{"id":"https://openalex.org/W2065319623","doi":"https://doi.org/10.1128/jvi.02353-07","title":"Importance of Protease Cleavage Sites within and Flanking Human Immunodeficiency Virus Type 1 Transframe Protein p6* for Spatiotemporal Regulation of Protease Activation","display_name":"Importance of Protease Cleavage Sites within and Flanking Human Immunodeficiency Virus Type 1 Transframe Protein p6* for Spatiotemporal Regulation of Protease Activation","publication_year":2008,"publication_date":"2008-03-06","ids":{"openalex":"https://openalex.org/W2065319623","doi":"https://doi.org/10.1128/jvi.02353-07","mag":"2065319623","pmid":"https://pubmed.ncbi.nlm.nih.gov/18321978","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2293064"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.02353-07","doi":"https://doi.org/10.1128/jvi.02353-07","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.02353-07","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2293064","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083208706","display_name":"Christine Ludwig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140742","display_name":"Institute of Medical Microbiology and Hygiene","ror":"https://ror.org/04xqmb911","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210140742"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christine Ludwig","raw_affiliation_strings":["Institute of Medical Microbiology and Hygiene, Molecular Microbiology and Gene Therapy Unit, University of Regensburg, 93053 Regensburg, Germany","Molecular Microbiology and Gene Therapy Unit, Institute of Medical Microbiology and Hygiene, University of Regensburg, 93053 Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Hygiene, Molecular Microbiology and Gene Therapy Unit, University of Regensburg, 93053 Regensburg, Germany","institution_ids":["https://openalex.org/I4210140742","https://openalex.org/I60668342"]},{"raw_affiliation_string":"Molecular Microbiology and Gene Therapy Unit, Institute of Medical Microbiology and Hygiene, University of Regensburg, 93053 Regensburg, Germany","institution_ids":["https://openalex.org/I4210140742","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074359421","display_name":"Andreas Leiherer","orcid":"https://orcid.org/0000-0003-3776-5704","observed_orcids":["https://orcid.org/0000-0003-3776-5704"]},"institutions":[{"id":"https://openalex.org/I4210140742","display_name":"Institute of Medical Microbiology and Hygiene","ror":"https://ror.org/04xqmb911","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210140742"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Leiherer","raw_affiliation_strings":["Institute of Medical Microbiology and Hygiene, Molecular Microbiology and Gene Therapy Unit, University of Regensburg, 93053 Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Hygiene, Molecular Microbiology and Gene Therapy Unit, University of Regensburg, 93053 Regensburg, Germany","institution_ids":["https://openalex.org/I4210140742","https://openalex.org/I60668342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020871813","display_name":"Ralf Wagner","orcid":"https://orcid.org/0000-0002-2029-3846","observed_orcids":["https://orcid.org/0000-0002-2029-3846"]},"institutions":[{"id":"https://openalex.org/I4210140742","display_name":"Institute of Medical Microbiology and Hygiene","ror":"https://ror.org/04xqmb911","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210140742"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ralf Wagner","raw_affiliation_strings":["Institute of Medical Microbiology and Hygiene, Molecular Microbiology and Gene Therapy Unit, University of Regensburg, 93053 Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Hygiene, Molecular Microbiology and Gene Therapy Unit, University of Regensburg, 93053 Regensburg, Germany","institution_ids":["https://openalex.org/I4210140742","https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020871813"],"corresponding_institution_ids":["https://openalex.org/I4210140742","https://openalex.org/I60668342"],"apc_list":null,"apc_paid":null,"fwci":1.5406,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.81051148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"82","issue":"9","first_page":"4573","last_page":"4584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-protease","display_name":"HIV-1 protease","score":0.9290000200271606},{"id":"https://openalex.org/keywords/proteolytic-cleavage-sites","display_name":"proteolytic cleavage sites","score":0.8870000243186951},{"id":"https://openalex.org/keywords/protease-activation","display_name":"protease activation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/virus-maturation","display_name":"virus maturation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/gag-processing","display_name":"Gag processing","score":0.777999997138977},{"id":"https://openalex.org/keywords/virus-infectivity","display_name":"viral infectivity","score":0.9319999814033508},{"id":"https://openalex.org/keywords/protease-inhibition","display_name":"protease inhibition","score":0.5289999842643738},{"id":"https://openalex.org/keywords/proviral-clones","display_name":"proviral clones","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.8640270233154297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7570503950119019},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.7177180051803589},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.7014790773391724},{"id":"https://openalex.org/C83100098","wikidata":"https://www.wikidata.org/wiki/Q106297070","display_name":"NS2-3 protease","level":4,"score":0.6587097644805908},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5664994120597839},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5624231696128845},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.535646915435791},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5154669880867004},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4853445589542389},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4484250843524933},{"id":"https://openalex.org/C133672593","wikidata":"https://www.wikidata.org/wiki/Q5130990","display_name":"Cleavage factor","level":4,"score":0.4188053011894226},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2738940417766571},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26539361476898193},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.1761954426765442},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12298890948295593},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011533","descriptor_name":"Proviruses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054301","descriptor_name":"gag Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.02353-07","doi":"https://doi.org/10.1128/jvi.02353-07","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.02353-07","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2293064","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2293064","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:18321978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18321978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:68178","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/68178/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2293064","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2293064","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W4720620","https://openalex.org/W1479817512","https://openalex.org/W1497441623","https://openalex.org/W1497981811","https://openalex.org/W1538136349","https://openalex.org/W1552946031","https://openalex.org/W1566748200","https://openalex.org/W1569669680","https://openalex.org/W1594139320","https://openalex.org/W1595806441","https://openalex.org/W1601178986","https://openalex.org/W1621280022","https://openalex.org/W1647530782","https://openalex.org/W1824849326","https://openalex.org/W1865732864","https://openalex.org/W1871968141","https://openalex.org/W1898585322","https://openalex.org/W1966952510","https://openalex.org/W1974261771","https://openalex.org/W1974964476","https://openalex.org/W1979274458","https://openalex.org/W1982440127","https://openalex.org/W1986248827","https://openalex.org/W1999362507","https://openalex.org/W2003669476","https://openalex.org/W2008682449","https://openalex.org/W2009166706","https://openalex.org/W2012849918","https://openalex.org/W2014734546","https://openalex.org/W2018282787","https://openalex.org/W2021812253","https://openalex.org/W2022380758","https://openalex.org/W2024131050","https://openalex.org/W2044629616","https://openalex.org/W2047210077","https://openalex.org/W2049056798","https://openalex.org/W2052215228","https://openalex.org/W2059483766","https://openalex.org/W2068351715","https://openalex.org/W2073292063","https://openalex.org/W2077195277","https://openalex.org/W2084387914","https://openalex.org/W2087297426","https://openalex.org/W2093119385","https://openalex.org/W2103069739","https://openalex.org/W2105698649","https://openalex.org/W2105795307","https://openalex.org/W2107911156","https://openalex.org/W2112727291","https://openalex.org/W2117231776","https://openalex.org/W2121882125","https://openalex.org/W2127923731","https://openalex.org/W2136714840","https://openalex.org/W2140460338","https://openalex.org/W2145758010","https://openalex.org/W2152989668","https://openalex.org/W2154596724","https://openalex.org/W2162531088","https://openalex.org/W2165732545","https://openalex.org/W2168438176","https://openalex.org/W2169408873","https://openalex.org/W2170011654","https://openalex.org/W2172500117","https://openalex.org/W3084023616"],"related_works":["https://openalex.org/W2804931458","https://openalex.org/W1497981811","https://openalex.org/W2593083371","https://openalex.org/W606401144","https://openalex.org/W2117231776","https://openalex.org/W2049056798","https://openalex.org/W2416973096","https://openalex.org/W2121882125","https://openalex.org/W179128689","https://openalex.org/W4210814709"],"abstract_inverted_index":{"The":[0],"human":[1],"immunodeficiency":[2],"virus":[3,90,200],"type":[4],"1":[5],"(HIV-1)":[6],"protease":[7],"(PR)":[8],"has":[9],"recently":[10],"been":[11],"shown":[12,191],"to":[13,36,168,179,192,216],"be":[14,193],"inhibited":[15],"by":[16],"its":[17],"propeptide":[18],"p6*":[19,23,41,61,148,211],"in":[20,71,94,117,130,174,201],"vitro.":[21,72],"As":[22],"itself":[24],"is":[25,213],"a":[26,121,125,202],"PR":[27,222],"substrate,":[28],"the":[29,38,76,112,118,147,221,227],"primary":[30],"goal":[31],"of":[32,40,104,120,162,184,220,226],"this":[33,163],"study":[34],"was":[35],"determine":[37],"importance":[39],"cleavage":[42,56,78,98,114,145,164,212],"for":[43,66,85],"HIV-1":[44],"maturation":[45,183],"and":[46,59,64,68,83,87,92,107,139,172,223],"infectivity.":[47],"For":[48],"that":[49,210],"purpose,":[50],"short":[51],"peptide":[52],"variants":[53],"mimicking":[54],"proposed":[55],"sites":[57],"within":[58],"flanking":[60,122],"were":[62,81,190],"designed":[63],"analyzed":[65,84],"qualitative":[67],"quantitative":[69],"hydrolysis":[70,128,161],"Proviral":[73],"clones":[74],"comprising":[75],"selected":[77],"site":[79,99,115,123,165],"mutations":[80,143,159],"established":[82],"Gag":[86,156],"Pol":[88],"processing,":[89],"maturation,":[91],"infectivity":[93,171],"cultured":[95,175],"cells.":[96],"Amino-terminal":[97],"mutation":[100],"caused":[101],"aberrant":[102],"processing":[103,138,157,225],"nucleocapsid":[105],"proteins":[106],"delayed":[108],"replication":[109],"kinetics.":[110],"Blocking":[111],"internal":[113],"resulted":[116],"utilization":[119],"at":[124,146],"significantly":[126],"decreased":[127],"rate":[129],"vitro,":[131],"which":[132],"however":[133],"did":[134],"not":[135],"affect":[136],"Gag-Pol":[137],"viral":[140,170,228],"replication.":[141],"Although":[142],"blocking":[144],"carboxyl":[149],"terminus":[150],"yielded":[151],"noninfectious":[152],"virions":[153],"exhibiting":[154],"severe":[155],"defects,":[158],"retarding":[160],"neither":[166],"seemed":[167,178],"impact":[169],"propagation":[173],"cells":[176],"nor":[177],"interfere":[180],"with":[181,198],"overall":[182],"released":[185],"viruses.":[186],"Interestingly,":[187],"these":[188],"mutants":[189],"clearly":[194],"disadvantaged":[195],"when":[196],"challenged":[197],"wild-type":[199],"dual":[203],"competition":[204],"assay.":[205],"In":[206],"sum,":[207],"we":[208],"conclude":[209],"absolutely":[214],"essential":[215],"allow":[217],"complete":[218],"activation":[219],"subsequent":[224],"precursors.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
