{"id":"https://openalex.org/W2065030592","doi":"https://doi.org/10.1097/moo.0b013e32830e20db","title":"State-of-the-art mechanisms of intracochlear drug delivery","display_name":"State-of-the-art mechanisms of intracochlear drug delivery","publication_year":2008,"publication_date":"2008-09-16","ids":{"openalex":"https://openalex.org/W2065030592","doi":"https://doi.org/10.1097/moo.0b013e32830e20db","mag":"2065030592","pmid":"https://pubmed.ncbi.nlm.nih.gov/18797291","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6457114"},"language":"en","primary_location":{"id":"doi:10.1097/moo.0b013e32830e20db","doi":"https://doi.org/10.1097/moo.0b013e32830e20db","is_oa":false,"landing_page_url":"https://doi.org/10.1097/moo.0b013e32830e20db","pdf_url":null,"source":{"id":"https://openalex.org/S184974915","display_name":"Current Opinion in Otolaryngology & Head & Neck Surgery","issn_l":"1068-9508","issn":["1068-9508","1080-8086","1531-6998"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Otolaryngology & Head & Neck Surgery","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6457114","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057695807","display_name":"David A. Borkholder","orcid":"https://orcid.org/0000-0002-0606-0536","observed_orcids":["https://orcid.org/0000-0002-0606-0536"]},"institutions":[{"id":"https://openalex.org/I155173764","display_name":"Rochester Institute of Technology","ror":"https://ror.org/00v4yb702","country_code":"US","type":"education","lineage":["https://openalex.org/I155173764"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David A Borkholder","raw_affiliation_strings":["Department of Electrical Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA. david.borkholder@rit.edu","Departments of Electrical Engineering and Microsystems Engineering, Rochester Institute of Technology, USA","Departments of Otolaryngology and Biomedical Engineering at the University of Rochester, Rochester, New York, USA","e-mail: [email\u00a0protected]","to David A. Borkholder, PhD, Associate Professor, Department of Electrical Engineering, Rochester Institute of Technology, 79 Lomb Memorial Drive, Rochester, NY 14623, USA Tel: +1 585 475 6067"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA. david.borkholder@rit.edu","institution_ids":["https://openalex.org/I155173764"]},{"raw_affiliation_string":"Departments of Electrical Engineering and Microsystems Engineering, Rochester Institute of Technology, USA","institution_ids":["https://openalex.org/I155173764"]},{"raw_affiliation_string":"Departments of Otolaryngology and Biomedical Engineering at the University of Rochester, Rochester, New York, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"to David A. Borkholder, PhD, Associate Professor, Department of Electrical Engineering, Rochester Institute of Technology, 79 Lomb Memorial Drive, Rochester, NY 14623, USA Tel: +1 585 475 6067","institution_ids":["https://openalex.org/I155173764"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057695807"],"corresponding_institution_ids":["https://openalex.org/I155173764","https://openalex.org/I28792581","https://openalex.org/I5388228"],"apc_list":null,"apc_paid":null,"fwci":0.6091,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.43478261,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"16","issue":"5","first_page":"472","last_page":"477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.12849999964237213,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracochlear-drug-delivery","display_name":"intracochlear drug delivery","score":0.9959999918937683},{"id":"https://openalex.org/keywords/meniere-s-disease","display_name":"Meniere's disease","score":0.8939999938011169},{"id":"https://openalex.org/keywords/sudden-sensorineural-hearing-loss","display_name":"sudden sensorineural hearing loss","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.984000027179718},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.9890000224113464},{"id":"https://openalex.org/keywords/round-window-membrane","display_name":"round window membrane","score":0.9010000228881836},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.6190000176429749},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.7789999842643738},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hair-cell-regeneration","display_name":"hair cell regeneration","score":0.9139999747276306},{"id":"https://openalex.org/keywords/vestibular-dysfunction","display_name":"vestibular dysfunction","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8787959814071655},{"id":"https://openalex.org/C2780757810","wikidata":"https://www.wikidata.org/wiki/Q263574","display_name":"Round window","level":3,"score":0.8499768972396851},{"id":"https://openalex.org/C2778500370","wikidata":"https://www.wikidata.org/wiki/Q212344","display_name":"Inner ear","level":2,"score":0.7533990144729614},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6720919609069824},{"id":"https://openalex.org/C190041318","wikidata":"https://www.wikidata.org/wiki/Q596832","display_name":"Vestibular system","level":2,"score":0.4673994183540344},{"id":"https://openalex.org/C2780607864","wikidata":"https://www.wikidata.org/wiki/Q928697","display_name":"Sensorineural hearing loss","level":3,"score":0.431915283203125},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.42435330152511597},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.37384793162345886},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.29402434825897217},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.14346051216125488},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08044874668121338},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003639","descriptor_name":"Hearing Loss, Sudden","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008575","descriptor_name":"Meniere Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014432","descriptor_name":"Tympanic Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/moo.0b013e32830e20db","doi":"https://doi.org/10.1097/moo.0b013e32830e20db","is_oa":false,"landing_page_url":"https://doi.org/10.1097/moo.0b013e32830e20db","pdf_url":null,"source":{"id":"https://openalex.org/S184974915","display_name":"Current Opinion in Otolaryngology & Head & Neck Surgery","issn_l":"1068-9508","issn":["1068-9508","1080-8086","1531-6998"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Otolaryngology & Head & Neck Surgery","raw_type":"journal-article"},{"id":"pmid:18797291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18797291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in otolaryngology & head and neck surgery","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5440711","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6457114","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6457114","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6457114","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Otolaryngol Head Neck Surg","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5440711","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6457114","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6534069257","display_name":"Improved Micro-Technologies for Inner Ear Drug Delivery","funder_award_id":"K25DC008291","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W51680574","https://openalex.org/W635436406","https://openalex.org/W1557808140","https://openalex.org/W1598203568","https://openalex.org/W1963528294","https://openalex.org/W1964000981","https://openalex.org/W1965451288","https://openalex.org/W1967888989","https://openalex.org/W1968758657","https://openalex.org/W1969206855","https://openalex.org/W1970704620","https://openalex.org/W1974964629","https://openalex.org/W1984749525","https://openalex.org/W1985564483","https://openalex.org/W1986088298","https://openalex.org/W1989439243","https://openalex.org/W1991106174","https://openalex.org/W1997474957","https://openalex.org/W2002875893","https://openalex.org/W2006904223","https://openalex.org/W2014454013","https://openalex.org/W2014808977","https://openalex.org/W2015407997","https://openalex.org/W2019202778","https://openalex.org/W2023572143","https://openalex.org/W2024048100","https://openalex.org/W2025750796","https://openalex.org/W2030152831","https://openalex.org/W2030877917","https://openalex.org/W2032775938","https://openalex.org/W2032813892","https://openalex.org/W2044563281","https://openalex.org/W2047465917","https://openalex.org/W2048258735","https://openalex.org/W2051610600","https://openalex.org/W2054771268","https://openalex.org/W2055591179","https://openalex.org/W2056990798","https://openalex.org/W2057798989","https://openalex.org/W2058359348","https://openalex.org/W2058532244","https://openalex.org/W2059160058","https://openalex.org/W2060516472","https://openalex.org/W2068916367","https://openalex.org/W2069618340","https://openalex.org/W2069763162","https://openalex.org/W2074553406","https://openalex.org/W2074744017","https://openalex.org/W2075928102","https://openalex.org/W2076055635","https://openalex.org/W2076408736","https://openalex.org/W2082360664","https://openalex.org/W2082819975","https://openalex.org/W2083888986","https://openalex.org/W2085890965","https://openalex.org/W2089721045","https://openalex.org/W2092866020","https://openalex.org/W2094899800","https://openalex.org/W2095274746","https://openalex.org/W2098987136","https://openalex.org/W2099405676","https://openalex.org/W2105493567","https://openalex.org/W2119058219","https://openalex.org/W2128377889","https://openalex.org/W2139839870","https://openalex.org/W2141569557","https://openalex.org/W2146432775","https://openalex.org/W2151176501","https://openalex.org/W2152608606","https://openalex.org/W2157934298","https://openalex.org/W2171885092","https://openalex.org/W2176800073","https://openalex.org/W2315109968","https://openalex.org/W2325091766","https://openalex.org/W2334644780","https://openalex.org/W2411236030","https://openalex.org/W2470371922"],"related_works":["https://openalex.org/W2803880641","https://openalex.org/W66047808","https://openalex.org/W1972158701","https://openalex.org/W7169847264","https://openalex.org/W6968309914","https://openalex.org/W1965534915","https://openalex.org/W1047238016","https://openalex.org/W2037243367","https://openalex.org/W2971162904","https://openalex.org/W4413351468"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Treatment":[3],"of":[4,28,59,66,81,99,112,154,168,186],"auditory":[5],"and":[6,23,35,51,61,69,118,122,130,166],"vestibular":[7,131],"dysfunction":[8],"has":[9,135],"become":[10,124],"increasingly":[11],"dependent":[12],"on":[13,90,161],"inner":[14,143,155],"ear":[15,156],"drug":[16,157],"delivery.":[17],"Recent":[18],"advances":[19],"in":[20,44],"molecular":[21],"therapy":[22,175],"nanotechnology":[24],"have":[25],"pushed":[26],"development":[27,176],"alternate":[29],"delivery":[30,58,98,127,140,158,182],"methodologies":[31],"involving":[32],"both":[33,49],"transtympanic":[34,107],"direct":[36,180],"intracochlear":[37,181],"infusions.":[38],"This":[39],"review":[40],"examines":[41],"recent":[42],"developments":[43],"the":[45,64,91,114,142,169],"field":[46],"relevant":[47],"to":[48,75,141,171],"clinical":[50],"animal":[52],"research":[53],"environments.":[54],"RECENT":[55],"FINDINGS:":[56],"Transtympanic":[57],"gentamicin":[60],"corticosteroids":[62],"for":[63,95,147],"treatment":[65],"Meniere's":[67],"disease":[68],"sudden":[70],"sensorineural":[71],"hearing":[72],"loss":[73],"continues":[74],"be":[76,172],"clinically":[77],"relevant,":[78],"with":[79,183],"understanding":[80,185],"pharmacokinetics":[82],"becoming":[83],"more":[84,102],"closely":[85],"studied.":[86],"Stabilizing":[87],"matrices":[88],"placed":[89],"round":[92,115],"window":[93,116],"membrane":[94,117],"sustained":[96],"passive":[97],"compounds":[100],"offer":[101],"controlled":[103],"dosing":[104],"profiles":[105],"than":[106],"injections.":[108],"Nanoparticles":[109],"are":[110],"capable":[111],"traversing":[113],"cochlear":[119],"membranous":[120],"partitions,":[121],"may":[123],"useful":[125],"gene":[126],"platforms.":[128],"Cochlear":[129],"hair":[132],"cell":[133],"regeneration":[134],"been":[136],"demonstrated":[137],"by":[138],"vector":[139],"ear,":[144],"offering":[145],"promise":[146],"future":[148],"advanced":[149],"therapies.":[150],"SUMMARY:":[151],"Optimal":[152],"methods":[153],"will":[159,177],"depend":[160],"toxicity,":[162],"therapeutic":[163],"dose":[164],"range,":[165],"characteristics":[167],"agent":[170],"delivered.":[173],"Advanced":[174],"likely":[178],"require":[179],"detailed":[184],"associated":[187],"pharmacokinetics.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}