{"id":"https://openalex.org/W2064572097","doi":"https://doi.org/10.1104/pp.104.900157","title":"Natural Variation in Arabidopsis. How Do We Find the Causal Genes?","display_name":"Natural Variation in Arabidopsis. How Do We Find the Causal Genes?","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W2064572097","doi":"https://doi.org/10.1104/pp.104.900157","mag":"2064572097","pmid":"https://pubmed.ncbi.nlm.nih.gov/15955918","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1150374"},"language":"en","primary_location":{"id":"doi:10.1104/pp.104.900157","doi":"https://doi.org/10.1104/pp.104.900157","is_oa":false,"landing_page_url":"https://doi.org/10.1104/pp.104.900157","pdf_url":null,"source":{"id":"https://openalex.org/S42294715","display_name":"PLANT PHYSIOLOGY","issn_l":"0032-0889","issn":["0032-0889","1532-2548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1150374","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003440649","display_name":"Detlef Weigel","orcid":"https://orcid.org/0000-0002-2114-7963","observed_orcids":["https://orcid.org/0000-0002-2114-7963"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Detlef Weigel","raw_affiliation_strings":["Department of Molecular Biology, Max Planck Institute for Developmental Biology, D\u201372076 Tuebingen, Germany (D.W.); Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 (D.W.); and Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089 (M.N.)","Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089 (M.N.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Max Planck Institute for Developmental Biology, D\u201372076 Tuebingen, Germany (D.W.); Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 (D.W.); and Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089 (M.N.)","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1307098950","https://openalex.org/I4210112458"]},{"raw_affiliation_string":"Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089 (M.N.)","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001507986","display_name":"Magnus Nordborg","orcid":"https://orcid.org/0000-0001-7178-9748","observed_orcids":["https://orcid.org/0000-0001-7178-9748"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Magnus Nordborg","raw_affiliation_strings":["Department of Molecular Biology, Max Planck Institute for Developmental Biology, D\u201372076 Tuebingen, Germany (D.W.); Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 (D.W.); and Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089 (M.N.)","Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089 (M.N.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Max Planck Institute for Developmental Biology, D\u201372076 Tuebingen, Germany (D.W.); Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 (D.W.); and Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089 (M.N.)","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1307098950","https://openalex.org/I4210112458"]},{"raw_affiliation_string":"Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089 (M.N.)","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3851,"currency":"USD","value_usd":3851},"apc_paid":null,"fwci":5.0344,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.96076777,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"138","issue":"2","first_page":"567","last_page":"568"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12828","display_name":"Plant Genetic and Mutation Studies","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-genetic-variation","display_name":"natural genetic variation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.9879999756813049},{"id":"https://openalex.org/keywords/wild-strains","display_name":"wild isolate","score":0.6389999985694885},{"id":"https://openalex.org/keywords/causal-gene-identification","display_name":"causal gene identification","score":0.734000027179718},{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.8999999761581421},{"id":"https://openalex.org/keywords/qtl-mapping","display_name":"QTL mapping","score":0.7630000114440918},{"id":"https://openalex.org/keywords/fine-mapping","display_name":"fine mapping","score":0.6909999847412109},{"id":"https://openalex.org/keywords/quantitative-trait-nucleotides","display_name":"quantitative trait nucleotides","score":0.8159999847412109},{"id":"https://openalex.org/keywords/near-isogenic-lines","display_name":"near-isogenic lines","score":0.8130000233650208},{"id":"https://openalex.org/keywords/allelic-variation","display_name":"allelic variation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/dna-polymorphism","display_name":"DNA polymorphism","score":0.6589999794960022},{"id":"https://openalex.org/keywords/transgenic-complementation","display_name":"transgenic complementation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/epistasis","display_name":"epistasis","score":0.5680000185966492},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.4880000054836273},{"id":"https://openalex.org/keywords/local-adaptation","display_name":"local adaptation","score":0.5479999780654907},{"id":"https://openalex.org/keywords/genetic-linkage","display_name":"genetic linkage","score":0.37400001287460327},{"id":"https://openalex.org/keywords/mendelian-inheritance","display_name":"Mendelian inheritance","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.9005392789840698},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.7097365260124207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5781404972076416},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5653402209281921},{"id":"https://openalex.org/C2776608160","wikidata":"https://www.wikidata.org/wiki/Q4785462","display_name":"Natural (archaeology)","level":2,"score":0.5372486114501953},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.419540673494339},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3939174711704254},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33061516284942627},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.07472974061965942},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.05934101343154907},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1104/pp.104.900157","doi":"https://doi.org/10.1104/pp.104.900157","is_oa":false,"landing_page_url":"https://doi.org/10.1104/pp.104.900157","pdf_url":null,"source":{"id":"https://openalex.org/S42294715","display_name":"PLANT PHYSIOLOGY","issn_l":"0032-0889","issn":["0032-0889","1532-2548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1150374","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1150374","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiol","raw_type":"Text"},{"id":"pmid:15955918","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15955918","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant physiology","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mpg.de:256901","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/256901","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plant Physiology, v.138, 567-568 (2005)","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1150374","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1150374","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.5365999937057495,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1584910068","https://openalex.org/W1952267772","https://openalex.org/W1972866676","https://openalex.org/W2004004088","https://openalex.org/W2008047653","https://openalex.org/W2008147924","https://openalex.org/W2066672169","https://openalex.org/W2073917725","https://openalex.org/W2092388446","https://openalex.org/W2134070988","https://openalex.org/W2134666031","https://openalex.org/W2145371252"],"related_works":["https://openalex.org/W2469595958","https://openalex.org/W2149803480","https://openalex.org/W4248608288","https://openalex.org/W2085767084","https://openalex.org/W2084332007","https://openalex.org/W2086764330","https://openalex.org/W1987864324","https://openalex.org/W122094907","https://openalex.org/W2809893817","https://openalex.org/W2103841044"],"abstract_inverted_index":{"According":[0],"to":[1,50,63,65,72,85,116,158,170,193,197,262,317,356,372,436,538,553,558,576,587,676,681,701,721,737,755,808,834,860,907,931,940,970,973,980,983,1012,1033,1068,1076,1126,1177,1243,1247,1262,1296],"PubMed,":[2],"more":[3,88,968,1018,1044,1162],"than":[4,496,987,1020,1046],"one-third":[5],"of":[6,23,29,32,58,70,78,107,167,200,207,239,298,306,324,340,350,361,367,375,394,400,439,449,455,481,489,524,534,547,600,605,612,625,638,705,745,780,813,853,862,864,872,887,893,1039,1062,1106,1119,1134,1168,1239,1266],"all":[7,480,814],"papers":[8],"on":[9,1131],"natural":[10,739,1189],"genetic":[11,125,189,253,365,458,740,837,1257,1281],"variation":[12,38,97,160,459,565,567,741,838],"in":[13,40,48,55,98,223,242,249,434,468,506,531,556,659,715,742,818,846,920,1110,1153,1159,1201,1203,1222,1285,1317,1329],"Arabidopsis":[14,33,660,746,821,854,880],"(Arabidopsis":[15],"thaliana)":[16],"have":[17,84,615,726,752,1081,1195,1289],"been":[18,378,504,616,735,753,832,1082,1196],"published":[19],"since":[20],"the":[21,26,67,73,93,105,108,165,171,179,185,201,205,237,264,268,272,276,280,310,322,334,341,395,398,440,450,453,465,490,548,588,590,595,601,622,636,682,685,703,706,729,783,824,870,956,984,1003,1037,1098,1111,1117,1157,1166,1237,1248,1255,1297,1302,1318,1330],"beginning":[22],"2004,":[24],"underscoring":[25],"rapid":[27],"growth":[28],"this":[30,290,332,522,528,672,844,1040,1079,1291,1322],"area":[31],"research.":[34],"Motivations":[35],"for":[36,267,321,359,409,709,768,856,884,899,958,1078,1100,1216,1268],"studying":[37],"found":[39,134],"wild":[41,613],"strains":[42,614,855,876,894,961,1001],"range":[43],"from":[44,688,717,1002,1024,1143],"simply":[45,1308],"exploiting":[46,823],"it":[47,312,472,574,904],"order":[49,557],"find":[51,198],"new":[52],"genes":[53,94,187,300,626,1241],"involved":[54],"specific":[56,100],"aspects":[57],"plant":[59,1256],"physiology":[60],"or":[61,227,327,651,1198],"development,":[62],"trying":[64],"understand":[66],"molecular":[68],"basis":[69],"adaptations":[71],"local":[74,1331],"environment.":[75],"However,":[76,903],"irrespective":[77],"our":[79],"ultimate":[80],"goal,":[81],"we":[82,543,802,1252,1288,1293],"first":[83],"solve":[86],"two":[87],"immediate":[89],"problems.":[90],"Which":[91],"are":[92,112,132,148,155,301,484,674,772,803,877,967,1015,1048,1065,1171,1199],"that":[95,122,127,211,289,352,382,405,425,446,479,545,578,641,728,830,909,924,962,1022,1060,1074,1145,1175,1254,1278,1312],"affect":[96],"a":[99,292,325,362,368,373,429,437,447,461,507,536,539,560,569,579,609,632,644,891,946,964,1054,1132,1264,1309,1326],"trait?":[101],"And,":[102],"what":[103,1269,1272],"is":[104,121,188,212,233,291,313,519,529,575,583,621,629,635,881,905,923,992],"nature":[106],"allelic":[109,159,564,581],"differences?":[110],"These":[111],"unfortunately":[113],"difficult":[114,572,1298],"questions":[115],"answer.":[117],"The":[118,1103],"main":[119],"reason":[120],"although":[123],"major":[124,146],"differences":[126,154,1152,1284],"segregate":[128],"as":[129,214,573,618,978,994,1050,1301],"Mendelian":[130,713],"factors":[131],"sometimes":[133],"(e.g.":[135,1084],"Bowman":[136],"et":[137,141,516,665,695,748,764,787,797,840,1090],"al.,":[138,142,517,666,696,749,765,788,798,841,1091],"1993;":[139],"Grant":[140],"1995),":[143],"alleles":[144,384,1127,1148],"with":[145,204,385,511,631,643,981,1053,1113,1128,1156,1224],"effects":[147,297,1130],"an":[149,209,224,250,806,941,1211,1305],"exception.":[150],"Even":[151,1161],"drastic":[152],"phenotypic":[153,296,387,431],"often":[156,302,1017],"due":[157,930,939,1067],"at":[161,275,460,568,810],"several":[162,348,546],"loci,":[163],"and":[164,270,304,397,566,598,692,790,950,997,1086,1149,1207,1271],"contribution":[166],"each":[168,974],"locus":[169,217,463,1158],"phenotype":[172,966,1154],"can":[173,256,353,849,895,1057,1137,1183,1229,1294],"be":[174,354,474,554,677,896,929,955,971,1010,1165,1178,1184,1210,1244],"quite":[175],"small.":[176],"Thus,":[177],"while":[178],"most":[180],"direct":[181,623,915],"approach":[182,210,673],"toward":[183],"identifying":[184],"causal":[186,273,561,932,948,1069],"mapping,":[190,501],"one":[191,245,406,426,848,1056,1136],"needs":[192],"use":[194,1167],"statistical":[195,943],"methods":[196,261,1073],"regions":[199,781],"genome":[202,785],"associated":[203,1052],"trait":[206,216,283,329,374,399,454,467,1133],"interest,":[208,1135],"known":[213,993],"quantitative":[215,282,328,336],"(QTL)":[218],"mapping.":[219,653],"Initial":[220],"QTL":[221,246,269,326,441,537,1218],"mapping":[222,535,597,700,911,1219],"F2,":[225],"backcross,":[226],"recombinant":[228],"inbred":[229],"line":[230],"(RIL)":[231],"population":[232,995],"usually":[234],"followed":[235],"by":[236,760,989,1234],"creation":[238],"near-isogenic":[240],"lines,":[241],"which":[243,502,732,866,1170],"only":[244,1180,1215],"region":[247,371],"segregates":[248],"otherwise":[251],"identical":[252],"background.":[254],"One":[255,620],"then":[257,850],"apply":[258],"conventional":[259,1217],"fine-mapping":[260],"identify":[263],"gene(s)":[265],"responsible":[266,708],"ultimately":[271],"changes":[274],"nucleotide":[277,816],"level":[278],"(hence":[279],"term":[281],"nucleotide).":[284],"It":[285],"goes":[286],"without":[287],"saying":[288],"slow":[293],"process.":[294],"Because":[295,654,875],"individual":[299],"small":[303],"because":[305,527,1000],"complex":[307],"interactions":[308],"between":[309,392,563,945],"genes,":[311],"generally":[314],"not":[315,520,913,928,1066,1096,1214,1274],"easy":[316],"obtain":[318],"definitive":[319],"proof":[320,1277],"identification":[323,360,599,624,637],"nucleotide.":[330],"For":[331],"reason,":[333],"mammalian":[335],"genetics":[337],"community":[338,1258],"(Members":[339],"Complex":[342],"Trait":[343],"Consortium,":[344],"2003)":[345],"has":[346,377,428,503,831,1313],"proposed":[347,617,1083],"lines":[349],"experimentation":[351],"combined":[355],"provide":[357,493,914,1231,1325],"evidence":[358,495],"QTL,":[363],"once":[364,889,1181],"linkage":[366,648],"particular":[369,580,645],"genomic":[370],"interest":[376],"established.":[379],"DNA":[380,792,826],"polymorphisms":[381,817],"distinguish":[383],"different":[386,411,430,820,901,1204],"effects.":[388],"A":[389,917],"mechanistic":[390],"link":[391,562],"function":[393],"gene":[396,451,707,949],"interest.":[401],"Functional":[402],"studies":[403,795,1108,1124,1228],"showing":[404],"allele":[407,427,1307,1323],"has,":[408],"example,":[410,959],"biochemical":[412],"properties.":[413],"Transgenic":[414],"complementation.":[415],"Allele":[416],"replacement":[417],"through":[418,671,775,791],"homologous":[419,462],"recombination.":[420],"Deficiency":[421],"complementation":[422],"test":[423],"(showing":[424],"effect":[432],"when":[433],"trans":[435],"knockout":[438,448],"candidate).":[442],"Mutational":[443],"analysis":[444,1118],"(demonstrating":[445],"affects":[452],"interest).":[456],"Natural":[457],"affecting":[464],"same":[466,825,1004],"another":[469],"species.":[470],"Obviously,":[471],"will":[473,492,867,1095,1164,1209],"rare":[475],"(and":[476],"rarely":[477],"necessary)":[478],"these":[482,885,921,1063,1208],"criteria":[483,491,549],"fulfilled.":[485],"In":[486,684,800,1250],"addition,":[487,801],"some":[488],"stronger":[494],"others.":[497],"Interestingly,":[498],"unambiguous":[499],"fine":[500],"achieved":[505],"particularly":[508],"heroic":[509],"effort":[510,807],"tomato":[512],"(Lycopersicon":[513],"esculentum;":[514],"Fridman":[515],"2000),":[518,750,1092],"among":[521],"set":[523,1265],"criteria,":[525],"apparently":[526],"unrealistic":[530],"mammals.":[532],"Short":[533],"single":[540,815],"gene,":[541,731],"however,":[542],"agree":[544],"listed":[550],"above":[551],"need":[552,1099,1176],"met":[555],"claim":[559],"trait.":[570,633,1249],"As":[571],"demonstrate":[577],"variant":[582,1311],"indeed":[584,1324],"causally":[585,1245],"related":[586,972,1019],"phenotype,":[589,646],"rate-limiting":[591],"step":[592],"typically":[593,656],"remains":[594],"initial":[596],"QTL.":[602,683],"Several":[603],"types":[604],"whole-genome":[606],"analyses":[607,922],"across":[608,782],"large":[610],"panel":[611],"shortcuts.":[619],"whose":[627],"expression":[628],"correlated":[630],"Another":[634],"sequence":[639,668],"variants":[640,669,1282],"correlate":[642],"so-called":[647],"disequilibrium":[649],"(LD)":[650],"association":[652,762,770,873,944,1107,1123,1225],"LD":[655,699,910],"decays":[657],"rapidly":[658],"(over":[661],"25\u201350":[662],"kb;":[663],"Nordborg":[664],"2005),":[667],"identified":[670,1049],"expected":[675,988,1047],"very":[678],"closely":[679],"linked":[680,1246],"canonical":[686],"example":[687],"human":[689,836],"genetics,":[690],"Ha\u0308stbacka":[691],"colleagues":[693],"(Ha\u0308stbacka":[694],"1992)":[697],"used":[698,833],"refine":[702],"location":[704],"diastrophic":[710],"dysplasia":[711],"(a":[712],"disease":[714],"humans)":[716],"over":[718],"1":[719],"Mb":[720],"about":[722,757],"60":[723],"kb.":[724],"We":[725],"demonstrated":[727],"FRIGIDA":[730],"had":[733],"previously":[734],"shown":[736],"underlie":[738],"flowering":[743],"response":[744],"(Johanson":[747],"could":[751],"mapped":[754],"within":[756],"30":[758],"kb":[759],"marker":[761,1029],"(Hagenblad":[763],"2004).":[766],"Panels":[767],"genome-wide":[769],"scans":[771],"becoming":[773],"available":[774],"sequencing":[776],"efforts":[777],"targeting":[778],"thousands":[779,859],"entire":[784],"(Nordborg":[786],"2005)":[789],"array":[793,827],"hybridization":[794,828],"(Borevitz":[796],"2003).":[799],"currently":[804,1200],"undertaking":[805],"discover":[809],"least":[811],"half":[812],"20":[819],"strains,":[822],"technology":[829],"assay":[835],"(Hinds":[839],"2005).":[842],"With":[843],"information":[845,1030,1233],"hand,":[847],"genotype":[851],"hundreds":[852,861],"many":[857,900,1043,1061],"(i.e.":[858],"thousands)":[863],"markers,":[865],"greatly":[868],"increase":[869],"power":[871,1105],"studies.":[874,1102,1226],"naturally":[878,1279],"inbred,":[879],"uniquely":[882],"suited":[883],"kinds":[886],"studies:":[888],"genotyped,":[890],"collection":[892],"repeatedly":[897,1185],"assayed":[898],"phenotypes.":[902],"important":[906],"remember":[908],"does":[912,1270,1273,1321],"evidence.":[916],"confounding":[918],"factor":[919],"marker-trait":[925,1070],"associations":[926,1064],"may":[927,998,1009],"relationships":[933],"(or":[934],"even":[935],"linkage),":[936],"but":[937,1093,1182,1220],"rather":[938],"unexpected":[942],"(unknown)":[947],"other":[951,975,1114],"genes.":[952],"This":[953,991],"would":[954,1259],"case,":[957],"if":[960],"show":[963],"certain":[965],"likely":[969,1242],"(genome":[976],"wide,":[977],"opposed":[979],"respect":[982],"causative":[985],"loci)":[986],"chance.":[990],"structure":[996],"occur":[999],"geographic":[1005],"area,":[1006],"where":[1007],"they":[1008,1094],"exposed":[1011],"similar":[1013],"environments,":[1014],"also":[1016,1221,1230],"those":[1021],"come":[1023],"geographically":[1025],"distant":[1026],"regions.":[1027],"Genome-wide":[1028],"allows":[1031],"us":[1032],"gain":[1034],"insight":[1035],"into":[1036],"severity":[1038],"problem.":[1041],"When":[1042],"markers":[1045],"significantly":[1051],"trait,":[1055],"safely":[1058],"assume":[1059],"relationships.":[1071],"Statistical":[1072],"help":[1075],"correct":[1077],"problem":[1080],"Devlin":[1085],"Roeder,":[1087],"1999;":[1088],"Pritchard":[1089],"bypass":[1097],"experimental":[1101,1120],"true":[1104],"lies":[1109],"combination":[1112,1223],"approaches,":[1115],"especially":[1116],"populations.":[1121],"If":[1122],"point":[1125],"opposite":[1129],"quickly":[1138],"generate":[1139],"multiple":[1140],"F2":[1141,1173],"populations":[1142,1174],"parents":[1144],"harbor":[1146],"contrasting":[1147],"determine":[1150],"whether":[1151],"cosegregate":[1155],"question.":[1160],"powerful":[1163],"RILs,":[1169],"immortalized":[1172],"genotyped":[1179],"phenotyped":[1186],"(just":[1187],"like":[1188],"strains).":[1190],"Some":[1191],"50":[1192],"RIL":[1193],"sets":[1194],"produced":[1197],"production":[1202],"laboratories":[1205],"(www.inra.fr/qtlat/NaturalVar/RILSummary.htm),":[1206],"invaluable":[1212],"resource":[1213],"Expression":[1227],"valuable":[1232],"further":[1235],"narrowing":[1236],"list":[1238],"candidate":[1240],"summary,":[1251],"feel":[1253],"do":[1260],"well":[1261],"adopt":[1263],"standards":[1267],"constitute":[1275],"acceptable":[1276],"occurring":[1280],"cause":[1283],"phenotype.":[1286],"Once":[1287],"solved":[1290],"problem,":[1292],"turn":[1295],"questions,":[1299],"such":[1300],"following.":[1303],"Is":[1304],"unusual":[1306],"deleterious":[1310],"become":[1314],"fortuitously":[1315],"fixed":[1316],"population?":[1319],"Or,":[1320],"fitness":[1327],"advantage":[1328],"environment?":[1332]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}