{"id":"https://openalex.org/W2065024025","doi":"https://doi.org/10.1073/pnas.0506581102","title":"Conversion of nicotine to nornicotine in Nicotiana tabacum is mediated by CYP82E4, a cytochrome P450 monooxygenase","display_name":"Conversion of nicotine to nornicotine in Nicotiana tabacum is mediated by CYP82E4, a cytochrome P450 monooxygenase","publication_year":2005,"publication_date":"2005-09-28","ids":{"openalex":"https://openalex.org/W2065024025","doi":"https://doi.org/10.1073/pnas.0506581102","mag":"2065024025","pmid":"https://pubmed.ncbi.nlm.nih.gov/16192354","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1253577"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0506581102","doi":"https://doi.org/10.1073/pnas.0506581102","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0506581102","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1253577","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033167515","display_name":"Balazs Siminszky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Balazs Siminszky","raw_affiliation_strings":["Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546-0312; and Department of Crop Science, North Carolina State University, Raleigh, NC 27695-7620"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546-0312; and Department of Crop Science, North Carolina State University, Raleigh, NC 27695-7620","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081083329","display_name":"Lily B. Gavilano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lily Gavilano","raw_affiliation_strings":["Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546-0312; and Department of Crop Science, North Carolina State University, Raleigh, NC 27695-7620"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546-0312; and Department of Crop Science, North Carolina State University, Raleigh, NC 27695-7620","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075508136","display_name":"Steven W. Bowen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven W. Bowen","raw_affiliation_strings":["Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546-0312; and Department of Crop Science, North Carolina State University, Raleigh, NC 27695-7620"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546-0312; and Department of Crop Science, North Carolina State University, Raleigh, NC 27695-7620","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029469294","display_name":"Ralph E. Dewey","orcid":"https://orcid.org/0000-0003-1924-3777","observed_orcids":["https://orcid.org/0000-0003-1924-3777"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph E. Dewey","raw_affiliation_strings":["Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546-0312; and Department of Crop Science, North Carolina State University, Raleigh, NC 27695-7620"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546-0312; and Department of Crop Science, North Carolina State University, Raleigh, NC 27695-7620","institution_ids":["https://openalex.org/I137902535","https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8908,"has_fulltext":false,"cited_by_count":178,"citation_normalized_percentile":{"value":0.91647123,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"102","issue":"41","first_page":"14919","last_page":"14924"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11237","display_name":"Plant Gene Expression Analysis","score":0.03359999880194664,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nornicotine","display_name":"nornicotine","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cytochrome-p450-monooxygenases","display_name":"cytochrome P450 monooxygenase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/nicotiana-tabacum","display_name":"tobacco","score":0.9039999842643738},{"id":"https://openalex.org/keywords/tobacco-alkaloids","display_name":"tobacco alkaloids","score":0.9039999842643738},{"id":"https://openalex.org/keywords/n-nitrosonornicotine","display_name":"N'-nitrosonornicotine","score":0.968999981880188},{"id":"https://openalex.org/keywords/gene-family-expression","display_name":"gene family expression","score":0.4690000116825104},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.7940000295639038},{"id":"https://openalex.org/keywords/leaf-senescence","display_name":"leaf senescence","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tobacco-curing","display_name":"tobacco curing","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C2776166849","wikidata":"https://www.wikidata.org/wiki/Q907939","display_name":"Nornicotine","level":3,"score":0.9988687038421631},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.7777856588363647},{"id":"https://openalex.org/C2776975794","wikidata":"https://www.wikidata.org/wiki/Q419308","display_name":"Anabasine","level":3,"score":0.6131236553192139},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.5167859792709351},{"id":"https://openalex.org/C2781205006","wikidata":"https://www.wikidata.org/wiki/Q181095","display_name":"Nicotiana tabacum","level":3,"score":0.4945525825023651},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.45207783579826355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4518605172634125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38776347041130066},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3500199317932129},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3394278883934021},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3253478407859802},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.18682518601417542},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12309828400611877},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020224","descriptor_name":"Expressed Sequence Tags","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.0506581102","doi":"https://doi.org/10.1073/pnas.0506581102","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0506581102","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:176905","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1253577","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:16192354","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16192354","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:1253577","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1253577/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:176905","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1253577","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W32456633","https://openalex.org/W1515404266","https://openalex.org/W1549647993","https://openalex.org/W1925002711","https://openalex.org/W1966102412","https://openalex.org/W1973223683","https://openalex.org/W1987195836","https://openalex.org/W1997828131","https://openalex.org/W2001823559","https://openalex.org/W2006639378","https://openalex.org/W2006998778","https://openalex.org/W2007407648","https://openalex.org/W2008996050","https://openalex.org/W2026268799","https://openalex.org/W2026361884","https://openalex.org/W2038973920","https://openalex.org/W2065144094","https://openalex.org/W2070611230","https://openalex.org/W2076780060","https://openalex.org/W2087133769","https://openalex.org/W2087852258","https://openalex.org/W2106882534","https://openalex.org/W2109975826","https://openalex.org/W2140731628","https://openalex.org/W2158714788","https://openalex.org/W2951769065","https://openalex.org/W6605411539"],"related_works":["https://openalex.org/W2002286378","https://openalex.org/W2014120943","https://openalex.org/W2150920296","https://openalex.org/W1578828103","https://openalex.org/W2516820399","https://openalex.org/W2772116158","https://openalex.org/W6979834357","https://openalex.org/W6998503119","https://openalex.org/W4401560685","https://openalex.org/W2075690206"],"abstract_inverted_index":{"Nornicotine":[0,14],"is":[1,7,46],"a":[2,48,58,68,83,121,217,229],"secondary":[3],"tobacco":[4,19,52,56,96,145,244],"alkaloid":[5,50,109],"that":[6,66,89,98,168,196,213],"produced":[8],"by":[9],"the":[10,26,29,32,38,72,107,111,118,131,151,156,176,181,203,222],"N-demethylation":[11],"of":[12,31,42,61,71,120,124,150,158,175,180,191,205,221],"nicotine.":[13],"production":[15],"and":[16,40,79,239],"accumulation":[17],"in":[18,28,51,54,110,141,160,170,202,243],"are":[20,90],"undesirable":[21],"because":[22],"nornicotine":[23,45,75,104,159,237],"serves":[24],"as":[25,106,216],"precursor":[27],"synthesis":[30,157],"well":[33],"characterized":[34],"carcinogen":[35],"N'-nitrosonornicotine":[36,241],"during":[37,76],"curing":[39],"processing":[41],"tobacco.":[43],"Although":[44,173],"typically":[47],"minor":[49],"plants,":[53],"many":[55],"populations":[57],"high":[59],"percentage":[60],"individuals":[62],"can":[63],"be":[64],"found":[65],"convert":[67],"substantial":[69],"proportion":[70],"nicotine":[73,101,206,218,226],"to":[74,86,117,164,167,207,235],"leaf":[77],"senescence":[78],"curing.":[80],"We":[81],"used":[82],"microarray-based":[84],"strategy":[85],"identify":[87],"genes":[88],"differentially":[91],"regulated":[92],"between":[93],"closely":[94,125],"related":[95,126],"lines":[97],"accumulate":[99],"either":[100],"(nonconverters)":[102],"or":[103],"(converters)":[105],"predominant":[108],"cured":[112],"leaf.":[113],"These":[114],"experiments":[115],"led":[116],"identification":[119],"small":[122],"number":[123],"cytochrome":[127],"P450":[128,182],"genes,":[129],"designated":[130],"CYP82E2":[132,152],"family,":[133],"whose":[134],"collective":[135],"transcript":[136],"levels":[137,165],"were":[138],"consistently":[139],"higher":[140],"converter":[142,162],"versus":[143],"nonconverter":[144,171],"lines.":[146],"RNA":[147],"interference-induced":[148],"silencing":[149],"gene":[153],"family":[154,183],"suppressed":[155],"strong":[161],"plants":[163],"similar":[166],"observed":[169],"individuals.":[172],"each":[174],"six":[177],"identified":[178],"members":[179],"share":[184],">90%":[185],"nucleotide":[186],"sequence":[187],"identity,":[188],"sense":[189],"expression":[190,210],"three":[192],"selected":[193],"isoforms":[194],"revealed":[195,212],"only":[197],"one":[198],"(CYP82E4v1)":[199],"was":[200],"involved":[201],"conversion":[204],"nornicotine.":[208],"Yeast":[209],"analysis":[211],"CYP82E4v1":[214],"functions":[215],"demethylase.":[219],"Identification":[220],"gene(s)":[223],"responsible":[224],"for":[225],"demethylation":[227],"provides":[228],"potentially":[230],"powerful":[231],"tool":[232],"toward":[233],"efforts":[234],"minimize":[236],"levels,":[238],"thereby":[240],"formation,":[242],"products.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
