{"id":"https://openalex.org/W2065310944","doi":"https://doi.org/10.1111/febs.12121","title":"Vancomycin: ligand recognition, dimerization and super\u2010complex formation","display_name":"Vancomycin: ligand recognition, dimerization and super\u2010complex formation","publication_year":2013,"publication_date":"2013-01-09","ids":{"openalex":"https://openalex.org/W2065310944","doi":"https://doi.org/10.1111/febs.12121","mag":"2065310944","pmid":"https://pubmed.ncbi.nlm.nih.gov/23298227"},"language":"en","primary_location":{"id":"doi:10.1111/febs.12121","doi":"https://doi.org/10.1111/febs.12121","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.12121","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022021788","display_name":"Zhiguang Jia","orcid":"https://orcid.org/0000-0002-9902-4832","observed_orcids":["https://orcid.org/0000-0002-9902-4832"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"ZhiGuang Jia","raw_affiliation_strings":["School of Chemistry and Molecular Biosciences The University of Queensland Brisbane Qld Australia","School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Qld, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences The University of Queensland Brisbane Qld Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Qld, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075731186","display_name":"Megan L. O\u2019Mara","orcid":"https://orcid.org/0000-0002-8764-1585","observed_orcids":["https://orcid.org/0000-0002-8764-1585"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Megan L. O'Mara","raw_affiliation_strings":["Institute for Molecular Bioscience The University of Queensland Brisbane Qld Australia","Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience The University of Queensland Brisbane Qld Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007474207","display_name":"Johannes Zuegg","orcid":"https://orcid.org/0000-0001-6240-6020","observed_orcids":["https://orcid.org/0000-0001-6240-6020"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Johannes Zuegg","raw_affiliation_strings":["Institute for Molecular Bioscience The University of Queensland Brisbane Qld Australia","Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience The University of Queensland Brisbane Qld Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074910442","display_name":"Matthew A. Cooper","orcid":"https://orcid.org/0000-0003-3147-3460","observed_orcids":["https://orcid.org/0000-0003-3147-3460"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthew A. Cooper","raw_affiliation_strings":["Institute for Molecular Bioscience The University of Queensland Brisbane Qld Australia","Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience The University of Queensland Brisbane Qld Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060550957","display_name":"Alan Edward Mark","orcid":"https://orcid.org/0000-0001-5880-4798","observed_orcids":["https://orcid.org/0000-0001-5880-4798"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Alan E. Mark","raw_affiliation_strings":["Institute for Molecular Bioscience The University of Queensland Brisbane Qld Australia","School of Chemistry and Molecular Biosciences The University of Queensland Brisbane Qld Australia","Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, Australia","School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Qld, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience The University of Queensland Brisbane Qld Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences The University of Queensland Brisbane Qld Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"raw_affiliation_string":"School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Qld, Australia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060550957"],"corresponding_institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.7529,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.84306364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"280","issue":"5","first_page":"1294","last_page":"1307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.271699994802475,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.041200000792741776,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":1.0},{"id":"https://openalex.org/keywords/lipid-ii","display_name":"lipid II","score":0.7590000033378601},{"id":"https://openalex.org/keywords/ligand-binding","display_name":"ligand binding","score":0.7419999837875366},{"id":"https://openalex.org/keywords/face-to-face-dimer","display_name":"face-to-face dimer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cell-wall-synthesis-inhibition","display_name":"cell wall synthesis inhibition","score":0.7710000276565552},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.9639999866485596},{"id":"https://openalex.org/keywords/structural-water","display_name":"structural water","score":0.8149999976158142},{"id":"https://openalex.org/keywords/vancomycin-resistance","display_name":"vancomycin resistance","score":0.9359999895095825},{"id":"https://openalex.org/keywords/peptide-ligands","display_name":"peptide ligands","score":0.4959999918937683},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.7968600988388062},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.7595139741897583},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.670251727104187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6651684641838074},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5254560708999634},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.42630526423454285},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.42622992396354675},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3960549235343933},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.2185336947441101},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2185281217098236},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16912400722503662},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16870683431625366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14770936965942383},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.06375998258590698},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05985116958618164},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/febs.12121","doi":"https://doi.org/10.1111/febs.12121","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.12121","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmid:23298227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23298227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"},{"id":"pmh:oai:openresearch-repository.anu.edu.au:1885/31980","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1885/31980","pdf_url":null,"source":{"id":"https://openalex.org/S4306402539","display_name":"ANU Open Research (Australian National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118347636","host_organization_name":"Australian National University","host_organization_lineage":["https://openalex.org/I118347636"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The FEBS Journal","raw_type":"Journal article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.8100000023841858,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1491824558","https://openalex.org/W1963724555","https://openalex.org/W1966078827","https://openalex.org/W1975488587","https://openalex.org/W1980145079","https://openalex.org/W1995816895","https://openalex.org/W1999052918","https://openalex.org/W2002097614","https://openalex.org/W2003586412","https://openalex.org/W2008163771","https://openalex.org/W2008185727","https://openalex.org/W2015886919","https://openalex.org/W2016904985","https://openalex.org/W2027154929","https://openalex.org/W2035266068","https://openalex.org/W2037788435","https://openalex.org/W2038079257","https://openalex.org/W2039092914","https://openalex.org/W2044337051","https://openalex.org/W2044979812","https://openalex.org/W2047298235","https://openalex.org/W2052147832","https://openalex.org/W2052867831","https://openalex.org/W2052964493","https://openalex.org/W2064768191","https://openalex.org/W2065811877","https://openalex.org/W2067174909","https://openalex.org/W2067875468","https://openalex.org/W2073097129","https://openalex.org/W2080881823","https://openalex.org/W2083344288","https://openalex.org/W2084726562","https://openalex.org/W2085812687","https://openalex.org/W2086945873","https://openalex.org/W2093127646","https://openalex.org/W2095958235","https://openalex.org/W2103945336","https://openalex.org/W2117446733","https://openalex.org/W2123216606","https://openalex.org/W2124763838","https://openalex.org/W2128169009","https://openalex.org/W2128572087","https://openalex.org/W2128824543","https://openalex.org/W2129197867","https://openalex.org/W2136013622","https://openalex.org/W2137783720","https://openalex.org/W2147723850","https://openalex.org/W2154917071","https://openalex.org/W2160110350","https://openalex.org/W2346147835","https://openalex.org/W2898532680"],"related_works":["https://openalex.org/W2605052975","https://openalex.org/W2026584619","https://openalex.org/W2789853462","https://openalex.org/W3184550385","https://openalex.org/W2411721195","https://openalex.org/W4379058335","https://openalex.org/W2344602400","https://openalex.org/W4220805161","https://openalex.org/W1971851066","https://openalex.org/W2087490697"],"abstract_inverted_index":{"The":[0,96,136,179],"antibiotic":[1],"vancomycin":[2,61,192,202],"targets":[3],"lipid":[4,72],"II,":[5,73],"blocking":[6],"cell":[7],"wall":[8],"synthesis":[9],"in":[10,63,130,147,189,198],"Gram-positive":[11],"bacteria.":[12],"Despite":[13],"extensive":[14],"study,":[15,37],"questions":[16],"remain":[17],"regarding":[18],"how":[19],"it":[20],"recognizes":[21],"its":[22,196],"primary":[23],"ligand":[24,50,163,193],"and":[25,52,83,105,114,142,165,167,195],"what":[26],"is":[27],"the":[28,47,74,77,80,92,99,111,115,122,124,148,157,160,170,183,191,199],"most":[29],"biologically":[30],"relevant":[31],"form":[32],"of":[33,49,54,79,91,121,132,139,156,159,172,186,201],"vancomycin.":[34,55],"In":[35],"this":[36],"molecular":[38],"dynamics":[39],"simulation":[40],"techniques":[41],"have":[42],"been":[43,128],"used":[44],"to":[45,86],"examine":[46],"process":[48],"binding":[51,164],"dimerization":[53,166],"Starting":[56],"from":[57,71],"one":[58],"or":[59],"more":[60],"monomers":[62],"solution,":[64],"together":[65],"with":[66],"different":[67],"peptide":[68],"ligands":[69],"derived":[70],"simulations":[75,97],"predict":[76],"structures":[78,93],"ligated":[81],"monomeric":[82],"dimeric":[84],"complexes":[85],"within":[87],"0.1":[88],"nm":[89],"rmsd":[90],"determined":[94],"experimentally.":[95],"reproduce":[98],"conformation":[100],"transitions":[101],"observed":[102,146],"by":[103],"NMR":[104,125],"suggest":[106],"that":[107,169],"proposed":[108],"differences":[109],"between":[110,162],"crystal":[112],"structure":[113,117],"solution":[116],"are":[118],"an":[119],"artifact":[120],"way":[123],"data":[126],"has":[127,151],"interpreted":[129],"terms":[131],"a":[133,153],"structural":[134,187],"model.":[135],"spontaneous":[137],"formation":[138,171],"both":[140],"back-to-back":[141],"face-to-face":[143,173],"dimers":[144,174],"was":[145],"simulations.":[149],"This":[150],"allowed":[152],"detailed":[154],"analysis":[155],"origin":[158],"cooperatively":[161],"suggests":[168],"could":[175],"be":[176],"functionally":[177],"significant.":[178],"work":[180],"also":[181],"highlights":[182],"possible":[184],"role":[185,197],"water":[188],"stabilizing":[190],"complex":[194],"manifestation":[200],"resistance.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}