{"id":"https://openalex.org/W2065405015","doi":"https://doi.org/10.1006/bbrc.1999.0675","title":"Changes in Hypothalamic Agouti-Related Protein (AGRP), but not \u03b1-MSH or Pro-Opiomelanocortin Concentrations in Dietary-Obese and Food-Restricted Rats","display_name":"Changes in Hypothalamic Agouti-Related Protein (AGRP), but not \u03b1-MSH or Pro-Opiomelanocortin Concentrations in Dietary-Obese and Food-Restricted Rats","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W2065405015","doi":"https://doi.org/10.1006/bbrc.1999.0675","mag":"2065405015","pmid":"https://pubmed.ncbi.nlm.nih.gov/10329427"},"language":"en","primary_location":{"id":"doi:10.1006/bbrc.1999.0675","doi":"https://doi.org/10.1006/bbrc.1999.0675","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1999.0675","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049326787","display_name":"Joanne Allison Harrold","orcid":"https://orcid.org/0000-0002-0899-4586","observed_orcids":["https://orcid.org/0000-0002-0899-4586"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Joanne A. Harrold","raw_affiliation_strings":["Department of Medicine, University of Liverpool, Liverpool, United Kingdom. harrold@liverpool.ac.uk","Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Liverpool, Liverpool, United Kingdom. harrold@liverpool.ac.uk","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114948439","display_name":"Gareth Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gareth Williams","raw_affiliation_strings":["Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059695945","display_name":"Peter S. Widdowson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter S. Widdowson","raw_affiliation_strings":["Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049326787"],"corresponding_institution_ids":["https://openalex.org/I146655781"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":3.1735,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.93225806,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"258","issue":"3","first_page":"574","last_page":"577"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agouti-related-protein","display_name":"agouti-related protein","score":0.9919999837875366},{"id":"https://openalex.org/keywords/alpha-msh","display_name":"alpha-melanocyte-stimulating hormone","score":0.9860000014305115},{"id":"https://openalex.org/keywords/proopiomelanocortin","display_name":"proopiomelanocortin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/melanocortin-4-receptor","display_name":"melanocortin-4 receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9769999980926514},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.878000020980835},{"id":"https://openalex.org/keywords/dietary-restriction","display_name":"dietary restriction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/energy-balance","display_name":"energy balance","score":0.8730000257492065},{"id":"https://openalex.org/keywords/feeding-behaviour","display_name":"feeding behaviour","score":0.859000027179718},{"id":"https://openalex.org/keywords/competitive-antagonists","display_name":"competitive antagonists","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.9014185667037964},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8929435014724731},{"id":"https://openalex.org/C2779993316","wikidata":"https://www.wikidata.org/wiki/Q6591465","display_name":"Melanocortin","level":3,"score":0.7349535226821899},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6732829213142395},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5481394529342651},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5341600179672241},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5327560901641846},{"id":"https://openalex.org/C43295716","wikidata":"https://www.wikidata.org/wiki/Q21118676","display_name":"Melanocortin 4 receptor","level":4,"score":0.5206415057182312},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.46562808752059937},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44557690620422363},{"id":"https://openalex.org/C2780989459","wikidata":"https://www.wikidata.org/wiki/Q423981","display_name":"Melanocyte-stimulating hormone","level":3,"score":0.4452039897441864},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4323369860649109},{"id":"https://openalex.org/C2777241137","wikidata":"https://www.wikidata.org/wiki/Q24784850","display_name":"Melanocortin receptor","level":4,"score":0.4134373664855957},{"id":"https://openalex.org/C3018685816","wikidata":"https://www.wikidata.org/wiki/Q213449","display_name":"Food intake","level":2,"score":0.41136303544044495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3953911066055298},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17720156908035278}],"mesh":[{"descriptor_ui":"D000521","descriptor_name":"alpha-MSH","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005508","descriptor_name":"Food Deprivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054366","descriptor_name":"Agouti Signaling Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054369","descriptor_name":"Agouti-Related Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/bbrc.1999.0675","doi":"https://doi.org/10.1006/bbrc.1999.0675","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1999.0675","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:10329427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10329427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1606342288","https://openalex.org/W1966999658","https://openalex.org/W1970163196","https://openalex.org/W1988115040","https://openalex.org/W1989860098","https://openalex.org/W2006444995","https://openalex.org/W2010142606","https://openalex.org/W2016261339","https://openalex.org/W2016877878","https://openalex.org/W2017244979","https://openalex.org/W2061240699","https://openalex.org/W2065389660","https://openalex.org/W2076377925","https://openalex.org/W2078762652","https://openalex.org/W2080870548","https://openalex.org/W2089358222","https://openalex.org/W2129221666","https://openalex.org/W2130421120","https://openalex.org/W2147741187","https://openalex.org/W2153867200","https://openalex.org/W2171010063"],"related_works":["https://openalex.org/W1972000079","https://openalex.org/W2171010063","https://openalex.org/W2043322678","https://openalex.org/W2140549760","https://openalex.org/W2143890627","https://openalex.org/W2147741187","https://openalex.org/W2103710153","https://openalex.org/W2045730168","https://openalex.org/W2002091441","https://openalex.org/W2051509791"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}