{"id":"https://openalex.org/W2064570836","doi":"https://doi.org/10.1126/science.6302845","title":"Identity of HeLa Cell Determinants Acquired by Vesicular Stomatitis Virus with a Tumor Antigen","display_name":"Identity of HeLa Cell Determinants Acquired by Vesicular Stomatitis Virus with a Tumor Antigen","publication_year":1983,"publication_date":"1983-06-03","ids":{"openalex":"https://openalex.org/W2064570836","doi":"https://doi.org/10.1126/science.6302845","mag":"2064570836","pmid":"https://pubmed.ncbi.nlm.nih.gov/6302845"},"language":"en","primary_location":{"id":"doi:10.1126/science.6302845","doi":"https://doi.org/10.1126/science.6302845","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.6302845","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031299871","display_name":"Lynn Mallory Little","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn M. Little","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics and Department of Pathology, Harvard Medical School, and Division of Infectious Diseases, Children's Hospital Medical Center, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics and Department of Pathology, Harvard Medical School, and Division of Infectious Diseases, Children's Hospital Medical Center, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089501922","display_name":"J Z\u00e1vada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Zavada","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics and Department of Pathology, Harvard Medical School, and Division of Infectious Diseases, Children's Hospital Medical Center, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics and Department of Pathology, Harvard Medical School, and Division of Infectious Diseases, Children's Hospital Medical Center, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064063895","display_name":"Channing J. Der","orcid":"https://orcid.org/0000-0002-7751-2747","observed_orcids":["https://orcid.org/0000-0002-7751-2747"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Channing J. Der","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics and Department of Pathology, Harvard Medical School, and Division of Infectious Diseases, Children's Hospital Medical Center, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics and Department of Pathology, Harvard Medical School, and Division of Infectious Diseases, Children's Hospital Medical Center, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013907686","display_name":"Alice Shih-hou Huang","orcid":"https://orcid.org/0000-0002-4795-3402","observed_orcids":["https://orcid.org/0000-0002-4795-3402"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice S. Huang","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics and Department of Pathology, Harvard Medical School, and Division of Infectious Diseases, Children's Hospital Medical Center, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics and Department of Pathology, Harvard Medical School, and Division of Infectious Diseases, Children's Hospital Medical Center, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5776,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.89141136,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"220","issue":"4601","first_page":"1069","last_page":"1071"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.29420000314712524,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.29420000314712524,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.2750999927520752,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.2498999983072281,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vesicular-stomatitis-virus","display_name":"vesicular stomatitis virus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-antigens","display_name":"tumor antigens","score":0.699999988079071},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.46700000762939453},{"id":"https://openalex.org/keywords/neutralization","display_name":"neutralization","score":0.39100000262260437},{"id":"https://openalex.org/keywords/antiserum-precipitation","display_name":"antiserum precipitation","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.9422557353973389},{"id":"https://openalex.org/C2779057330","wikidata":"https://www.wikidata.org/wiki/Q162762","display_name":"Vesicular stomatitis virus","level":3,"score":0.9229657053947449},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.818427324295044},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6259908676147461},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5625348687171936},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5409797430038452},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5290488004684448},{"id":"https://openalex.org/C2909090456","wikidata":"https://www.wikidata.org/wiki/Q162762","display_name":"Vesicular stomatitis Indiana virus","level":4,"score":0.5216518044471741},{"id":"https://openalex.org/C2910348395","wikidata":"https://www.wikidata.org/wiki/Q162762","display_name":"Vesicular Stomatitis","level":4,"score":0.43911001086235046},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.390005886554718},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19184038043022156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10496106743812561}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014721","descriptor_name":"Vesicular stomatitis Indiana virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.6302845","doi":"https://doi.org/10.1126/science.6302845","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.6302845","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:6302845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6302845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W141340800","https://openalex.org/W1486018843","https://openalex.org/W1988088718","https://openalex.org/W1990247259","https://openalex.org/W2005106104","https://openalex.org/W2019993710","https://openalex.org/W2045393455","https://openalex.org/W2049116391","https://openalex.org/W2077775312","https://openalex.org/W2079988647","https://openalex.org/W2081052677","https://openalex.org/W2093846750"],"related_works":["https://openalex.org/W2089828390","https://openalex.org/W2075522946","https://openalex.org/W2081052677","https://openalex.org/W1608529859","https://openalex.org/W2097861996","https://openalex.org/W1511401752","https://openalex.org/W2019993710","https://openalex.org/W2093137807","https://openalex.org/W2001213446","https://openalex.org/W2005414353"],"abstract_inverted_index":{"Growth":[0],"of":[1,44,54],"vesicular":[2],"stomatitis":[3],"virus":[4],"(VSV)":[5],"in":[6,10],"HeLa":[7,29,55],"cells":[8],"results":[9],"progeny":[11],"containing":[12],"non-VSV":[13,22],"antigens":[14,23,64],"with":[15],"a":[16,50],"molecular":[17],"weight":[18],"around":[19],"75,000.":[20],"The":[21],"were":[24],"detected":[25],"by":[26],"antiserums":[27,33,46],"to":[28,49],"cell":[30],"determinants.":[31],"These":[32],"precipitate":[34],"whole":[35],"virions":[36],"but":[37],"do":[38],"not":[39],"neutralize":[40],"them.":[41],"Because":[42],"one":[43],"the":[45],"is":[47],"directed":[48],"tumor-specific":[51],"surface":[52],"antigen":[53],"cells,":[56],"it":[57],"appears":[58],"that":[59],"VSV":[60],"specifically":[61],"acquires":[62],"such":[63],"during":[65],"its":[66],"passage":[67],"through":[68],"human":[69],"tumor":[70],"cells.":[71]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
