{"id":"https://openalex.org/W2064528186","doi":"https://doi.org/10.1186/2051-1426-2-s3-p176","title":"Induction of systemic anti-melanoma immunity through intratumoral TLR-7/8 activation","display_name":"Induction of systemic anti-melanoma immunity through intratumoral TLR-7/8 activation","publication_year":2014,"publication_date":"2014-11-06","ids":{"openalex":"https://openalex.org/W2064528186","doi":"https://doi.org/10.1186/2051-1426-2-s3-p176","mag":"2064528186"},"language":"en","primary_location":{"id":"doi:10.1186/2051-1426-2-s3-p176","doi":"https://doi.org/10.1186/2051-1426-2-s3-p176","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2051-1426-2-s3-p176","pdf_url":"https://jitc.bmj.com/content/jitc/2/Suppl_3/P176.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/jitc/2/Suppl_3/P176.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100675151","display_name":"Manisha Singh","orcid":"https://orcid.org/0000-0003-1983-4921","observed_orcids":["https://orcid.org/0000-0003-1983-4921","https://orcid.org/0000-0002-9453-5844"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Manisha Singh","raw_affiliation_strings":["Department of Melanoma Medical Oncology","The University of Texas MD Anderson Cancer Center","Department of Melanoma Medical Oncology, the University of Texas, MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Melanoma Medical Oncology","institution_ids":[]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Melanoma Medical Oncology, the University of Texas, MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081367567","display_name":"Hiep Khong","orcid":"https://orcid.org/0000-0003-4888-7862","observed_orcids":["https://orcid.org/0000-0003-4888-7862"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiep Khong","raw_affiliation_strings":["Department of Melanoma Medical Oncology","The University of Texas MD Anderson Cancer Center","Department of Melanoma Medical Oncology, the University of Texas, MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Melanoma Medical Oncology","institution_ids":[]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Melanoma Medical Oncology, the University of Texas, MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056223928","display_name":"Zhimin Dai","orcid":"https://orcid.org/0000-0001-7065-6038","observed_orcids":["https://orcid.org/0000-0001-7065-6038"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhimin Dai","raw_affiliation_strings":["Department of Melanoma Medical Oncology","The University of Texas MD Anderson Cancer Center","Department of Melanoma Medical Oncology, the University of Texas, MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Melanoma Medical Oncology","institution_ids":[]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Melanoma Medical Oncology, the University of Texas, MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017576585","display_name":"John P. Vasilakos","orcid":"https://orcid.org/0000-0002-1075-9665","observed_orcids":["https://orcid.org/0000-0002-1075-9665"]},"institutions":[{"id":"https://openalex.org/I1340755506","display_name":"3M (United States)","ror":"https://ror.org/00mgss748","country_code":"US","type":"company","lineage":["https://openalex.org/I1340755506"]},{"id":"https://openalex.org/I4210145772","display_name":"Kindeva Drug Delivery (United States)","ror":"https://ror.org/04j0nks26","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145772"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P Vasilakos","raw_affiliation_strings":["3M Company","3M Drug Delivery Systems Division","3M Drug Delivery Systems Division, 3M Company, St. Paul, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3M Company","institution_ids":["https://openalex.org/I1340755506"]},{"raw_affiliation_string":"3M Drug Delivery Systems Division","institution_ids":["https://openalex.org/I4210145772"]},{"raw_affiliation_string":"3M Drug Delivery Systems Division, 3M Company, St. Paul, USA","institution_ids":["https://openalex.org/I1340755506","https://openalex.org/I4210145772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033798832","display_name":"Patrick Hwu","orcid":"https://orcid.org/0000-0002-8293-1313","observed_orcids":["https://orcid.org/0000-0002-8293-1313","https://orcid.org/0000-0003-0554-2856"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Hwu","raw_affiliation_strings":["Department of Melanoma Medical Oncology","The University of Texas MD Anderson Cancer Center","Department of Melanoma Medical Oncology, the University of Texas, MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Melanoma Medical Oncology","institution_ids":[]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Melanoma Medical Oncology, the University of Texas, MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044032746","display_name":"Willem W. Overwijk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Willem W Overwijk","raw_affiliation_strings":["Department of Melanoma Medical Oncology","The University of Texas MD Anderson Cancer Center","Department of Melanoma Medical Oncology, the University of Texas, MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Melanoma Medical Oncology","institution_ids":[]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Melanoma Medical Oncology, the University of Texas, MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100675151"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.11695824,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2","issue":"S3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8740000128746033},{"id":"https://openalex.org/keywords/systemic-antitumor-immunity","display_name":"systemic antitumor immunity","score":0.8069999814033508},{"id":"https://openalex.org/keywords/imiquimod","display_name":"imiquimod","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8057010173797607},{"id":"https://openalex.org/C2779112978","wikidata":"https://www.wikidata.org/wiki/Q423417","display_name":"Imiquimod","level":2,"score":0.7847816944122314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.772818922996521},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.6262196898460388},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5416659712791443},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4955826997756958},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4803158640861511},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46979865431785583},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16910791397094727},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16818827390670776}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/2051-1426-2-s3-p176","doi":"https://doi.org/10.1186/2051-1426-2-s3-p176","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2051-1426-2-s3-p176","pdf_url":"https://jitc.bmj.com/content/jitc/2/Suppl_3/P176.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3263485","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4288567","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4288567","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4288567","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Immunother Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/2051-1426-2-s3-p176","doi":"https://doi.org/10.1186/2051-1426-2-s3-p176","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2051-1426-2-s3-p176","pdf_url":"https://jitc.bmj.com/content/jitc/2/Suppl_3/P176.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8799999952316284}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2064528186.pdf","grobid_xml":"https://content.openalex.org/works/W2064528186.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1676851385","https://openalex.org/W2089738194","https://openalex.org/W2156066416","https://openalex.org/W2010333332","https://openalex.org/W2130208695","https://openalex.org/W1964915313","https://openalex.org/W2588948315","https://openalex.org/W4406768048","https://openalex.org/W1944300754","https://openalex.org/W2133403756"],"abstract_inverted_index":{"Meeting":[0],"abstracts":[1],"Intratumoral":[2],"immune":[3],"activation":[4],"can":[5],"induce":[6],"systemic":[7],"immunity":[8],"and":[9],"anti-tumor":[10],"activity.":[11],"Imiquimod":[12],"is":[13,19],"a":[14],"cream-formulated,":[15],"TLR-7":[16],"agonist":[17],"that":[18],"FDA-approved":[20],"for":[21],"the":[22,35,40],"treatment":[23],"of":[24],"non-melanoma":[25],"skin":[26],"cancers,":[27],"but":[28],"has":[29],"limited":[30],"activity":[31],"against":[32],"melanoma.":[33],"In":[34],"current":[36],"study,":[37],"we":[38],"studied":[39]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
