{"id":"https://openalex.org/W2064508145","doi":"https://doi.org/10.1046/j.1525-1500.1999.99041.x","title":"Helicobacter pylori Infection on the Risk of Stomach Cancer and Chronic Atrophic Gastritis","display_name":"Helicobacter pylori Infection on the Risk of Stomach Cancer and Chronic Atrophic Gastritis","publication_year":1999,"publication_date":"1999-09-03","ids":{"openalex":"https://openalex.org/W2064508145","doi":"https://doi.org/10.1046/j.1525-1500.1999.99041.x","mag":"2064508145","pmid":"https://pubmed.ncbi.nlm.nih.gov/10468887"},"language":"en","primary_location":{"id":"doi:10.1046/j.1525-1500.1999.99041.x","doi":"https://doi.org/10.1046/j.1525-1500.1999.99041.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1525-1500.1999.99041.x","pdf_url":null,"source":{"id":"https://openalex.org/S197761248","display_name":"Cancer Detection and Prevention","issn_l":"0361-090X","issn":["0361-090X","1525-1500","1873-443X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Detection <html_ent glyph=\"@amp;\" ascii=\"&\"/> Prevention","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100661022","display_name":"Zuo\u2010Feng Zhang","orcid":"https://orcid.org/0000-0002-4669-3995","observed_orcids":["https://orcid.org/0000-0002-4669-3995"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zuo-Feng Zhang","raw_affiliation_strings":["Department of Epidemiology, School of Public Health, University of California, Los Angeles 90095-1772, USA. zfzhang@ucla.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, University of California, Los Angeles 90095-1772, USA. zfzhang@ucla.edu","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089633724","display_name":"Robert C. Kurtz","orcid":"https://orcid.org/0009-0002-6493-3136","observed_orcids":["https://orcid.org/0009-0002-6493-3136"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert C. Kurtz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016615488","display_name":"David S. Klimstra","orcid":"https://orcid.org/0000-0001-8814-1702","observed_orcids":["https://orcid.org/0000-0001-8814-1702"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David S. Klimstra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104706903","display_name":"Guo\u2010Pei Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guo-Pei Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100739026","display_name":"Ming Hua Sun","orcid":"https://orcid.org/0009-0006-3798-1772","observed_orcids":["https://orcid.org/0009-0006-3798-1772"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020686995","display_name":"Susan Harlap","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan Harlap","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068873690","display_name":"James Roger Marshall","orcid":"https://orcid.org/0000-0001-8956-5945","observed_orcids":["https://orcid.org/0000-0001-8956-5945"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James R. Marshall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6999,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.84326784,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"23","issue":"5","first_page":"357","last_page":"367"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori-infection","display_name":"Helicobacter pylori infection","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.843999981880188},{"id":"https://openalex.org/keywords/gastric-adenocarcinoma","display_name":"gastric adenocarcinoma","score":0.9419999718666077},{"id":"https://openalex.org/keywords/chronic-atrophic-gastritis","display_name":"chronic atrophic gastritis","score":1.0},{"id":"https://openalex.org/keywords/gastric-carcinogenesis","display_name":"gastric carcinogenesis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cancer-risk-factors","display_name":"cancer risk factors","score":0.8119999766349792},{"id":"https://openalex.org/keywords/barrett-s-esophagus","display_name":"Barrett's esophagus","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.83228600025177},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.8042753338813782},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7909142971038818},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.7342559695243835},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7057858109474182},{"id":"https://openalex.org/C2780342937","wikidata":"https://www.wikidata.org/wiki/Q1826391","display_name":"Atrophic gastritis","level":4,"score":0.693041980266571},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6595004796981812},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.5641125440597534},{"id":"https://openalex.org/C2778677798","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Gastritis","level":3,"score":0.5351553559303284},{"id":"https://openalex.org/C2780561475","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Chronic gastritis","level":4,"score":0.5244362950325012},{"id":"https://openalex.org/C2779454504","wikidata":"https://www.wikidata.org/wiki/Q189588","display_name":"Stomach cancer","level":3,"score":0.5054562091827393},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4912835955619812},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4705158770084381},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.44831401109695435},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.4160766005516052}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005757","descriptor_name":"Gastritis, Atrophic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D005757","descriptor_name":"Gastritis, Atrophic","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012923","descriptor_name":"Social Class","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1525-1500.1999.99041.x","doi":"https://doi.org/10.1046/j.1525-1500.1999.99041.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1525-1500.1999.99041.x","pdf_url":null,"source":{"id":"https://openalex.org/S197761248","display_name":"Cancer Detection and Prevention","issn_l":"0361-090X","issn":["0361-090X","1525-1500","1873-443X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Detection <html_ent glyph=\"@amp;\" ascii=\"&\"/> Prevention","raw_type":"journal-article"},{"id":"pmid:10468887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10468887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer detection and prevention","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G113393988","display_name":"HELICOBACTER PYLORI MALNUTRITION AND GASTRIC CANCER","funder_award_id":"R03CA077954","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1435024265","display_name":null,"funder_award_id":"CA09142","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1543282891","display_name":null,"funder_award_id":"CA-16 042","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1903666658","display_name":"Molecular Epidemiology Cancer Training Program","funder_award_id":"T32CA009142","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3586596048","display_name":null,"funder_award_id":"CA 77954","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000898870","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016042","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W798854675","https://openalex.org/W1517038934","https://openalex.org/W1558856267","https://openalex.org/W1869777705","https://openalex.org/W1925114179","https://openalex.org/W1928757746","https://openalex.org/W1946101213","https://openalex.org/W1965653329","https://openalex.org/W1971849405","https://openalex.org/W1973986539","https://openalex.org/W1975664925","https://openalex.org/W1984086668","https://openalex.org/W1984499682","https://openalex.org/W1994863727","https://openalex.org/W2000772918","https://openalex.org/W2002313026","https://openalex.org/W2009083974","https://openalex.org/W2015410734","https://openalex.org/W2021335575","https://openalex.org/W2024629965","https://openalex.org/W2035930633","https://openalex.org/W2043018752","https://openalex.org/W2043698485","https://openalex.org/W2044124936","https://openalex.org/W2049305559","https://openalex.org/W2053746009","https://openalex.org/W2067412540","https://openalex.org/W2069646542","https://openalex.org/W2070152937","https://openalex.org/W2075538163","https://openalex.org/W2077643591","https://openalex.org/W2086258355","https://openalex.org/W2086716942","https://openalex.org/W2104244059","https://openalex.org/W2109237610","https://openalex.org/W2138011982","https://openalex.org/W2160504871","https://openalex.org/W2244591164","https://openalex.org/W2285875120","https://openalex.org/W2320937221","https://openalex.org/W2321415533","https://openalex.org/W2403678709","https://openalex.org/W2413836750","https://openalex.org/W2417673902","https://openalex.org/W2422282719"],"related_works":["https://openalex.org/W2026860891","https://openalex.org/W2374149423","https://openalex.org/W2320937221","https://openalex.org/W2965674425","https://openalex.org/W2802514000","https://openalex.org/W2086716942","https://openalex.org/W4407798097","https://openalex.org/W1970974308","https://openalex.org/W2131644309","https://openalex.org/W2164377137"],"abstract_inverted_index":{"Helicobacter":[0],"pylori":[1,27,88,109,157,231,271],"infection":[2,28,89,110,158,232,272],"is":[3],"associated":[4,106,161],"with":[5,41,49,107,130,133,162,169,174,176,197,210],"gastric":[6,34,126,199],"adenocarcinoma.":[7],"However,":[8],"the":[9,23,44,223,237,247,265],"mechanisms":[10],"of":[11,25,43,137,164,240,242,249,260],"this":[12],"interaction":[13],"are":[14],"still":[15],"unclear.":[16],"This":[17,36,190],"study":[18,37],"was":[19,90,111,159,192],"conducted":[20],"to":[21,69,268],"explore":[22],"effects":[24],"H.":[26,87,108,156,230,270],"on":[29],"early":[30,238,266],"and":[31,54,120,149,152,201,208,254],"late":[32],"stage":[33,239,267],"carcinogenesis.":[35],"included":[38],"134":[39],"patients":[40,48,168,175,196,209],"adenocarcinoma":[42],"stomach":[45,165,170,250,261],"(ACS),":[46],"67":[47],"chronic":[50,202],"atrophic":[51],"gastritis":[52,203],"(CAG),":[53],"65":[55],"normal":[56,131],"controls":[57,215],"recruited":[58],"at":[59],"Memorial":[60],"Sloan-Kettering":[61],"Cancer":[62,81],"Center":[63],"(MSKCC)":[64],"from":[65,252],"November":[66,70],"1,":[67,71],"1992":[68],"1994.":[72],"Epidemiologic":[73],"data":[74],"were":[75,97,172,204,212],"collected":[76],"by":[77,92],"a":[78],"modified":[79],"National":[80],"Institute":[82],"Health":[83],"Habits":[84],"History":[85],"Questionnaire.":[86],"diagnosed":[91],"pathological":[93],"evaluation.":[94],"Risk":[95],"factors":[96],"analyzed":[98],"using":[99],"logistic":[100],"regression.":[101],"The":[102],"odds":[103],"ratio":[104],"(OR)":[105],"10.4":[112],"[95%":[113],"confidence":[114],"interval":[115],"(CI):":[116],"2.6-41.6]":[117],"for":[118,125,135,186,258],"CAG":[119,177,211],"11.2":[121],"(95%":[122],"CI:":[123,182,220],"2.5-50.3)":[124],"cancer":[127,166,171,200,251,262],"in":[128,222,236,246,273],"comparison":[129],"controls,":[132],"adjustment":[134],"pack-years":[136],"smoking,":[138],"alcohol":[139],"drinking,":[140],"body":[141],"mass":[142],"index,":[143],"total":[144],"caloric":[145],"intake,":[146,151],"dietary":[147],"fat":[148],"fiber":[150],"Barrett's":[153],"esophagus.":[154],"But":[155],"not":[160,245],"risk":[163],"when":[167,194],"compared":[173],"(OR":[178,216],"=":[179,217],"0.6,":[180],"95%":[181,219],"0.3-1.3)":[183],"after":[184],"controlling":[185],"potential":[187],"confounding":[188],"variables.":[189],"association":[191],"persistent":[193],"only":[195],"both":[198],"considered":[205,213],"as":[206,214],"cases":[207],"0.7,":[218],"0.3-2.0)":[221],"multivariate":[224],"analysis.":[225],"Our":[226],"results":[227],"suggest":[228],"that":[229,256],"may":[233],"be":[234],"involved":[235],"development":[241,248],"CAG,":[243,253],"but":[244],"indicate":[255],"strategies":[257],"prevention":[259],"should":[263],"target":[264],"eliminate":[269],"high-risk":[274],"populations.":[275]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}