{"id":"https://openalex.org/W2064550239","doi":"https://doi.org/10.1002/stem.1274","title":"Epigenetic Regulation of Survivin by Bmi1 Is Cell Type Specific During Corticogenesis and in Gliomas","display_name":"Epigenetic Regulation of Survivin by Bmi1 Is Cell Type Specific During Corticogenesis and in Gliomas","publication_year":2012,"publication_date":"2012-11-07","ids":{"openalex":"https://openalex.org/W2064550239","doi":"https://doi.org/10.1002/stem.1274","mag":"2064550239","pmid":"https://pubmed.ncbi.nlm.nih.gov/23132836"},"language":"en","primary_location":{"id":"doi:10.1002/stem.1274","doi":"https://doi.org/10.1002/stem.1274","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.1274","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018779706","display_name":"Serena Acquati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Serena Acquati","raw_affiliation_strings":["Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]},{"raw_affiliation_string":"Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071636658","display_name":"Azzura Greco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Azzura Greco","raw_affiliation_strings":["Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]},{"raw_affiliation_string":"Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032166923","display_name":"Danilo Licastro","orcid":"https://orcid.org/0000-0001-8372-9355","observed_orcids":["https://orcid.org/0000-0001-8372-9355"]},"institutions":[{"id":"https://openalex.org/I2801626668","display_name":"AREA Science Park","ror":"https://ror.org/01dt7qh15","country_code":"IT","type":"facility","lineage":["https://openalex.org/I2801626668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Danilo Licastro","raw_affiliation_strings":["CBM S.c.r.l. AREA SCIENCE PARK, Basovizza, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CBM S.c.r.l. AREA SCIENCE PARK, Basovizza, Trieste, Italy","institution_ids":["https://openalex.org/I2801626668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072824065","display_name":"Heeta Bhagat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Heeta Bhagat","raw_affiliation_strings":["Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]},{"raw_affiliation_string":"Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025512229","display_name":"Dario Ceric","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dario Ceric","raw_affiliation_strings":["Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]},{"raw_affiliation_string":"Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068333772","display_name":"Zefferino Rossini","orcid":"https://orcid.org/0000-0002-1169-6846","observed_orcids":["https://orcid.org/0000-0002-1169-6846"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zefferino Rossini","raw_affiliation_strings":["Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]},{"raw_affiliation_string":"Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060589391","display_name":"Joan Grieve","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joan Grieve","raw_affiliation_strings":["Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom","institution_ids":["https://openalex.org/I4210151618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074223820","display_name":"Maya Shaked-Rabi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maya Shaked-Rabi","raw_affiliation_strings":["Division of Neuropathology, and Department of Neurodegeneration, UCL Institute of Neurology, Queen Square, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuropathology, and Department of Neurodegeneration, UCL Institute of Neurology, Queen Square, London, United Kingdom","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113485177","display_name":"Nick V. Henriquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick V. Henriquez","raw_affiliation_strings":["Division of Neuropathology, and Department of Neurodegeneration, UCL Institute of Neurology, Queen Square, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuropathology, and Department of Neurodegeneration, UCL Institute of Neurology, Queen Square, London, United Kingdom","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005354758","display_name":"Sebastian Brandner","orcid":"https://orcid.org/0000-0002-9821-0342","observed_orcids":["https://orcid.org/0000-0002-9821-0342","https://orcid.org/0000-0002-8635-7195"]},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sebastian Brandner","raw_affiliation_strings":["Division of Neuropathology, and Department of Neurodegeneration, UCL Institute of Neurology, Queen Square, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuropathology, and Department of Neurodegeneration, UCL Institute of Neurology, Queen Square, London, United Kingdom","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090923781","display_name":"Elia Stupka","orcid":"https://orcid.org/0000-0003-3154-4011","observed_orcids":["https://orcid.org/0000-0003-3154-4011"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elia Stupka","raw_affiliation_strings":["Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]},{"raw_affiliation_string":"Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013573764","display_name":"Silvia Marino","orcid":"https://orcid.org/0000-0002-9612-2883","observed_orcids":["https://orcid.org/0000-0002-9612-2883"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Silvia Marino","raw_affiliation_strings":["Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]},{"raw_affiliation_string":"Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5013573764"],"corresponding_institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":1.3238,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.7864224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"1","first_page":"190","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmi1","display_name":"BMI1","score":0.9710000157356262},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-1","display_name":"PRC1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.7770000100135803},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.5509999990463257},{"id":"https://openalex.org/keywords/cortical-development","display_name":"cortical development","score":0.7369999885559082},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.984000027179718},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.8659999966621399},{"id":"https://openalex.org/keywords/glioma-stem-cells","display_name":"glioma stem cells","score":0.8759999871253967},{"id":"https://openalex.org/keywords/stem-cell-self-renewal","display_name":"stem cell self-renewal","score":0.6039999723434448},{"id":"https://openalex.org/keywords/conditional-gene-activation","display_name":"conditional gene activation","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2778987575","wikidata":"https://www.wikidata.org/wiki/Q21145992","display_name":"BMI1","level":3,"score":0.939667284488678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8831502199172974},{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.7365286946296692},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.6509263515472412},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5937914848327637},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5901380777359009},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5760641098022461},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5419940948486328},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.536107063293457},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.500262975692749},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.49961066246032715},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4271393120288849},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2899287939071655},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2148456871509552},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16410371661186218}],"mesh":[{"descriptor_ui":"D000077022","descriptor_name":"Survivin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056484","descriptor_name":"Jumonji Domain-Containing Histone Demethylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D063150","descriptor_name":"Polycomb Repressive Complex 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/stem.1274","doi":"https://doi.org/10.1002/stem.1274","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.1274","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},{"id":"pmid:23132836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23132836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1382893","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1382893/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"STEM CELLS , 31 (1) pp. 190-202. (2013)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2545119290","display_name":null,"funder_award_id":"G0800020","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4535551028","display_name":null,"funder_award_id":"85704","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320050","display_name":"Ataxia UK","ror":"https://ror.org/03192vt15"},{"id":"https://openalex.org/F4320320096","display_name":"Samantha Dickson Brain Tumour Trust","ror":"https://ror.org/01k33dw46"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1481473039","https://openalex.org/W1555449469","https://openalex.org/W1558742074","https://openalex.org/W1964374858","https://openalex.org/W1966383291","https://openalex.org/W1967240484","https://openalex.org/W1971576831","https://openalex.org/W1977836335","https://openalex.org/W1980017984","https://openalex.org/W1986072799","https://openalex.org/W1989643386","https://openalex.org/W1995652309","https://openalex.org/W2001113618","https://openalex.org/W2001176921","https://openalex.org/W2008735740","https://openalex.org/W2010941702","https://openalex.org/W2014006702","https://openalex.org/W2018235103","https://openalex.org/W2019406647","https://openalex.org/W2022434488","https://openalex.org/W2024791894","https://openalex.org/W2039703653","https://openalex.org/W2040827479","https://openalex.org/W2044843189","https://openalex.org/W2046667238","https://openalex.org/W2048281866","https://openalex.org/W2049771264","https://openalex.org/W2053811330","https://openalex.org/W2053900401","https://openalex.org/W2056122831","https://openalex.org/W2062759109","https://openalex.org/W2076375511","https://openalex.org/W2079492199","https://openalex.org/W2082559623","https://openalex.org/W2082998819","https://openalex.org/W2090160159","https://openalex.org/W2091579735","https://openalex.org/W2092015913","https://openalex.org/W2094743676","https://openalex.org/W2102693681","https://openalex.org/W2109610561","https://openalex.org/W2111846773","https://openalex.org/W2123509170","https://openalex.org/W2140815401","https://openalex.org/W2140987848","https://openalex.org/W2153019757","https://openalex.org/W2155310347","https://openalex.org/W2157976581","https://openalex.org/W2158535498","https://openalex.org/W2289847171","https://openalex.org/W7074230359"],"related_works":["https://openalex.org/W2049771264","https://openalex.org/W745744196","https://openalex.org/W2127630080","https://openalex.org/W4232680489","https://openalex.org/W2315630015","https://openalex.org/W70729136","https://openalex.org/W2802284156","https://openalex.org/W2043141640","https://openalex.org/W4406243886","https://openalex.org/W2790208264"],"abstract_inverted_index":{"Polycomb":[0,24],"group":[1],"proteins":[2],"are":[3],"essential":[4],"regulators":[5],"of":[6,22,62,68,71,88],"stem":[7,34,144],"cell":[8,80],"function":[9],"during":[10],"embryonic":[11],"development":[12],"and":[13,82,129,142],"in":[14,31,40,56],"adult":[15],"tissue":[16],"homeostasis.":[17],"Bmi1,":[18],"a":[19,51,73,95],"key":[20],"component":[21],"the":[23,69,126,138,148,153],"Repressive":[25],"Complex":[26],"1,":[27],"is":[28,79,103],"highly":[29],"expressed":[30],"undifferentiated":[32,113],"neural":[33],"cells":[35,90,119,145],"(NSC)":[36],"as":[37,39,115,117],"well":[38,116],"several":[41],"human":[42],"cancers":[43],"including":[44],"high-grade":[45],"gliomas--highly":[46],"aggressive":[47],"brain":[48],"tumors.":[49],"Using":[50],"conditional":[52],"gene":[53],"activation":[54],"approach":[55],"mice,":[57],"we":[58,99],"show":[59,100],"that":[60,101,140],"overexpression":[61],"Bmi1":[63,159],"induces":[64],"repressive":[65],"epigenetic":[66],"regulation":[67],"promoter":[70,128],"Survivin,":[72],"well-characterized":[74],"antiapoptotic":[75],"protein.":[76],"This":[77],"phenomenon":[78],"type-specific":[81],"it":[83],"leads":[84],"to":[85],"apoptotic":[86,133],"death":[87],"progenitor":[89],"exclusively":[91],"upon":[92],"commitment":[93],"toward":[94],"neuronal":[96],"fate.":[97],"Moreover,":[98],"this":[102],"triggered":[104],"by":[105,157],"increased":[106,158],"oxidative":[107],"stress-induced":[108],"DNA":[109],"damage.":[110],"In":[111],"contrast,":[112],"NSC":[114],"glioma-initiating":[118],"display":[120],"an":[121],"open":[122],"chromatin":[123],"configuration":[124],"at":[125],"Survivin":[127],"do":[130],"not":[131],"undergo":[132],"death.":[134],"These":[135],"findings":[136],"raise":[137],"possibility":[139],"normal":[141],"neoplastic":[143],"depend":[146],"on":[147],"same":[149],"mechanism":[150],"for":[151],"surviving":[152],"hyperproliferative":[154],"state":[155],"induced":[156],"expression.":[160]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}