{"id":"https://openalex.org/W2065054759","doi":"https://doi.org/10.1021/sb500358y","title":"Synthetic Biology of Multicellular Systems: New Platforms and Applications for Animal Cells and Organisms","display_name":"Synthetic Biology of Multicellular Systems: New Platforms and Applications for Animal Cells and Organisms","publication_year":2014,"publication_date":"2014-12-19","ids":{"openalex":"https://openalex.org/W2065054759","doi":"https://doi.org/10.1021/sb500358y","mag":"2065054759","pmid":"https://pubmed.ncbi.nlm.nih.gov/25524091","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4476972"},"language":"en","primary_location":{"id":"doi:10.1021/sb500358y","doi":"https://doi.org/10.1021/sb500358y","is_oa":false,"landing_page_url":"https://doi.org/10.1021/sb500358y","pdf_url":null,"source":{"id":"https://openalex.org/S54167817","display_name":"ACS Synthetic Biology","issn_l":"2161-5063","issn":["2161-5063"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Synthetic Biology","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4476972","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063267847","display_name":"Joseph S. Markson","orcid":"https://orcid.org/0000-0002-3167-3887","observed_orcids":["https://orcid.org/0000-0002-3167-3887"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph S. Markson","raw_affiliation_strings":["Howard Hughes Medical Institute, Division of Biology and Biological Engineering, and Department of Applied Physics, California Institute of Technology , Pasadena, California 91125, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Division of Biology and Biological Engineering, and Department of Applied Physics, California Institute of Technology , Pasadena, California 91125, United States","institution_ids":["https://openalex.org/I122411786","https://openalex.org/I1344073410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014076497","display_name":"Michael B. Elowitz","orcid":"https://orcid.org/0000-0002-1221-0967","observed_orcids":["https://orcid.org/0000-0002-1221-0967"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael B. Elowitz","raw_affiliation_strings":["Howard Hughes Medical Institute,\rDivision of Biology and Biological Engineering, and Department of\rApplied Physics, California Institute of Technology, Pasadena, California 91125, United States","Howard Hughes Medical Institute,#R#Division of Biology and Biological Engineering, and Department of#R#Applied Physics, California Institute of Technology, Pasadena, California 91125, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute,\rDivision of Biology and Biological Engineering, and Department of\rApplied Physics, California Institute of Technology, Pasadena, California 91125, United States","institution_ids":["https://openalex.org/I122411786","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Howard Hughes Medical Institute,#R#Division of Biology and Biological Engineering, and Department of#R#Applied Physics, California Institute of Technology, Pasadena, California 91125, United States","institution_ids":["https://openalex.org/I122411786","https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014076497"],"corresponding_institution_ids":["https://openalex.org/I122411786","https://openalex.org/I1344073410"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"12","first_page":"875","last_page":"876"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8457000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8457000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.13770000636577606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"synthetic biology","score":0.828000009059906},{"id":"https://openalex.org/keywords/multicellular-systems","display_name":"multicellular systems","score":0.9649999737739563},{"id":"https://openalex.org/keywords/animal-cells","display_name":"animal cells","score":0.8420000076293945},{"id":"https://openalex.org/keywords/multicellular-organisms","display_name":"multicellular organisms","score":0.7369999885559082},{"id":"https://openalex.org/keywords/synthetic-gene-circuits","display_name":"synthetic gene circuits","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cell-engineering","display_name":"cell engineering","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.7010287046432495},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5269214510917664},{"id":"https://openalex.org/C518677369","wikidata":"https://www.wikidata.org/wiki/Q202833","display_name":"Social media","level":2,"score":0.509138286113739},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.48956045508384705},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.47704237699508667},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.4653611481189728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22416755557060242},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1031961441040039},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1021/sb500358y","doi":"https://doi.org/10.1021/sb500358y","is_oa":false,"landing_page_url":"https://doi.org/10.1021/sb500358y","pdf_url":null,"source":{"id":"https://openalex.org/S54167817","display_name":"ACS Synthetic Biology","issn_l":"2161-5063","issn":["2161-5063"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Synthetic Biology","raw_type":"journal-article"},{"id":"pmid:25524091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25524091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS synthetic biology","raw_type":"Editorial"},{"id":"pmh:oai:europepmc.org:3437886","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4476972","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4476972","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4476972","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Synth Biol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.716.8799","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.716.8799","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.elowitz.caltech.edu/publications/2014_Markson_ACSSynBio.pdf","raw_type":"text"},{"id":"pmh:oai:authors.library.caltech.edu:54242","doi":null,"is_oa":false,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20150130-091522471","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3437886","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4476972","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3214090172","display_name":"Bottom-up reconstitution of BMP morphogenetic pattern formation","funder_award_id":"F32AR067103","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2004868096","https://openalex.org/W2013971421"],"related_works":["https://openalex.org/W2416678800","https://openalex.org/W7099784308","https://openalex.org/W2795239381","https://openalex.org/W2117847381","https://openalex.org/W2725831004","https://openalex.org/W634364059","https://openalex.org/W4367461236","https://openalex.org/W2054189030","https://openalex.org/W4388523263","https://openalex.org/W2176579366"],"abstract_inverted_index":{"Like":[0],"life":[1],"itself,":[2],"synthetic":[3,10,56,63,71],"biology":[4,64],"began":[5],"with":[6],"unicellular":[7,66],"\\norganisms.":[8],"Early":[9],"biologists":[11],"built":[12],"genetic":[13,29,33,72],"circuits":[14],"\\nin":[15],"model":[16],"prokaryotes":[17,44],"and":[18,26,38,45,79],"yeast":[19,46],"because":[20],"of":[21,28,55,76],"their":[22],"relative":[23],"\\nbiological":[24],"simplicity":[25],"ease":[27],"manipulation.":[30],"With":[31],"\\nsuperior":[32],"tools,":[34],"faster":[35],"generation":[36],"times,":[37],"betterunderstood":[39],"endogenous":[40],"gene":[41],"expression":[42],"machinery,":[43],"were":[47],"(and":[48],"remain)":[49],"appealing":[50],"hosts":[51],"for":[52],"the":[53],"engineering":[54],"systems.":[57],"Now":[58],"in":[59,65],"its":[60],"second":[61],"decade,":[62],"organisms":[67],"has":[68],"produced":[69],"myriad":[70],"circuits,":[73],"a":[74],"number":[75],"industrial":[77],"applications,":[78],"fundamental":[80],"new":[81],"biological":[82],"insights":[83],"unlikely":[84],"to":[85],"have":[86],"emerged":[87],"from":[88],"nonsynthetic":[89],"approaches.":[90]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
