{"id":"https://openalex.org/W2064664689","doi":"https://doi.org/10.1158/1538-7445.prca2012-ia22","title":"Abstract IA22: Molecular Imaging of androgen receptor signalling in CRPC","display_name":"Abstract IA22: Molecular Imaging of androgen receptor signalling in CRPC","publication_year":2012,"publication_date":"2012-02-06","ids":{"openalex":"https://openalex.org/W2064664689","doi":"https://doi.org/10.1158/1538-7445.prca2012-ia22","mag":"2064664689"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.prca2012-ia22","doi":"https://doi.org/10.1158/1538-7445.prca2012-ia22","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.prca2012-ia22","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015396908","display_name":"Steven M. Larson","orcid":"https://orcid.org/0000-0002-6111-7507","observed_orcids":["https://orcid.org/0000-0002-6111-7507"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven M. Larson","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Joe Fox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joe Fox","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017288060","display_name":"Michael J. Morris","orcid":"https://orcid.org/0000-0002-9454-0096","observed_orcids":["https://orcid.org/0000-0002-9454-0096"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Morris","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066159059","display_name":"Michael J. Evans","orcid":"https://orcid.org/0000-0003-4947-1316","observed_orcids":["https://orcid.org/0000-0003-4947-1316"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Evans","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068928963","display_name":"Jason Stuart Lewis","orcid":"https://orcid.org/0000-0001-7065-4534","observed_orcids":["https://orcid.org/0000-0001-7065-4534"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Lewis","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050136149","display_name":"John Laurence Humm","orcid":"https://orcid.org/0000-0003-4245-5591","observed_orcids":["https://orcid.org/0000-0003-4245-5591"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Humm","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034963668","display_name":"Charles L. Sawyers","orcid":"https://orcid.org/0000-0003-4955-6475","observed_orcids":["https://orcid.org/0000-0003-4955-6475"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles L. Sawyers","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072850546","display_name":"Howard I. Scher","orcid":"https://orcid.org/0000-0002-6791-9324","observed_orcids":["https://orcid.org/0000-0002-6791-9324"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard I. Scher","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"4_Supplement","first_page":"IA22","last_page":"IA22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.25369998812675476,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.08579999953508377,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9160000085830688},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9160000085830688},{"id":"https://openalex.org/keywords/molecular-imaging","display_name":"molecular imaging","score":0.7590000033378601},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.7170000076293945},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"positron emission tomography","score":0.6539999842643738},{"id":"https://openalex.org/keywords/fluorodeoxyglucose","display_name":"fluorodeoxyglucose","score":0.6259999871253967},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.35100001096725464},{"id":"https://openalex.org/keywords/drug-displacement","display_name":"drug displacement","score":0.5709999799728394},{"id":"https://openalex.org/keywords/pharmacodynamic-markers","display_name":"pharmacodynamic biomarkers","score":0.8479999899864197},{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":0.7239999771118164},{"id":"https://openalex.org/keywords/antibody-imaging","display_name":"antibody imaging","score":0.4699999988079071},{"id":"https://openalex.org/keywords/tumor-response-to-therapy","display_name":"tumor response to therapy","score":0.492000013589859},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.8803543448448181},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7287724018096924},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.5741114616394043},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5643287301063538},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5275245308876038},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5125441551208496},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47271010279655457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40267422795295715},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3602105677127838},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33368831872940063},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3230692744255066},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.18892547488212585}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.prca2012-ia22","doi":"https://doi.org/10.1158/1538-7445.prca2012-ia22","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.prca2012-ia22","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2050551827","https://openalex.org/W2066588899","https://openalex.org/W2096001110"],"related_works":["https://openalex.org/W2524641066","https://openalex.org/W2085562053","https://openalex.org/W4401589532","https://openalex.org/W7164388594","https://openalex.org/W4385655345","https://openalex.org/W2767214731","https://openalex.org/W3012303545","https://openalex.org/W4411117354","https://openalex.org/W2050551827","https://openalex.org/W2442795568"],"abstract_inverted_index":{"Abstract":[0],"Androgen":[1],"receptor":[2,97,380],"(AR)":[3],"plays":[4],"a":[5,45,53,206,252,339],"key":[6],"role":[7],"in":[8,35,67,99,172,233,298,321,345,352,382,394],"development":[9],"of":[10,18,56,83,95,120,128,158,183,192,208,218,249,312,335,342,378,387],"castrate-resistant":[11],"prostate":[12,101],"cancer":[13,102],"(CRPC),":[14],"the":[15,19,59,64,71,93,108,118,126,144,156,190,239,244,322,333,353,388],"lethal":[16],"form":[17],"disease.":[20],"For":[21,39],"this":[22,40,129,247],"reason":[23],"we":[24,42,75,110,131,329],"have":[25,43,76,111,132,142,167,176,221,268],"developed":[26,133],"Molecular":[27,376],"Imaging":[28,377],"(MI)":[29],"methods":[30],"to":[31,79,87,116,164,272,291,324,331,337],"study":[32],"AR,":[33,52,201],"both":[34],"laboratory":[36,72,323],"and":[37,86,92,105,141,147,154,170,175,189,296,303,328],"clinic.":[38,354],"work":[41,130],"used":[44,77,232],"radiotracer":[46],"that":[47,155,178,203,210,223,246,279],"is":[48,151,205,241,251,265],"highly":[49],"specific":[50],"for":[51,73,196,255],"flourine-18":[54],"analog":[55],"dihydrotestoterone,":[57],"(FDHT)":[58],"most":[60],"abundant":[61],"androgen":[62,379],"at":[63],"tissue":[65],"level":[66],"human":[68,100],"cancers.":[69],"In":[70,107],"example,":[74],"FDHT":[78,145,159,169,199,229],"document":[80],"AR":[81,96,123,152,227,263,313,343,350],"binding":[82,146,264],"novel":[84],"drugs":[85,224],"determine":[88,117],"their":[89],"relative":[90],"affinity":[91],"number":[94],"sites":[98],"cell":[103],"lines":[104],"xenografts.":[106],"clinic":[109],"imaged":[112],"patients":[113,174,261],"with":[114,243,285,300,349],"CRPC":[115,173,383],"impact":[119,311],"therapies":[121],"on":[122,138,315,392],"expression.":[124],"During":[125],"course":[127],"quantitative":[134],"kinetic":[135],"models":[136],"based":[137],"PET":[139,286],"imaging":[140,281],"shown":[143,222,320],"uptake":[148],"into":[149],"cancers":[150],"dependent,":[153],"metabolites":[157],"do":[160,211],"not":[161,212],"bind":[162],"appreciably":[163],"AR.":[165],"We":[166,220,277],"compared":[168],"FDG":[171,197],"determined":[177],"there":[179,204],"are":[180,214,307],"an":[181],"average":[182],"17":[184],"tumors":[185,195],"per":[186],"patient":[187],"(n=107),":[188],"90%":[191],"metabolically":[193],"active":[194],"or":[198],"express":[200],"but":[202,213,258],"group":[207],"lesions":[209,269],"detected":[215],"by":[216],"metabolism":[217],"FDG.":[219],"which":[225,270],"target":[226],"displace":[228],"completely":[230,266],"when":[231],"full":[234],"pharmacologic":[235],"doses.":[236],"So":[237],"far":[238],"data":[240],"consistent":[242],"view":[245],"type":[248],"displacement":[250],"necessary":[253],"condition":[254],"tumor":[256],"response,":[257],"clearly":[259],"some":[260],"whose":[262],"blocked":[267],"continue":[271],"progress":[273],"through":[274],"unknown":[275],"mechanisms.":[276],"believe":[278],"molecular":[280],"using":[282],"antibodies":[283,336],"labeled":[284],"emitters":[287],"will":[288],"add":[289],"greatly":[290],"our":[292],"knowledge":[293],"about":[294],"CRPC,":[295],"studies":[297],"man":[299,346],"89Zr-DFO":[301],"J591,":[302],"antibody":[304],"targeting":[305],"PSMA":[306,316],"just":[308],"beginning.":[309],"The":[310],"signaling":[314,344,381],"expression":[317],"has":[318],"been":[319],"be":[325],"down":[326],"regulation,":[327],"intend":[330],"explore":[332],"use":[334],"provide":[338],"pharmacodynamic":[340],"biomarker":[341],"during":[347],"therapy":[348],"blockers":[351],"Citation":[355],"Format:":[356],"Steven":[357],"M.":[358],"Larson,":[359],"Joe":[360],"Fox,":[361],"Michael":[362,364],"Morris,":[363],"Evans,":[365],"Jason":[366],"Lewis,":[367],"John":[368],"Humm,":[369],"Charles":[370],"L.":[371],"Sawyers,":[372],"Howard":[373],"I.":[374],"Scher.":[375],"[abstract].":[384],"In:":[385],"Proceedings":[386],"AACR":[389],"Special":[390],"Conference":[391],"Advances":[393],"Prostate":[395],"Cancer":[396,406],"Research;":[397],"2012":[398],"Feb":[399],"6-9;":[400],"Orlando,":[401],"FL.":[402],"Philadelphia":[403],"(PA):":[404],"AACR;":[405],"Res":[407],"2012;72(4":[408],"Suppl):Abstract":[409],"nr":[410],"IA22.":[411]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
