{"id":"https://openalex.org/W2064347238","doi":"https://doi.org/10.1021/bi00797a009","title":"Effect of substrate structure on the rate of the catalytic step in the liver alcohol dehydrogenase mechanism","display_name":"Effect of substrate structure on the rate of the catalytic step in the liver alcohol dehydrogenase mechanism","publication_year":1971,"publication_date":"1971-10-12","ids":{"openalex":"https://openalex.org/W2064347238","doi":"https://doi.org/10.1021/bi00797a009","mag":"2064347238","pmid":"https://pubmed.ncbi.nlm.nih.gov/4334279"},"language":"en","primary_location":{"id":"doi:10.1021/bi00797a009","doi":"https://doi.org/10.1021/bi00797a009","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00797a009","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Robert L. Brooks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert L. Brooks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110875015","display_name":"Joseph D. Shore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph D. Shore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":6.308,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.97384795,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"10","issue":"21","first_page":"3855","last_page":"3858"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-alcohol-dehydrogenase","display_name":"liver alcohol dehydrogenase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/substrate-structure","display_name":"substrate structure","score":0.7120000123977661},{"id":"https://openalex.org/keywords/catalytic-rate","display_name":"catalytic rate","score":0.8270000219345093},{"id":"https://openalex.org/keywords/enzyme-mechanism","display_name":"enzyme mechanism","score":0.6480000019073486},{"id":"https://openalex.org/keywords/alcohol-dehydrogenase","display_name":"alcohol dehydrogenase","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C2777344606","wikidata":"https://www.wikidata.org/wiki/Q410754","display_name":"Alcohol dehydrogenase","level":3,"score":0.7736366987228394},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7031323909759521},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.6353720426559448},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.6149668097496033},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.6070395708084106},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5952278971672058},{"id":"https://openalex.org/C2781415988","wikidata":"https://www.wikidata.org/wiki/Q4713306","display_name":"Alcohol oxidoreductase","level":4,"score":0.4742683172225952},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.4660305678844452},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3947930335998535},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38864612579345703},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29572105407714844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15598806738853455},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.1375950574874878},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10236170887947083},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000432","descriptor_name":"Methanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000433","descriptor_name":"1-Propanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005470","descriptor_name":"Fluorometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00797a009","doi":"https://doi.org/10.1021/bi00797a009","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00797a009","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:4334279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4334279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W132282532","https://openalex.org/W173174986","https://openalex.org/W1533946522","https://openalex.org/W1583558678","https://openalex.org/W1959540130","https://openalex.org/W1989001537","https://openalex.org/W2004964509","https://openalex.org/W2014667345","https://openalex.org/W2043392162","https://openalex.org/W2045535388","https://openalex.org/W2055550103","https://openalex.org/W2066724168","https://openalex.org/W2068625312","https://openalex.org/W2329174981","https://openalex.org/W2330219707"],"related_works":["https://openalex.org/W1997645827","https://openalex.org/W1966382672","https://openalex.org/W1999074506","https://openalex.org/W2058213227","https://openalex.org/W1980505953","https://openalex.org/W2023588906","https://openalex.org/W132793955","https://openalex.org/W1980129726","https://openalex.org/W2467085734","https://openalex.org/W1949397723"],"abstract_inverted_index":{"ADVERTISEMENT":[0],"RETURN":[1],"TO":[2],"ISSUEPREVArticleNEXTEffect":[3],"of":[4,10,57,92,118],"substrate":[5],"structure":[6],"on":[7,129,157],"the":[8,11,15,54,85,90,119,130,143,146,151,158,164],"rate":[9],"catalytic":[12],"step":[13],"in":[14],"liver":[16],"alcohol":[17],"dehydrogenase":[18],"mechanismRobert":[19],"L.":[20],"Brooks":[21],"and":[22,67,72,101,145,162,178,180],"Joseph":[23],"D.":[24],"ShoreCite":[25],"this:":[26],"Biochemistry":[27],"1971,":[28],"10,":[29],"21,":[30],"3855\u20133858Publication":[31],"Date":[32],"(Print):October":[33],"12,":[34],"1971Publication":[35],"History":[36],"Published":[37],"online1":[38],"May":[39],"2002Published":[40],"inissue":[41],"12":[42],"October":[43],"1971https://pubs.acs.org/doi/10.1021/bi00797a009https://doi.org/10.1021/bi00797a009research-articleACS":[44],"PublicationsRequest":[45],"reuse":[46],"permissionsArticle":[47],"Views423Altmetric-Citations44LEARN":[48],"ABOUT":[49],"THESE":[50],"METRICSArticle":[51],"Views":[52],"are":[53,76,89],"COUNTER-compliant":[55],"sum":[56],"full":[58],"text":[59],"article":[60,124],"downloads":[61],"since":[62],"November":[63],"2008":[64],"(both":[65],"PDF":[66],"HTML)":[68],"across":[69],"all":[70],"institutions":[71],"individuals.":[73],"These":[74],"metrics":[75],"regularly":[77],"updated":[78,102],"to":[79,84],"reflect":[80],"usage":[81],"leading":[82],"up":[83],"last":[86],"few":[87],"days.Citations":[88],"number":[91],"other":[93],"articles":[94],"citing":[95],"this":[96],"article,":[97],"calculated":[98],"by":[99],"Crossref":[100,108],"daily.":[103],"Find":[104,154],"more":[105,155],"information":[106,156],"about":[107,142],"citation":[109],"counts.The":[110],"Altmetric":[111,159],"Attention":[112,160],"Score":[113,161],"is":[114,166],"a":[115,122,135],"quantitative":[116],"measure":[117],"attention":[120],"that":[121],"research":[123],"has":[125],"received":[126],"online.":[127],"Clicking":[128],"donut":[131],"icon":[132],"will":[133],"load":[134],"page":[136],"at":[137],"altmetric.com":[138],"with":[139,174],"additional":[140],"details":[141],"score":[144,165],"social":[147],"media":[148],"presence":[149],"for":[150],"given":[152],"article.":[153],"how":[163],"calculated.":[167],"Share":[168,183],"Add":[169],"toView":[170],"InAdd":[171],"Full":[172],"Text":[173],"ReferenceAdd":[175],"Description":[176],"ExportRISCitationCitation":[177],"abstractCitation":[179],"referencesMore":[181],"Options":[182],"onFacebookTwitterWechatLinked":[184],"InRedditEmail":[185],"Other":[186],"access":[187],"optionsGet":[188],"e-Alertsclose":[189],"Get":[190],"e-Alerts":[191]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
