{"id":"https://openalex.org/W2065045634","doi":"https://doi.org/10.1002/aja.1001500104","title":"The effect of vinblastine\u2010induced microtubule loss on kidney podocyte morphology","display_name":"The effect of vinblastine\u2010induced microtubule loss on kidney podocyte morphology","publication_year":1977,"publication_date":"1977-09-01","ids":{"openalex":"https://openalex.org/W2065045634","doi":"https://doi.org/10.1002/aja.1001500104","mag":"2065045634","pmid":"https://pubmed.ncbi.nlm.nih.gov/930851"},"language":"en","primary_location":{"id":"doi:10.1002/aja.1001500104","doi":"https://doi.org/10.1002/aja.1001500104","is_oa":false,"landing_page_url":"https://doi.org/10.1002/aja.1001500104","pdf_url":null,"source":{"id":"https://openalex.org/S69635808","display_name":"American Journal of Anatomy","issn_l":"0002-9106","issn":["0002-9106","1553-0795"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Anatomy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113673062","display_name":"Peter M. Andrews","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter M. Andrews","raw_affiliation_strings":["Department of Cell Biology, The University of Texas Health Science Center at Dallas, Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, The University of Texas Health Science Center at Dallas, Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, Texas 75235","institution_ids":["https://openalex.org/I4210094379","https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113673062"],"corresponding_institution_ids":["https://openalex.org/I4210094379","https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":1.0775,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.76516854,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"150","issue":"1","first_page":"53","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vinblastine","display_name":"vinblastine","score":0.9490000009536743},{"id":"https://openalex.org/keywords/podocytes","display_name":"podocytes","score":0.6629999876022339},{"id":"https://openalex.org/keywords/podocyte-morphology","display_name":"podocyte morphology","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cytoplasmic-inclusions","display_name":"cytoplasmic inclusions","score":0.765999972820282},{"id":"https://openalex.org/keywords/pedicel","display_name":"pedicel","score":0.6349999904632568},{"id":"https://openalex.org/keywords/drug-induced-nephrotoxicity","display_name":"drug-induced nephrotoxicity","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2777146197","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Podocyte","level":4,"score":0.904334545135498},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.8747889995574951},{"id":"https://openalex.org/C2777132456","wikidata":"https://www.wikidata.org/wiki/Q282629","display_name":"Vinblastine","level":3,"score":0.822108805179596},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.8000221252441406},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6137451529502869},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4856966435909271},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.4582793414592743},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3559139370918274},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3535005748271942},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18498292565345764},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.09945619106292725},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.060284316539764404},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/aja.1001500104","doi":"https://doi.org/10.1002/aja.1001500104","is_oa":false,"landing_page_url":"https://doi.org/10.1002/aja.1001500104","pdf_url":null,"source":{"id":"https://openalex.org/S69635808","display_name":"American Journal of Anatomy","issn_l":"0002-9106","issn":["0002-9106","1553-0795"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Anatomy","raw_type":"journal-article"},{"id":"pmid:930851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/930851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of anatomy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W78637630","https://openalex.org/W158321532","https://openalex.org/W1975680163","https://openalex.org/W1976283239","https://openalex.org/W1998766450","https://openalex.org/W2014510861","https://openalex.org/W2069155858","https://openalex.org/W2098513597","https://openalex.org/W2127911529","https://openalex.org/W2319266929","https://openalex.org/W2320818345","https://openalex.org/W2411384222","https://openalex.org/W2414044881","https://openalex.org/W2470846090","https://openalex.org/W3035871689","https://openalex.org/W4253248585"],"related_works":["https://openalex.org/W132912996","https://openalex.org/W1975680163","https://openalex.org/W3035871689","https://openalex.org/W1964129879","https://openalex.org/W2005608465","https://openalex.org/W30943759","https://openalex.org/W2016356246","https://openalex.org/W4243680877","https://openalex.org/W2162251379","https://openalex.org/W2081929054"],"abstract_inverted_index":{"The":[0],"effect":[1],"of":[2,5,43,56,75,95],"intravenous":[3],"injections":[4],"vinblastine":[6,103],"sulfate":[7],"on":[8],"the":[9,33,50,79,91],"renal":[10],"glomerular":[11],"epithelium":[12],"was":[13],"studied":[14],"by":[15],"scanning":[16],"and":[17,37,40,64,93],"transmission":[18],"electron":[19],"microscopy.":[20],"Two":[21],"hours":[22],"after":[23,102],"treatment":[24,104],"with":[25,53],"vinblastine,":[26],"microtubules":[27,87],"were":[28],"almost":[29],"completely":[30],"lost":[31],"from":[32],"podocyte":[34,58,96,111],"cell":[35,81],"bodies":[36],"major":[38,59,97],"processes,":[39],"crystalline":[41],"inclusions":[42],"a":[44],"tubular":[45],"nature":[46],"had":[47],"appeared":[48,71],"within":[49],"cytoplasm.":[51],"Coincident":[52],"this":[54],"loss":[55],"microtubules,":[57],"processes":[60],"at":[61],"first":[62],"collapsed":[63],"then":[65],"became":[66],"significantly":[67],"thinner":[68],"as":[69],"they":[70],"to":[72,78,89],"lose":[73],"much":[74],"their":[76],"cytoplasm":[77],"nucleated":[80],"body.":[82],"These":[83],"observations":[84],"suggest":[85],"that":[86],"serve":[88],"maintain":[90],"shape":[92],"integrity":[94],"processes.":[98],"At":[99],"no":[100],"time":[101],"did":[105],"we":[106],"note":[107],"any":[108],"alteration":[109],"in":[110],"pedicel":[112],"morphology.":[113]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
