{"id":"https://openalex.org/W2065136241","doi":"https://doi.org/10.1093/nar/gku1227","title":"Rpb4/7 facilitates RNA polymerase II CTD dephosphorylation","display_name":"Rpb4/7 facilitates RNA polymerase II CTD dephosphorylation","publication_year":2014,"publication_date":"2014-11-21","ids":{"openalex":"https://openalex.org/W2065136241","doi":"https://doi.org/10.1093/nar/gku1227","mag":"2065136241","pmid":"https://pubmed.ncbi.nlm.nih.gov/25416796","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4267648"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gku1227","doi":"https://doi.org/10.1093/nar/gku1227","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku1227","pdf_url":"https://academic.oup.com/nar/article-pdf/42/22/13674/17424420/gku1227.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/42/22/13674/17424420/gku1227.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080331727","display_name":"Paula Allepuz\u2010Fuster","orcid":"https://orcid.org/0000-0003-4544-146X","observed_orcids":["https://orcid.org/0000-0003-4544-146X"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]},{"id":"https://openalex.org/I4210154586","display_name":"Instituto de Biolog\u00eda Funcional y Gen\u00f3mica","ror":"https://ror.org/055cmx385","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210154586"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Paula Allepuz-Fuster","raw_affiliation_strings":["1Instituto de Biolog\u00eda Funcional y Gen\u00f3mica, CSIC/Universidad de Salamanca, Salamanca 37007, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Instituto de Biolog\u00eda Funcional y Gen\u00f3mica, CSIC/Universidad de Salamanca, Salamanca 37007, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210154586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018975964","display_name":"Veronica Martinez-Fernandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191420491","display_name":"Universidad de Ja\u00e9n","ror":"https://ror.org/0122p5f64","country_code":"ES","type":"education","lineage":["https://openalex.org/I191420491"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ver\u00f3nica Mart\u00ednez-Fern\u00e1ndez","raw_affiliation_strings":["2Departamento de Biolog\u00eda Experimental, Facultad de Ciencias Experimentales, Universidad de Ja\u00e9n, Ja\u00e9n 23071, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Departamento de Biolog\u00eda Experimental, Facultad de Ciencias Experimentales, Universidad de Ja\u00e9n, Ja\u00e9n 23071, Spain","institution_ids":["https://openalex.org/I191420491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068020739","display_name":"Ana Isabel Garrido-Godino","orcid":"https://orcid.org/0000-0002-7389-1372","observed_orcids":["https://orcid.org/0000-0002-7389-1372"]},"institutions":[{"id":"https://openalex.org/I191420491","display_name":"Universidad de Ja\u00e9n","ror":"https://ror.org/0122p5f64","country_code":"ES","type":"education","lineage":["https://openalex.org/I191420491"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana I. Garrido-Godino","raw_affiliation_strings":["2Departamento de Biolog\u00eda Experimental, Facultad de Ciencias Experimentales, Universidad de Ja\u00e9n, Ja\u00e9n 23071, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Departamento de Biolog\u00eda Experimental, Facultad de Ciencias Experimentales, Universidad de Ja\u00e9n, Ja\u00e9n 23071, Spain","institution_ids":["https://openalex.org/I191420491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045755590","display_name":"Sergio Alonso-Aguado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]},{"id":"https://openalex.org/I4210154586","display_name":"Instituto de Biolog\u00eda Funcional y Gen\u00f3mica","ror":"https://ror.org/055cmx385","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210154586"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergio Alonso-Aguado","raw_affiliation_strings":["1Instituto de Biolog\u00eda Funcional y Gen\u00f3mica, CSIC/Universidad de Salamanca, Salamanca 37007, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Instituto de Biolog\u00eda Funcional y Gen\u00f3mica, CSIC/Universidad de Salamanca, Salamanca 37007, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210154586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064272402","display_name":"Steven D. Hanes","orcid":"https://orcid.org/0000-0002-9069-6878","observed_orcids":["https://orcid.org/0000-0002-9069-6878"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven D. Hanes","raw_affiliation_strings":["3Department of Biochemistry and Molecular Biology, Upstate Medical University, Syracuse, NY 13210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Biochemistry and Molecular Biology, Upstate Medical University, Syracuse, NY 13210, USA","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029959217","display_name":"Francisco Navarro","orcid":"https://orcid.org/0000-0002-4180-422X","observed_orcids":["https://orcid.org/0000-0002-4180-422X"]},"institutions":[{"id":"https://openalex.org/I191420491","display_name":"Universidad de Ja\u00e9n","ror":"https://ror.org/0122p5f64","country_code":"ES","type":"education","lineage":["https://openalex.org/I191420491"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Navarro","raw_affiliation_strings":["2Departamento de Biolog\u00eda Experimental, Facultad de Ciencias Experimentales, Universidad de Ja\u00e9n, Ja\u00e9n 23071, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Departamento de Biolog\u00eda Experimental, Facultad de Ciencias Experimentales, Universidad de Ja\u00e9n, Ja\u00e9n 23071, Spain","institution_ids":["https://openalex.org/I191420491"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068426332","display_name":"Olga Calvo","orcid":"https://orcid.org/0000-0002-9786-7916","observed_orcids":["https://orcid.org/0000-0002-9786-7916"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]},{"id":"https://openalex.org/I4210154586","display_name":"Instituto de Biolog\u00eda Funcional y Gen\u00f3mica","ror":"https://ror.org/055cmx385","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210154586"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Olga Calvo","raw_affiliation_strings":["1Instituto de Biolog\u00eda Funcional y Gen\u00f3mica, CSIC/Universidad de Salamanca, Salamanca 37007, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Instituto de Biolog\u00eda Funcional y Gen\u00f3mica, CSIC/Universidad de Salamanca, Salamanca 37007, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210154586"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5068426332"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210154586"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":1.2115,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.76070929,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"42","issue":"22","first_page":"13674","last_page":"13688"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":0.8880000114440918},{"id":"https://openalex.org/keywords/rpb4","display_name":"Rpb4","score":0.8859999775886536},{"id":"https://openalex.org/keywords/rpb7","display_name":"Rpb7","score":0.9900000095367432},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.7760000228881836},{"id":"https://openalex.org/keywords/ser5-phosphorylation","display_name":"Ser5 phosphorylation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/ser2-phosphorylation","display_name":"Ser2 phosphorylation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ssu72","display_name":"Ssu72","score":0.8889999985694885},{"id":"https://openalex.org/keywords/fcp1","display_name":"FCP1","score":0.9570000171661377},{"id":"https://openalex.org/keywords/ctd-phosphatase","display_name":"CTD phosphatase","score":0.9150000214576721},{"id":"https://openalex.org/keywords/ctd-kinase","display_name":"CTD kinase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/peptidyl-prolyl-cis-trans-isomerase","display_name":"peptidyl-prolyl isomerase","score":0.9449999928474426},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.4880000054836273},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9359999895095825}],"concepts":[{"id":"https://openalex.org/C125533998","wikidata":"https://www.wikidata.org/wiki/Q1024499","display_name":"CTD","level":2,"score":0.9676846265792847},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.8975036144256592},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7050765752792358},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6135920286178589},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5442015528678894},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.5034183859825134},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5032348036766052},{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.4973433315753937},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4623172879219055},{"id":"https://openalex.org/C154816499","wikidata":"https://www.wikidata.org/wiki/Q21120535","display_name":"Transcription factor II F","level":5,"score":0.4447588324546814},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.43804487586021423},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43106186389923096},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37499475479125977},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3515971302986145},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3047845959663391},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2999890446662903},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.24996453523635864},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.1954229474067688},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.18735066056251526},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072340","descriptor_name":"NIMA-Interacting Peptidylprolyl Isomerase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019696","descriptor_name":"Peptidylprolyl Isomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D039221","descriptor_name":"mRNA Cleavage and Polyadenylation Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/nar/gku1227","doi":"https://doi.org/10.1093/nar/gku1227","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku1227","pdf_url":"https://academic.oup.com/nar/article-pdf/42/22/13674/17424420/gku1227.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3240284","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4267648","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25416796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25416796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4267648","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4267648/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/235368","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/235368","pdf_url":"https://orbi.uliege.be/bitstream/2268/235368/1/Allepuz-Fuster%20et%20al.pdf","source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Research (2014)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.778.3972","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.778.3972","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/5c/63/gku1227.PMC4267648.pdf","raw_type":"text"},{"id":"pmh:oai:digital.csic.es:10261/116233","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/116233","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1093/nar/gku1227","doi":"https://doi.org/10.1093/nar/gku1227","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku1227","pdf_url":"https://academic.oup.com/nar/article-pdf/42/22/13674/17424420/gku1227.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2573280126","display_name":null,"funder_award_id":"BIO258","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G8113588972","display_name":null,"funder_award_id":"BIO258","funder_id":"https://openalex.org/F4320326754","funder_display_name":"Junta de Andaluc\u00eda"},{"id":"https://openalex.org/G8362913619","display_name":"Yeast Ess1, a Conserved PPlase Essential for Mitosis","funder_award_id":"R01GM055108","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320326754","display_name":"Junta de Andaluc\u00eda","ror":"https://ror.org/01jem9c82"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2065136241.pdf","grobid_xml":"https://content.openalex.org/works/W2065136241.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1510239612","https://openalex.org/W1522516056","https://openalex.org/W1526043578","https://openalex.org/W1600651336","https://openalex.org/W1911817655","https://openalex.org/W1963728829","https://openalex.org/W1963837739","https://openalex.org/W1965591721","https://openalex.org/W1966695149","https://openalex.org/W1967522002","https://openalex.org/W1967938775","https://openalex.org/W1970438229","https://openalex.org/W1972137518","https://openalex.org/W1978050694","https://openalex.org/W1981930838","https://openalex.org/W1985450378","https://openalex.org/W1986144447","https://openalex.org/W1987314819","https://openalex.org/W1989849863","https://openalex.org/W1992273230","https://openalex.org/W2001406822","https://openalex.org/W2005880805","https://openalex.org/W2006215395","https://openalex.org/W2007943229","https://openalex.org/W2012466702","https://openalex.org/W2013298988","https://openalex.org/W2019429295","https://openalex.org/W2025037044","https://openalex.org/W2032742580","https://openalex.org/W2035689855","https://openalex.org/W2045536653","https://openalex.org/W2045755743","https://openalex.org/W2045959839","https://openalex.org/W2047562490","https://openalex.org/W2049858249","https://openalex.org/W2057008616","https://openalex.org/W2057991981","https://openalex.org/W2058752763","https://openalex.org/W2059691911","https://openalex.org/W2059768092","https://openalex.org/W2063296736","https://openalex.org/W2066780692","https://openalex.org/W2068441965","https://openalex.org/W2071177849","https://openalex.org/W2073290239","https://openalex.org/W2074304165","https://openalex.org/W2079151217","https://openalex.org/W2080365558","https://openalex.org/W2081322742","https://openalex.org/W2083899801","https://openalex.org/W2085309970","https://openalex.org/W2090678715","https://openalex.org/W2091107314","https://openalex.org/W2092558918","https://openalex.org/W2094398789","https://openalex.org/W2095551138","https://openalex.org/W2097621806","https://openalex.org/W2100649212","https://openalex.org/W2102136488","https://openalex.org/W2103010558","https://openalex.org/W2104531065","https://openalex.org/W2106923196","https://openalex.org/W2108259296","https://openalex.org/W2117800899","https://openalex.org/W2117984182","https://openalex.org/W2121169843","https://openalex.org/W2123603532","https://openalex.org/W2123889592","https://openalex.org/W2124064316","https://openalex.org/W2126730534","https://openalex.org/W2129214044","https://openalex.org/W2130619792","https://openalex.org/W2132198636","https://openalex.org/W2134290451","https://openalex.org/W2134954412","https://openalex.org/W2135969650","https://openalex.org/W2136662134","https://openalex.org/W2137595543","https://openalex.org/W2137778853","https://openalex.org/W2140448223","https://openalex.org/W2142647781","https://openalex.org/W2145049521","https://openalex.org/W2151082116","https://openalex.org/W2151788241","https://openalex.org/W2153549621","https://openalex.org/W2156566553","https://openalex.org/W2157087271","https://openalex.org/W2160720092","https://openalex.org/W2163753548","https://openalex.org/W2168696636","https://openalex.org/W2171711481","https://openalex.org/W2315705994","https://openalex.org/W6665083878","https://openalex.org/W6665098157"],"related_works":["https://openalex.org/W7095289444","https://openalex.org/W4389777699","https://openalex.org/W6986188889","https://openalex.org/W2288723780","https://openalex.org/W2287864176","https://openalex.org/W2080365558","https://openalex.org/W2067660764","https://openalex.org/W2134290451","https://openalex.org/W2019429295","https://openalex.org/W1573273416"],"abstract_inverted_index":{"The":[0],"Rpb4":[1,138],"and":[2,23,28,77,85,106,126,143,153,160,179,191],"Rpb7":[3],"subunits":[4],"of":[5,15,34,55,61,65,69,79,83,91,102,196],"eukaryotic":[6],"RNA":[7],"polymerase":[8],"II":[9],"(RNAPII)":[10],"participate":[11],"in":[12,45,52,174,186],"a":[13,49,127,184,199],"variety":[14],"processes":[16],"from":[17],"transcription,":[18],"DNA":[19],"repair,":[20],"mRNA":[21],"export":[22],"decay,":[24],"to":[25,96,150,204],"translation":[26],"regulation":[27],"stress":[29],"response.":[30],"However,":[31],"their":[32],"mechanism(s)":[33],"action":[35],"remains":[36],"unclear.":[37],"Here,":[38],"we":[39,182],"show":[40,136],"that":[41,87,130,137,154,168,201],"the":[42,56,62,70,75,89,97,109,132,151,171,194],"Rpb4/7":[43,92,188],"heterodimer":[44],"Saccharomyces":[46],"cerevisiae":[47],"plays":[48],"key":[50],"role":[51,200],"controlling":[53],"phosphorylation":[54,68,101],"carboxy":[57],"terminal":[58],"domain":[59],"(CTD)":[60],"Rpb1":[63],"subunit":[64],"RNAPII.":[66],"Proper":[67],"CTD":[71,117,121,133],"is":[72,139,170,202],"critical":[73],"for":[74,141],"synthesis":[76],"processing":[78],"RNAPII":[80,98,205],"transcripts.":[81],"Deletion":[82],"RPB4,":[84],"mutations":[86],"disrupt":[88],"integrity":[90],"or":[93],"its":[94],"recruitment":[95,147],"complex,":[99],"increased":[100],"Ser2,":[103],"Ser5,":[104],"Ser7":[105],"Thr4":[107],"within":[108],"CTD.":[110],"RPB4":[111],"interacted":[112],"genetically":[113],"with":[114,158],"genes":[115],"encoding":[116],"phosphatases":[118,145],"(SSU72,":[119],"FCP1),":[120],"kinases":[122],"(KIN28,":[123],"CTK1,":[124],"SRB10)":[125],"prolyl":[128],"isomerase":[129],"targets":[131],"(ESS1).":[134],"We":[135],"important":[140],"Ssu72":[142],"Fcp1":[144,169],"association,":[146],"and/or":[148],"accessibility":[149],"CTD,":[152],"this":[155],"correlates":[156],"strongly":[157],"Ser5P":[159],"Ser2P":[161],"levels,":[162],"respectively.":[163],"Our":[164],"data":[165],"also":[166],"suggest":[167,183],"Thr4P":[172],"phosphatase":[173],"yeast.":[175],"Based":[176],"on":[177],"these":[178],"other":[180],"results,":[181],"model":[185],"which":[187],"helps":[189],"recruit":[190],"potentially":[192],"stimulate":[193],"activity":[195],"CTD-modifying":[197],"enzymes,":[198],"central":[203],"function.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}