{"id":"https://openalex.org/W2064753109","doi":"https://doi.org/10.1158/0008-5472.can-08-0288","title":"Breast Cancer\u2013Associated Fibroblasts Confer AKT1-Mediated Epigenetic Silencing of Cystatin M in Epithelial Cells","display_name":"Breast Cancer\u2013Associated Fibroblasts Confer AKT1-Mediated Epigenetic Silencing of Cystatin M in Epithelial Cells","publication_year":2008,"publication_date":"2008-12-15","ids":{"openalex":"https://openalex.org/W2064753109","doi":"https://doi.org/10.1158/0008-5472.can-08-0288","mag":"2064753109","pmid":"https://pubmed.ncbi.nlm.nih.gov/19074894","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2821873"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-08-0288","doi":"https://doi.org/10.1158/0008-5472.can-08-0288","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-08-0288","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/68/24/10257/2599703/10257.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/68/24/10257/2599703/10257.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087822712","display_name":"Huey-Jen L. Lin","orcid":"https://orcid.org/0000-0003-1726-6385","observed_orcids":["https://orcid.org/0000-0003-1726-6385"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huey-Jen L. Lin","raw_affiliation_strings":["1Division of Medical Technology, School of Allied Medical Professions,","2Human Cancer Genetics Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Medical Technology, School of Allied Medical Professions,","institution_ids":[]},{"raw_affiliation_string":"2Human Cancer Genetics Program,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087553034","display_name":"Tao Zuo","orcid":"https://orcid.org/0000-0002-2125-7548","observed_orcids":["https://orcid.org/0000-0002-2125-7548","https://orcid.org/0000-0001-8450-5281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Zuo","raw_affiliation_strings":["1Division of Medical Technology, School of Allied Medical Professions,","2Human Cancer Genetics Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Medical Technology, School of Allied Medical Professions,","institution_ids":[]},{"raw_affiliation_string":"2Human Cancer Genetics Program,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016301782","display_name":"Ching\u2010Hung Lin","orcid":"https://orcid.org/0000-0003-2403-4056","observed_orcids":["https://orcid.org/0000-0003-2403-4056"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ching-Hung Lin","raw_affiliation_strings":["7Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109681454","display_name":"Chieh Ti Kuo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chieh Ti Kuo","raw_affiliation_strings":["2Human Cancer Genetics Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Human Cancer Genetics Program,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072858554","display_name":"Sandya Liyanarachchi","orcid":"https://orcid.org/0000-0002-1857-5246","observed_orcids":["https://orcid.org/0000-0002-1857-5246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandya Liyanarachchi","raw_affiliation_strings":["2Human Cancer Genetics Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Human Cancer Genetics Program,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103095795","display_name":"Shuying Sun","orcid":"https://orcid.org/0000-0003-3974-6996","observed_orcids":["https://orcid.org/0000-0003-3974-6996"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuying Sun","raw_affiliation_strings":["3Mathematical Biosciences Institute, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Mathematical Biosciences Institute, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103063920","display_name":"Rulong Z. Shen","orcid":"https://orcid.org/0000-0001-8143-2582","observed_orcids":["https://orcid.org/0000-0001-8143-2582"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rulong Shen","raw_affiliation_strings":["4Pathology,","Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Pathology,","institution_ids":[]},{"raw_affiliation_string":"Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068012765","display_name":"Daniel E. Deatherage","orcid":"https://orcid.org/0000-0001-8914-8359","observed_orcids":["https://orcid.org/0000-0001-8914-8359"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel E. Deatherage","raw_affiliation_strings":["2Human Cancer Genetics Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Human Cancer Genetics Program,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000357133","display_name":"Dustin Potter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dustin Potter","raw_affiliation_strings":["2Human Cancer Genetics Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Human Cancer Genetics Program,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070690685","display_name":"Lisa Asamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa Asamoto","raw_affiliation_strings":["1Division of Medical Technology, School of Allied Medical Professions,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Medical Technology, School of Allied Medical Professions,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091196188","display_name":"Shili Lin","orcid":"https://orcid.org/0000-0003-2467-4491","observed_orcids":["https://orcid.org/0000-0003-2467-4491"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shili Lin","raw_affiliation_strings":["6Statistics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Statistics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio and","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019710145","display_name":"Pearlly S. Yan","orcid":"https://orcid.org/0000-0003-1965-4920","observed_orcids":["https://orcid.org/0000-0003-1965-4920"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pearlly S. Yan","raw_affiliation_strings":["2Human Cancer Genetics Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Human Cancer Genetics Program,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017953971","display_name":"Ann\u2010Lii Cheng","orcid":"https://orcid.org/0000-0002-9152-6512","observed_orcids":["https://orcid.org/0000-0002-9152-6512"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ann-Lii Cheng","raw_affiliation_strings":["7Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040645408","display_name":"Michael C. Ostrowski","orcid":"https://orcid.org/0000-0003-2948-6297","observed_orcids":["https://orcid.org/0000-0003-2948-6297"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael C. Ostrowski","raw_affiliation_strings":["5Molecular and Cellular Biochemistry, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Molecular and Cellular Biochemistry, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049119185","display_name":"Tim H.\u2010M. Huang","orcid":"https://orcid.org/0000-0001-5985-9176","observed_orcids":["https://orcid.org/0000-0001-5985-9176"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tim H.-M. Huang","raw_affiliation_strings":["2Human Cancer Genetics Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Human Cancer Genetics Program,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6901,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.90550908,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"68","issue":"24","first_page":"10257","last_page":"10266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-associated-fibroblasts","display_name":"breast cancer-associated fibroblasts","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cst6","display_name":"CST6","score":0.8550000190734863},{"id":"https://openalex.org/keywords/akt1","display_name":"AKT1","score":0.7490000128746033},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.9670000076293945},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.8700000047683716},{"id":"https://openalex.org/keywords/inpp4b","display_name":"INPP4B","score":0.8190000057220459},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.7450000047683716},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8019999861717224},{"id":"https://openalex.org/keywords/epithelial-fibroblast-interaction","display_name":"epithelial-fibroblast interaction","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cell-cell-contact","display_name":"cell-cell contact","score":0.7070000171661377},{"id":"https://openalex.org/keywords/de-novo-methylation","display_name":"de novo methylation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.5759999752044678},{"id":"https://openalex.org/keywords/breast-epithelial-cells","display_name":"breast epithelial cells","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7418800592422485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6865726113319397},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6354033946990967},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6315059661865234},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5970197319984436},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.5683081746101379},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5209547281265259},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.45810461044311523},{"id":"https://openalex.org/C114691636","wikidata":"https://www.wikidata.org/wiki/Q5031434","display_name":"Cancer epigenetics","level":5,"score":0.4414239823818207},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4170871376991272},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.41463959217071533},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3993023633956909},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.365548700094223},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.177018404006958},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1575133204460144},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.12390682101249695},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11946487426757812}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055332","descriptor_name":"Cystatin M","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.can-08-0288","doi":"https://doi.org/10.1158/0008-5472.can-08-0288","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-08-0288","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/68/24/10257/2599703/10257.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:19074894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19074894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2821873","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2821873/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-08-0288","doi":"https://doi.org/10.1158/0008-5472.can-08-0288","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-08-0288","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/68/24/10257/2599703/10257.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1318956625","display_name":null,"funder_award_id":"BC073892","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3549828030","display_name":null,"funder_award_id":"NIH T32","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4175688466","display_name":"Mathematical Biosciences Institute","funder_award_id":"0112050","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4834638667","display_name":"Genetic analysis of ras/ets pathways in endothelial cell migration and survival","funder_award_id":"R01CA053271","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4941813046","display_name":"Interrogating Epigenetic Changes in Cancer Genomes","funder_award_id":"U54CA113001","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6402400982","display_name":null,"funder_award_id":"U54CA113001","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6609328491","display_name":"CpG Island Methylator Phenotypes in Breast Cancer","funder_award_id":"R01CA069065","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7835228812","display_name":null,"funder_award_id":"KG081123","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G8100315603","display_name":"Genetic Analysis of the Breast Tumor Microenvironment","funder_award_id":"P01CA097189","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8411705149","display_name":"Postdoctoral Training in Cancer Genetics","funder_award_id":"T32CA106196","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2064753109.pdf","grobid_xml":"https://content.openalex.org/works/W2064753109.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1565166977","https://openalex.org/W1896854564","https://openalex.org/W1966133006","https://openalex.org/W1971201484","https://openalex.org/W1979165906","https://openalex.org/W1993645975","https://openalex.org/W1998415342","https://openalex.org/W2007366900","https://openalex.org/W2012124753","https://openalex.org/W2030535867","https://openalex.org/W2053421436","https://openalex.org/W2055525890","https://openalex.org/W2056524601","https://openalex.org/W2059479474","https://openalex.org/W2062809449","https://openalex.org/W2068104482","https://openalex.org/W2070604157","https://openalex.org/W2070942270","https://openalex.org/W2071668875","https://openalex.org/W2072342613","https://openalex.org/W2073996456","https://openalex.org/W2075432652","https://openalex.org/W2096127904","https://openalex.org/W2098192588","https://openalex.org/W2101037339","https://openalex.org/W2105615579","https://openalex.org/W2113869887","https://openalex.org/W2118454754","https://openalex.org/W2119615097","https://openalex.org/W2120865735","https://openalex.org/W2125712765","https://openalex.org/W2130201056","https://openalex.org/W2141410747","https://openalex.org/W2141646403","https://openalex.org/W2148680303","https://openalex.org/W2149426454","https://openalex.org/W2153961184","https://openalex.org/W2157795344","https://openalex.org/W2161744213","https://openalex.org/W2162647235","https://openalex.org/W2166647372","https://openalex.org/W2168991217","https://openalex.org/W3175417087","https://openalex.org/W4230530631","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W2766036023","https://openalex.org/W2071668875","https://openalex.org/W2068104482","https://openalex.org/W2945741645","https://openalex.org/W4367316027","https://openalex.org/W62213400","https://openalex.org/W7155568852","https://openalex.org/W2040099100","https://openalex.org/W1980218813","https://openalex.org/W3092847082"],"abstract_inverted_index":{"The":[0,98,143],"interplay":[1],"between":[2,153],"histone":[3],"modifications":[4],"and":[5,86,88,156],"promoter":[6],"hypermethylation":[7,56],"provides":[8],"a":[9,124],"causative":[10],"explanation":[11],"for":[12],"epigenetic":[13,108,163],"gene":[14,39],"silencing":[15,114],"in":[16,46,65,106,117,187],"cancer.":[17],"Less":[18],"is":[19,40,59,93,169],"known":[20],"about":[21],"the":[22,33,71,77,96,112,137,147,157,171,180],"upstream":[23],"initiators":[24],"that":[25,32,101,160],"direct":[26,150],"this":[27,107,162,166],"process.":[28],"Here,":[29],"we":[30],"report":[31],"Cystatin":[34],"M":[35],"(CST6)":[36],"tumor":[37,129],"suppressor":[38],"concurrently":[41],"down-regulated":[42],"with":[43,51,61],"other":[44],"loci":[45],"breast":[47,118],"epithelial":[48,66,141,154,183],"cells":[49,155],"cocultured":[50],"cancer-associated":[52],"fibroblasts":[53,131,159,186],"(CAF).":[54],"Promoter":[55],"of":[57,115,139,149,182],"CST6":[58,116],"associated":[60],"aberrant":[62],"AKT1":[63],"activation":[64],"cells,":[67],"as":[68,70],"well":[69],"disabled":[72],"INNP4B":[73],"regulator":[74],"resulting":[75],"from":[76],"suppression":[78],"by":[79,84,135],"CAFs.":[80],"Repressive":[81],"chromatin,":[82],"marked":[83],"trimethyl-H3K27":[85],"dimethyl-H3K9,":[87],"de":[89],"novo":[90],"DNA":[91],"methylation":[92],"established":[94],"at":[95],"promoter.":[97],"findings":[99,122],"suggest":[100],"microenvironmental":[102],"stimuli":[103],"are":[104],"triggers":[105],"cascade,":[109],"leading":[110],"to":[111,178],"long-term":[113],"tumors.":[119],"Our":[120],"present":[121],"implicate":[123],"causal":[125],"mechanism":[126],"defining":[127],"how":[128],"stromal":[130],"support":[132],"neoplastic":[133],"progression":[134],"manipulating":[136],"epigenome":[138],"mammary":[140],"cells.":[142],"result":[144],"also":[145],"highlights":[146],"importance":[148],"cell-cell":[151],"contact":[152],"surrounding":[158],"confer":[161],"perturbation.":[164],"Because":[165],"two-way":[167],"interaction":[168],"anticipated,":[170],"described":[172],"coculture":[173],"system":[174],"can":[175],"be":[176],"used":[177],"determine":[179],"effect":[181],"factors":[184],"on":[185],"future":[188],"studies.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}