{"id":"https://openalex.org/W2064801725","doi":"https://doi.org/10.1021/bi00253a024","title":"Comparison of Crystal Structures of Two Homologous Proteins: Structural Origin of Altered Domain Interactions in Immunoglobulin Light-Chain Dimers","display_name":"Comparison of Crystal Structures of Two Homologous Proteins: Structural Origin of Altered Domain Interactions in Immunoglobulin Light-Chain Dimers","publication_year":1994,"publication_date":"1994-12-01","ids":{"openalex":"https://openalex.org/W2064801725","doi":"https://doi.org/10.1021/bi00253a024","mag":"2064801725","pmid":"https://pubmed.ncbi.nlm.nih.gov/7993911"},"language":"en","primary_location":{"id":"doi:10.1021/bi00253a024","doi":"https://doi.org/10.1021/bi00253a024","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00253a024","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000324518","display_name":"D.B. Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.-B. Huang","raw_affiliation_strings":["Center for Mechanistic Biology and Biotechnology, Argonne National Laboratory, Illinois 60439-4833"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Mechanistic Biology and Biotechnology, Argonne National Laboratory, Illinois 60439-4833","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106234433","display_name":"Chong Hwan Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C.-H. Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111757466","display_name":"C. F. Ainsworth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Ainsworth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056911622","display_name":"Axel T. Br\u00fcnger","orcid":"https://orcid.org/0000-0001-5121-2036","observed_orcids":["https://orcid.org/0000-0001-5121-2036"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. T. Bruenger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022241543","display_name":"Manfred Eulitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Eulitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106893539","display_name":"Alan Solomon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Solomon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108232641","display_name":"Fred J. Stevens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. J. Stevens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111705198","display_name":"Marianne Schiffer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Schiffer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.8014,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.86076663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"33","issue":"49","first_page":"14848","last_page":"14857"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.07649999856948853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunoglobulin-light-chains","display_name":"immunoglobulin light chains","score":0.7360000014305115},{"id":"https://openalex.org/keywords/domain-domain-interfaces","display_name":"domain-domain interfaces","score":0.6420000195503235},{"id":"https://openalex.org/keywords/hydrogen-bond-network","display_name":"hydrogen bond network","score":0.890999972820282},{"id":"https://openalex.org/keywords/crystal-packing","display_name":"crystal packing","score":0.8069999814033508},{"id":"https://openalex.org/keywords/temperature-factor","display_name":"temperature factor","score":0.5799999833106995},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.7729324102401733},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.699914813041687},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.6658796072006226},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.6099766492843628},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.591342568397522},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5765691995620728},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.5738213658332825},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.5691205859184265},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.5630720257759094},{"id":"https://openalex.org/C149774189","wikidata":"https://www.wikidata.org/wiki/Q24770541","display_name":"Immunoglobulin domain","level":3,"score":0.5534656643867493},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4999735355377197},{"id":"https://openalex.org/C2777166331","wikidata":"https://www.wikidata.org/wiki/Q17104122","display_name":"Molecular replacement","level":3,"score":0.4630551338195801},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.37295693159103394},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21505889296531677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17976778745651245},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16700097918510437},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1622782051563263},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1310890018939972},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0758959949016571},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001536","descriptor_name":"Bence Jones Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001704","descriptor_name":"Biopolymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007145","descriptor_name":"Immunoglobulin kappa-Chains","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00253a024","doi":"https://doi.org/10.1021/bi00253a024","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00253a024","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:7993911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7993911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2148534264","display_name":"PROTEINS IN MULTIPLE MYELOMA AND RELATED BLOOD DISORDERS","funder_award_id":"R01CA010056","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6837003917","display_name":"High Performance Computing for Biomedical Research","funder_award_id":"P41RR006009","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8227280832","display_name":"Biophysics of Myeloma Pathology","funder_award_id":"R01DK043757","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W656827624","https://openalex.org/W1608052268","https://openalex.org/W1910395270","https://openalex.org/W1920467840","https://openalex.org/W1962221856","https://openalex.org/W1965856700","https://openalex.org/W1966880762","https://openalex.org/W1969222787","https://openalex.org/W1971389550","https://openalex.org/W1972190404","https://openalex.org/W1972562199","https://openalex.org/W1975532077","https://openalex.org/W1977478904","https://openalex.org/W1993390869","https://openalex.org/W1997552850","https://openalex.org/W2001874111","https://openalex.org/W2004360551","https://openalex.org/W2004473597","https://openalex.org/W2005997381","https://openalex.org/W2011695744","https://openalex.org/W2014694459","https://openalex.org/W2017367781","https://openalex.org/W2021006752","https://openalex.org/W2032570195","https://openalex.org/W2040239455","https://openalex.org/W2042987185","https://openalex.org/W2043488172","https://openalex.org/W2046379347","https://openalex.org/W2054356935","https://openalex.org/W2064567434","https://openalex.org/W2065335184","https://openalex.org/W2066459154","https://openalex.org/W2067694850","https://openalex.org/W2075840460","https://openalex.org/W2084763593","https://openalex.org/W2087027341"],"related_works":["https://openalex.org/W1973768337","https://openalex.org/W2053346136","https://openalex.org/W2028561217","https://openalex.org/W1965856700","https://openalex.org/W1966162593","https://openalex.org/W2049416425","https://openalex.org/W2080210263","https://openalex.org/W2075840460","https://openalex.org/W1997552850","https://openalex.org/W2098189476"],"abstract_inverted_index":{"The":[0,18,205],"sequence":[1],"and":[2,27],"structure":[3,123],"of":[4,43,47,54,92,133,151,165,181,186,193,207,218,224,249,255,269,280,283,290],"a":[5,201,257],"second":[6],"human":[7],"kappa":[8,73],"1":[9],"immunoglobulin":[10],"light-chain":[11],"variable":[12,65,75],"domain,":[13,76],"Wat,":[14],"has":[15],"been":[16],"determined.":[17],"R-factor":[19],"is":[20,60,124,143,163],"15.7%":[21],"for":[22,127,147,293],"1.9-A":[23],"data.":[24],"One":[25,216],"hundred":[26],"ninety-five":[28],"water":[29,34,49],"molecules":[30,35,50],"were":[31,36,214],"identified;":[32],"30":[33],"located":[37],"in":[38,41,89,98,105,109,153,157,169,175,200,210,287],"identical":[39],"positions":[40,132],"each":[42],"the":[44,48,55,63,70,83,93,112,116,120,125,130,134,137,149,158,166,170,173,178,191,197,211,222,225,238,245,250,267,270,276,281,284,294,297],"monomers.":[45],"Some":[46],"are":[51],"integral":[52],"parts":[53],"domains.":[56,298],"This":[57,141],"light":[58],"chain":[59],"encoded":[61,69],"by":[62,148,155,184,188],"same":[64,126],"domain":[66,122],"gene":[67],"that":[68,220],"previously":[71],"characterized":[72],"I":[74],"Rei.":[77,176],"Due":[78],"to":[79],"limited":[80],"somatic":[81],"mutation,":[82],"two":[84,138,212],"highly":[85],"homologous":[86],"proteins":[87],"differ":[88],"only":[90],"20":[91],"108":[94],"residues.":[95],"Wat":[96,159,246,271],"crystallized":[97,104],"space":[99,106],"group":[100,107],"P6(4)":[101],"while":[102],"Rei":[103,154],"P6(1);":[108],"both":[110,128],"crystals,":[111],"asymmetric":[113],"unit":[114],"was":[115,228],"noncovalent":[117],"dimer.":[118],"Although":[119],"basic":[121],"proteins,":[129],"relative":[131],"domains":[135,174,227,282],"within":[136,237,296],"dimers":[139],"differ.":[140],"difference":[142],"most":[144],"likely":[145],"accounted":[146],"replacement":[150,185],"Tyr36":[152,162],"Phe":[156,189],"protein.":[160],"Residue":[161],"part":[164],"hydrogen-bonding":[167,179],"network":[168,192],"interface":[171],"between":[172,196],"Losing":[177],"capability":[180],"residue":[182],"36":[183],"Tyr":[187],"alters":[190],"hydrogen":[194],"bonds":[195],"domains,":[198],"resulting":[199],"different":[202,234,240,277,288],"domain-domain":[203],"contact.":[204],"details":[206],"lattice":[208],"contacts":[209,251],"crystals":[213],"compared.":[215],"type":[217],"contact":[219],"extends":[221],"beta-sheet":[223],"individual":[226],"conserved,":[229],"but":[230],"because":[231],"it":[232],"involved":[233],"symmetry":[235],"elements":[236],"crystal,":[239,247],"crystal":[241,272],"packing":[242],"resulted.":[243],"In":[244],"one":[248],"shows":[252],"an":[253,263],"example":[254],"how":[256,275],"symmetrical":[258],"binding":[259],"site":[260],"can":[261],"\"bind\"":[262],"asymmetrical":[264],"object.":[265],"Further,":[266],"examination":[268],"also":[273],"illustrates":[274],"crystalline":[278],"environments":[279],"dimer":[285],"results":[286],"distributions":[289],"temperature":[291],"factors":[292],"residues":[295]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}