{"id":"https://openalex.org/W2065311998","doi":"https://doi.org/10.1016/j.vaccine.2014.10.004","title":"Live virus vaccines based on a yellow fever vaccine backbone: Standardized template with key considerations for a risk/benefit assessment","display_name":"Live virus vaccines based on a yellow fever vaccine backbone: Standardized template with key considerations for a risk/benefit assessment","publication_year":2014,"publication_date":"2014-10-27","ids":{"openalex":"https://openalex.org/W2065311998","doi":"https://doi.org/10.1016/j.vaccine.2014.10.004","mag":"2065311998","pmid":"https://pubmed.ncbi.nlm.nih.gov/25446819","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4656044"},"language":"en","primary_location":{"id":"doi:10.1016/j.vaccine.2014.10.004","doi":"https://doi.org/10.1016/j.vaccine.2014.10.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2014.10.004","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0264410X14013644/pdf","source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0264410X14013644/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055066987","display_name":"Thomas P. C. Monath","orcid":"https://orcid.org/0000-0001-7509-4599","observed_orcids":["https://orcid.org/0000-0001-7509-4599"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas P. Monath","raw_affiliation_strings":["Kleiner Perkins Caufield & Byers, Menlo Park, CA 94025, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kleiner Perkins Caufield & Byers, Menlo Park, CA 94025, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stephen J. Seligman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen J. Seligman","raw_affiliation_strings":["Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA. Electronic address: stephen_seligman@nymc.edu","Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA. Electronic address: stephen_seligman@nymc.edu","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112100183","display_name":"James S. Robertson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65163767","display_name":"National Institute for Biological Standards and Control","ror":"https://ror.org/03dnc6n82","country_code":"GB","type":"facility","lineage":["https://openalex.org/I65163767"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James S. Robertson","raw_affiliation_strings":["National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, UK","institution_ids":["https://openalex.org/I65163767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109132742","display_name":"Bruno Guy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Guy","raw_affiliation_strings":["Discovery Department, Sanofi Pasteur, 69280 Marcy l'Etoile, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Department, Sanofi Pasteur, 69280 Marcy l'Etoile, France","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026077934","display_name":"Edward B. Hayes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edward B. Hayes","raw_affiliation_strings":["Barcelona Centre for International Health Research (CRESIB), 08036 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barcelona Centre for International Health Research (CRESIB), 08036 Barcelona, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111853376","display_name":"RICHARD C. CONDIT","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard C. Condit","raw_affiliation_strings":["Department of Molecular Genetics & Microbiology, University of Florida, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics & Microbiology, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112753394","display_name":"Jean Louis Excler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1310987316","display_name":"International AIDS Vaccine Initiative","ror":"https://ror.org/05ayv2203","country_code":"US","type":"funder","lineage":["https://openalex.org/I1310987316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean Louis Excler","raw_affiliation_strings":["International AIDS Vaccine Initiative (IAVI), New York, NY 10004, USA; U.S. Military HIV Research Program (MHRP), Bethesda, MD 20817, USA","International AIDS Vaccine Initiative (IAVI), New York, NY 10004, USA","U.S. Military HIV Research Program (MHRP), Bethesda, MD 20817, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International AIDS Vaccine Initiative (IAVI), New York, NY 10004, USA; U.S. Military HIV Research Program (MHRP), Bethesda, MD 20817, USA","institution_ids":["https://openalex.org/I1310987316"]},{"raw_affiliation_string":"International AIDS Vaccine Initiative (IAVI), New York, NY 10004, USA","institution_ids":["https://openalex.org/I1310987316"]},{"raw_affiliation_string":"U.S. Military HIV Research Program (MHRP), Bethesda, MD 20817, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071677024","display_name":"Lisa Marie Mac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210113904","display_name":"National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention","ror":"https://ror.org/01wjn2x92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210113904"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Marie Mac","raw_affiliation_strings":["Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210113904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050023597","display_name":"Baevin Carbery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210113904","display_name":"National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention","ror":"https://ror.org/01wjn2x92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210113904"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baevin Carbery","raw_affiliation_strings":["Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210113904"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090873920","display_name":"Robert T. Chen","orcid":"https://orcid.org/0000-0002-3094-8367","observed_orcids":["https://orcid.org/0000-0002-3094-8367"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210113904","display_name":"National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention","ror":"https://ror.org/01wjn2x92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210113904"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert T. Chen","raw_affiliation_strings":["Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210113904"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181190671"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":{"value":3620,"currency":"USD","value_usd":3620},"fwci":1.2534,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.7430907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"33","issue":"1","first_page":"62","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/live-attenuated-vaccine","display_name":"live attenuated vaccine","score":0.7369999885559082},{"id":"https://openalex.org/keywords/viral-vector-vaccines","display_name":"viral vector vaccines","score":0.7889999747276306},{"id":"https://openalex.org/keywords/japanese-encephalitis-vaccine","display_name":"Japanese encephalitis vaccine","score":0.9039999842643738},{"id":"https://openalex.org/keywords/dengue-vaccine","display_name":"dengue vaccine","score":0.9369999766349792},{"id":"https://openalex.org/keywords/flavivirus-vectors","display_name":"flavivirus vectors","score":0.6489999890327454},{"id":"https://openalex.org/keywords/vaccine-safety-assessment","display_name":"vaccine safety assessment","score":0.7820000052452087},{"id":"https://openalex.org/keywords/risk-benefit-assessment","display_name":"risk-benefit assessment","score":0.9169999957084656},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C2779308166","wikidata":"https://www.wikidata.org/wiki/Q18388297","display_name":"Dengue vaccine","level":4,"score":0.8384442925453186},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8264966607093811},{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.8167645931243896},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.6879752278327942},{"id":"https://openalex.org/C2780568436","wikidata":"https://www.wikidata.org/wiki/Q1165479","display_name":"Flavivirus","level":3,"score":0.6647630333900452},{"id":"https://openalex.org/C2779141303","wikidata":"https://www.wikidata.org/wiki/Q738292","display_name":"Japanese encephalitis","level":4,"score":0.5852222442626953},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.5675612092018127},{"id":"https://openalex.org/C2779131611","wikidata":"https://www.wikidata.org/wiki/Q154874","display_name":"Yellow fever","level":3,"score":0.5476504564285278},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.5219718217849731},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5215946435928345},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.4724593162536621},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.47137439250946045},{"id":"https://openalex.org/C138894074","wikidata":"https://www.wikidata.org/wiki/Q7201694","display_name":"Plaque reduction neutralization test","level":4,"score":0.4497046172618866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43835243582725525},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.39579105377197266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35162824392318726},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.2881123423576355},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1777670681476593},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.1456805169582367},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.11009520292282104},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015005","descriptor_name":"Yellow fever virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.vaccine.2014.10.004","doi":"https://doi.org/10.1016/j.vaccine.2014.10.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2014.10.004","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0264410X14013644/pdf","source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},{"id":"pmid:25446819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25446819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"Journal Article"},{"id":"pmh:oai:diposit.ub.edu:2445/69265","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2445/69265","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Articles publicats en revistes (ISGlobal)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4656044","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4656044","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Vaccine","raw_type":"Text"},{"id":"pmh:oai:touroscholar.touro.edu:nymc_fac_pubs-6396","doi":null,"is_oa":false,"landing_page_url":"https://touroscholar.touro.edu/nymc_fac_pubs/5470","pdf_url":null,"source":{"id":"https://openalex.org/S4377196437","display_name":"Touro Scholar (Touro College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200437953","host_organization_name":"Touro College","host_organization_lineage":["https://openalex.org/I200437953"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NYMC Faculty Publications","raw_type":"article"},{"id":"pmh:oai:www.recercat.cat:2072/258013","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/69265","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.vaccine.2014.10.004","doi":"https://doi.org/10.1016/j.vaccine.2014.10.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2014.10.004","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0264410X14013644/pdf","source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7543494365","display_name":null,"funder_award_id":"CC999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306138","display_name":"International AIDS Vaccine Initiative","ror":"https://ror.org/05ayv2203"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2065311998.pdf","grobid_xml":"https://content.openalex.org/works/W2065311998.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W100841038","https://openalex.org/W165805697","https://openalex.org/W1540004901","https://openalex.org/W1561176636","https://openalex.org/W1965938470","https://openalex.org/W1971366791","https://openalex.org/W1973418613","https://openalex.org/W1979617709","https://openalex.org/W1980971590","https://openalex.org/W1981895261","https://openalex.org/W1981999511","https://openalex.org/W1990720325","https://openalex.org/W1993929543","https://openalex.org/W1994761465","https://openalex.org/W1995259721","https://openalex.org/W1996680680","https://openalex.org/W2000918486","https://openalex.org/W2004331253","https://openalex.org/W2004688624","https://openalex.org/W2005397602","https://openalex.org/W2006146542","https://openalex.org/W2010436800","https://openalex.org/W2011574578","https://openalex.org/W2015471688","https://openalex.org/W2022107986","https://openalex.org/W2027116769","https://openalex.org/W2027598863","https://openalex.org/W2030100825","https://openalex.org/W2031711763","https://openalex.org/W2032448279","https://openalex.org/W2035489708","https://openalex.org/W2037043230","https://openalex.org/W2044886599","https://openalex.org/W2047596114","https://openalex.org/W2050052145","https://openalex.org/W2051421384","https://openalex.org/W2052335488","https://openalex.org/W2058288703","https://openalex.org/W2061484834","https://openalex.org/W2061769992","https://openalex.org/W2062715434","https://openalex.org/W2071141273","https://openalex.org/W2074311607","https://openalex.org/W2076461286","https://openalex.org/W2077661149","https://openalex.org/W2079898725","https://openalex.org/W2082237898","https://openalex.org/W2084649840","https://openalex.org/W2086448648","https://openalex.org/W2092885275","https://openalex.org/W2093891930","https://openalex.org/W2094268281","https://openalex.org/W2095139263","https://openalex.org/W2097288560","https://openalex.org/W2097369344","https://openalex.org/W2097790240","https://openalex.org/W2099694719","https://openalex.org/W2101365180","https://openalex.org/W2105127871","https://openalex.org/W2106056357","https://openalex.org/W2109100918","https://openalex.org/W2111671329","https://openalex.org/W2113583073","https://openalex.org/W2116471574","https://openalex.org/W2116573148","https://openalex.org/W2117739952","https://openalex.org/W2117769971","https://openalex.org/W2119510581","https://openalex.org/W2121374421","https://openalex.org/W2128694535","https://openalex.org/W2130049797","https://openalex.org/W2135650467","https://openalex.org/W2137592373","https://openalex.org/W2139221797","https://openalex.org/W2140048277","https://openalex.org/W2140602455","https://openalex.org/W2146456832","https://openalex.org/W2149705618","https://openalex.org/W2153374142","https://openalex.org/W2155003010","https://openalex.org/W2155660565","https://openalex.org/W2157908499","https://openalex.org/W2159409064","https://openalex.org/W2164294248","https://openalex.org/W2164465906","https://openalex.org/W2170973086","https://openalex.org/W2171716852","https://openalex.org/W2172283372","https://openalex.org/W2285580281","https://openalex.org/W2748684917","https://openalex.org/W4292218400","https://openalex.org/W4297832232","https://openalex.org/W6650604227","https://openalex.org/W6979128719"],"related_works":["https://openalex.org/W2006146542","https://openalex.org/W2037043230","https://openalex.org/W2109100918","https://openalex.org/W2466534784","https://openalex.org/W2113583073","https://openalex.org/W2791292804","https://openalex.org/W2053115160","https://openalex.org/W7095567593","https://openalex.org/W2145400502","https://openalex.org/W2004688624"],"abstract_inverted_index":{"The":[0,46,139,180,290,306],"Brighton":[1,307],"Collaboration":[2,308],"Viral":[3],"Vector":[4],"Vaccines":[5],"Safety":[6],"Working":[7],"Group":[8],"(V3SWG)":[9],"was":[10],"formed":[11],"to":[12,50,208,284,318],"evaluate":[13],"the":[14,28,62,68,98,110,160,231,236,255,273,277,285,300,319],"safety":[15,175,249],"of":[16,30,91,101,123,152,159,189,192,238,245,248,276,304,321],"live,":[17],"recombinant":[18,323],"viral":[19,38,324],"vaccines":[20,40,115],"incorporating":[21],"genes":[22,100,122],"from":[23],"heterologous":[24],"viruses":[25],"inserted":[26],"into":[27,109,128],"backbone":[29],"another":[31],"virus":[32,35,94,131,260],"(so-called":[33],"\"chimeric":[34],"vaccines\").":[36],"Many":[37],"vector":[39,325],"are":[41,133],"in":[42,57,134,146,169,187,202,221,282],"advanced":[43],"clinical":[44,137,171],"trials.":[45,172],"first":[47],"such":[48],"vaccine":[49,66,77,141,165,259,280],"be":[51,313],"approved":[52],"for":[53,97,230],"marketing":[54],"(to":[55],"date":[56],"Australia,":[58],"Thailand,":[59],"Malaysia,":[60],"and":[61,125,132,205,250,302],"Philippines)":[63],"is":[64,226],"a":[65,75,82,150,199,262,269,316],"against":[67],"flavivirus,":[69],"Japanese":[70],"encephalitis":[71],"(JE),":[72],"which":[73],"employs":[74],"licensed":[76],"(yellow":[78],"fever":[79],"17D)":[80],"as":[81,261,315],"vector.":[83],"In":[84,235,264],"this":[85,265],"vaccine,":[86],"two":[87],"envelope":[88],"proteins":[89],"(prM-E)":[90],"YF":[92,129,257,287],"17D":[93,130,258,288],"were":[95,252],"exchanged":[96],"corresponding":[99],"JE":[102,111],"virus,":[103],"with":[104],"additional":[105],"attenuating":[106],"mutations":[107],"incorporated":[108],"gene":[112],"inserts.":[113],"Similar":[114],"have":[116,177,215],"been":[117,167,178,216],"constructed":[118],"by":[119,298],"inserting":[120],"prM-E":[121],"dengue":[124,140,162,194,204],"West":[126],"Nile":[127],"late":[135],"stage":[136],"studies.":[138],"is,":[142],"however,":[143],"more":[144],"complex":[145],"that":[147,214,229],"it":[148],"requires":[149],"mixture":[151],"four":[153,161],"live":[154],"vectors":[155],"each":[156],"expressing":[157],"one":[158],"serotypes.":[163,234],"This":[164],"has":[166],"evaluated":[168],"multiple":[170],"No":[173],"significant":[174,200],"concerns":[176],"found.":[179],"Phase":[181],"3":[182],"trials":[183],"met":[184],"their":[185],"endpoints":[186],"terms":[188],"overall":[190],"reduction":[191,201],"confirmed":[193],"fever,":[195],"and,":[196],"most":[197],"importantly":[198],"severe":[203],"hospitalization":[206],"due":[207],"dengue.":[209],"However,":[210],"based":[211],"on":[212],"results":[213],"published":[217],"so":[218],"far,":[219],"efficacy":[220,251],"preventing":[222],"serotype":[223],"2":[224],"infection":[225],"less":[227],"than":[228],"other":[232,322],"three":[233],"development":[237],"these":[239],"chimeric":[240],"vaccines,":[241],"an":[242],"important":[243],"series":[244],"comparative":[246],"studies":[247],"made":[253],"using":[254],"parental":[256,286],"benchmark.":[263],"paper,":[266],"we":[267],"use":[268],"standardized":[270],"template":[271,291,310],"describing":[272],"key":[274,296],"characteristics":[275],"novel":[278],"flavivirus":[279],"vectors,":[281],"comparison":[283],"vaccine.":[289],"facilitates":[292],"scientific":[293],"discourse":[294],"among":[295],"stakeholders":[297],"increasing":[299],"transparency":[301],"comparability":[303],"information.":[305],"V3SWG":[309],"may":[311],"also":[312],"useful":[314],"guide":[317],"evaluation":[320],"vaccines.":[326]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}