{"id":"https://openalex.org/W2065083333","doi":"https://doi.org/10.1177/000456329803500213","title":"Determination of Free Fatty Acids in Human Bile by High-Performance Liquid Chromatography","display_name":"Determination of Free Fatty Acids in Human Bile by High-Performance Liquid Chromatography","publication_year":1998,"publication_date":"1998-03-01","ids":{"openalex":"https://openalex.org/W2065083333","doi":"https://doi.org/10.1177/000456329803500213","mag":"2065083333","pmid":"https://pubmed.ncbi.nlm.nih.gov/9547901"},"language":"en","primary_location":{"id":"doi:10.1177/000456329803500213","doi":"https://doi.org/10.1177/000456329803500213","is_oa":false,"landing_page_url":"https://doi.org/10.1177/000456329803500213","pdf_url":null,"source":{"id":"https://openalex.org/S175011280","display_name":"Annals of Clinical Biochemistry International Journal of Laboratory Medicine","issn_l":"0004-5632","issn":["0004-5632","1758-1001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical Biochemistry: International Journal of Laboratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111676288","display_name":"Yasushi Hori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Hori","raw_affiliation_strings":["Department of Hygiene and Preventive Medicine, Niigata University School of Medicine, Japan","Department of Hygiene and Preventive Medicine, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata City 951, Niigata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Preventive Medicine, Niigata University School of Medicine, Japan","institution_ids":["https://openalex.org/I71395657"]},{"raw_affiliation_string":"Department of Hygiene and Preventive Medicine, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata City 951, Niigata","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086257267","display_name":"Kazutoshi Nakamura","orcid":"https://orcid.org/0000-0002-8618-7632","observed_orcids":["https://orcid.org/0000-0002-8618-7632"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazutoshi Nakamura","raw_affiliation_strings":["Department of Hygiene and Preventive Medicine, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata City 951, Niigata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Preventive Medicine, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata City 951, Niigata","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101835110","display_name":"Masaharu Yamamoto","orcid":"https://orcid.org/0000-0001-6933-2503","observed_orcids":["https://orcid.org/0000-0001-6933-2503"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaharu Yamamoto","raw_affiliation_strings":["Department of Hygiene and Preventive Medicine, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata City 951, Niigata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Preventive Medicine, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata City 951, Niigata","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035434845","display_name":"Kenji Shimada","orcid":"https://orcid.org/0000-0002-6670-3118","observed_orcids":["https://orcid.org/0000-0002-6670-3118"]},"institutions":[{"id":"https://openalex.org/I114838220","display_name":"Niigata University of Pharmacy and Medical and Life Sciences","ror":"https://ror.org/00dnbtf70","country_code":"JP","type":"education","lineage":["https://openalex.org/I114838220"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Shimada","raw_affiliation_strings":["Department of Analytical Chemistry, Niigata College of Pharmacy, Niigata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Niigata College of Pharmacy, Niigata","institution_ids":["https://openalex.org/I114838220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008843086","display_name":"Hiroto Nakadaira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroto Nakadaira","raw_affiliation_strings":["Department of Hygiene and Preventive Medicine, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata City 951, Niigata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Preventive Medicine, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata City 951, Niigata","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023536904","display_name":"Norio Shibuya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norio Shibuya","raw_affiliation_strings":["Biochemical Laboratory, Niigata College of Medical Technology, Niigata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemical Laboratory, Niigata College of Medical Technology, Niigata","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109186224","display_name":"Kazuo Endoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo Endoh","raw_affiliation_strings":["Department of Hygiene and Preventive Medicine, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata City 951, Niigata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene and Preventive Medicine, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata City 951, Niigata","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071221404","display_name":"Kazuei Ogoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092137","display_name":"Niigata Cancer Center Hospital","ror":"https://ror.org/00e18hs98","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210092137"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuei Ogoshi","raw_affiliation_strings":["Niigata Cancer Hospital, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Niigata Cancer Hospital, Niigata, Japan","institution_ids":["https://openalex.org/I4210092137"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.3056,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.51752431,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"35","issue":"2","first_page":"279","last_page":"282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.0689999982714653,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0340999998152256,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":1.0},{"id":"https://openalex.org/keywords/human-bile","display_name":"human bile","score":0.906000018119812},{"id":"https://openalex.org/keywords/gallbladder-bile","display_name":"gallbladder bile","score":0.9890000224113464},{"id":"https://openalex.org/keywords/carboxylic-acid-derivatization","display_name":"carboxylic acid derivatization","score":0.8019999861717224},{"id":"https://openalex.org/keywords/fatty-acid-extraction","display_name":"fatty acid extraction","score":0.5519999861717224},{"id":"https://openalex.org/keywords/gallstones","display_name":"gallstones","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8139066696166992},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.8010149002075195},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6600675582885742},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.5913088917732239},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.5863350629806519},{"id":"https://openalex.org/C2777148285","wikidata":"https://www.wikidata.org/wiki/Q64386","display_name":"Gallbladder","level":2,"score":0.5295620560646057},{"id":"https://openalex.org/C34381374","wikidata":"https://www.wikidata.org/wiki/Q37144","display_name":"Cartridge","level":2,"score":0.5103747248649597},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4517688751220703},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21494054794311523},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.145516037940979},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1087026298046112},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001649","descriptor_name":"Bile Duct Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002769","descriptor_name":"Cholelithiasis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005704","descriptor_name":"Gallbladder","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/000456329803500213","doi":"https://doi.org/10.1177/000456329803500213","is_oa":false,"landing_page_url":"https://doi.org/10.1177/000456329803500213","pdf_url":null,"source":{"id":"https://openalex.org/S175011280","display_name":"Annals of Clinical Biochemistry International Journal of Laboratory Medicine","issn_l":"0004-5632","issn":["0004-5632","1758-1001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical Biochemistry: International Journal of Laboratory Medicine","raw_type":"journal-article"},{"id":"pmid:9547901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9547901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1919018029","https://openalex.org/W1968443641","https://openalex.org/W2002527452","https://openalex.org/W2028857821","https://openalex.org/W2063708057","https://openalex.org/W2072391003","https://openalex.org/W2094529216","https://openalex.org/W2136956104"],"related_works":["https://openalex.org/W2066842726","https://openalex.org/W2347513186","https://openalex.org/W2029152867","https://openalex.org/W2050986152","https://openalex.org/W3141218856","https://openalex.org/W2000249127","https://openalex.org/W2068931010","https://openalex.org/W1963609374","https://openalex.org/W1973808308","https://openalex.org/W2370859207"],"abstract_inverted_index":{"We":[0],"developed":[1],"a":[2,25],"high-performance":[3],"liquid":[4],"chromatography":[5],"(HPLC)":[6],"method":[7,61],"for":[8,55],"free":[9],"fatty":[10],"acids":[11],"(FFAs)":[12],"analysis":[13],"in":[14,24,94,119],"bile.":[15],"In":[16],"this":[17,88],"method,":[18,89],"FFAs":[19],"were":[20],"extracted":[21],"from":[22],"bile":[23,77,97],"single":[26],"step":[27],"using":[28],"an":[29],"Isolute":[30],"ODS":[31],"cartridge,":[32],"derivatized":[33],"with":[34,45],"9-anthryldiazomethane":[35],"(ADAM).":[36],"ADAM":[37],"was":[38,53,78,84,108,116],"chosen":[39],"because":[40],"of":[41,71,98,105],"its":[42],"high":[43],"reactivity":[44],"carboxylic":[46],"acid":[47],"at":[48],"room":[49],"temperature.":[50],"Then,":[51],"HPLC":[52],"used":[54],"separating":[56],"and":[57,66,80,114],"quantifying":[58],"FFAs.":[59,122],"This":[60],"proved":[62],"to":[63,74],"be":[64],"simple":[65],"time-saving.":[67],"The":[68,102],"mean":[69,103],"recovery":[70],"FFA":[72,92,107],"added":[73],"human":[75],"gallbladder":[76,96],"97.6%,":[79],"the":[81,95,120],"detection":[82],"limit":[83],"100-250":[85],"pg.":[86],"Using":[87],"we":[90],"determined":[91],"concentrations":[93],"11":[99],"gallstone":[100],"patients.":[101],"concentration":[104],"total":[106],"0.61":[109],"(SD":[110],"=":[111],"0.41)":[112],"mmol/L,":[113],"there":[115],"wide":[117],"variation":[118],"individual":[121]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
