{"id":"https://openalex.org/W2065062933","doi":"https://doi.org/10.1038/nsb0198-74","title":"Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations","display_name":"Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2065062933","doi":"https://doi.org/10.1038/nsb0198-74","mag":"2065062933","pmid":"https://pubmed.ncbi.nlm.nih.gov/9437433"},"language":"en","primary_location":{"id":"doi:10.1038/nsb0198-74","doi":"https://doi.org/10.1038/nsb0198-74","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nsb0198-74","pdf_url":null,"source":{"id":"https://openalex.org/S4394735520","display_name":"Nature Structural Biology","issn_l":"1072-8368","issn":["1072-8368","2331-365X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Structural Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003963332","display_name":"Ravichandran N. Venkataramani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravichandran Venkataramani","raw_affiliation_strings":["Wistar Institute, Philadelphia, Pennsylvania, USA","The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wistar Institute, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082147626","display_name":"Kunchithapadam Swaminathan","orcid":"https://orcid.org/0000-0001-7940-1090","observed_orcids":["https://orcid.org/0000-0001-7940-1090"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kunchithapadam Swaminathan","raw_affiliation_strings":["The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061620397","display_name":"Ronen Marmorstein","orcid":"https://orcid.org/0000-0003-4373-4752","observed_orcids":["https://orcid.org/0000-0003-4373-4752","https://orcid.org/0000-0002-9755-7838"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ronen Marmorstein","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA","Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA","The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061620397"],"corresponding_institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":8.6974,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.98277609,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"1","first_page":"74","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0544000007212162,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p18ink4c","display_name":"p18INK4c","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cdk4-6-inhibition","display_name":"CDK4/6 inhibition","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.8769999742507935},{"id":"https://openalex.org/keywords/g1-s-cell-cycle-arrest","display_name":"G1/S cell cycle arrest","score":0.7950000166893005},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C113241181","wikidata":"https://www.wikidata.org/wiki/Q24784174","display_name":"Ankyrin repeat","level":3,"score":0.8519920110702515},{"id":"https://openalex.org/C182800266","wikidata":"https://www.wikidata.org/wiki/Q414971","display_name":"Ankyrin","level":3,"score":0.7918511033058167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6726500988006592},{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.5117282867431641},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.488498330116272},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.47553491592407227},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44773852825164795},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.4389136731624603},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4115239977836609},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4102054238319397},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.3905518651008606},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3412327766418457},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.22832918167114258},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12293422222137451}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017089","descriptor_name":"Ankyrin Repeat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050763","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051361","descriptor_name":"Cyclin-Dependent Kinase 6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nsb0198-74","doi":"https://doi.org/10.1038/nsb0198-74","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nsb0198-74","pdf_url":null,"source":{"id":"https://openalex.org/S4394735520","display_name":"Nature Structural Biology","issn_l":"1072-8368","issn":["1072-8368","2331-365X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Structural Biology","raw_type":"journal-article"},{"id":"pmid:9437433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9437433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature structural biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1481344232","https://openalex.org/W1592215560","https://openalex.org/W1596201444","https://openalex.org/W1599757231","https://openalex.org/W1603300564","https://openalex.org/W1657540544","https://openalex.org/W1726597626","https://openalex.org/W1781531090","https://openalex.org/W1923050340","https://openalex.org/W1969222787","https://openalex.org/W1973341288","https://openalex.org/W1975914851","https://openalex.org/W1983348452","https://openalex.org/W1996607909","https://openalex.org/W1999330214","https://openalex.org/W2003907692","https://openalex.org/W2005788053","https://openalex.org/W2021805025","https://openalex.org/W2027744191","https://openalex.org/W2028231353","https://openalex.org/W2031338911","https://openalex.org/W2032384795","https://openalex.org/W2032437848","https://openalex.org/W2033098008","https://openalex.org/W2033156691","https://openalex.org/W2038440122","https://openalex.org/W2040687166","https://openalex.org/W2052221882","https://openalex.org/W2052912081","https://openalex.org/W2056008853","https://openalex.org/W2066848701","https://openalex.org/W2070437632","https://openalex.org/W2077433384","https://openalex.org/W2078248419","https://openalex.org/W2081489336","https://openalex.org/W2085593164","https://openalex.org/W2089623038","https://openalex.org/W2106315897","https://openalex.org/W2109413613","https://openalex.org/W2128705810","https://openalex.org/W2133335149","https://openalex.org/W2151131756","https://openalex.org/W2161378573","https://openalex.org/W2161743998","https://openalex.org/W2317073734","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W163453318","https://openalex.org/W1999698703","https://openalex.org/W2092611270","https://openalex.org/W1511872330","https://openalex.org/W1585309559","https://openalex.org/W1967923230","https://openalex.org/W2129113144","https://openalex.org/W2077433384","https://openalex.org/W2045603413","https://openalex.org/W178030036"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}