],"requires":[195],"destabilization":[197],"local":[199],"chain,":[204],"vivo":[207],"might":[208],"possible":[210],"cell":[212],"membranes":[213],"partly":[218],"folded":[219],"forms.":[221]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
