{"id":"https://openalex.org/W2065040872","doi":"https://doi.org/10.2332/allergolint.55.395","title":"A Prospective Survey on Safety of Sustained-Release Theophylline in Treatment of Asthma and COPD","display_name":"A Prospective Survey on Safety of Sustained-Release Theophylline in Treatment of Asthma and COPD","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2065040872","doi":"https://doi.org/10.2332/allergolint.55.395","mag":"2065040872","pmid":"https://pubmed.ncbi.nlm.nih.gov/17130682"},"language":"en","primary_location":{"id":"doi:10.2332/allergolint.55.395","doi":"https://doi.org/10.2332/allergolint.55.395","is_oa":true,"landing_page_url":"https://doi.org/10.2332/allergolint.55.395","pdf_url":null,"source":{"id":"https://openalex.org/S116585092","display_name":"Allergology International","issn_l":"1323-8930","issn":["1323-8930","1440-1592"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergology International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2332/allergolint.55.395","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109195951","display_name":"Sohei Makino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254740","display_name":"Japanese Society of Allergology","ror":"https://ror.org/0263b6f89","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4405254740"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Sohei Makino","raw_affiliation_strings":["Internal Medicine, Jobu Hospital for Respiratory Disease, Maebashi, Gunma, Japan. s-makino@dokkyomed.ac.jp","Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Jobu Hospital for Respiratory Disease, Maebashi, Gunma, Japan. s-makino@dokkyomed.ac.jp","institution_ids":[]},{"raw_affiliation_string":"Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan","institution_ids":["https://openalex.org/I4405254740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058878517","display_name":"Mitsuru Adachi","orcid":"https://orcid.org/0000-0001-7596-0864","observed_orcids":["https://orcid.org/0000-0001-7596-0864"]},"institutions":[{"id":"https://openalex.org/I4405254740","display_name":"Japanese Society of Allergology","ror":"https://ror.org/0263b6f89","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4405254740"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuru Adachi","raw_affiliation_strings":["Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan","institution_ids":["https://openalex.org/I4405254740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082008116","display_name":"Ken Ohta","orcid":"https://orcid.org/0000-0001-9734-4579","observed_orcids":["https://orcid.org/0000-0001-9734-4579"]},"institutions":[{"id":"https://openalex.org/I4405254740","display_name":"Japanese Society of Allergology","ror":"https://ror.org/0263b6f89","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4405254740"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Ohta","raw_affiliation_strings":["Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan","institution_ids":["https://openalex.org/I4405254740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031437356","display_name":"Norio Kihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254740","display_name":"Japanese Society of Allergology","ror":"https://ror.org/0263b6f89","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4405254740"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio Kihara","raw_affiliation_strings":["Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan","institution_ids":["https://openalex.org/I4405254740"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sigenori Nakajima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254740","display_name":"Japanese Society of Allergology","ror":"https://ror.org/0263b6f89","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4405254740"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sigenori Nakajima","raw_affiliation_strings":["Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan","institution_ids":["https://openalex.org/I4405254740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111957038","display_name":"Sankei Nishima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254740","display_name":"Japanese Society of Allergology","ror":"https://ror.org/0263b6f89","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4405254740"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sankei Nishima","raw_affiliation_strings":["Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan","institution_ids":["https://openalex.org/I4405254740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029514198","display_name":"Takeshi Fukuda","orcid":"https://orcid.org/0000-0001-7196-1413","observed_orcids":["https://orcid.org/0000-0001-7196-1413"]},"institutions":[{"id":"https://openalex.org/I4405254740","display_name":"Japanese Society of Allergology","ror":"https://ror.org/0263b6f89","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4405254740"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Fukuda","raw_affiliation_strings":["Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan","institution_ids":["https://openalex.org/I4405254740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102078194","display_name":"Terumasa Miyamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254740","display_name":"Japanese Society of Allergology","ror":"https://ror.org/0263b6f89","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4405254740"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Terumasa Miyamoto","raw_affiliation_strings":["Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on the Safety of Sustained-Release Theophylline and Injectable Methylxanthines (CST), Committee for Asthma Prevention and Management Guidelines in the Japanese Society of Allergology, Tokyo, Japan","institution_ids":["https://openalex.org/I4405254740"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109195951"],"corresponding_institution_ids":["https://openalex.org/I4405254740"],"apc_list":{"value":2280,"currency":"USD","value_usd":2280},"apc_paid":{"value":2280,"currency":"USD","value_usd":2280},"fwci":0.7919,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.75857024,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"55","issue":"4","first_page":"395","last_page":"402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sustained-release-theophylline","display_name":"sustained-release theophylline","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.7950000166893005},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8389999866485596},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9829999804496765},{"id":"https://openalex.org/keywords/chronic-bronchitis","display_name":"chronic bronchitis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.9679999947547913},{"id":"https://openalex.org/keywords/macrolide-antibiotics","display_name":"macrolide antibiotics","score":0.9760000109672546},{"id":"https://openalex.org/keywords/concomitant-drug-use","display_name":"concomitant drug use","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C2778095195","wikidata":"https://www.wikidata.org/wiki/Q407308","display_name":"Theophylline","level":2,"score":0.8743336200714111},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7781013250350952},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7688366174697876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6585999727249146},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.42232850193977356},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3339143991470337},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3150451183319092},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24978718161582947}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001991","descriptor_name":"Bronchitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003625","descriptor_name":"Data Collection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011358","descriptor_name":"Product Surveillance, Postmarketing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016907","descriptor_name":"Adverse Drug Reaction Reporting Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018927","descriptor_name":"Anti-Asthmatic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018927","descriptor_name":"Anti-Asthmatic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018927","descriptor_name":"Anti-Asthmatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D033461","descriptor_name":"Hyperuricemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2332/allergolint.55.395","doi":"https://doi.org/10.2332/allergolint.55.395","is_oa":true,"landing_page_url":"https://doi.org/10.2332/allergolint.55.395","pdf_url":null,"source":{"id":"https://openalex.org/S116585092","display_name":"Allergology International","issn_l":"1323-8930","issn":["1323-8930","1440-1592"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergology International","raw_type":"journal-article"},{"id":"pmid:17130682","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17130682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergology international : official journal of the Japanese Society of Allergology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.621.1055","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.621.1055","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ai.jsaweb.jp/pdf/055040395.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:4debd2a7196940cc960803571be739ed","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4debd2a7196940cc960803571be739ed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Allergology International, Vol 55, Iss 4, Pp 395-402 (2006)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2332/allergolint.55.395","doi":"https://doi.org/10.2332/allergolint.55.395","is_oa":true,"landing_page_url":"https://doi.org/10.2332/allergolint.55.395","pdf_url":null,"source":{"id":"https://openalex.org/S116585092","display_name":"Allergology International","issn_l":"1323-8930","issn":["1323-8930","1440-1592"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergology International","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320327689","display_name":"Japan Allergy Foundation","ror":"https://ror.org/00hqc6w79"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1488504374","https://openalex.org/W1895829060","https://openalex.org/W1964870760","https://openalex.org/W1965600709","https://openalex.org/W1976722278","https://openalex.org/W1988854276","https://openalex.org/W2013407710","https://openalex.org/W2031591363","https://openalex.org/W2052225778","https://openalex.org/W2077523026","https://openalex.org/W2081665188","https://openalex.org/W2087509980","https://openalex.org/W2093705266","https://openalex.org/W2096247755","https://openalex.org/W2110694086","https://openalex.org/W2133769637","https://openalex.org/W2182915855","https://openalex.org/W2333181346","https://openalex.org/W2336612646","https://openalex.org/W2486710377","https://openalex.org/W2514854216","https://openalex.org/W2991832304","https://openalex.org/W3043121236"],"related_works":["https://openalex.org/W7098263719","https://openalex.org/W7096587199","https://openalex.org/W1994222374","https://openalex.org/W2162691728","https://openalex.org/W2034497364","https://openalex.org/W2399993720","https://openalex.org/W4365793092","https://openalex.org/W2378284348","https://openalex.org/W109312296","https://openalex.org/W2410898048"],"abstract_inverted_index":{"BACKGROUND:":[0],"Theophylline":[1],"is":[2,199],"a":[3],"useful":[4],"drug":[5],"for":[6,36,40,117],"the":[7,45,66,76,95,131,141,175],"treatment":[8],"of":[9,20,27,70,78,98,119,156,170,177,215],"asthma.":[10],"The":[11,33,68,83,101,154,192],"Asthma":[12,41],"Prevention":[13],"and":[14,26,43,52,106,111,182],"Management":[15,42],"Guidelines":[16],"(JGL)":[17],"recommend":[18,57],"use":[19,118,169],"sustained-release":[21,58,120,171,197],"theophylline":[22,121,172,198],"products":[23,30,122,173],"as":[24,31,62,64,201,203],"controllers":[25],"injectable":[28],"aminophylline":[29],"relievers.":[32],"Global":[34,38],"Initiative":[35],"Asthma:":[37],"Strategy":[39],"Prevention,":[44],"NHLB/WHP":[46],"Workshop":[47],"Report":[48],"1995":[49],"(GINA,":[50],"1995)":[51],"guidelines":[53],"in":[54,65,87,123,130,143,164,179,183],"Western":[55],"countries":[56],"theophylline,":[59],"but":[60],"not":[61],"positively":[63],"JGL.":[67],"aim":[69],"this":[71,144,180],"survey":[72,84,194],"was":[73,85,159],"to":[74,161,210],"determine":[75],"occurrence":[77],"serious":[79,135],"adverse":[80,136,152,157,207],"reactions.":[81,153],"METHODS:":[82],"conducted":[86],"66":[88],"institutions":[89],"staffed":[90],"by":[91,94],"physicians":[92],"certified":[93],"Japanese":[96],"Society":[97],"Allergology":[99],"(JSA).":[100],"target":[102],"diseases":[103],"were":[104,128,138,186],"asthma":[105],"COPD":[107],"including":[108],"chronic":[109],"bronchitis":[110],"pulmonary":[112],"emphysema,":[113],"which":[114],"are":[115],"indications":[116],"Japan.":[124],"RESULTS:":[125],"3,921":[126],"patients":[127,142,148,165,184],"included":[129],"safety":[132],"evaluation.":[133],"No":[134],"reactions":[137,158,208],"observed":[139],"among":[140],"survey,":[145,181],"although":[146,206],"54":[147],"(1.38%)":[149],"exhibited":[150],"non-serious":[151],"incidence":[155],"found":[160],"be":[162],"high":[163],"who":[166,185],"had":[167],"begun":[168],"at":[174],"time":[176],"registration":[178],"concomitantly":[187],"taking":[188],"macrolide":[189],"antibiotics.":[190],"CONCLUSIONS:":[191],"present":[193],"demonstrates":[195],"that":[196],"safe,":[200],"long":[202],"used":[204],"appropriately,":[205],"tend":[209],"develop":[211],"early":[212],"after":[213],"initiation":[214],"administration.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}