{"id":"https://openalex.org/W2064495656","doi":"https://doi.org/10.1158/1538-7445.am10-3139","title":"Abstract 3139: Chromosomal copy number alterations involved in Ras/PI3-kinase pathway in endometrial carcinomas","display_name":"Abstract 3139: Chromosomal copy number alterations involved in Ras/PI3-kinase pathway in endometrial carcinomas","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2064495656","doi":"https://doi.org/10.1158/1538-7445.am10-3139","mag":"2064495656"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-3139","doi":"https://doi.org/10.1158/1538-7445.am10-3139","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-3139","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004301579","display_name":"Yuji Ikeda","orcid":"https://orcid.org/0000-0003-1633-5385","observed_orcids":["https://orcid.org/0000-0003-1633-5385"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Ikeda","raw_affiliation_strings":["1Department of OB&GYN, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of OB&GYN, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010124046","display_name":"Katsutoshi Oda","orcid":"https://orcid.org/0000-0002-2468-9573","observed_orcids":["https://orcid.org/0000-0002-2468-9573"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsutoshi Oda","raw_affiliation_strings":["1Department of OB&GYN, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of OB&GYN, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053887768","display_name":"Satsuki Murayama-Hosokawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satsuki Murayama-Hosokawa","raw_affiliation_strings":["1Department of OB&GYN, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of OB&GYN, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091207706","display_name":"Shunsuke Nakagawa","orcid":"https://orcid.org/0000-0003-3299-7370","observed_orcids":["https://orcid.org/0000-0003-3299-7370"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunsuke Nakagawa","raw_affiliation_strings":["1Department of OB&GYN, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of OB&GYN, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049613195","display_name":"Shumpei Ishikawa","orcid":"https://orcid.org/0000-0003-4392-090X","observed_orcids":["https://orcid.org/0000-0003-4392-090X"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shumpei Ishikawa","raw_affiliation_strings":["2Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085203051","display_name":"Shogo Yamamoto","orcid":"https://orcid.org/0000-0002-5564-2567","observed_orcids":["https://orcid.org/0000-0002-5564-2567"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shogo Yamamoto","raw_affiliation_strings":["2Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113623340","display_name":"Keiko Shoji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiko Shoji","raw_affiliation_strings":["1Department of OB&GYN, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of OB&GYN, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113880429","display_name":"Yuriko Uehara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuriko Uehara","raw_affiliation_strings":["1Department of OB&GYN, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of OB&GYN, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111761250","display_name":"Osamu Wada Hiraike","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Hiraike","raw_affiliation_strings":["1Department of OB&GYN, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of OB&GYN, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031155428","display_name":"Kei Kawana","orcid":"https://orcid.org/0000-0003-1919-8830","observed_orcids":["https://orcid.org/0000-0003-1919-8830"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei Kawana","raw_affiliation_strings":["1Department of OB&GYN, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of OB&GYN, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108226924","display_name":"Tetsu Yano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsu Yano","raw_affiliation_strings":["1Department of OB&GYN, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of OB&GYN, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113680132","display_name":"Frank McCormick","orcid":"https://orcid.org/0000-0002-6619-7120","observed_orcids":["https://orcid.org/0000-0002-6619-7120"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank McCormick","raw_affiliation_strings":["3Cancer Research Institute, The University of California, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Cancer Research Institute, The University of California, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112267027","display_name":"Shiro K\u014dzuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shiro Kozuma","raw_affiliation_strings":["1Department of OB&GYN, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of OB&GYN, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111581168","display_name":"Yuji Taketani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Taketani","raw_affiliation_strings":["1Department of OB&GYN, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of OB&GYN, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001413231","display_name":"Hiroyuki Aburatani","orcid":"https://orcid.org/0000-0003-0438-1544","observed_orcids":["https://orcid.org/0000-0003-0438-1544"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Aburatani","raw_affiliation_strings":["2Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"3139","last_page":"3139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.2985999882221222,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.2985999882221222,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.2167000025510788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.0966000035405159,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/chromosomal-copy-number-alterations","display_name":"chromosomal copy number alterations","score":0.9679999947547913},{"id":"https://openalex.org/keywords/copy-number-neutral-loss-of-heterozygosity","display_name":"copy number neutral loss of heterozygosity","score":0.9179999828338623},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9430000185966492},{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.9980000257492065},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.9570000171661377},{"id":"https://openalex.org/keywords/homozygous-deletion","display_name":"homozygous deletion","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9143109321594238},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7082048654556274},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.6642096042633057},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6367019414901733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5125033855438232},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.43459251523017883},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.42609840631484985},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4074169993400574},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3718150854110718},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3296445608139038},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20081698894500732},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.17189621925354004}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-3139","doi":"https://doi.org/10.1158/1538-7445.am10-3139","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-3139","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2089092431","https://openalex.org/W2034514162","https://openalex.org/W2313052974","https://openalex.org/W2045891438","https://openalex.org/W2013355610","https://openalex.org/W2028837470","https://openalex.org/W2010002962","https://openalex.org/W2154893943","https://openalex.org/W2047577938","https://openalex.org/W2047271282"],"abstract_inverted_index":{"Abstract":[0],"[Objectives]:":[1],"Activation":[2],"of":[3,58,69,127,162,168,187,210,264,269,284,291,335,340],"Ras/PI3-kinase":[4],"(PI3K)":[5],"pathway":[6,31,88,117,256,294,299],"plays":[7],"a":[8,55],"direct":[9],"causal":[10],"role":[11],"in":[12,19,37,66,85,93,114,118,141,165,213,220,237,253,289,303,313],"human":[13],"cancer.":[14,95],"Oncogenic":[15],"mutant":[16],"Ras":[17,25,59],"remains":[18],"active":[20],"state,":[21],"and":[22,49,60,122,148,156,181,197,217,266,271,295],"activates":[23],"various":[24],"effectors,":[26],"including":[27,107],"PI3K":[28],"pathway.":[29,240],"Ras/PI3K":[30,87,116,239,255,293,315],"activating":[32],"mutations":[33],"are":[34,89],"very":[35],"frequent":[36],"endometrial":[38,94,119,143,304],"cancer,":[39],"as":[40],"reported":[41,65,78,277],"at":[42,73,79,152,201,207],"35-55%":[43],"for":[44,47,51,344],"PTEN,":[45],"25-36%":[46],"PIK3CA":[48,155,211],"10-20%":[50],"K-Ras.":[52],"NF1":[53,202,246],"is":[54,77],"negative":[56],"regulator":[57],"its":[61],"alterations":[62,105,312],"have":[63],"been":[64,276],"several":[67],"types":[68,283],"tumors.":[70,223],"Although":[71],"LOH":[72,180,184,199,263,322,323],"PTEN":[74,163,265,270],"locus":[75,164],"(10q23.3)":[76],"15-30%,":[80],"other":[81,250],"chromosomal":[82,102],"imbalances":[83],"involved":[84,113,236,252],"the":[86,115,125,188,208,238,242,254,292,297,307,314,336,341],"not":[90,275],"well":[91],"characterized":[92],"In":[96,191],"this":[97],"study,":[98],"we":[99,131,204,226],"focused":[100],"on":[101],"copy":[103,108],"number":[104,109],"(CNAs),":[106],"neutral":[110],"(CNN)":[111],"LOH,":[112],"carcinomas.":[120],"[Materials":[121],"Methods]:":[123],"Under":[124],"approval":[126],"institutional":[128],"ethical":[129],"committees,":[130],"performed":[132],"250K":[133],"or":[134,233],"50K":[135],"Single":[136],"Nucleotide":[137],"Polymorphism":[138],"(SNP)":[139],"arrays":[140],"31":[142,169],"carcinomas":[144,305],"with":[145,173,178,183,231,245,249,306],"paired":[146],"DNA":[147],"examined":[149],"allele-specific":[150],"CNAs":[151,235,251,285],"K-Ras,":[153],"NF1,":[154,272],"PTEN.":[157],"[Results]:":[158],"We":[159],"detected":[160,227],"deletions":[161,175,247,268],"eight":[166],"out":[167],"(26%)":[170],"tumors;":[171],"one":[172,194,232],"homozygous":[174,267],"(HD),":[176],"four":[177,214,221,243],"CNN":[179,262],"three":[182,198],"without":[185],"gain":[186],"opposite":[189],"allele.":[190],"addition":[192],"to":[193],"HD":[195],"(3%)":[196],"(10%)":[200],"locus,":[203],"found":[205],"gains":[206],"loci":[209],"(3q26.3)":[212],"(13%)":[215,222],"tumors":[216,230,244],"K-Ras":[218],"(12p12.1)":[219],"Taken":[224],"together,":[225],"12":[228],"(39%)":[229],"more":[234],"All":[241],"coexist":[248],"(Table).":[257],"[Conclusion]:":[258],"Our":[259],"data":[260],"unveiled":[261],"which":[273],"had":[274],"by":[278],"conventional":[279],"CGH":[280],"analysis.":[281],"Various":[282],"might":[286,300],"play":[287],"roles":[288],"activation":[290],"targeting":[296],"Ras-PI3K":[298,308],"be":[301],"effective":[302],"related":[309],"CNAs.Table.Coexistent":[310],"CN":[311],"pathwayPTEN":[316],"(Loss)PIK3CA":[317],"(Gain)K-Ras":[318],"(Gain)NF1":[319],"(Loss)LOH":[320],"Gain":[321,324],"LOHLOHGain":[325],"HDLOHGainGainLOH":[326],"Citation":[327],"Format:":[328],"{Authors}.":[329],"{Abstract":[330],"title}":[331],"[abstract].":[332],"In:":[333],"Proceedings":[334],"101st":[337],"Annual":[338],"Meeting":[339],"American":[342],"Association":[343],"Cancer":[345,355],"Research;":[346],"2010":[347],"Apr":[348],"17-21;":[349],"Washington,":[350],"DC.":[351],"Philadelphia":[352],"(PA):":[353],"AACR;":[354],"Res":[356],"2010;70(8":[357],"Suppl):Abstract":[358],"nr":[359],"3139.":[360]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}