{"id":"https://openalex.org/W2064150552","doi":"https://doi.org/10.1172/jci119219","title":"Shear stress induction of the tissue factor gene.","display_name":"Shear stress induction of the tissue factor gene.","publication_year":1997,"publication_date":"1997-02-15","ids":{"openalex":"https://openalex.org/W2064150552","doi":"https://doi.org/10.1172/jci119219","mag":"2064150552","pmid":"https://pubmed.ncbi.nlm.nih.gov/9045878","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/507858"},"language":"en","primary_location":{"id":"doi:10.1172/jci119219","doi":"https://doi.org/10.1172/jci119219","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci119219","pdf_url":"http://www.jci.org/articles/view/119219/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/119219/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025028759","display_name":"Kurt Ming-Chao Lin","orcid":"https://orcid.org/0000-0003-1371-5569","observed_orcids":["https://orcid.org/0000-0003-1371-5569"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M C Lin","raw_affiliation_strings":["Department of Bioengineering and Institute for Biomedical Engineering, University of California, San Diego, La Jolla 92093-0412, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Institute for Biomedical Engineering, University of California, San Diego, La Jolla 92093-0412, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035369818","display_name":"Fanny Almus-Jacobs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F Almus-Jacobs","raw_affiliation_strings":["Department of Bioengineering and Institute for Biomedical Engineering , University of California , San Diego , La Jolla , California 92093- 0412 ;","University of California at San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Institute for Biomedical Engineering , University of California , San Diego , La Jolla , California 92093- 0412 ;","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"University of California at San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025846764","display_name":"Hsiao\u2010Huei Chen","orcid":"https://orcid.org/0000-0003-2914-6057","observed_orcids":["https://orcid.org/0000-0003-2914-6057"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H H Chen","raw_affiliation_strings":["Department of Bioengineering and Institute for Biomedical Engineering , University of California , San Diego , La Jolla , California 92093- 0412 ;","University of California at San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Institute for Biomedical Engineering , University of California , San Diego , La Jolla , California 92093- 0412 ;","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"University of California at San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070032076","display_name":"Graham C. Parry","orcid":"https://orcid.org/0000-0002-3009-4947","observed_orcids":["https://orcid.org/0000-0002-3009-4947"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G C Parry","raw_affiliation_strings":["Department of Immunology and Vascular Biology , The Scripps Research Institute , La Jolla , California 92037","Scripps Research Institute#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Vascular Biology , The Scripps Research Institute , La Jolla , California 92037","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Scripps Research Institute#TAB#","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075629445","display_name":"Nigel Mackman","orcid":"https://orcid.org/0000-0002-9170-7700","observed_orcids":["https://orcid.org/0000-0002-9170-7700"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Mackman","raw_affiliation_strings":["Department of Immunology and Vascular Biology , The Scripps Research Institute , La Jolla , California 92037","Scripps Research Institute#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Vascular Biology , The Scripps Research Institute , La Jolla , California 92037","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Scripps Research Institute#TAB#","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J Y Shyy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Y Shyy","raw_affiliation_strings":["Department of Bioengineering and Institute for Biomedical Engineering , University of California , San Diego , La Jolla , California 92093- 0412 ;","University of California at San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Institute for Biomedical Engineering , University of California , San Diego , La Jolla , California 92093- 0412 ;","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"University of California at San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068335042","display_name":"Shu Chien","orcid":"https://orcid.org/0000-0003-0332-285X","observed_orcids":["https://orcid.org/0000-0003-0332-285X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Chien","raw_affiliation_strings":["Department of Bioengineering and Institute for Biomedical Engineering , University of California , San Diego , La Jolla , California 92093- 0412 ;","University of California at San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Institute for Biomedical Engineering , University of California , San Diego , La Jolla , California 92093- 0412 ;","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"University of California at San Diego","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":11.4877,"has_fulltext":true,"cited_by_count":233,"citation_normalized_percentile":{"value":0.99073705,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"99","issue":"4","first_page":"737","last_page":"744"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.9509999752044678},{"id":"https://openalex.org/keywords/gene-induction","display_name":"gene induction","score":0.5289999842643738},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.859000027179718},{"id":"https://openalex.org/keywords/sp1-phosphorylation","display_name":"Sp1 phosphorylation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/egr1","display_name":"EGR1","score":0.9169999957084656},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.578000009059906},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5630000233650208},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7680000066757202},{"id":"https://openalex.org/keywords/procoagulant-activity","display_name":"procoagulant activity","score":0.8790000081062317},{"id":"https://openalex.org/keywords/okadaic-acid","display_name":"okadaic acid","score":0.8399999737739563},{"id":"https://openalex.org/keywords/laminar-shear-stress","display_name":"laminar shear stress","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6304243206977844},{"id":"https://openalex.org/C57467964","wikidata":"https://www.wikidata.org/wiki/Q14888082","display_name":"Sp1 transcription factor","level":5,"score":0.597392737865448},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5586754679679871},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.543670654296875},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5189989805221558},{"id":"https://openalex.org/C2776953658","wikidata":"https://www.wikidata.org/wiki/Q414042","display_name":"Okadaic acid","level":4,"score":0.4991884231567383},{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.4606160819530487},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.4380711615085602},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4203358292579651},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.35050147771835327},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34821343421936035},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.3371807336807251},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.284741073846817},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16834750771522522},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11127841472625732},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1095552146434784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07116663455963135},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013925","descriptor_name":"Thromboplastin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013925","descriptor_name":"Thromboplastin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016329","descriptor_name":"Sp1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018056","descriptor_name":"Hemorheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1172/jci119219","doi":"https://doi.org/10.1172/jci119219","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci119219","pdf_url":"http://www.jci.org/articles/view/119219/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:507858","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/507858","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:9045878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9045878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.333.6677","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.6677","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www-bioeng.ucsd.edu/research/research_groups/chien_lab/PDFs/LinMC_TF1997.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.842.9132","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.842.9132","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dm5migu4zj3pb.cloudfront.net/manuscripts/119000/119219/JCI97119219.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1172/jci119219","doi":"https://doi.org/10.1172/jci119219","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci119219","pdf_url":"http://www.jci.org/articles/view/119219/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1337687520","display_name":null,"funder_award_id":"HL-19454","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4842490454","display_name":"Biomechanics of the Heart, Vessels, and Blood Cells","funder_award_id":"P01HL043026","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6276581941","display_name":null,"funder_award_id":"HL43026","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8798458621","display_name":"Molecular Mechanism of Endothelial Migration Under Flow","funder_award_id":"R01HL019454","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000136085","display_name":null,"funder_award_id":"HL43026","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G965982975","display_name":null,"funder_award_id":"HL56707","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2064150552.pdf","grobid_xml":"https://content.openalex.org/works/W2064150552.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1493889956","https://openalex.org/W1507312029","https://openalex.org/W1508491294","https://openalex.org/W1548437752","https://openalex.org/W1567544003","https://openalex.org/W1580041996","https://openalex.org/W1936770188","https://openalex.org/W1964304127","https://openalex.org/W1964814612","https://openalex.org/W1970083280","https://openalex.org/W1971499128","https://openalex.org/W1974881056","https://openalex.org/W1978139625","https://openalex.org/W1979647722","https://openalex.org/W1981727007","https://openalex.org/W1987183412","https://openalex.org/W1988185657","https://openalex.org/W1991300666","https://openalex.org/W1992803891","https://openalex.org/W1996358960","https://openalex.org/W1999083451","https://openalex.org/W2001381510","https://openalex.org/W2006184287","https://openalex.org/W2009594902","https://openalex.org/W2015782951","https://openalex.org/W2019673194","https://openalex.org/W2022104672","https://openalex.org/W2031131334","https://openalex.org/W2031805948","https://openalex.org/W2032812024","https://openalex.org/W2051864488","https://openalex.org/W2052917676","https://openalex.org/W2063767041","https://openalex.org/W2068125806","https://openalex.org/W2069370313","https://openalex.org/W2071366179","https://openalex.org/W2072737643","https://openalex.org/W2077708687","https://openalex.org/W2078789063","https://openalex.org/W2100124039","https://openalex.org/W2110404024","https://openalex.org/W2124149576","https://openalex.org/W2128539657","https://openalex.org/W2134812217","https://openalex.org/W2150608680","https://openalex.org/W2157603347","https://openalex.org/W2159929059","https://openalex.org/W2164228805","https://openalex.org/W2168592519","https://openalex.org/W2331293529","https://openalex.org/W2341345696","https://openalex.org/W2427423710","https://openalex.org/W4235362895","https://openalex.org/W4246545334"],"related_works":["https://openalex.org/W7100728719","https://openalex.org/W2104519045","https://openalex.org/W2377840862","https://openalex.org/W2351949032","https://openalex.org/W2373292060","https://openalex.org/W2158438088","https://openalex.org/W2021219725","https://openalex.org/W1990782417","https://openalex.org/W2256945679","https://openalex.org/W2078789063"],"abstract_inverted_index":{"Using":[0],"flow":[1],"channel,":[2],"we":[3],"report":[4],"that":[5,56,139,150,168],"the":[6,40,44,49,65,76,81,85,143,154,160,169],"application":[7],"of":[8,17,39,48,64,75,87,114,128,145,163,173,189],"a":[9,14,34,57,96,186],"laminar":[10],"shear":[11,91,99,140,151,170],"stress":[12,100,141,171],"induced":[13],"transient":[15,37],"increase":[16,111],"tissue":[18],"factor":[19,136],"(TF)":[20],"procoagulant":[21],"activity":[22,162,184],"in":[23,43,112],"human":[24],"umbilical":[25],"vein":[26],"endothelial":[27],"cells":[28,119],"(HUVEC),":[29],"which":[30],"was":[31,70,109],"accompanied":[32],"by":[33],"rapid":[35],"and":[36,67],"induction":[38,172],"TF":[41,52,88,174],"mRNA":[42],"HUVEC.":[45],"Functional":[46],"analysis":[47],"2.2":[50],"kb":[51],"5'":[53],"promoter":[54,89],"indicated":[55],"GC-rich":[58],"region":[59],"containing":[60],"three":[61],"copies":[62],"each":[63],"EGR-1":[66,82],"Sp1":[68,77,94,122,137,182],"sites":[69],"required":[71],"for":[72],"induction.":[73],"Mutation":[74],"sites,":[78,83],"but":[79],"not":[80],"attenuated":[84],"response":[86],"to":[90,120],"stress.":[92],"Thus,":[93],"is":[95,177],"newly":[97],"defined":[98],"responsive":[101],"element.":[102],"Electrophoretic":[103],"mobility":[104],"shift":[105],"assays":[106],"showed":[107,149],"there":[108],"no":[110],"binding":[113],"nuclear":[115,130],"extracts":[116,131],"from":[117],"sheared":[118],"an":[121,180],"consensus":[123],"site.":[124],"In":[125],"contrast,":[126],"immunoblotting":[127],"these":[129],"with":[132,185],"antibody":[133],"against":[134],"transcription":[135],"demonstrated":[138],"increased":[142,159,181],"phosphorylation":[144],"Sp1.":[146,164,190],"We":[147],"also":[148],"stress,":[152],"like":[153],"phosphatase":[155],"inhibitor":[156],"okadaic":[157],"acid,":[158],"transcriptional":[161,183],"These":[165],"findings":[166],"suggest":[167],"gene":[175],"expression":[176],"mediated":[178],"through":[179],"concomitant":[187],"hyperphosphorylation":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
