{"id":"https://openalex.org/W2065359334","doi":"https://doi.org/10.1016/j.atherosclerosis.2014.03.035","title":"PPAR\u03b3 activation does not affect endothelin activity in non-diabetic patients with hypertension or hypercholesterolemia","display_name":"PPAR\u03b3 activation does not affect endothelin activity in non-diabetic patients with hypertension or hypercholesterolemia","publication_year":2014,"publication_date":"2014-04-06","ids":{"openalex":"https://openalex.org/W2065359334","doi":"https://doi.org/10.1016/j.atherosclerosis.2014.03.035","mag":"2065359334","pmid":"https://pubmed.ncbi.nlm.nih.gov/24769306"},"language":"en","primary_location":{"id":"doi:10.1016/j.atherosclerosis.2014.03.035","doi":"https://doi.org/10.1016/j.atherosclerosis.2014.03.035","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.atherosclerosis.2014.03.035","pdf_url":null,"source":{"id":"https://openalex.org/S206830620","display_name":"Atherosclerosis","issn_l":"0021-9150","issn":["0021-9150","1879-1484"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Atherosclerosis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057057284","display_name":"Umberto Campia","orcid":"https://orcid.org/0000-0002-7894-3565","observed_orcids":["https://orcid.org/0000-0002-7894-3565"]},"institutions":[{"id":"https://openalex.org/I4210154815","display_name":"MedStar Heart & Vascular Institute","ror":"https://ror.org/0405m4551","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210154815","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Umberto Campia","raw_affiliation_strings":["MedStar Cardiovascular Research Network, MedStar Heart Institute, 110 Irving Street NW, Room NA-1041, Washington, DC 20010, USA. Electronic address: umberto.campia@medstar.net","MedStar Cardiovascular Research Network, MedStar Heart Institute, 110 Irving Street NW, Room NA-1041, Washington, DC 20010, USA"],"raw_orcid":"https://orcid.org/0000-0002-7894-3565","affiliations":[{"raw_affiliation_string":"MedStar Cardiovascular Research Network, MedStar Heart Institute, 110 Irving Street NW, Room NA-1041, Washington, DC 20010, USA. Electronic address: umberto.campia@medstar.net","institution_ids":["https://openalex.org/I4210154815"]},{"raw_affiliation_string":"MedStar Cardiovascular Research Network, MedStar Heart Institute, 110 Irving Street NW, Room NA-1041, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I4210154815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050024432","display_name":"Linda A. Matuskey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154815","display_name":"MedStar Heart & Vascular Institute","ror":"https://ror.org/0405m4551","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210154815","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda A. Matuskey","raw_affiliation_strings":["MedStar Cardiovascular Research Network, MedStar Heart Institute, 110 Irving Street NW, Room NA-1041, Washington, DC 20010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Cardiovascular Research Network, MedStar Heart Institute, 110 Irving Street NW, Room NA-1041, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I4210154815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037604705","display_name":"Manfredi Tesauro","orcid":"https://orcid.org/0000-0002-3967-1552","observed_orcids":["https://orcid.org/0000-0002-3967-1552"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Manfredi Tesauro","raw_affiliation_strings":["System Medicine, University of Tor Vergata, Viale Oxford, 81, 00133 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"System Medicine, University of Tor Vergata, Viale Oxford, 81, 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022926640","display_name":"Carmine Cardillo","orcid":"https://orcid.org/0000-0001-5182-3005","observed_orcids":["https://orcid.org/0000-0001-5182-3005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmine Cardillo","raw_affiliation_strings":["Internal Medicine, Catholic University, Largo A. Gemelli, 8, 00168 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Catholic University, Largo A. Gemelli, 8, 00168 Rome, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043669959","display_name":"Julio A. Panza","orcid":"https://orcid.org/0000-0001-8652-8110","observed_orcids":["https://orcid.org/0000-0001-8652-8110"]},"institutions":[{"id":"https://openalex.org/I1321686444","display_name":"Westchester Medical Center","ror":"https://ror.org/03fcgva33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321686444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julio A. Panza","raw_affiliation_strings":["Westchester Medical Center, 100 Woods Road, Macy Pavilion, Room 102, Valhalla, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westchester Medical Center, 100 Woods Road, Macy Pavilion, Room 102, Valhalla, NY, USA","institution_ids":["https://openalex.org/I1321686444"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057057284"],"corresponding_institution_ids":["https://openalex.org/I4210154815"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":0.1366,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.50173761,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"234","issue":"2","first_page":"436","last_page":"440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.8223000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.8223000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.1315000057220459,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":0.9700000286102295},{"id":"https://openalex.org/keywords/ppargamma-activation","display_name":"PPAR\u03b3 activation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/endothelin-a-receptor","display_name":"ETA receptor","score":0.828000009059906},{"id":"https://openalex.org/keywords/bq-123","display_name":"BQ-123","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7549999952316284},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":1.0},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9449999928474426},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/non-diabetic-patients","display_name":"non-diabetic patients","score":0.8650000095367432},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8339999914169312},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C2778384471","wikidata":"https://www.wikidata.org/wiki/Q417765","display_name":"Pioglitazone","level":4,"score":0.940690815448761},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8328702449798584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7611023187637329},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7438287138938904},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6371637582778931},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6099664568901062},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5404714941978455},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.49279120564460754},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.47913166880607605},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09681826829910278}],"mesh":[{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004219","descriptor_name":"District of Columbia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005542","descriptor_name":"Forearm","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D065130","descriptor_name":"Endothelin A Receptor Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.atherosclerosis.2014.03.035","doi":"https://doi.org/10.1016/j.atherosclerosis.2014.03.035","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.atherosclerosis.2014.03.035","pdf_url":null,"source":{"id":"https://openalex.org/S206830620","display_name":"Atherosclerosis","issn_l":"0021-9150","issn":["0021-9150","1879-1484"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Atherosclerosis","raw_type":"journal-article"},{"id":"pmid:24769306","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24769306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Atherosclerosis","raw_type":"Journal Article"},{"id":"pmh:oai:art.torvergata.it:2108/89865","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/89865","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1973780824","https://openalex.org/W1977986167","https://openalex.org/W1984030224","https://openalex.org/W1995765328","https://openalex.org/W1999742888","https://openalex.org/W2005419407","https://openalex.org/W2009282512","https://openalex.org/W2033663811","https://openalex.org/W2039617541","https://openalex.org/W2047591801","https://openalex.org/W2059279349","https://openalex.org/W2063204422","https://openalex.org/W2063573267","https://openalex.org/W2088080019","https://openalex.org/W2090204227","https://openalex.org/W2093655696","https://openalex.org/W2114778001","https://openalex.org/W2117479622","https://openalex.org/W2120381920","https://openalex.org/W2120814678","https://openalex.org/W2123404136","https://openalex.org/W2126327417","https://openalex.org/W2128899850","https://openalex.org/W2129708297","https://openalex.org/W2143064967","https://openalex.org/W2148663698","https://openalex.org/W2149183386","https://openalex.org/W2162804111","https://openalex.org/W2171533490","https://openalex.org/W2341645956","https://openalex.org/W4240449862"],"related_works":["https://openalex.org/W2120814678","https://openalex.org/W2125948026","https://openalex.org/W2315056969","https://openalex.org/W2003515701","https://openalex.org/W2391458185","https://openalex.org/W2062768357","https://openalex.org/W2334693352","https://openalex.org/W2129563873","https://openalex.org/W2989424478","https://openalex.org/W2021673229"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
