{"id":"https://openalex.org/W2065447152","doi":"https://doi.org/10.1074/jbc.270.41.23895","title":"Amino-terminal Deletions Enhance Aggregation of \u03b2-Amyloid Peptides in Vitro","display_name":"Amino-terminal Deletions Enhance Aggregation of \u03b2-Amyloid Peptides in Vitro","publication_year":1995,"publication_date":"1995-10-01","ids":{"openalex":"https://openalex.org/W2065447152","doi":"https://doi.org/10.1074/jbc.270.41.23895","mag":"2065447152","pmid":"https://pubmed.ncbi.nlm.nih.gov/7592576"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.270.41.23895","doi":"https://doi.org/10.1074/jbc.270.41.23895","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.270.41.23895","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.270.41.23895","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007207994","display_name":"Christian J. Pike","orcid":"https://orcid.org/0000-0003-4577-7668","observed_orcids":["https://orcid.org/0000-0003-4577-7668"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christian J. Pike","raw_affiliation_strings":["Department of Psychobiology, University of California, Irvine 92717-4550, USA","Department of Psychobiology, Institute for Brain Aging and Dementia, University of California, Irvine, California 92717-4550"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychobiology, University of California, Irvine 92717-4550, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Psychobiology, Institute for Brain Aging and Dementia, University of California, Irvine, California 92717-4550","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003827387","display_name":"Michael James Overman","orcid":"https://orcid.org/0000-0001-5377-135X","observed_orcids":["https://orcid.org/0000-0001-5377-135X"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Overman","raw_affiliation_strings":["Department of Psychobiology, Institute for Brain Aging and Dementia, University of California, Irvine, California 92717-4550"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychobiology, Institute for Brain Aging and Dementia, University of California, Irvine, California 92717-4550","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109127771","display_name":"Carl W. Cotman","orcid":"https://orcid.org/0000-0001-6533-9062","observed_orcids":["https://orcid.org/0000-0001-6533-9062"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl W. Cotman","raw_affiliation_strings":["Department of Psychobiology, Institute for Brain Aging and Dementia, University of California, Irvine, California 92717-4550"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychobiology, Institute for Brain Aging and Dementia, University of California, Irvine, California 92717-4550","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007207994"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.3414,"has_fulltext":false,"cited_by_count":308,"citation_normalized_percentile":{"value":0.93870115,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"270","issue":"41","first_page":"23895","last_page":"23898"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9549999833106995},{"id":"https://openalex.org/keywords/n-terminal-truncation","display_name":"N-terminal truncation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/peptide-aggregation","display_name":"peptide aggregation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9559999704360962},{"id":"https://openalex.org/keywords/beta-sheet-fibrils","display_name":"\u03b2-sheet fibrils","score":0.7940000295639038},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.9319999814033508},{"id":"https://openalex.org/keywords/fibril-nucleation","display_name":"fibril nucleation","score":0.765999972820282},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.375},{"id":"https://openalex.org/keywords/circular-dichroism","display_name":"circular dichroism","score":0.7459999918937683},{"id":"https://openalex.org/keywords/transmission-electron-microscopy","display_name":"transmission electron microscopy","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7712832689285278},{"id":"https://openalex.org/C2779664074","wikidata":"https://www.wikidata.org/wiki/Q3518405","display_name":"Terminal (telecommunication)","level":2,"score":0.6983388662338257},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5784172415733337},{"id":"https://openalex.org/C3018824666","wikidata":"https://www.wikidata.org/wiki/Q284398","display_name":"Amino terminal","level":4,"score":0.5081222057342529},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5062569975852966},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4769517481327057},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43954622745513916},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3487909138202667},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.34395715594291687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27133315801620483},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20253020524978638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08397814631462097},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.270.41.23895","doi":"https://doi.org/10.1074/jbc.270.41.23895","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.270.41.23895","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:7592576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7592576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.270.41.23895","doi":"https://doi.org/10.1074/jbc.270.41.23895","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.270.41.23895","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2786542186","display_name":"GENETIC AND BIOCHEMICAL EVENTS IN AB-INDUCED APOPTOSIS","funder_award_id":"R01AG012663","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1486013008","https://openalex.org/W1504320357","https://openalex.org/W1531666134","https://openalex.org/W1552345552","https://openalex.org/W1554535382","https://openalex.org/W1960543132","https://openalex.org/W1977823998","https://openalex.org/W1979543098","https://openalex.org/W1980906872","https://openalex.org/W1981545549","https://openalex.org/W1981570625","https://openalex.org/W1982635793","https://openalex.org/W1984996311","https://openalex.org/W1989972829","https://openalex.org/W1991435932","https://openalex.org/W2011424449","https://openalex.org/W2013833879","https://openalex.org/W2014550271","https://openalex.org/W2016341410","https://openalex.org/W2019369720","https://openalex.org/W2021417643","https://openalex.org/W2032665239","https://openalex.org/W2033382511","https://openalex.org/W2034478391","https://openalex.org/W2036288989","https://openalex.org/W2038012168","https://openalex.org/W2046847750","https://openalex.org/W2049471629","https://openalex.org/W2051261126","https://openalex.org/W2058110454","https://openalex.org/W2059062385","https://openalex.org/W2065199872","https://openalex.org/W2065235688","https://openalex.org/W2067811915","https://openalex.org/W2071310220","https://openalex.org/W2071953900","https://openalex.org/W2079430002","https://openalex.org/W2081182167","https://openalex.org/W2081678091","https://openalex.org/W2081897353","https://openalex.org/W2086278983","https://openalex.org/W2087969945","https://openalex.org/W2094411486","https://openalex.org/W2101119637","https://openalex.org/W2108689038","https://openalex.org/W2130144581"],"related_works":["https://openalex.org/W1981545549","https://openalex.org/W4306725349","https://openalex.org/W1960543132","https://openalex.org/W4230001627","https://openalex.org/W2034337797","https://openalex.org/W2580085714","https://openalex.org/W1587774683","https://openalex.org/W1963518601","https://openalex.org/W2989703803","https://openalex.org/W2901128464"],"abstract_inverted_index":{"beta-Amyloid":[0],"protein,":[1],"which":[2],"assembles":[3],"into":[4,184],"pathological":[5,198],"aggregates":[6],"deposited":[7],"in":[8,17,20,129,168],"Alzheimer's":[9],"disease":[10],"brain":[11],"tissue,":[12],"exhibits":[13],"N-terminal":[14,28,81,178],"heterogeneity":[15,29],"both":[16],"vitro":[18],"and":[19,34,62,65,134,142,145,165,188],"vivo.":[21],"To":[22,117],"investigate":[23],"the":[24,31,124,130,197],"effects":[25],"of":[26,37,43,123,137,170,182,200],"this":[27],"on":[30],"assembly":[32],"characteristics":[33],"biophysical":[35,121],"properties":[36,136],"beta-amyloid,":[38],"we":[39],"synthesized":[40],"a":[41],"series":[42],"peptides":[44,79,103,139,147,192],"with":[45,80,155],"progressively":[46],"shortened":[47],"N":[48],"termini":[49,67],"(initial":[50],"residues":[51],"at":[52,105,113],"positions":[53],"beta":[54,56,58,60,63,71,74,107,115],"1,":[55],"4,":[57],"8,":[59],"12,":[61],"17)":[64],"C":[66],"extending":[68],"to":[69,88],"residue":[70,106,114],"40":[72],"or":[73],"42.":[75],"We":[76],"report":[77],"that":[78,177,190],"deletions":[82,179],"exhibit":[83],"enhanced":[84],"peptide":[85],"aggregation":[86,149,181],"relative":[87],"full-length":[89,125],"species,":[90],"as":[91],"quantitatively":[92],"assessed":[93],"by":[94],"sedimentation":[95,98],"analyses.":[96],"Overall,":[97],"levels":[99],"were":[100,127,140],"greater":[101],"for":[102,110],"terminating":[104,112],"42":[108],"than":[109],"those":[111],"40.":[116],"determine":[118],"if":[119],"established":[120],"features":[122],"protein":[126],"maintained":[128],"truncated":[131,146],"peptides,":[132],"structural":[133],"bioactive":[135],"these":[138],"examined":[141],"compared.":[143],"Full-length":[144],"exhibiting":[148],"showed":[150],"circular":[151],"dichroism":[152],"spectra":[153],"consistent":[154],"predominant":[156],"beta-sheet":[157,186],"conformation,":[158],"fibrillar":[159],"morphology":[160],"under":[161],"transmission":[162],"electron":[163],"microscopy,":[164],"significant":[166],"toxicity":[167],"cultures":[169],"rat":[171],"hippocampal":[172],"neurons.":[173],"These":[174],"data":[175],"demonstrate":[176],"enhance":[180],"beta-amyloid":[183],"neurotoxic,":[185],"fibrils":[187],"suggest":[189],"such":[191],"may":[193],"initiate":[194],"and/or":[195],"nucleate":[196],"deposition":[199],"beta-amyloid.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
