{"id":"https://openalex.org/W2064976397","doi":"https://doi.org/10.1002/eji.1830150413","title":"Autoantibodies to anti\u2010DNA with anti\u2010allotypic and anti\u2010idiotypic specificities in (NZB \u00d7 NZW)F1 mice","display_name":"Autoantibodies to anti\u2010DNA with anti\u2010allotypic and anti\u2010idiotypic specificities in (NZB \u00d7 NZW)F1 mice","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W2064976397","doi":"https://doi.org/10.1002/eji.1830150413","mag":"2064976397","pmid":"https://pubmed.ncbi.nlm.nih.gov/2580714"},"language":"en","primary_location":{"id":"doi:10.1002/eji.1830150413","doi":"https://doi.org/10.1002/eji.1830150413","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830150413","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015837535","display_name":"Dan Eilat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Dan Eilat","raw_affiliation_strings":["The Clinical Immunology Unit, Department of Medicine A, Hadassah University Hospital, Jerusalem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Clinical Immunology Unit, Department of Medicine A, Hadassah University Hospital, Jerusalem","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000283507","display_name":"Ruth Fischel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ruth Fischel","raw_affiliation_strings":["The Clinical Immunology Unit, Department of Medicine A, Hadassah University Hospital, Jerusalem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Clinical Immunology Unit, Department of Medicine A, Hadassah University Hospital, Jerusalem","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110142607","display_name":"Avinoam Zlotnick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Avinoam Zlotnick","raw_affiliation_strings":["The Clinical Immunology Unit, Department of Medicine A, Hadassah University Hospital, Jerusalem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Clinical Immunology Unit, Department of Medicine A, Hadassah University Hospital, Jerusalem","institution_ids":["https://openalex.org/I2799899409"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015837535"],"corresponding_institution_ids":["https://openalex.org/I2799899409"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":0.8014,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.72855592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"15","issue":"4","first_page":"375","last_page":"381"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-dna-antibodies","display_name":"anti-DNA antibodies","score":0.9800000190734863},{"id":"https://openalex.org/keywords/anti-idiotypic-antibodies","display_name":"anti-idiotypic antibodies","score":0.7310000061988831},{"id":"https://openalex.org/keywords/nzb-w-f1-mice","display_name":"NZB/W F1 mice","score":0.8949999809265137},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.703000009059906},{"id":"https://openalex.org/keywords/igg2b","display_name":"IgG2b","score":0.6859999895095825},{"id":"https://openalex.org/keywords/allotypic-determinants","display_name":"allotypic determinants","score":0.8709999918937683},{"id":"https://openalex.org/keywords/idiotypic-determinants","display_name":"idiotypic determinants","score":0.906000018119812},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C74505204","wikidata":"https://www.wikidata.org/wiki/Q1047644","display_name":"Idiotype","level":4,"score":0.873375415802002},{"id":"https://openalex.org/C2780889450","wikidata":"https://www.wikidata.org/wiki/Q1432692","display_name":"Allotype","level":3,"score":0.7862166166305542},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.71970134973526},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6589310169219971},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.616954505443573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5995586514472961},{"id":"https://openalex.org/C2910082366","wikidata":"https://www.wikidata.org/wiki/Q1047644","display_name":"Immunoglobulin Idiotypes","level":5,"score":0.5880540013313293},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5470869541168213},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.5330464243888855},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5242602825164795},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49793505668640137},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.4607568383216858},{"id":"https://openalex.org/C48660041","wikidata":"https://www.wikidata.org/wiki/Q5989022","display_name":"Idiotopes","level":5,"score":0.44111478328704834}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007126","descriptor_name":"Immunoglobulin Allotypes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007130","descriptor_name":"Immunoglobulin Idiotypes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008814","descriptor_name":"Mice, Inbred NZB","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009194","descriptor_name":"Myeloma Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/eji.1830150413","doi":"https://doi.org/10.1002/eji.1830150413","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830150413","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:2580714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2580714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W838796895","https://openalex.org/W1040845057","https://openalex.org/W1481275674","https://openalex.org/W1777962868","https://openalex.org/W1938885059","https://openalex.org/W1965280829","https://openalex.org/W1986131464","https://openalex.org/W1990519687","https://openalex.org/W1994988800","https://openalex.org/W1995968349","https://openalex.org/W2005897635","https://openalex.org/W2022666138","https://openalex.org/W2044319977","https://openalex.org/W2054940720","https://openalex.org/W2059689182","https://openalex.org/W2065037415","https://openalex.org/W2072145209","https://openalex.org/W2084687013","https://openalex.org/W2090191258","https://openalex.org/W2094491585","https://openalex.org/W2095935128","https://openalex.org/W2096120658","https://openalex.org/W2104646232","https://openalex.org/W2114219896","https://openalex.org/W2139153089","https://openalex.org/W2140522164","https://openalex.org/W2147591689"],"related_works":["https://openalex.org/W1893408808","https://openalex.org/W2009918331","https://openalex.org/W2016433301","https://openalex.org/W2042663378","https://openalex.org/W2417456772","https://openalex.org/W1548796301","https://openalex.org/W1896828297","https://openalex.org/W2408608672","https://openalex.org/W1995968349","https://openalex.org/W2062930778"],"abstract_inverted_index":{"The":[0,94],"monoclonal":[1,48,65],"A52":[2,92],"(IgG2b,":[3],"kappa)":[4],"anti-DNA":[5,45],"autoantibody":[6],"represents":[7],"a":[8,84,111,121],"major":[9],"cross-reactive":[10],"idiotype":[11],"in":[12,75,100],"the":[13,43,76,79,91,108,117],"murine":[14],"and":[15,24,97],"human":[16],"autoimmune":[17],"response":[18],"to":[19,68],"DNA.":[20],"Examination":[21],"of":[22,63,90,110,120],"sera":[23],"purified":[25],"IgG":[26,95],"derived":[27],"from":[28,55],"(NZB":[29,58,101],"X":[30,59,102],"NZW)F1":[31,60,103],"mice":[32,36,104],"showed":[33],"that":[34],"these":[35,64],"develop":[37],"an":[38],"age-dependent":[39],"binding":[40],"reactivity":[41,52],"with":[42],"pure":[44],"IgG.":[46,93],"Three":[47],"antibodies":[49,66,82],"possessing":[50],"this":[51],"were":[53],"prepared":[54],"unprimed":[56],"female":[57],"mice.":[61],"One":[62],"appeared":[67],"be":[69],"directed":[70],"against":[71],"allotypic":[72],"determinants":[73,89],"present":[74],"NZB":[77],"IgG2b;":[78],"other":[80],"two":[81],"exhibited":[83],"marked":[85],"preference":[86],"for":[87],"idiotypic":[88],"anti-allotype":[96],"anti-idiotype":[98],"activities":[99],"may,":[105],"therefore,":[106],"represent":[107],"products":[109],"deregulated":[112],"immune":[113,123],"system":[114],"and/or":[115],"constitute":[116],"normal":[118],"elements":[119],"functional":[122],"regulation":[124],"system.":[125]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}