{"id":"https://openalex.org/W2064558773","doi":"https://doi.org/10.1128/jvi.01558-08","title":"Specific Inhibition of the PKR-Mediated Antiviral Response by the Murine Cytomegalovirus Proteins m142 and m143","display_name":"Specific Inhibition of the PKR-Mediated Antiviral Response by the Murine Cytomegalovirus Proteins m142 and m143","publication_year":2008,"publication_date":"2008-11-20","ids":{"openalex":"https://openalex.org/W2064558773","doi":"https://doi.org/10.1128/jvi.01558-08","mag":"2064558773","pmid":"https://pubmed.ncbi.nlm.nih.gov/19019949","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2620897"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.01558-08","doi":"https://doi.org/10.1128/jvi.01558-08","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01558-08","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2620897","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072932947","display_name":"Matthias Budt","orcid":"https://orcid.org/0000-0001-5960-515X","observed_orcids":["https://orcid.org/0000-0001-5960-515X"]},"institutions":[{"id":"https://openalex.org/I24359323","display_name":"Robert Koch Institute","ror":"https://ror.org/01k5qnb77","country_code":"DE","type":"government","lineage":["https://openalex.org/I24359323"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Budt","raw_affiliation_strings":["Division of Viral Infections, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Viral Infections, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany","institution_ids":["https://openalex.org/I24359323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043777763","display_name":"Lars Niederstadt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24359323","display_name":"Robert Koch Institute","ror":"https://ror.org/01k5qnb77","country_code":"DE","type":"government","lineage":["https://openalex.org/I24359323"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lars Niederstadt","raw_affiliation_strings":["Division of Viral Infections, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Viral Infections, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany","institution_ids":["https://openalex.org/I24359323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077244557","display_name":"Ralitsa S. Valchanova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24359323","display_name":"Robert Koch Institute","ror":"https://ror.org/01k5qnb77","country_code":"DE","type":"government","lineage":["https://openalex.org/I24359323"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralitsa S. Valchanova","raw_affiliation_strings":["Division of Viral Infections, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Viral Infections, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany","institution_ids":["https://openalex.org/I24359323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038051461","display_name":"Stipan Jonji\u0107","orcid":"https://orcid.org/0000-0001-5003-3108","observed_orcids":["https://orcid.org/0000-0001-5003-3108"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Stipan Jonjic\u0301","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072725079","display_name":"Wolfram Brune","orcid":"https://orcid.org/0000-0002-6078-5255","observed_orcids":["https://orcid.org/0000-0002-6078-5255"]},"institutions":[{"id":"https://openalex.org/I24359323","display_name":"Robert Koch Institute","ror":"https://ror.org/01k5qnb77","country_code":"DE","type":"government","lineage":["https://openalex.org/I24359323"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfram Brune","raw_affiliation_strings":["Division of Viral Infections, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Viral Infections, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany","institution_ids":["https://openalex.org/I24359323"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9484,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.85415307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"83","issue":"3","first_page":"1260","last_page":"1270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.739300012588501,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.739300012588501,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.24210000038146973,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/murine-cytomegalovirus","display_name":"murine cytomegalovirus","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pkr","display_name":"PKR","score":0.8389999866485596},{"id":"https://openalex.org/keywords/double-stranded-rna-dependent-protein-kinase","display_name":"double-stranded RNA-dependent protein kinase","score":0.8270000219345093},{"id":"https://openalex.org/keywords/eif2alpha-phosphorylation","display_name":"eIF2\u03b1 phosphorylation","score":0.890999972820282},{"id":"https://openalex.org/keywords/perk","display_name":"PERK","score":0.6520000100135803},{"id":"https://openalex.org/keywords/gcn2","display_name":"GCN2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dsrna-binding-protein","display_name":"dsRNA-binding proteins","score":0.722000002861023},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.5149999856948853},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C161238802","wikidata":"https://www.wikidata.org/wiki/Q14905690","display_name":"Protein kinase R","level":5,"score":0.9369567632675171},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8290070295333862},{"id":"https://openalex.org/C2777479484","wikidata":"https://www.wikidata.org/wiki/Q5323131","display_name":"EIF-2 kinase","level":5,"score":0.66306072473526},{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.6064046621322632},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5997850298881531},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.549706220626831},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5090815424919128},{"id":"https://openalex.org/C2776746152","wikidata":"https://www.wikidata.org/wiki/Q4775355","display_name":"Antiviral protein","level":4,"score":0.49927592277526855},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.44903847575187683},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.42896395921707153},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4176870882511139},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4134674370288849},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4076997637748718},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3887369930744171},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2694374918937683},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1471165418624878},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.1415521204471588},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.13732105493545532},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08532154560089111},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.056293606758117676}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012330","descriptor_name":"RNA, Double-Stranded","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015852","descriptor_name":"Eukaryotic Initiation Factor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019892","descriptor_name":"eIF-2 Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019892","descriptor_name":"eIF-2 Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.01558-08","doi":"https://doi.org/10.1128/jvi.01558-08","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01558-08","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2620897","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2620897","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:19019949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19019949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:RKI.de:1087","doi":null,"is_oa":false,"landing_page_url":"http://edoc.rki.de/docviews/abstract.php?id=1087","pdf_url":null,"source":{"id":"https://openalex.org/S4306400512","display_name":"Publication server of the Robert Koch Institute (Robert Kock Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24359323","host_organization_name":"Robert Koch Institute","host_organization_lineage":["https://openalex.org/I24359323"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2620897","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2620897","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2543170750","display_name":null,"funder_award_id":"SFB421","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5628546384","display_name":null,"funder_award_id":"TP B14","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W117116436","https://openalex.org/W592242822","https://openalex.org/W645171471","https://openalex.org/W646980015","https://openalex.org/W1501535630","https://openalex.org/W1536015357","https://openalex.org/W1558747066","https://openalex.org/W1559956236","https://openalex.org/W1562702833","https://openalex.org/W1569857352","https://openalex.org/W1693287923","https://openalex.org/W1759060244","https://openalex.org/W1963614469","https://openalex.org/W1967686012","https://openalex.org/W1972327788","https://openalex.org/W1973472843","https://openalex.org/W1982658424","https://openalex.org/W1994769674","https://openalex.org/W1998171883","https://openalex.org/W2009127910","https://openalex.org/W2014851246","https://openalex.org/W2017515700","https://openalex.org/W2026729363","https://openalex.org/W2031913105","https://openalex.org/W2039361749","https://openalex.org/W2044985510","https://openalex.org/W2048676149","https://openalex.org/W2049636398","https://openalex.org/W2050361028","https://openalex.org/W2050575361","https://openalex.org/W2051026238","https://openalex.org/W2052011130","https://openalex.org/W2052308758","https://openalex.org/W2060094569","https://openalex.org/W2060922355","https://openalex.org/W2065554630","https://openalex.org/W2074931193","https://openalex.org/W2077808289","https://openalex.org/W2078870286","https://openalex.org/W2079743290","https://openalex.org/W2080543785","https://openalex.org/W2080901528","https://openalex.org/W2084482466","https://openalex.org/W2085487477","https://openalex.org/W2086816308","https://openalex.org/W2090523809","https://openalex.org/W2094191346","https://openalex.org/W2097364153","https://openalex.org/W2098440166","https://openalex.org/W2101083359","https://openalex.org/W2101445704","https://openalex.org/W2102032614","https://openalex.org/W2108822954","https://openalex.org/W2115834887","https://openalex.org/W2119003997","https://openalex.org/W2120736516","https://openalex.org/W2122500419","https://openalex.org/W2122550126","https://openalex.org/W2125566625","https://openalex.org/W2129336550","https://openalex.org/W2131675463","https://openalex.org/W2132025920","https://openalex.org/W2141636174","https://openalex.org/W2148937272","https://openalex.org/W2149223196","https://openalex.org/W2153390922","https://openalex.org/W2166343003"],"related_works":["https://openalex.org/W1994769674","https://openalex.org/W2254401370","https://openalex.org/W2123507177","https://openalex.org/W2603501294","https://openalex.org/W2108822954","https://openalex.org/W1984036718","https://openalex.org/W2038904951","https://openalex.org/W4391965236","https://openalex.org/W2924007191","https://openalex.org/W2034869340"],"abstract_inverted_index":{"Double-stranded":[0],"RNA":[1],"(dsRNA)":[2],"produced":[3],"during":[4,126],"viral":[5,37,212],"infection":[6,127],"activates":[7],"several":[8],"cellular":[9],"antiviral":[10,249],"responses.":[11],"Among":[12],"the":[13,17,24,30,50,77,89,94,97,100,104,110,121,141,160,191,201,247,254],"best":[14],"characterized":[15,66],"is":[16,134,251],"shutoff":[18],"of":[19,76,96,106,114,123,150,163,169,190,205,256],"protein":[20,26,41,85],"synthesis":[21,86],"mediated":[22,136],"by":[23,137,140,195],"dsRNA-dependent":[25],"kinase":[27],"(PKR)":[28],"and":[29,52,62,82,99,116,131,172,176,182,207,225,258],"oligoadenylate":[31],"synthetase":[32],"(OAS)/RNase":[33],"L":[34,54,193],"system.":[35],"As":[36],"replication":[38,108,161],"depends":[39],"on":[40,219],"synthesis,":[42],"many":[43],"viruses":[44],"have":[45,64,214],"evolved":[46],"mechanisms":[47],"for":[48,253],"counteracting":[49],"PKR":[51,73,148,236],"OAS/RNase":[53,192],"pathways.":[55],"The":[56],"murine":[57],"cytomegalovirus":[58],"(MCMV)":[59],"proteins":[60,70,213],"m142":[61,115,171,175,206,257],"m143":[63,177],"been":[65],"as":[67],"dsRNA":[68],"binding":[69],"that":[71,120,210],"inhibit":[72],"activation,":[74],"phosphorylation":[75,125],"translation":[78],"initiation":[79],"factor":[80],"eIF2alpha,":[81],"a":[83],"subsequent":[84],"shutoff.":[87],"In":[88],"present":[90],"study":[91],"we":[92],"analyzed":[93],"contribution":[95],"PKR-":[98],"OAS-dependent":[101],"pathways":[102],"to":[103,179,230],"control":[105],"MCMV":[107,133,165,196,227],"in":[109,200,233,241],"absence":[111,204],"or":[112,146,154,203,216],"presence":[113,202],"m143.":[117,173,259],"We":[118],"show":[119],"induction":[122],"eIF2alpha":[124,143],"with":[128,167,184],"an":[129,164,188,223],"m142-":[130,224],"m143-deficient":[132,226],"specifically":[135],"PKR,":[138],"not":[139,198,239],"related":[142],"kinases":[144],"PERK":[145],"GCN2.":[147],"antagonists":[149],"vaccinia":[151],"virus":[152,157],"(E3L)":[153],"herpes":[155],"simplex":[156],"(gamma34.5)":[158],"rescued":[159],"defect":[162],"strain":[166,228],"deletions":[168],"both":[170],"Moreover,":[174],"bound":[178],"each":[180],"other":[181],"interacted":[183],"PKR.":[185],"By":[186],"contrast,":[187],"activation":[189],"pathway":[194],"was":[197],"detected":[199],"m143,":[208],"suggesting":[209],"these":[211],"little":[215],"no":[217],"influence":[218],"this":[220],"pathway.":[221],"Consistently,":[222],"replicated":[229],"high":[231],"titers":[232],"fibroblasts":[234],"lacking":[235,243],"but":[237],"did":[238],"replicate":[240],"cells":[242],"RNase":[244],"L.":[245],"Hence,":[246],"PKR-mediated":[248],"response":[250],"responsible":[252],"essentiality":[255]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
