{"id":"https://openalex.org/W2065407430","doi":"https://doi.org/10.1038/ncpneuro0325","title":"Randomized trial supports use of levetiracetam adjunctive therapy to treat partial seizures in children","display_name":"Randomized trial supports use of levetiracetam adjunctive therapy to treat partial seizures in children","publication_year":2006,"publication_date":"2006-10-23","ids":{"openalex":"https://openalex.org/W2065407430","doi":"https://doi.org/10.1038/ncpneuro0325","mag":"2065407430","pmid":"https://pubmed.ncbi.nlm.nih.gov/17057745"},"language":"en","primary_location":{"id":"doi:10.1038/ncpneuro0325","doi":"https://doi.org/10.1038/ncpneuro0325","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ncpneuro0325","pdf_url":null,"source":{"id":"https://openalex.org/S4210172272","display_name":"Nature Clinical Practice Neurology","issn_l":"1745-834X","issn":["1745-834X","1745-8358"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Clinical Practice Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059417834","display_name":"Frances E. Jensen","orcid":"https://orcid.org/0000-0001-7844-5518","observed_orcids":["https://orcid.org/0000-0001-7844-5518"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frances E Jensen","raw_affiliation_strings":["Harvard Medical School, Children's Hospital Boston, MA 02115, USA. frances.jensen@childrens.harvard.edu","Harvard Medical School and Director of Epilepsy Research at Children's Hospital, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Children's Hospital Boston, MA 02115, USA. frances.jensen@childrens.harvard.edu","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School and Director of Epilepsy Research at Children's Hospital, Boston","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113695468","display_name":"Blaise F. D. Bourgeois","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blaise FD Bourgeois","raw_affiliation_strings":["Division of Epilepsy and Clinical Neurophysiology at Children's Hospital Boston, Boston, MA, USA","Harvard Medical School and Director of Epilepsy Research at Children's Hospital, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epilepsy and Clinical Neurophysiology at Children's Hospital Boston, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Medical School and Director of Epilepsy Research at Children's Hospital, Boston","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059417834"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.19188504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"11","first_page":"596","last_page":"597"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levetiracetam","display_name":"levetiracetam","score":1.0},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.824999988079071},{"id":"https://openalex.org/keywords/focal-seizures","display_name":"focal seizures","score":0.9660000205039978},{"id":"https://openalex.org/keywords/pediatric-epilepsy","display_name":"pediatric epilepsy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9449999928474426},{"id":"https://openalex.org/keywords/synaptic-vesicle-glycoprotein-2a","display_name":"SV2A","score":0.8169999718666077},{"id":"https://openalex.org/keywords/seizure-control","display_name":"seizure control","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2777332695","wikidata":"https://www.wikidata.org/wiki/Q417227","display_name":"Levetiracetam","level":3,"score":0.9612014293670654},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.7694404125213623},{"id":"https://openalex.org/C3018162438","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Adjunctive treatment","level":2,"score":0.7164140939712524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6466164588928223},{"id":"https://openalex.org/C2777496795","wikidata":"https://www.wikidata.org/wiki/Q410069","display_name":"Piracetam","level":2,"score":0.5124276280403137},{"id":"https://openalex.org/C2777803345","wikidata":"https://www.wikidata.org/wiki/Q7140388","display_name":"partial seizures","level":3,"score":0.43801695108413696},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.33345597982406616},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.30858445167541504},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.24891844391822815},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1921921670436859},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12606367468833923}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/ncpneuro0325","doi":"https://doi.org/10.1038/ncpneuro0325","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ncpneuro0325","pdf_url":null,"source":{"id":"https://openalex.org/S4210172272","display_name":"Nature Clinical Practice Neurology","issn_l":"1745-834X","issn":["1745-834X","1745-8358"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Clinical Practice Neurology","raw_type":"journal-article"},{"id":"pmid:17057745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17057745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature clinical practice. Neurology","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1978558050","https://openalex.org/W2042487369","https://openalex.org/W2059275293","https://openalex.org/W2086759170","https://openalex.org/W2127801604"],"related_works":["https://openalex.org/W4232823569","https://openalex.org/W4242940249","https://openalex.org/W2331789957","https://openalex.org/W4415530319","https://openalex.org/W7209706888","https://openalex.org/W2070754328","https://openalex.org/W2372902309","https://openalex.org/W2042487369","https://openalex.org/W2069166395","https://openalex.org/W2408341621"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}