{"id":"https://openalex.org/W2064699474","doi":"https://doi.org/10.1016/s0006-8993(02)03291-2","title":"Diet-induced obesity increases \u03bc opioid receptor binding in specific regions of the rat brain","display_name":"Diet-induced obesity increases \u03bc opioid receptor binding in specific regions of the rat brain","publication_year":2002,"publication_date":"2002-10-01","ids":{"openalex":"https://openalex.org/W2064699474","doi":"https://doi.org/10.1016/s0006-8993(02)03291-2","mag":"2064699474","pmid":"https://pubmed.ncbi.nlm.nih.gov/12384255"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-8993(02)03291-2","doi":"https://doi.org/10.1016/s0006-8993(02)03291-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-8993(02)03291-2","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057634008","display_name":"Sharon L. Smith","orcid":"https://orcid.org/0000-0002-4801-8475","observed_orcids":["https://orcid.org/0000-0002-4801-8475"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sharon L Smith","raw_affiliation_strings":["Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049326787","display_name":"Joanne Allison Harrold","orcid":"https://orcid.org/0000-0002-0899-4586","observed_orcids":["https://orcid.org/0000-0002-0899-4586"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Joanne A Harrold","raw_affiliation_strings":["Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114948439","display_name":"Gareth Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gareth Williams","raw_affiliation_strings":["Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes and Endocrinology Research Group, Department of Medicine, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049326787"],"corresponding_institution_ids":["https://openalex.org/I146655781"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":1.1484,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.76258365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"953","issue":"1-2","first_page":"215","last_page":"222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.7829999923706055},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.9750000238418579},{"id":"https://openalex.org/keywords/palatable-diet","display_name":"palatable diet","score":0.828000009059906},{"id":"https://openalex.org/keywords/food-reward","display_name":"food reward","score":0.8330000042915344},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.7390000224113464},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/medial-preoptic-area","display_name":"medial preoptic area","score":0.7960000038146973},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.8230000138282776},{"id":"https://openalex.org/keywords/medial-habenula","display_name":"medial habenula","score":0.9240000247955322},{"id":"https://openalex.org/keywords/endopiriform-nucleus","display_name":"endopiriform nucleus","score":0.8659999966621399},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.906000018119812},{"id":"https://openalex.org/keywords/endogenous-opioids","display_name":"endogenous opioids","score":0.7129999995231628},{"id":"https://openalex.org/keywords/appetite-regulation","display_name":"appetite regulation","score":0.6069999933242798},{"id":"https://openalex.org/keywords/overeating","display_name":"overeating","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7825713157653809},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7594494819641113},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5427946448326111},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.49487704038619995},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.46477487683296204},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.45871666073799133},{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.43665021657943726},{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.4152142107486725},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3805197477340698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27035340666770935},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.24667847156524658},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.20980402827262878},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1987667679786682}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001066","descriptor_name":"Appetite","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020875","descriptor_name":"Enkephalin, Ala(2)-MePhe(4)-Gly(5)-","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020875","descriptor_name":"Enkephalin, Ala(2)-MePhe(4)-Gly(5)-","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0006-8993(02)03291-2","doi":"https://doi.org/10.1016/s0006-8993(02)03291-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-8993(02)03291-2","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},{"id":"pmid:12384255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12384255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research","raw_type":"Journal Article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/2e9757aa-66c5-4388-98bc-ae56e8a6bddd","doi":null,"is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/2e9757aa-66c5-4388-98bc-ae56e8a6bddd","pdf_url":null,"source":{"id":"https://openalex.org/S7407055359","display_name":"Explore Bristol Research","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Smith, SL, Harrold, JA & Williams, G 2002, 'Diet-induced obesity increases \u03bc opioid receptor binding in specific regions of the rat brain', Brain Research, vol. 953, pp. 215 - 222. https://doi.org/10.1016/S0006-8993(02)03291-2","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W249845531","https://openalex.org/W1523806406","https://openalex.org/W1680771593","https://openalex.org/W1766229553","https://openalex.org/W1874343805","https://openalex.org/W1920905732","https://openalex.org/W1970163196","https://openalex.org/W1974129689","https://openalex.org/W1978871711","https://openalex.org/W1989860098","https://openalex.org/W1991718758","https://openalex.org/W1996874511","https://openalex.org/W1998315221","https://openalex.org/W2000767529","https://openalex.org/W2000780784","https://openalex.org/W2001865657","https://openalex.org/W2002498312","https://openalex.org/W2007090131","https://openalex.org/W2012979196","https://openalex.org/W2017244979","https://openalex.org/W2017570416","https://openalex.org/W2027280572","https://openalex.org/W2027655628","https://openalex.org/W2033123455","https://openalex.org/W2034630550","https://openalex.org/W2037487060","https://openalex.org/W2045447561","https://openalex.org/W2051508663","https://openalex.org/W2051640748","https://openalex.org/W2052480992","https://openalex.org/W2062977162","https://openalex.org/W2063657673","https://openalex.org/W2064317908","https://openalex.org/W2065405015","https://openalex.org/W2067559264","https://openalex.org/W2070316919","https://openalex.org/W2076876824","https://openalex.org/W2081466847","https://openalex.org/W2094801187","https://openalex.org/W2098766452","https://openalex.org/W2129221666","https://openalex.org/W2163815564","https://openalex.org/W4205126376"],"related_works":["https://openalex.org/W1466412209","https://openalex.org/W2034692982","https://openalex.org/W4200526615","https://openalex.org/W2024873043","https://openalex.org/W1967288063","https://openalex.org/W2888212872","https://openalex.org/W2023236065","https://openalex.org/W2282137769","https://openalex.org/W1992840520","https://openalex.org/W4321597181"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}