{"id":"https://openalex.org/W2065327124","doi":"https://doi.org/10.1002/ana.410300206","title":"Neuritic pathology and dementia in alzheimer's disease","display_name":"Neuritic pathology and dementia in alzheimer's disease","publication_year":1991,"publication_date":"1991-08-01","ids":{"openalex":"https://openalex.org/W2065327124","doi":"https://doi.org/10.1002/ana.410300206","mag":"2065327124","pmid":"https://pubmed.ncbi.nlm.nih.gov/1910274"},"language":"en","primary_location":{"id":"doi:10.1002/ana.410300206","doi":"https://doi.org/10.1002/ana.410300206","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410300206","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036454720","display_name":"Ann Carolyn McKee","orcid":"https://orcid.org/0000-0003-2961-7488","observed_orcids":["https://orcid.org/0000-0003-2961-7488"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. C. McKee","raw_affiliation_strings":["Department of Neuropathology, Massachusetts General Hospital, Boston 02114","Department of Neuropathology, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropathology, Massachusetts General Hospital, Boston 02114","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neuropathology, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016853030","display_name":"Kenneth S. Kosik","orcid":"https://orcid.org/0000-0003-3224-5179","observed_orcids":["https://orcid.org/0000-0003-3224-5179"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. S. Kosik","raw_affiliation_strings":["Department of Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022852165","display_name":"Neil W. Kowall","orcid":"https://orcid.org/0000-0002-6624-0213","observed_orcids":["https://orcid.org/0000-0002-6624-0213"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. W. Kowall","raw_affiliation_strings":["Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA","Department of Neuropathology, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neuropathology, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5036454720"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":9.2344,"has_fulltext":false,"cited_by_count":361,"citation_normalized_percentile":{"value":0.98981178,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"30","issue":"2","first_page":"156","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dementia-severity","display_name":"dementia severity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.8500000238418579},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.996999979019165},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.968999981880188},{"id":"https://openalex.org/keywords/dystrophic-neurites","display_name":"dystrophic neurites","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6359999775886536},{"id":"https://openalex.org/keywords/neocortex","display_name":"neocortex","score":0.9269999861717224},{"id":"https://openalex.org/keywords/thioflavine-s","display_name":"thioflavine S","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.9580748677253723},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7123432159423828},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.6417379379272461},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5544878840446472},{"id":"https://openalex.org/C2779721402","wikidata":"https://www.wikidata.org/wiki/Q767442","display_name":"Neurofibrillary tangle","level":5,"score":0.5446684956550598},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.5357389450073242},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.5316451191902161},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.5283095240592957},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.455261766910553},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.43564897775650024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39174380898475647},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3912199139595032},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30632781982421875},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.30441999435424805},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25481417775154114},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.050888001918792725},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009454","descriptor_name":"Neurofibrils","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ana.410300206","doi":"https://doi.org/10.1002/ana.410300206","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410300206","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},{"id":"pmid:1910274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1910274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3308116063","display_name":null,"funder_award_id":"NS 01368-01","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7637191593","display_name":"Massachusetts Alzheimer's Disease Research Center","funder_award_id":"P50AG005134","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7982480268","display_name":"PATHOBIOLOGY OF TAU PROTEIN","funder_award_id":"R01AG006601","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8987844260","display_name":"CYTOSKELETAL DISORGANIZATION ALZHEIMER'S DISEASE","funder_award_id":"K08NS001368","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W100202513","https://openalex.org/W1250647964","https://openalex.org/W1488741626","https://openalex.org/W1569576869","https://openalex.org/W1967211332","https://openalex.org/W1969876437","https://openalex.org/W1974028432","https://openalex.org/W1979992126","https://openalex.org/W1982556153","https://openalex.org/W1984827962","https://openalex.org/W1991895227","https://openalex.org/W2007446596","https://openalex.org/W2009418390","https://openalex.org/W2013471403","https://openalex.org/W2013729857","https://openalex.org/W2020486984","https://openalex.org/W2026100040","https://openalex.org/W2036801925","https://openalex.org/W2039380404","https://openalex.org/W2041436943","https://openalex.org/W2052559661","https://openalex.org/W2059214757","https://openalex.org/W2060458492","https://openalex.org/W2062002803","https://openalex.org/W2072371192","https://openalex.org/W2074220453","https://openalex.org/W2075846906","https://openalex.org/W2086552679","https://openalex.org/W2091874081","https://openalex.org/W2091985395","https://openalex.org/W2103575664","https://openalex.org/W2112759299","https://openalex.org/W2124310598","https://openalex.org/W2134941195","https://openalex.org/W2156326104","https://openalex.org/W2162298355","https://openalex.org/W2171405125","https://openalex.org/W2186226783","https://openalex.org/W2912698975","https://openalex.org/W2993083418","https://openalex.org/W2998848300","https://openalex.org/W4248875019","https://openalex.org/W4297738240"],"related_works":["https://openalex.org/W2053116497","https://openalex.org/W1984311390","https://openalex.org/W1976357608","https://openalex.org/W2004803322","https://openalex.org/W2084957666","https://openalex.org/W2994627895","https://openalex.org/W2401434197","https://openalex.org/W2081126811","https://openalex.org/W1569576869","https://openalex.org/W2049695088"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"of":[2,10,16,30,46,181,192,210],"Alzheimer's":[3],"disease":[4,79],"(AD)":[5],"have":[6],"correlated":[7,187],"the":[8,14,43,47,53,105,153,179,189,208],"severity":[9,191],"dementia":[11,211],"with":[12,70,108,127,172,175,188],"either":[13],"number":[15,180],"senile":[17,31,72,115,125,159],"plaques":[18,73,116,126],"or":[19],"neurofibrillary":[20,75,118,129,185],"tangles.":[21,130],"We":[22],"used":[23],"antibodies":[24],"raised":[25],"against":[26],"amyloid":[27],"beta/A4":[28,87,96,136,196],"protein":[29,36,88,97,137,197],"plaque":[32],"cores":[33],"and":[34,42,56,66,74,117,139,178,184],"tau":[35],"as":[37,39,155,157],"well":[38,156],"thioflavine":[40],"S":[41],"Campbell-Switzer":[44],"modification":[45],"Hicks":[48,142],"silver":[49],"method":[50],"to":[51],"examine":[52],"hippocampal":[54],"formation":[55],"five":[57],"neocortical":[58,101,124,140],"regions":[59],"from":[60],"22":[61],"nondemented":[62],"elderly":[63],"control":[64,82,91,176],"subjects":[65,83,92,177],"34":[67,106],"demented":[68,132],"patients":[69,107,133,171],"cerebral":[71,195],"tangles,":[76,119],"without":[77],"complicating":[78],"processes.":[80],"Ten":[81],"(46%)":[84],"had":[85,94,113,123,134],"no":[86,100],"deposition.":[89],"Twelve":[90],"(54%)":[93],"widespread":[95,114,135],"deposition":[98,138,198],"but":[99,202],"neuritic":[102],"pathology.":[103],"Of":[104],"AD-type":[109],"changes,":[110],"27":[111],"(79%)":[112],"while":[120],"7":[121],"(21%)":[122],"few":[128],"All":[131],"tau-immunoreactive,":[141],"silver-positive":[143],"dystrophic":[144,165,182],"neurites.":[145],"The":[146],"neurites":[147,166,183],"were":[148,167],"found":[149],"both":[150],"free":[151],"in":[152,170,212],"neuropil":[154],"surrounding":[158],"plaques.":[160],"Quantitative":[161],"analysis":[162],"showed":[163],"that":[164],"significantly":[168],"increased":[169],"AD":[173],"compared":[174],"tangles":[186],"clinical":[190],"dementia.":[193],"Widespread":[194],"may":[199],"be":[200],"necessary":[201],"by":[203],"itself":[204],"is":[205],"insufficient":[206],"for":[207],"development":[209],"AD.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}