{"id":"https://openalex.org/W2064998580","doi":"https://doi.org/10.1016/0006-8993(95)01497-7","title":"Endogenous Alzheimer's brain factor and oxidized glutathione inhibit antagonist binding to the muscarinic receptor","display_name":"Endogenous Alzheimer's brain factor and oxidized glutathione inhibit antagonist binding to the muscarinic receptor","publication_year":1996,"publication_date":"1996-04-01","ids":{"openalex":"https://openalex.org/W2064998580","doi":"https://doi.org/10.1016/0006-8993(95)01497-7","mag":"2064998580","pmid":"https://pubmed.ncbi.nlm.nih.gov/8861612"},"language":"en","primary_location":{"id":"doi:10.1016/0006-8993(95)01497-7","doi":"https://doi.org/10.1016/0006-8993(95)01497-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-8993(95)01497-7","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046805860","display_name":"William H. Frey","orcid":"https://orcid.org/0000-0002-6373-0794","observed_orcids":["https://orcid.org/0000-0002-6373-0794"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"William H. Frey","raw_affiliation_strings":["Department of Neurology, The Alzheimer's Treatment and Research Center, St. Paul Ramsey Medical Center, St. Paul, MN 55101-2595, USA","Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Alzheimer's Treatment and Research Center, St. Paul Ramsey Medical Center, St. Paul, MN 55101-2595, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057034309","display_name":"Melissa M. Najarian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa M. Najarian","raw_affiliation_strings":["Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kavita S. Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kavita S. Kumar","raw_affiliation_strings":["Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010679483","display_name":"Carolyn R. Emory","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolyn R. Emory","raw_affiliation_strings":["Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046865657","display_name":"Patrick M. Menning","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick M. Menning","raw_affiliation_strings":["Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"John C. Frank","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John C. Frank","raw_affiliation_strings":["Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109265997","display_name":"Melissa N. Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa N. Johnson","raw_affiliation_strings":["Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006625551","display_name":"Thomas A. Ala","orcid":"https://orcid.org/0000-0001-9401-2114","observed_orcids":["https://orcid.org/0000-0001-9401-2114"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas A. Ala","raw_affiliation_strings":["Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Alzheimer's Treatment and Research Center, Ramsey Clinic/St. Paul Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101-2595, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5046805860"],"corresponding_institution_ids":[],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":0.6256,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.62626125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"714","issue":"1-2","first_page":"87","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8335000276565552,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8335000276565552,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.10520000010728836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glutathione-disulfide","display_name":"glutathione disulfide","score":0.9229999780654907},{"id":"https://openalex.org/keywords/free-radical-scavengers","display_name":"radical scavengers","score":0.8029999732971191},{"id":"https://openalex.org/keywords/trolox","display_name":"Trolox","score":0.7910000085830688},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.7599999904632568},{"id":"https://openalex.org/keywords/edta","display_name":"EDTA","score":0.527999997138977},{"id":"https://openalex.org/keywords/manganese","display_name":"manganese","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.706346333026886},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.6996934413909912},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6977241635322571},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5643167495727539},{"id":"https://openalex.org/C207723603","wikidata":"https://www.wikidata.org/wiki/Q17861926","display_name":"Muscarinic acetylcholine receptor M1","level":4,"score":0.5444021224975586},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49129146337509155},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4831116199493408},{"id":"https://openalex.org/C2776723954","wikidata":"https://www.wikidata.org/wiki/Q3001265","display_name":"Muscarinic antagonist","level":4,"score":0.4827525019645691},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4402892291545868},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3690641224384308},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3354477882385254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2861149311065674},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22695207595825195},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06644859910011292}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019803","descriptor_name":"Glutathione Disulfide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-8993(95)01497-7","doi":"https://doi.org/10.1016/0006-8993(95)01497-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-8993(95)01497-7","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},{"id":"pmid:8861612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8861612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W85419594","https://openalex.org/W143691342","https://openalex.org/W1496204826","https://openalex.org/W1524926009","https://openalex.org/W1562893987","https://openalex.org/W1906312058","https://openalex.org/W1975502012","https://openalex.org/W1999832838","https://openalex.org/W2033451304","https://openalex.org/W2036561640","https://openalex.org/W2040229420","https://openalex.org/W2046015012","https://openalex.org/W2061664301","https://openalex.org/W2063968553","https://openalex.org/W2075022492","https://openalex.org/W2078359031","https://openalex.org/W2078605117","https://openalex.org/W2082324452","https://openalex.org/W2082684133","https://openalex.org/W2093374391","https://openalex.org/W2094837638","https://openalex.org/W2104227586","https://openalex.org/W2146729934","https://openalex.org/W2171405125","https://openalex.org/W2210030290","https://openalex.org/W2312506853","https://openalex.org/W2409367303","https://openalex.org/W4232534952","https://openalex.org/W4232724991","https://openalex.org/W4245099829"],"related_works":["https://openalex.org/W2075022492","https://openalex.org/W2037497795","https://openalex.org/W2082324452","https://openalex.org/W1998111067","https://openalex.org/W1979278276","https://openalex.org/W1999832838","https://openalex.org/W4233475391","https://openalex.org/W1985959968","https://openalex.org/W1589787827","https://openalex.org/W2137629291"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}