{"id":"https://openalex.org/W2065115083","doi":"https://doi.org/10.1016/j.jalz.2011.05.615","title":"P1\u2010335: In vivo localization of aging and Alzheimer's disease effects on cortical gray matter in normal elderly and patients with mild cognitive impairment","display_name":"P1\u2010335: In vivo localization of aging and Alzheimer's disease effects on cortical gray matter in normal elderly and patients with mild cognitive impairment","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W2065115083","doi":"https://doi.org/10.1016/j.jalz.2011.05.615","mag":"2065115083"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2011.05.615","doi":"https://doi.org/10.1016/j.jalz.2011.05.615","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.615","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011950558","display_name":"Annapaola Prestia","orcid":"https://orcid.org/0000-0002-9881-9625","observed_orcids":["https://orcid.org/0000-0002-9881-9625"]},"institutions":[{"id":"https://openalex.org/I4210114614","display_name":"Centro San Giovanni di Dio Fatebenefratelli","ror":"https://ror.org/02davtb12","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210114614","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annapaola Prestia","raw_affiliation_strings":["IRCCS Fatebenefratelli, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Fatebenefratelli, Brescia, Italy","institution_ids":["https://openalex.org/I4210114614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083182585","display_name":"Annalisa Baglieri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162269","display_name":"Centro Neurolesi Bonino Pulejo","ror":"https://ror.org/05tzq2c96","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210162269"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annalisa Baglieri","raw_affiliation_strings":["IRCCS Centro Neurolesi \u201cBonino\u2010Pulejo\u201d Messina Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Centro Neurolesi \u201cBonino\u2010Pulejo\u201d Messina Italy","institution_ids":["https://openalex.org/I4210162269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001139681","display_name":"Matteo Bonetti","orcid":"https://orcid.org/0000-0001-7889-6810","observed_orcids":["https://orcid.org/0000-0001-7889-6810"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matteo Bonetti","raw_affiliation_strings":["Istituto Clinico Citt\u00e0 di Brescia Brescia Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Clinico Citt\u00e0 di Brescia Brescia Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015750240","display_name":"Paul E. Rasser","orcid":"https://orcid.org/0000-0003-3482-721X","observed_orcids":["https://orcid.org/0000-0003-3482-721X"]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Paul Rasser","raw_affiliation_strings":["University of Newcastle Callaghan Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Newcastle Callaghan Australia","institution_ids":["https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606557","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867","observed_orcids":["https://orcid.org/0000-0002-4720-8867","https://orcid.org/0000-0003-2476-2803","https://orcid.org/0000-0002-2305-8438"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Thompson","raw_affiliation_strings":["UCLA School Of Medicine, Los Angeles, California, United States ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA School Of Medicine, Los Angeles, California, United States ;","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051868596","display_name":"Giovanni Battista Frisoni","orcid":"https://orcid.org/0000-0001-7075-7082","observed_orcids":["https://orcid.org/0000-0001-7075-7082","https://orcid.org/0000-0002-6419-1753"]},"institutions":[{"id":"https://openalex.org/I4210114614","display_name":"Centro San Giovanni di Dio Fatebenefratelli","ror":"https://ror.org/02davtb12","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210114614","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Frisoni","raw_affiliation_strings":["IRCCS Fatebenefratelli, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Fatebenefratelli, Brescia, Italy","institution_ids":["https://openalex.org/I4210114614"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17517915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"4S_Part_6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.7659626007080078},{"id":"https://openalex.org/C200134340","wikidata":"https://www.wikidata.org/wiki/Q845664","display_name":"Voxel-based morphometry","level":4,"score":0.5699999332427979},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4824862778186798},{"id":"https://openalex.org/C3017819807","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy aging","level":2,"score":0.4803146719932556},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4775713086128235},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.46783745288848877},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.4594820737838745},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.458753377199173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44120484590530396},{"id":"https://openalex.org/C2779695026","wikidata":"https://www.wikidata.org/wiki/Q4692577","display_name":"Aging brain","level":3,"score":0.4376554489135742},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.424032986164093},{"id":"https://openalex.org/C166275286","wikidata":"https://www.wikidata.org/wiki/Q190095","display_name":"Gray (unit)","level":2,"score":0.41588613390922546},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3762815296649933},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.3734086751937866},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.37025877833366394},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3611398935317993},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.35093867778778076},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.328045129776001},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.1363888680934906},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.1329965591430664},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.09262216091156006}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2011.05.615","doi":"https://doi.org/10.1016/j.jalz.2011.05.615","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.615","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W72187248","https://openalex.org/W2093664131","https://openalex.org/W7099297361","https://openalex.org/W2159019462","https://openalex.org/W2023168194","https://openalex.org/W2136019660","https://openalex.org/W94822053","https://openalex.org/W2136288391","https://openalex.org/W3007582634","https://openalex.org/W2020623898"],"abstract_inverted_index":{"Progressive":[0],"brain":[1,67,314],"atrophy":[2,216],"occurs":[3],"in":[4,10,20,44,76,163,176,184,195,291,318,331,344,350],"the":[5,28,185,196,221,236,244,268,272,283,323],"cognitively":[6],"normal":[7,45,312],"elderly,":[8],"especially":[9],"temporal":[11,179],"and":[12,27,52,87,96,122,166,180,183,187,194,226,234,238,293,325],"prefrontal":[13],"cortices.":[14],"Many":[15],"of":[16,274,353],"these":[17],"changes":[18,31,56,133,287,330],"occur":[19],"areas":[21,295,342],"vulnerable":[22],"to":[23,38,50,110,128,141,210,220,235,260,340],"Alzheimer's":[24],"disease":[25,269],"(AD),":[26],"distributed":[29],"cortical":[30,55,139,157,246,305,341],"caused":[32],"by":[33,146,308],"AD":[34,62,111],"pathology":[35],"are":[36,348],"difficult":[37],"distinguish":[39,53],"from":[40,57,72,97,258],"structural":[41,329],"alterations":[42],"observed":[43],"aging.":[46,142],"Here":[47],"we":[48],"aimed":[49],"map":[51,129],"age-related":[54,286],"those":[58],"associated":[59,252],"with":[60,101,253],"early":[61,309,351],"pathology.":[63],"Structural":[64],"T1-weighted":[65],"high-resolution":[66],"MRI":[68],"scans":[69],"were":[70,126,288,334],"acquired":[71],"60":[73],"healthy":[74,89],"volunteers":[75],"two":[77],"age":[78],"groups:":[79],"20":[80],"young":[81],"adults":[82],"(YA)":[83],"(age:":[84,93,106],"33+/-4":[85],"years)":[86],"40":[88],"elderly":[90,99,171],"subjects":[91],"(HE)":[92],"71+/-6":[94],"years),":[95],"16":[98],"patients":[100,202,267,333],"mild":[102],"cognitive":[103],"impairment":[104],"(MCI)":[105],"73+/-5),":[107],"who":[108],"converted":[109],"within":[112],"around":[113],"2":[114],"years.":[115],"A":[116],"voxel-based":[117],"anatomical":[118],"mesh":[119],"modelling":[120],"technique":[121],"a":[123,147,319],"region-of-interest":[124],"analysis":[125],"used":[127],"gray":[130,158,214,247,316],"matter":[131,159,215,248,317],"volume":[132,207,249],"among":[134],"groups.":[135],"We":[136],"also":[137],"related":[138],"features":[140],"Aging":[143],"was":[144,250],"characterized":[145],"global":[148],"loss:":[149],"HE":[150,211],"group":[151,172],"had":[152],"on":[153,204,276,304],"average":[154,205],"10-11%":[155],"lower":[156],"density":[160],"than":[161],"YA":[162],"both":[164],"left":[165,222,237,277,324],"right":[167,227,239,284,326],"hemispheres":[168],"(p<.0001).":[169,212],"The":[170,311],"showed":[173],"10-30%":[174],"loss":[175],"widespread":[177,320],"frontal,":[178],"parietal":[181,294],"regions,":[182],"visual":[186],"sensorimotor":[188],"cortices":[189],"(showing":[190],"6-14%":[191],"atrophy,":[192],"p<.01)":[193],"direct":[197],"hippocampal":[198,229],"pathway":[199],"(p<.001).":[200,242],"MCI":[201,266,332],"show":[203],"8-9%":[206],"deficits":[208],"relative":[209],"Their":[213],"(6-15%)":[217],"mapped":[218,339],"primarily":[219,290],"(p":[223,231,279],"=":[224,232,263,280,299],".06)":[225],"polysynaptic":[228],"pathways":[230],".01)":[233],"olfactory":[240],"cortex":[241],"In":[243],"HE,":[245],"strongly":[251],"age,":[254],"(Pearson":[255],"correlations":[256],"ranging":[257],"-.5":[259],"-.9,":[261],"p":[262,298],".0001),":[264],"for":[265],"completely":[270],"obscured":[271],"effect":[273],"aging":[275,313],"hemisphere":[278],".10).":[281],"On":[282],"side,":[285],"detected":[289],"frontal":[292],"(Pearson's":[296],"r>-.5,":[297],".002),":[300],"without":[301],"detectable":[302],"effects":[303],"regions":[306],"targeted":[307],"AD.":[310,354],"loses":[315],"pattern":[321],"throughout":[322],"hemispheres.":[327],"Age-related":[328],"globally":[335],"less":[336],"prominent,":[337],"but":[338],"involved":[343],"memory":[345],"networks":[346],"that":[347],"affected":[349],"stages":[352]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
