{"id":"https://openalex.org/W2064974006","doi":"https://doi.org/10.1016/s0020-7292(96)02755-5","title":"Thrombomodulin, plasminogen activator inhibitor type 1 (PAI\u20101) and fibronectin as biomarkers of endothelial damage in preeclampsia and eclampsia","display_name":"Thrombomodulin, plasminogen activator inhibitor type 1 (PAI\u20101) and fibronectin as biomarkers of endothelial damage in preeclampsia and eclampsia","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W2064974006","doi":"https://doi.org/10.1016/s0020-7292(96)02755-5","mag":"2064974006","pmid":"https://pubmed.ncbi.nlm.nih.gov/8960994"},"language":"en","primary_location":{"id":"doi:10.1016/s0020-7292(96)02755-5","doi":"https://doi.org/10.1016/s0020-7292(96)02755-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0020-7292(96)02755-5","pdf_url":null,"source":{"id":"https://openalex.org/S4210216427","display_name":"International Journal of Gynecology & Obstetrics","issn_l":"0020-6695","issn":["0020-6695","0020-7292","1879-3479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gynecology &amp; Obstetrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111797945","display_name":"Mohamed Shaarawy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed Shaarawy","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt","Department of Obstetrics and Gynecology, Faculty of medicine, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of medicine, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070743720","display_name":"Hany El Didy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hany El Didy","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145487455"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":2.3224,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.85366684,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"55","issue":"2","first_page":"135","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9229999780654907},{"id":"https://openalex.org/keywords/eclampsia","display_name":"eclampsia","score":1.0},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.902999997138977},{"id":"https://openalex.org/keywords/thrombomodulin","display_name":"thrombomodulin","score":0.9679999947547913},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9229999780654907},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.9294543266296387},{"id":"https://openalex.org/C201267052","wikidata":"https://www.wikidata.org/wiki/Q414446","display_name":"Thrombomodulin","level":4,"score":0.8536006808280945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8407870531082153},{"id":"https://openalex.org/C2781276381","wikidata":"https://www.wikidata.org/wiki/Q552348","display_name":"Eclampsia","level":3,"score":0.7477759122848511},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.5001540184020996},{"id":"https://openalex.org/C2781219028","wikidata":"https://www.wikidata.org/wiki/Q5957994","display_name":"Hyperfibrinolysis","level":3,"score":0.49153932929039},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45937076210975647},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.45423856377601624},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3975551128387451},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3534694015979767},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3252301812171936},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.22708478569984436},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.1526206135749817},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.13885179162025452},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07365542650222778},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004461","descriptor_name":"Eclampsia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004461","descriptor_name":"Eclampsia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018180","descriptor_name":"Thrombomodulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0020-7292(96)02755-5","doi":"https://doi.org/10.1016/s0020-7292(96)02755-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0020-7292(96)02755-5","pdf_url":null,"source":{"id":"https://openalex.org/S4210216427","display_name":"International Journal of Gynecology & Obstetrics","issn_l":"0020-6695","issn":["0020-6695","0020-7292","1879-3479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gynecology &amp; Obstetrics","raw_type":"journal-article"},{"id":"pmid:8960994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8960994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W82852602","https://openalex.org/W1969698838","https://openalex.org/W1974873515","https://openalex.org/W1983186128","https://openalex.org/W1988179940","https://openalex.org/W1996230946","https://openalex.org/W2001930593","https://openalex.org/W2003576191","https://openalex.org/W2026053512","https://openalex.org/W2056041574","https://openalex.org/W2069895242","https://openalex.org/W2069998851","https://openalex.org/W2075856349","https://openalex.org/W2080736461","https://openalex.org/W2122859012","https://openalex.org/W2418949439"],"related_works":["https://openalex.org/W1987377042","https://openalex.org/W27072960","https://openalex.org/W2273268393","https://openalex.org/W2069053387","https://openalex.org/W2418949439","https://openalex.org/W2024810576","https://openalex.org/W2724326002","https://openalex.org/W4238814691","https://openalex.org/W2009542299","https://openalex.org/W203396607"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Preeclampsia":[1],"has":[2],"been":[3],"recently":[4],"suggested":[5],"to":[6,16],"be":[7,132],"an":[8],"endothelial":[9,24,145],"cell":[10],"disorder.":[11],"This":[12],"study":[13],"was":[14,99],"initiated":[15],"determine":[17],"the":[18,60,96,100,142],"levels":[19,84],"of":[20,23,62,85,95,144],"various":[21],"biomarkers":[22],"damage":[25,146],"in":[26,39,108,115,147],"preeclampsia":[27,116,148],"and":[28,53,70,88,117,122,139,149],"eclampsia.":[29,150],"METHODS:":[30],"Blood":[31],"samples":[32],"were":[33,76,90,119],"withdrawn":[34],"from":[35],"70":[36],"pregnant":[37],"women":[38,57],"their":[40],"third":[41],"trimester":[42],"grouped":[43],"as":[44],"25":[45],"mild":[46,109],"preeclampsia,":[47,50],"15":[48],"severe":[49],"10":[51],"eclampsia":[52,118],"20":[54],"normotensive":[55],"healthy":[56],"(controls)":[58],"for":[59,141],"determination":[61],"thrombomodulin":[63,87,138],"by":[64,67,72,79],"ELISA,":[65],"PAI-1":[66,140],"urokinase":[68],"method":[69],"fibronectin":[71,89,130],"radial":[73],"immunodiffusion.":[74],"Results":[75],"statistically":[77],"analyzed":[78],"Student's":[80],"t-test.":[81],"RESULTS:":[82],"Circulation":[83],"PAI-1,":[86],"increased":[91],"with":[92],"increasing":[93],"severity":[94],"disease.":[97],"Thrombomodulin":[98],"only":[101],"parameter":[102],"which":[103],"did":[104],"not":[105],"change":[106],"significantly":[107],"preeclampsia.":[110],"The":[111],"average":[112],"percent":[113],"increments":[114],"63%,":[120],"102%":[121],"132%,":[123],"respectively.":[124],"CONCLUSIONS:":[125],"These":[126],"results":[127],"demonstrate":[128],"that":[129],"may":[131],"a":[133],"more":[134],"valuable":[135],"biomarker":[136],"than":[137],"assessment":[143]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
